Patent application number | Description | Published |
20090069238 | ACTIVATABLE CLOSTRIDIAL TOXINS - Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids. | 03-12-2009 |
20110189162 | Modified Clostridial Toxins Comprising an Integrated Protease Cleavage Site-Binding Domain - The present specification discloses modified Clostridial toxins, compositions comprising an integrated protease cleavage site-binding domain, polynucleotide molecules encoding such modified Clostridial toxins and compositions comprising di-chain forms of such modified Clostridial toxins. | 08-04-2011 |
20110287517 | Degradable Clostridial Toxins - The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras. | 11-24-2011 |
20120207704 | Inhibiting Aberrant Blood Vessel Formation Using Growth Factor Retargeted Endopeptidases - The present specification discloses TVEMPs, compositions comprising such TVEMPs and methods of treating a disease or disorder associated with aberrant new blood vessel formation in a mammal using such TVEMP compositions. | 08-16-2012 |
20120207733 | Treating a Disease of Hyperproliferation Using Retargeted Endopeptidases - The present specification discloses TVEMPs, compositions comprising such TVEMPs and methods of treating cancer or a disease of hyperproliferation in a mammal using such TVEMP compositions. | 08-16-2012 |
20120207742 | Treatments Using PSMA Ligand Endopeptidases - The present specification discloses TVEMPs, compositions comprising such TVEMPs and methods of treating a prostate cancer, a benign prostatic hyperplasia, and/or neovascularization or pathological angiogenesis associated with a cancer in a mammal using such TVEMP compositions. | 08-16-2012 |
20120207743 | Inhibiting Aberrant Blood Vessel Formation Using Retargeted Endopeptidases - The present specification discloses TVEMPs, compositions comprising such TVEMPs and methods of treating a disease or disorder associated with aberrant new blood vessel formation in a mammal using such TVEMP compositions. | 08-16-2012 |
20120295330 | Methods Of Intracellular Conversion Of Single-Chain Proteins Into Their Di-Chain Form - The present specification discloses expression constructs comprising single-chain proteins comprising a di-chain loop region comprising an exogenous protease cleavage site and a protease that can cleave the exogenous protease cleavage site located within the di-chain loop, cell compositions comprising such expression construct, and intracellular methods of converting the single-chain protein into its di-chain form. | 11-22-2012 |
20130195838 | Methods of Treating Cancer Using Growth Factor Retargeted Endopeptidases - The present specification discloses TVEMPs, compositions comprising such TVEMPs and methods of treating cancer in a mammal using such TVEMP compositions. | 08-01-2013 |
20130196414 | DEGRADABLE CLOSTRIDIAL TOXINS - The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras. | 08-01-2013 |
20130224178 | Methods of Treating Cancer Using Glucagon-Like Hormone Retargeted Endopepidases - The present specification discloses TVEMPs, compositions comprising such TVEMPs and methods of treating cancer in a mammal using such TVEMP compositions. | 08-29-2013 |
20130273633 | DEGRADABLE CLOSTRIDIAL TOXINS - The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras. | 10-17-2013 |
20130288334 | DEGRADABLE CLOSTRIDIAL TOXINS - The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras. | 10-31-2013 |
20130330806 | DEGRADABLE CLOSTRIDIAL TOXINS - The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras. | 12-12-2013 |
20130330807 | DEGRADABLE CLOSTRIDIAL TOXINS - The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras. | 12-12-2013 |
20140030759 | Methods Of Intracellular Conversion Of Single-Chain Proteins Into Their Di-Chain Form - The present specification discloses expression constructs comprising single-chain proteins comprising a di-chain loop region comprising an exogenous protease cleavage site and a protease that can cleave the exogenous protease cleavage site located within the di-chain loop, cell compositions comprising such expression construct, and intracellular methods of converting the single-chain protein into its di-chain form. | 01-30-2014 |
20140127783 | Degradable Clostridial Toxins - The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras. | 05-08-2014 |
20140127784 | MODIFIED CLOSTRIDIAL TOXINS COMPRISING AN INTEGRATED PROTEASE CLEAVAGE SITE-BINDING DOMAIN - The present specification discloses modified Clostridial toxins, compositions comprising an integrated protease cleavage site-binding domain, polynucleotide molecules encoding such modified Clostridial toxins and compositions comprising di-chain forms of such modified Clostridial toxins. | 05-08-2014 |
20140220627 | Degradable Clostridial Toxins - The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras. | 08-07-2014 |