Rosa Maria
Rosa Maria Alvarez Escobar, Madrid ES
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20130029967 | Fused Imidazo [3,2 - D] Pyrazines as P13 Kinase Inhibitors - There is provided compounds of formula (I), wherein A | 01-31-2013 |
20130053371 | INHIBITORS OF PI3 KINASE - There is provided compounds of formula (I), wherein A | 02-28-2013 |
20130065883 | Triazolo [4, 5- B] Pyridin Derivatives - There is provided compounds of formula (I), wherein R | 03-14-2013 |
20130131057 | NEW BICYCLIC COMPOUNDS AS PI3-K AND MTOR INHIBITORS - There is provided compounds of formula (I), wherein A | 05-23-2013 |
20140256717 | MACROCYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS - There is provided compounds of formula I, wherein R1, R | 09-11-2014 |
Rosa Maria Alvarez-Escobar, Toledo ES
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20090012062 | Novel Substituted Pyrazinone Derivatives for Use in Mch-1 Mediated Diseases - The present invention concerns aryl and heteroaryl substituted pyrazinone derivatives having antagonistic melanin-concentrating hormone (MCH) activity, in particular MCH-1 activity according to the general Formula (I) | 01-08-2009 |
Rosa Maria Coco Martin, Valladolid ES
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20110164215 | DEVICE FOR ASSISTING AND PROTECTING VISION - The invention relates to a device comprising one left electrochromic filter ( | 07-07-2011 |
Rosa Maria Delgado Romero, Getafe ES
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20150274293 | System for a Vehicle with Redundant Computers - A control and/or management system for a vehicle includes at least one of: (A) at least two redundant vehicle management computers configured to generate system control commands for each maneuvering actuators and for each system actor based on the data acquired by the sensors; (B) at least two redundant remote interface units for interconnecting a sensor or a system actor with a vehicle management computer; (C) at least two redundant actuator control computers configured to generate control commands for each maneuvering actuator based on received maneuvering commands; and (D) a common interface for connecting an external computer, the common interface being directly connected to at least two redundant computers. | 10-01-2015 |
Rosa Maria Dominquez-Espinosa, Berkshire GB
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20150176035 | TWO-STAGE CONTINUOUS PROCESS FOR PRODUCING A SOLVENT - The present invention relates to a two stage continuous microbiological process for the production of solvents such as acetone, butanol and ethanol. Preferably, the process involves the use of a solventogenic bacteria such as clostridia. In the first (acidogenic) stage, the culture vessel is fed with fresh growth media at dilution rates that support fast growth and acid production. The culture flows into the second (solventogenic) stage, which is a separate culture vessel or vessels, designed to provide the culture with sufficient residence time to convert acids into solvents. Preferably this vessel is tubular or a series of linked batch vessels. | 06-25-2015 |
Rosa Maria Espinosa Ferrer, Barberà Del Vallès ES
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20150038721 | SOLID FORMS OF DABIGATRAN ETEXILATE MESYLATE AND PROCESSES FOR THEIR PREPARATION - It relates to solid forms of dabigatran etexilate mesylate, in particular dabigatran etexilate mesylate in crystalline Form A, and in amorphous form; to processes for their preparation, and to pharmaceutical compositions comprising them. It also relates to a crystalline form of dabigatran etexilate base (Form A), and to a process for its preparation. | 02-05-2015 |
Rosa Maria Figueras I Ventura, Princeton, NJ US
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20100202023 | Image Processing Method and Apparatus - An image processing method suitable for a printer unit, includes an error diffusion halftoning process arranged for quantizing and diffusing each pixel of an image including a set of subtractive primary colours (C′, M′, Y′), in an image including a quantized printer image including a set of ink drops (D | 08-12-2010 |
Rosa Maria Hernandez Martin, Vitoria ES
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20100297192 | USE OF MICROPARTICLES FOR VACCINES AND THE RELEASE OF BIOLOGICALLY ACTIVE MOLECULES - The invention relates to microparticles based on a PLGA biodegradable polymer and an alginate polymer which encapsulate immunologically active peptides or proteins. Said microparticles, and the pharmaceutical compositions developed from them and the uses thereof, are applicable to the field of human and animal health as a vaccine and system for releasing biologically active molecules. | 11-25-2010 |
Rosa Maria Hernandez Martin, Leoia (vizcaya) ES
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20160051485 | Biodegradable Bionanoparticles for Releasing the GSE24-2 Peptide, Method for the Production Thereof, and Use of Same - The invention relates to biodegradable PLGA bionanoparticles encapsulating the GSE24-2 peptide with telomerase activity and to pharmaceutical, cosmetic and biotechnological compositions comprising same. The pharmaceutical compositions are useful for treating diseases presenting a telomerase deficiency, such as dyskeratosis congenita, and diseases presenting ageing characteristics, such as Werner syndrome, Rothmund Thompson syndrome, and other diseases where there is DNA damage such as ataxia telangiectasia. The invention likewise relates to the method for producing said bionanoparticles by means of a w/o/w double emulsion technique. | 02-25-2016 |
Rosa Maria Lopez Barroso, La Habana MX
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20160106691 | CHEMICAL CHAPERONINS AS NOVEL MOLECULAR MODULATORS OF BETA PROTEIN AGGREGATION PRESENT IN CONFORMATIONAL DISEASES - This invention relates to chemistry and biochemistry applied to the field of medicine and is referred to a new method of prevention and therapeutic treatment of conformational diseases (CD), in particular to amyloid origin diseases by administrating an effective amount of one or more compounds, salts, prodrugs or solvates, which are considered herein as chemical chaperonins, of Formula I, | 04-21-2016 |
Rosa Maria Lopez Barroso, Habana CU
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20150217005 | METHOD FOR OBTAINING NOVEL DERIVATIVES OF NAPHTHALENE FOR THE IN VIVO DIAGNOSIS OF ALZHEIMER'S DISEASE - This invention relates to a chemistry branch, particularly to the field of compounds' organic synthesis that belong to the aromatic bicyclic or naphthalene category, used in the detection of amyloid sheets. These new naphthalene derivatives have a general formula: Wherein R represents mutually independent groups. In I: R | 08-06-2015 |
Rosa Maria Lozano Puerto, Madrid ES
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20080293816 | Use of 2,5-Dihydroxybenzenesulphonic Acid in the Production of Medicaments for the Treatment of Angiodependent Diseases Such as Cancer and Psoriasis - The invention relates to the use of 2,5-dihydroxybenzenesulfonic acid in the production of medicaments for the treatment of angiodependent diseases. More specifically, the invention relates to the use of the aforesaid compound and, in particular, the calcium and potassium salts thereof, for the treatment of two angiodependent diseases, which present a reduction in the apoptosis, namely cancer and psoriasis. The invention also discloses the antiproliferative, antimigratory, antiangiogenic and proapoptotic capacity of said family of compounds in non-quiescent cells. In addition, the invention details the potentiating effect of said compounds on known cytostatic medicines in the treatment of tumours and, specifically, on gliomas. The invention further relates to the therapeutic efficacy of said compounds, based on the combined antiproliferative, antiangiogenic and proapoptotic capacities thereof, in the treatment of chronic psoriatic plaques. | 11-27-2008 |
20090076140 | PHARMACEUTICAL COMPOSITIONS CONTAINING SULPHONIC ACID DERIVATIVES - A naphthalenesulfonic acid or quinolinesulfonic acid of formula (I), wherein A is N or a CR | 03-19-2009 |
20090111779 | METHODS OF USE FOR 2,5-DIHYDROXYBENZENE SULFONIC ACID COMPOUNDS FOR THE TREATMENT OF CANCER, ROSACEA AND PSORIASIS - The invention describes compositions and methods of use for 2,5-dihydroxybenzene sulfonic acid compounds and pharmaceutically acceptable salts thereof. The invention provides methods for (a) treating skin cancer; (b) treating cancer of the organs; (c) treating leukemia; (d) improving the efficacy of chemotherapy, radiation therapy and/or cancer immunotherapy; (e) treating rosacea; and (f) treating psoriasis by administration of a composition comprising at least one 2,5-dihydroxybenzene sulfonic acid compound or a pharmaceutically acceptable salt thereof, and, optionally at least one therapeutic agent. Also disclosed are compositions comprising administration of at least one 2,5-dihydroxybenzene sulfonic acid compound, or a pharmaceutically acceptable salt thereof, and, at least one therapeutic agent. In the invention the 2,5-dihydroxybenzene sulfonic acid compounds or pharmaceutically acceptable salts thereof are 2,5-dihydroxybenzene sulfonic acid, calcium 2,5-dihydroxybenzenesulfonate, potassium 2,5-dihydroxybenzenesulfonate, magnesium 2,5-dihydroxybenzenesulfonate and diethylamine 2,5-dihydroxybenzenesulfonate. | 04-30-2009 |
20110237555 | USE OF 2,5-DIHYDROXYBENZENE COMPOUNDS AND DERIVATIVES FOR THE TREATMENT OF ROSACEA - The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, rosacea. | 09-29-2011 |
20110257264 | USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR TREATING ACTINIC KERATOSIS - The present invention relates to the use of a 2,5-dihydroxybenzene derivative represented by Formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the therapeutic and/or prophylactic treatment of, inter alia, actinic keratosis. | 10-20-2011 |
20110311528 | USE OF 2,5-DIHYDROXYBENZENE COMPOUNDS AND DERIVATIVES FOR THE TREATMENT OF PSORIASIS - The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, psoriasis. | 12-22-2011 |
20120015912 | USE OF 2,5-DIHYDROXYBENZENE FOR THE TREATMENT OF OCULAR DISEASES - The present invention relates to the use of a compound of Formula (I | 01-19-2012 |
20120087904 | Use Of 2,5-Dihydroxybenzene Compounds And Derivatives For The Treatment Of Skin Cancer - The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, skin cancer. | 04-12-2012 |
20120087947 | USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR TREATING DERMATITIS - The present invention relates to the use of a 2,5-dihydroxybenzene derivative represented by Formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the therapeutic and/or prophylactic treatment of, inter alia, dermatitis. | 04-12-2012 |
20130203851 | Use of 2,5-Dihydroxybenzenesulfonic Acid in the Manufacturing of Medicines, Applicable to the Treatment of Angiodependent Diseases - Provided is the use of 2,5-dihydroxybenzenesulfonic acid in the production of medicaments for the treatment of angiodependent diseases. More specifically, described is the use of the aforesaid compound and, in particular, the calcium and potassium salts thereof, for the treatment of two angiodependent diseases, which present a reduction in the apoptosis, namely cancer and psoriasis. Also described is the antiproliferative, antimigratory, antiangiogenic and proapoptotic capacity of said family of compounds in non-quiescent cells. In addition, described is the potentiating effect of said compounds on known cytostatic medicines in the treatment of tumours and, specifically, on gliomas. Additionally, the therapeutic efficacy of said compounds, based on the combined anti proliferative, antiangiogenic and proapaptotic capacities thereof, in the treatment of chronic psoriatic plaques is provided. | 08-08-2013 |
20140018330 | Use Of 2,5-Dihydroxybenzene Compounds And Derivatives For The Treatment Of Rosacea - The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, rosacea. | 01-16-2014 |
20140206654 | USE OF 2,5-DIHYDROXYBENZENE COMPOUNDS AND DERIVATIVES FOR THE TREATMENT OF HEMATOLOGICAL DYSCRASIAS AND CANCER OF AN ORGAN - The present invention refers to the use of a compound of Formula (I′) or pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of hematological dyscrasias, including myelodysplastic syndromes (MDSs) and for improving the efficacy of chemotherapy, radiation therapy and/or cancer immunotherapy. In addition, it relates to the use of a compound of formula (I″) for the treatment and/or prophylaxis of cancer of an organ. | 07-24-2014 |
20140328778 | Use of 2,5-Dihydroxybenzene Derivatives for Treating Dermatitis - The present invention relates to the use of a 2,5-dihydroxybenzene derivative represented by Formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the therapeutic and/or prophylactic treatment of, inter alia, dermatitis. | 11-06-2014 |
20140328823 | Use Of 2,5-Dihydroxybenzene Compounds And Derivatives For The Treatment Of Skin Cancer - The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, skin cancer. | 11-06-2014 |
20150141476 | Use Of 2,5-Dihydroxybenzene Compounds And Derivatives For The Treatment Of Rosacea - The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, rosacea. | 05-21-2015 |
Rosa Maria Martinez Perallon, Aachen DE
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20120134323 | Managing User Registrations of Roaming IMS Users - Techniques for managing a registration of a roaming user terminal ( | 05-31-2012 |
20120185578 | Managing Roaming Agreements between IMS Networks - A technique for managing an automatically established roaming agreement between two IMS networks ( | 07-19-2012 |
Rosa Maria Mas Ferreiro, Habana CU
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20100021574 | Pharmaceutical Composition and Procedure to Treat and Prevent Prostatic Hyperplasia and Prostatitis from the Royal Palm (Roystonea regia) Fruits - A method for obtaining a pharmaceutical composition from | 01-28-2010 |
20100022649 | Pharmaceutical Composition and Procedure to Treat and Prevent Prostatic Hyperplasia and Prostatitis From the Royal Palm (Roystonea regia) Fruits - A method for treating and/or preventing BPH prostatitis, alopecia and hirsutism including administering a medication of the pharmaceutical composition obtained from the green or mature fruits of | 01-28-2010 |
Rosa Maria Mengual Molina, Alicante JP
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20100099151 | VERTICAL SUBMERSIBLE PHOTOBIOREACTOR FOR OBTAINING BIOFUELS - The invention relates to a vertical submersible photobioreactor for obtaining biofuels, consisting of: vertical towers ( | 04-22-2010 |
Rosa Maria Montoliu Gombau, Barcelona ES
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20090094764 | Glycol based pigmetnt preparation for mass dyeing of polyacrylonitrile fibers - The invention relates to a process for mass dyeing of polyacrylonitrile, wherein there is incorporated into a solution of acrylonitrile polymer or copolymer a pigment preparation which comprises | 04-16-2009 |
Rosa Maria Ortuno Mingarro, Barcelona ES
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20100105680 | SUBSTITUTED DIMETHYLCYCLOBUTYL COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS - The present invention relates to substituted dimethylcyclobutyl compounds of general formula I, a process for their preparation, medicaments comprising said substituted dimethylcyclobutyl compounds as well as the use of said substituted dimethylcyclobutyl compounds for the preparation of medicaments, which are particularly suitable for the prophylaxis and/or treatment of disorders or diseases that are at least partially mediated via sigma receptors. | 04-29-2010 |
Rosa Maria Osuna Aguilar, Puerto Santa Marie (cadiz) ES
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20120003715 | Process for Producing Recombinant Lyosomal Using Insect Larvae - A method for expressing and industrial scale production of recombinant lysosomal enzymes utilizing insect larva including the steps of infecting an insect larva population of the species | 01-05-2012 |
Rosa Maria Palacin, L'Hospitalet De Llobregat ES
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20150295236 | ACTIVE SUBSTANCE FOR ELECTRODE FOR A SODIUM ION BATTERY - The present invention relates to a negative electrode material for a sodium ion battery, and to a method for producing it. | 10-15-2015 |
Rosa Maria Pinto Sole, Barcelona ES
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20100255459 | CONTROL FOR VIRUS DETECTION ASSAYS BASED ON REVERSE-TRANSCRIPTION POLYMERASE CHAIN REACTION - A method for the accurate quantification of a virus in a sample, by reverse transcription polymerase chain reaction (RT-PCR), includes: adding a known concentration of a Mengo virus to the sample as control for the nucleic acids extraction step, the Mengo virus being a mutant strain with the same growth properties than those of the wild-type Mengo virus, and with non-pathogenic capacity; performing a nucleic acids extraction to obtain a nucleic acids suspension; analyzing the nucleic acids suspension by RT-PCR with primers and probes; quantifying the amplimers resulting from the RT-PCR; determining the concentration of the virus in the sample by comparison of the value obtained with an appropriate standard curve; and determining the concentration of the Mengo virus by comparison of the value obtained with an appropriate standard curve. | 10-07-2010 |
Rosa Maria Salgado Curiel, Mexico D.f MX
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20100297056 | COMPOSITION BASED ON PERHYDROSQUALENE AND COLLAGEN-POLYVINYLPYRROLIDONE FOR FILLING MINOR CUTANEOUS DEPRESSIONS - The present invention concerns a composition based on collagen-polyvinylpyrrolidone and perhydrosqualene for filling by intracutaneous delivery route minor depressions of the skin in order to enhance the appearance thereof without causing a negative immune reaction or rejection of the extraneous body, a method for preparing the composition and the use thereof in the prevention and treatment of minor depressions in the skin by means of a temporary mechanical effect thereby avoiding the encapsulation of the substance, since depending among various factors on time, some compositions eventually cause a reaction to the extraneous body, leading to inflammation of the treated area and fibrosis. The composition as per the invention has the characteristic of being prepared to a controlled alkaline PH and forms a stable emulsion without foam. | 11-25-2010 |
Rosa Maria Teixeira Tagae Biaggio, Sao Jose Dos Campos - Sp BR
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20130045175 | Use of Skin Permeation and Retention Enhancer Compound in Cosmetic and Pharmaceutical Compositions and Cosmetic and Pharmaceutical Products Containing Said Compound - The present invention relates to the use of a compound of general formula: wherein X is a CiO-24 carbon chain with “n” unsaturations wherein “n” is an integer from zero to 3 for the preparation of a cosmetic composition and a pharmaceutical composition to increase the skin permeation and retention of active ingredients. The present invention is suitable for cosmetic and pharmaceutical products the activity of which is enhanced with increased permeation and retention of active ingredients in the skin as a treatment for cellulite and fat accumulation, acne treatment, skin whitening amongst others. | 02-21-2013 |
Rosa Maria Teixeira Tage Biaggio, Sao Jose Dos Campos BR
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20110091946 | Enzymatic Process for Obtaining a Fatty Ester - The aim of the present invention is to obtain fatty esters from fatty acids derived from vegetable oils and butters, through an enzymatic process, so that said esters can act as emollients, emulsifiers and co-emulsifiers with differentiated performance, having high spreadability and slidability compared to the prior-art products. More specifically, the present invention relates to an enzymatic process for obtaining a fatty ester, comprising: a) obtaining a fatty acid through the enzymatic hydrolysis (saponification) of vegetable oils and butters selected from cupuagu butter, sapucainha butter, ucu{acute over (υ)}ba butter, murumuru butter, palm olein, pataua oil, tucuma oil, inaja oil, passion fruit oil, pequi oil and nasturtium oil; b) reacting the fatty acid with a fatty alcohol selected from capric alcohol, caprylic alcohol, isoamylic alcohol, lauric alcohol, myristic alcohol, lorol (70:30 mixture of lauric alcohol and myristic alcohol), cetyl alcohol, stearyl alcohol, cetostearyl alcohol (70:30 mixture of cetyl alcohol and stearyl alcohol), sorbitol, sorbitan, glycerin, polyglycerin, other polyols and mixture thereof, in the presence of an enzyme, in at least one reactor, at a temperature of from 40 to 80 QC; c) stirring the reaction solution; d) removing moisture from the reaction medium; e) vacuum filtering said solution to obtain the fatty ester. The fatty esters obtained through the process of the present invention can be used in the preparation of cosmetic compositions. | 04-21-2011 |
Rosa Maria Torres Calderon, Toulouse FR
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20110060485 | METHOD AND DEVICE FOR OPTIMIZING A TAKEOFF PROCEDURE OF AN AIRCRAFT - An optimization method and device for a take-off procedure of an aircraft. The device ( | 03-10-2011 |
Rosa Maria Varela Montolla, Cadiz ES
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20110059850 | PHYTOTOXIC HALOGENATED DERIVATIVES OF BENZOXAZINONES - The invention relates to phytotoxic halogenated derivatives of benzoxazinones. The aim of the invention relates to the production of novel phytosanitary products that are suitable for agricultural weed control, based on natural chemical substances. The invention comprises novel chemical compounds having high levels of phytotoxic activity and the preparation methods thereof. Said substances are derived from natural products with the 1,4-benzoxazin-3-one skeleton involved in different chemical defense interactions in plants. The inventive compounds have suitable phytotoxic activity levels for use in weed control and for use as stable models for the development of novel phytosanitary products based on the 1,4-benzoxazin-3-one skeleton. | 03-10-2011 |
Rosa Maria Yanez Gonzalez, Madrid ES
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20090148419 | USE OF ADIPOSE TISSUE DERIVED MESENCHYMAL STEM CELLS FOR THE TREATMENT OF GRAFT VERSUS HOST DISEASE - The present invention relates to the use of a particular type of adipose tissue derived mesenchymal stem cells (AD-MSCs), which exert immunosuppressive properties, in the manufacture of a pharmaceutical composition for the prevention and treatment of the graft-versus-host disease (GVHD) produced after allogeneic hematopoietic stem cell transplantation. | 06-11-2009 |
Rosa María Ayala DÍaz, Madrid ES
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20160122819 | METHOD FOR QUANTIFYING THE LEVEL OF MINIMAL RESIDUAL DISEASE IN A SUBJECT - The present invention belongs to the field of diagnosis of disease. Thus the present invention is focused on a method and kit for quantifying the level of minimal residual disease (MRD) in a subject who has been treated for said disease, which comprises: | 05-05-2016 |
Rosa María Ferraz Colomina, Bellaterra (barcelona) ES
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20110233073 | BIOSENSOR FOR DETECTING ANTI-HIV ANTIBODIES - The present invention provides a biosensor that can detect anti-HIV antibodies in a biological sample, based on the combined use of a genetically modified, allosteric enzyme, and a matrix with microelectrode networks. One of the benefits of this biosensor is its high sensitivity, simplicity on the detection and portability. | 09-29-2011 |
Rosa María Hernández Martín, Vitoria ES
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20110212060 | USE OF MICROPARTICLES CONTAINING GENETICALLY MODIFIED CELLS IN THE TREATMENT OF NEURODEGENERATIVE DISEASES - The present invention relates to methods for the treatment of neurodegenerative diseases by means of the use of microparticles comprising genetically modified cells expressing neurotrophic and/or angiogenic factors and wherein said microparticles are administered by means of implantation at the cerebral cortex level. | 09-01-2011 |
Rosa María Lozano Puerto, Madrid ES
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20120077785 | METHODS OF USE FOR 2,5-DIHYDROXYBENZENE SULFONIC ACID COMPOUNDS FOR THE TREATMENT OF CANCER, ROSACEA AND PSORIASIS - The invention describes compositions and methods of use for 2,5-dihydroxybenzene sulfonic acid compounds and pharmaceutically acceptable salts thereof. The invention provides methods for (a) treating skin cancer; (b) treating cancer of the organs; (c) treating leukemia; (d) improving the efficacy of chemotherapy, radiation therapy and/or cancer immunotherapy; (e) treating rosacea; and (f) treating psoriasis by administration of a composition comprising at least one 2,5-dihydroxybenzene sulfonic acid compound or a pharmaceutically acceptable salt thereof, and, optionally at least one therapeutic agent. Also disclosed are compositions comprising administration of at least one 2,5-dihydroxybenzene sulfonic acid compound, or a pharmaceutically acceptable salt thereof, and, at least one therapeutic agent. In the invention the 2,5-dihydroxybenzene sulfonic acid compounds or pharmaceutically acceptable salts thereof are 2,5-dihydroxybenzene sulfonic acid, calcium 2,5-dihydroxybenzenesulfonate, potassium 2,5-dihydroxybenzenesulfonate, magnesium 2,5-dihydroxybenzenesulfonate and diethylamine 2,5-dihydroxybenzenesulfonate. | 03-29-2012 |
20120142780 | USE OF 2,5-DIHYDROXYBENZENESULFONIC ACID IN THE MANUFACTURING OF MEDICINES, APPLICABLE TO THE TREATMENT OF ANGIODEPENDENT DISEASES - The invention relates to the use of 2,5-dihydroxybenzenesulfonic acid in the production of medicaments for the treatment of angiodependent diseases. More specifically, the invention relates to the use of the aforesaid compound and, in particular, the calcium and potassium salts thereof, for the treatment of two angiodependent diseases, which present a reduction in the apoptosis, namely cancer and psoriasis. The invention also discloses the antiproliferative, antimigratory, antiangiogenic and proapoptotic capacity of said family of compounds in non-quiescent cells. In addition, the invention details the potentiating effect of said compounds on known cytostatic medicines in the treatment of tumours and, specifically, on gliomas. The invention further relates to the therapeutic efficacy of said compounds, based on the combined antiproliferative, antiangiogenic and proapaptotic capacities thereof, in the treatment of chronic psoriatic plaques. | 06-07-2012 |