Ruddock
David B. Ruddock, Houston, TX US
Patent application number | Description | Published |
---|---|---|
20140360734 | PACKER SETTING MECHANISM - A packer system including a packer and a setting mechanism. The setting mechanism has a setting piston that is actuatable in response to a fluid pressure in order to set the packer with the setting piston. The setting mechanism prevents actuation of the setting piston until the pressure is decreased below a threshold pressure from a value greater than the threshold pressure. A method of setting a packer is also included. | 12-11-2014 |
Grenfell Saxon Ruddock, South Australia AU
Patent application number | Description | Published |
---|---|---|
20100044506 | AIRCRAFT - A method of retrofitting retractable floats to an aircraft such as a floatplane. The aircraft considered have existing landing gear such as wheeled landing gear to equip said aircraft to optionally takeoff or land on a solid surface such as a beach or landing strip, the method including the steps of: a) mounting at least one float retraction arm to the aircraft; and b) attaching the floats to the float retraction arm. Each float includes an air travel position in which it is secured close to the float retraction arm mounting location and/or the fuselage, and a deployed position in which the float is lower than the existing landing gear. In following the float retraction paths of travel of the float retraction arm and the floats between the air travel and deployed positions, the floats do not interfere with the existing landing gear or its operation. | 02-25-2010 |
John M. Ruddock, Westfield, IN US
Patent application number | Description | Published |
---|---|---|
20100025317 | REPLACEABLE FILTER CARTRIDGE - A filter assembly wherein a housing seat ( | 02-04-2010 |
John Noel Ruddock, Bebington GB
Patent application number | Description | Published |
---|---|---|
20090057447 | Aerosols - The design of the spray nozzle in an aerosol dispenser controls the characteristics of the spray that is produced. In a nozzle that comprises the elements of a multiplicity of inlet channels leading to a swirl chamber and an outlet orifice, the perception of wetness of a spray, such as an aqueous alcoholic deodorant spray, can be reduced by dimensioning the respective elements so that the sum of the widths of the inlet channels is less than the diameter of the swirl chamber and at least 1.5 times the diameter of the outlet orifice and the outlet orifice has a diameter of at least 0.3 mm together with the inlet channels being short, such as less than 0.5 mm. The new nozzle is especially suitable for spraying compositions having a low volatile organic carbon content and compositions comprising a significant proportion of water. | 03-05-2009 |
Kyle B. Ruddock, Fishers, IN US
Patent application number | Description | Published |
---|---|---|
20120303202 | ROBOTIC VEHICLE CONTROLLER - A control system is provided for automatically moving at least one machine along a desired path. | 11-29-2012 |
Lloyd Ruddock, Oulu FI
Patent application number | Description | Published |
---|---|---|
20120202245 | Method for Producing Natively Folded Proteins in a Prokaryotic Host - The present invention relates to a method for producing a protein of interest containing one or more disulfide bonds in its native state. The method comprises that a prokaryotic host cell is genetically engineered to express the protein of interest and a sulfhydryl oxidase in the cytoplasm of the host cell. The protein of interest is formed in a soluble form and contains disulfide bonds due to the presence of the sulfhydryl oxidase in the cytoplasm of said host cell. The present invention relates also to a prokaryotic host cell and a vector system for producing a protein of interest containing natively folded disulfide bonds. | 08-09-2012 |
20140342398 | Method for producing disulfide bond containing proteins in a prokaryotic cytoplasm - The present invention relates to a method for producing natively folded disulfide bond containing proteins in a prokaryotic host. The method comprises that in the cytoplasm of a prokaryotic cell is expressed protein(s) of interest that naturally contain disulfide bonds and naturally occurring or inverted transmembrane enzyme, wherein the cysteines of the active site(s) are naturally or after genetic engineering located towards the prokaryotic cytoplasm. The enzyme is selected from the group of VKOR, inverted VKOR (iVKOR) and inverted Dsb B (iDsb B). In the prokaryotic cell is also expressed cytoplasmic DsbA or a corresponding protein being capable of providing electrons to the active site(s) of VKOR, iVKOR or iDsbB. The invention relates also to a prokaryotic host cell and a vector system for producing natively folded disulfide bond containing proteins. | 11-20-2014 |
Mark W. Ruddock, Co Antrim GB
Patent application number | Description | Published |
---|---|---|
20120135886 | METHOD FOR DETECTION OF, OR THE RISK OF, BLADDER CANCER - The present invention provides a method for the detection of or the risk of bladder cancer in a patient, comprising the step of detecting the presence of a combination of at least two biomarkers selected from CEA, VEGF, IL-8, NGAL, NSE, IL-2, EGF, TM, d-Dimer, MMP-9, IL-6, IL-4, MMP-9/NGAL, FAS, CRP, TUP and NMP22 in one or more samples isolated from a patient wherein the presence of a combination of at least two biomarkers in the one or more samples indicates the presence or risk of bladder cancer. | 05-31-2012 |
Mark W. Ruddock, Crumlin GB
Patent application number | Description | Published |
---|---|---|
20140072987 | METHODS OF DETECING BLADDER CANCER - The disclosure relates to methods of detecting bladder cancer including assaying a patient sample for the levels of certain combinations of biomarkers. The disclosure also relates to methods for determining the efficacy of a drug for the treatment of bladder cancer. | 03-13-2014 |
Mark William Ruddock, Northern Ireland GB
Patent application number | Description | Published |
---|---|---|
20110183317 | DETERMINING THE SENSITIVITY OF A CELL TO A DRUG - The present invention provides an in vitro method for determining the resistance or sensitivity of a cell line or patient sample to a deoxyribonucleoside kinase-dependent drug, wherein the method comprises the steps of: (i) treating a patient sample or cell line, or a portion thereof, with a deoxyribonucleoside kinase-dependent drug; (ii) lysing the cells of the patient sample or cell line from step (i); (iii) optionally, mixing a portion of the cell lysate from step (ii) with a bioluminescent reporter bacteria incorporating a gene coding for deoxyribonucleoside kinase; (iv) mixing a portion of the cell lysate from (ii) with a bioluminescent reporter bacteria incorporating a gene coding for a deoxyribonucleoside kinase and a deoxyribonucleoside kinase transcription promoter; (v) mixing a portion of the cell lysate from step (ii) with a bioluminescent reporter bacteria incorporating a gene coding for a deoxyribonucleoside kinase, a deoxyribonucleoside kinase transcription promoter and a dephosphorylating agent; and (vi) measuring the bioluminescence of each of the mixtures from steps (iii) to (v), wherein the comparative levels of bioluminescence of each of the mixtures provides a measure of the resistance or sensitivity to the drug. | 07-28-2011 |
Mark William Ruddock, Crumlin GB
Patent application number | Description | Published |
---|---|---|
20150269311 | DIAGNOSIS AND RISK STRATIFICATION OF BLADDER CANCER - The invention provides a method of defining the likelihood of a subject having bladder cancer, comprising the steps of: | 09-24-2015 |