Patent application number | Description | Published |
20080312321 | THERAPEUTIC SUBSTITUTED CYCLOPENTANES - Therapeutic compounds are disclosed herein. | 12-18-2008 |
20090012145 | THERAPEUTIC ESTERS - A compound comprising | 01-08-2009 |
20090062344 | THERAPEUTIC SUBSTITUTED PIPERIDONE COMPOUNDS - Compounds comprising | 03-05-2009 |
20090099249 | THERAPEUTIC LACTAMS - Disclosed herein is a compound having a structure | 04-16-2009 |
20090143461 | SUBSTITUTED CYCLOPENTANES HAVING PROSTAGLANDIN ACTIVITY - Disclosed herein are compounds having a formula: | 06-04-2009 |
20090186866 | THERAPEUTIC BETA-LACTAMS - Compounds comprising | 07-23-2009 |
20090186885 | THERAPEUTIC COMPOUNDS - Disclosed herein is a compound according to one of the formulas | 07-23-2009 |
20090197962 | SUBSTITUTED CYCLOPENTANES HAVING PROSTAGLANDIN ACTIVITY - Therapeutic compounds, compositions, methods, and medicaments related thereto are disclosed herein. | 08-06-2009 |
20090239858 | THERAPEUTIC AMIDES - Compounds comprising | 09-24-2009 |
20090239869 | THERAPEUTIC SUBSTITUTED CYCLOPENTANES - Therapeutic compounds are disclosed herein. Methods, compositions, and medicaments related thereto are also disclosed. The compounds described herein are used to treat ocular conditions, bowel disease and baldness. | 09-24-2009 |
20090239930 | THERAPEUTIC COMPOUNDS - Compounds comprising | 09-24-2009 |
20090247594 | THERAPEUTIC COMPOUNDS - Disclosed herein is a compound having a structure | 10-01-2009 |
20090275646 | THERAPEUTIC COMPOUNDS - Compounds having a structure | 11-05-2009 |
20090318449 | THERAPEUTIC LACTAMS - Compounds comprising | 12-24-2009 |
20100063303 | THERAPEUTIC COMPOUNDS - Compound having the formula below are disclosed herein: formula (I). Therapeutic methods, compositions, and medicaments related thereto are also disclosed. | 03-11-2010 |
20100173981 | THERAPEUTIC COMPOUNDS - Disclosed herein is a compound according to one of the formulas or a pharmaceutically acceptable salt thereof, medicaments for the treatment of glaucoma or ocular hypertension and compositions related thereto, as further elaborated herein. | 07-08-2010 |
20100280250 | THERAPEUTIC AND DELIVERY METHODS OF PROSTAGLANDIN EP4 AGONISTS - A compound comprising a prodrug of a prostaglandin EP | 11-04-2010 |
20100317872 | THERAPEUTIC COMPOUNDS - A compound having a substituted five or six-membered carbocycle or heterocycle directly bonded to a substituted aryl or heteroaryl ring, wherein said compound has an EC | 12-16-2010 |
20110082184 | CYCLOPENTANE HEPTAN(ENE)OIC ACID, 2-HETEROARYLALKENYL DERIVATIVES AS THERAPEUTIC AGENTS - A compound comprising | 04-07-2011 |
20110130439 | CYCLOPENTANE HEPTAN(ENE)OIC ACID, 2-HETEROARYLALKENYL DERIVATIVES AS THERAPEUTIC AGENTS - A compound comprising | 06-02-2011 |
20110136872 | STABLE AQUEOUS COMPOSITIONS OF PROSTGLANDIN AGONIST PRODRUGS AND METHODS FOR USE THEREOF - The present invention is based on the discovery that a marked increase in aqueous stability (and thereby shelf life) of prostanoid agonist prodrug compositions is achieved by incorporating into the compositions certain well-defined carboxylic acids, and thereafter adjusting the pH of the compositions from about 4.0 to about 8.0. As a result, the compositions and methods of the invention provide the aqueous stability required for marketable topical drug treatments of a wide variety of ocular disorders. | 06-09-2011 |
20110152328 | Combination Therapy For Glaucoma - Disclosed herein is method of treating glaucoma or ocular hypertension comprising administering a prostaglandin agonist and a second therapeutically active agent to a mammal in need thereof, wherein said second therapeutically active agent is selected from: β-Blockers, Adrenergic Agonists, non-selective adrenergic agonists, α2-selective adrenergic agonists, Carbonic Anhydrase Inhibitors, Cholinergic Agonists, direct acting cholinergic agonists, chlolinesterase inhibitors, Glutamate Antagonists, Ca | 06-23-2011 |
20110152797 | PROSTAGLANDINS AND ANALOGUES AS AGENTS FOR LOWERING INTRAOCULAR PRESSURE - The present invention relates to cyclopentane heptenoic acid-5-cis-2-(3α-hydroxy or lower alkyloxy-5-thienylpentyl)-3,5-dihydroxy, [1α, 2β, 3α, 5α] compounds, lower alkyl, hydroxyl lower alkyl and indole lower alkyl amides and esters thereof as potent ocular hypotensives that are particularly suited for the management of glaucoma. | 06-23-2011 |
20110294893 | NON-ACIDIC CYCLOPENTANE HEPTANOIC ACID, 2-CYCLOALKYL OR ARYLALKYL DERIVATIVES AS THERAPEUTIC AGENTS - The present invention provides cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compounds, which may be substituted in the 1-position with amino, amido, ether or ester groups, e.g., a 1-OH cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) compound. The cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) compounds of the present invention are potent ocular hypotensives, and are particularly suitable for the management of glaucoma. Moreover, the cyclopentane heptanoic, 2-(cycloalkyl or arylalkyl) compounds of this invention are smooth muscle relaxants with broad application in systemic hypertensive and pulmonary diseases; smooth muscle relaxants with application in gastrointestinal disease, reproduction, fertility, incontinence, shock, etc. | 12-01-2011 |
20120136011 | COMPOUNDS AND METHODS FOR SKIN REPAIR - The disclosure provides compositions and methods for treating a skin blemish. The compositions comprise a therapeutically effective amount of a compound useful for treating skin blemishes such as wounds, scars and wrinkles. | 05-31-2012 |
20120142684 | COMPOUNDS AND METHODS FOR SKIN REPAIR - The disclosure provides compositions and methods for treating a skin blemish. The compositions comprise a therapeutically effective amount of a compound useful for treating skin blemishes such as wounds, scars and wrinkles. | 06-07-2012 |
20120178798 | SUBSTITUTED CYCLOPENTANES HAVING PROSTAGLANDIN ACTIVITY - Disclosed herein are compounds having a formula: | 07-12-2012 |
20120295972 | Ester Derivatives of Bimatoprost Compositions and Methods - Provided herein, inter alia, are prodrugs of bimatoprost, methods of using the same and compositions including the same. | 11-22-2012 |
20130029992 | N,N-DIALKYLALKYLENYL ESTERS, COMPOSITIONS THEREOF, AND METHODS FOR USE THEREOF - The invention provides well defined N,N-dialkylalkenyl ester compounds for treating glaucoma or ocular hypertension. The esters of the invention are particularly advantageous due to their stability in aqueous solutions. | 01-31-2013 |
20130245283 | THERAPEUTIC AND DELIVERY METHODS OF PROSTAGLANDIN EP4 AGONISTS - A compound comprising a prodrug of a prostaglandin EP | 09-19-2013 |
20130324606 | Ester Derivatives of Bimatoprost Compositions and Methods - Provided herein, inter alia, are prodrugs of bimatoprost, methods of using the same and compositions including the same. | 12-05-2013 |
20140057975 | REDUCED CENTRAL CORNEAL THICKENING BY USE OF HYDROPHILIC ESTER PRODRUGS OF BETA-CHLOROCYCLOPENTANES - Compositions and methods for treating glaucoma are provided. In particular hydrophilic ester prodrugs and their use to reduce central corneal thickening is provided. | 02-27-2014 |
20140107124 | NOVEL PROSTAMIDES FOR THE TREATMENT OF GLAUCOMA AND RELATED DISEASES - Disclosed herein are compositions comprising an amide related to a prostaglandin and a biogenic amine. Other aspects relate to certain chemical compounds, pharmaceutical compositions, and methods of treating glaucoma. | 04-17-2014 |
20140142042 | SKIN WOUND HEALING AND SCAR REDUCTION WITH PROSTAGLANDIN EP4 AGONIST COMBINATIONS - A combination of a prostaglandin EP4 agonist and an effective amount of: a prostaglandin EP2 agonist, a skin growth factor, a small peptide, a small inhibitory RNA targeting excess chronic inflammation or fibrosis, a cytokine with beneficial anti-inflammatory activity, an adenosine A2a receptor agonist, an anti-oxidant, or a combination thereof, may be used to treat skin wounds or scars. | 05-22-2014 |
20140142092 | COMPOUNDS AND METHODS FOR SKIN REPAIR - The disclosure provides compositions and methods for wound healing and scar reduction. The compositions and methods of the invention include at least one mixed EP2/EP4 agonist set forth herein. Wounds and or scars that can be treated by the compositions and methods of the invention can arise from events such as surgery, trauma, disease, mechanical injury, burn, radiation, poisoning, and the like. | 05-22-2014 |
20140171661 | REDUCED CENTRAL CORNEAL THICKENING BY USE OF HYDROPHILIC ESTER PRODRUGS OF BETA-CHLOROCYCLOPENTANES - Compositions and methods for treating glaucoma are provided. In particular hydrophilic ester prodrugs and their use to reduce central corneal thickening is provided. | 06-19-2014 |
20140235681 | Combination therapy for glaucoma - Disclosed herein is method of treating glaucoma or ocular hypertension comprising administering a prostaglandin agonist and a second therapeutically active agent to a mammal in need thereof, wherein said second therapeutically active agent is selected from: β-Blockers, Adrenergic Agonists, non-selective adrenergic agonists, α | 08-21-2014 |
20140271780 | PROSTAMIDE-CONTAINING INTRAOCULAR IMPLANT - Prostamide-containing biodegradable intraocular implants, prostamide compounds, prostamide-containing pharmaceutical compositions, and methods for making and using such implants and compositions for the immediate and sustained reduction of intraocular pressure and treatment of glaucoma in an eye of a patient are described. | 09-18-2014 |
20140275272 | PROSTAMIDES FOR ENHANCEMENT OF LEPTIN PRODUCTION - Prostamides such as bimatoprost and its pro-drugs for enhancement of leptin production and appetite suppression. | 09-18-2014 |