Patent application number | Description | Published |
20090017455 | Methods and systems for detecting and/or sorting targets - Provided herein are methods and systems for detecting and/or sorting targets in a sample based on the combined use of polynucleotide-encoded-protein and substrate polynucleotides. The polynucleotide-encoded protein is comprised of a protein that specifically binds to a predetermined target and of an encoding polynucleotide that specifically binds to a substrate polynucleotide, wherein the substrate polynucleotide is attached to a substrate. | 01-15-2009 |
20090036324 | ARRAYS, SUBSTRATES, DEVICES, METHODS AND SYSTEMS FOR DETECTING TARGET MOLECULES - Arrays and substrates comprising a material, in particular capture agents and/or detectable targets, attached to the substrates along substantially parallel lines forming a barcoded pattern and related methods and systems. | 02-05-2009 |
20090263912 | NANOWIRES AND NANORIBBONS AS SUBWAVELENGTH OPTICAL WAVEGUIDES AND THEIR USE AS COMPONENTS IN PHOTONIC CIRCUITS AND DEVICES - A microfluidic optical sensor utilizes at least one subwavelength nanowire or nanoribbon waveguide coupled to a fluidic structure having at least one nanofluidic channel through which one or more molecular species are conveyed. In response to optical pumping (e.g., a laser source) the waveguide optically interrogates nearby molecular species retained within said fluidic structure to detect chemical species in response to optical characterization of small (on the order of sub-picoliter) volumes of solution. Characterization is performed in response to evanescent wave sensing. In one aspect, optical characterization is selected from the group of optical characterizations consisting of absorbance, fluorescence and surface enhanced Raman spectroscopy (SERS). | 10-22-2009 |
20090283751 | NANOTUBES AND DEVICES FABRICATED THEREFROM - Nanofluidic devices incorporating inorganic nanotubes fluidly coupled to channels or nanopores for supplying a fluid containing chemical or biochemical species are described. In one aspect, two channels are fluidly interconnected with a nanotube. Electrodes on opposing sides of the nanotube establish electrical contact with the fluid therein. A bias current is passed between the electrodes through the fluid, and current changes are detected to ascertain the passage of select molecules, such as DNA, through the nanotube. In another aspect, a gate electrode is located proximal the nanotube between the two electrodes thus forming a nanofluidic transistor. The voltage applied to the gate controls the passage of ionic species through the nanotube selected as either or both ionic polarities. In either of these aspects the nanotube can be modified, or functionalized, to control the selectivity of detection or passage. | 11-19-2009 |
20100075428 | Monolithic Multinozzle Emitters for Nanoelectrospray Mass Spectrometry - Novel and significantly simplified procedures for fabrication of fully integrated nanoelectrospray emitters have been described. For nanofabricated monolithic multinozzle emitters (NM | 03-25-2010 |
20110039717 | METHODS AND SYSTEMS FOR DETECTING AND/OR SORTING TARGETS - Provided herein are methods and systems for detecting and/or sorting targets in a sample based on the combined use of polynucleotide-encoded protein and substrate polynucleotides. The polynucleotide-encoded protein is comprised of a protein that specifically binds to a predetermined target and of an encoding polynucleotide that specifically binds to a substrate polynucleotide, wherein the substrate polynucleotide is attached to a substrate. | 02-17-2011 |
20110233512 | VERTICAL INTEGRATED SILICON NANOWIRE FIELD EFFECT TRANSISTORS AND METHODS OF FABRICATION - Vertical integrated field effect transistor circuits and methods are described which are fabricated from Silicon, Germanium, or a combination Silicon and Germanium based on nanowires grown in place on the substrate. By way of example, vertical integrated transistors are formed from one or more nanowires which have been insulated, had a gate deposited thereon, and to which a drain is coupled to the exposed tips of one or more of the nanowires. The nanowires are preferably grown over a surface or according to a desired pattern in response to dispersing metal nanoclusters over the desired portions of the substrate. In one preferred implementation, SiCl | 09-29-2011 |
20120171778 | FUNCTIONALIZATION OF NANOFLUIDIC CHANNELS - A functionalized nanofluidic channel and method for functionalization that provides control over the ionic environment and geometry of the nanofluidic channel with the immobilization of biomolecules on the inner surface of the channel and use of high ionic concentration solutions. In one embodiment, the surface charge of the nanochannel is controlled with the immobilization of a protein such as streptavidin in the nanochannel. In another embodiment, the biomolecules are receptors and changes in nanochannel conductance indicates ligand binding events. The functionalized nanofluidic channel can be easily adapted for use with microchannel arrays. | 07-05-2012 |