Patent application number | Description | Published |
20090252762 | NOVEL PROTEOSOME-LIPOSACCHARIDE VACCINE ADJUVANT - An adjuvant complex composed of bacterial outer membrane protein proteosomes complexed to bacterial liposaccharide is prepared to contain the component parts under a variety of conditions. The complex can be formulated with antigenic material to form immunogenic compositions, vaccines and immunotherapeutics. An induced immune response includes protective antibodies and/or type 1 cytokines is shown for a variety of protocols. | 10-08-2009 |
20090318337 | Compositions and methods for activating innate and allergic immunity - Methods for making and using therapeutic formulations of Proteosome-based immunoactive compositions are provided. The immunogenic compositions, which include Proteosomes and liposaccharides, may be used to elicit or enhance a nonspecific innate immune response to, for example, treat or prevent infectious disease. In addition, after activating the innate immune system, immunogenic compositions further containing an antigen may be used to elicit a specific adaptive immune response. Furthermore, provided are compositions capable of altering hyperreactive responses or inflammatory immune responses, such as allergic reactions. Such compositions may be used as a prophylactic, or in various clinical settings to treat or prevent infectious disease (such as parasite, fungal, bacterial or viral infections), or to alter inappropriate inflammatory immune responses (such as allergic reactions or asthma). | 12-24-2009 |
20090324639 | COMPOSITIONS AND METHODS FOR ACTIVATING INNATE AND ALLERGIC IMMUNITY - Methods for making and using therapeutic formulations of Proteosome-based immunoactive compositions are provided. The immunogenic compositions, which include Proteosomes and liposaccharides, may be used to elicit or enhance a nonspecific innate immune response to, for example, treat or prevent infectious disease. In addition, after activating the innate immune system, immunogenic compositions further containing an antigen may be used to elicit a specific adaptive immune response. Furthermore, provided are compositions capable of altering hyperreactive responses or inflammatory immune responses, such as allergic reactions. Such compositions may be used as a prophylactic, or in various clinical settings to treat or prevent infectious disease (such as parasite, fungal, bacterial or viral infections), or to alter inappropriate inflammatory immune responses (such as allergic reactions or asthma). | 12-31-2009 |
Patent application number | Description | Published |
20100093035 | NOVEL STREPTOCOCCUS ANTIGENS - proteins and polynucleotides encoding them are disclosed. Said proteins are antigenic and therefore useful vaccine components for the prophylaxis or therapy of | 04-15-2010 |
20120276140 | COMPOSITIONS AND METHODS FOR ACTIVATING INNATE AND ALLERGIC IMMUNITY - Methods for making and using therapeutic formulations of Proteosome-based immunoactive compositions are provided. The immunogenic compositions, which include Proteosomes and liposaccharides, may be used to elicit or enhance a nonspecific innate immune response to, for example, treat or prevent infectious disease. In addition, after activating the innate immune system, immunogenic compositions further containing an antigen may be used to elicit a specific adaptive immune response. Furthermore, provided are compositions capable of altering hyperreactive responses or inflammatory immune responses, such as allergic reactions. Such compositions may be used as a prophylactic, or in various clinical settings to treat or prevent infectious disease (such as parasite, fungal, bacterial or viral infections), or to alter inappropriate inflammatory immune responses (such as allergic reactions or asthma). | 11-01-2012 |
20120308596 | NOVEL STREPTOCOCCUS ANTIGENS - proteins and polynucleotides encoding them are disclosed. Said proteins are antigenic and therefore useful vaccine components for the prophylaxis or therapy of | 12-06-2012 |
20130095498 | NOVEL GROUP B STREPTOCOCCUS ANTIGENS | 04-18-2013 |
20140234374 | COMPOSITIONS AND METHODS FOR ACTIVATING INNATE AND ALLERGIC IMMUNITY - Methods for making and using therapeutic formulations of Proteosome-based immunoactive compositions are provided. The immunogenic compositions, which include Proteosomes and liposaccharides, may be used to elicit or enhance a nonspecific innate immune response to, for example, treat or prevent infectious disease. In addition, after activating the innate immune system, immunogenic compositions further containing an antigen may be used to elicit a specific adaptive immune response. Furthermore, provided are compositions capable of altering hyperreactive responses or inflammatory immune responses, such as allergic reactions. Such compositions may be used as a prophylactic, or in various clinical settings to treat or prevent infectious disease (such as parasite, fungal, bacterial or viral infections), or to alter inappropriate inflammatory immune responses (such as allergic reactions or asthma). | 08-21-2014 |
Patent application number | Description | Published |
20090290450 | HEAD-MOUNTED DISPLAY APPARATUS FOR PROFILING SYSTEM - A head-mounted display to visualize a medium through a surface by displaying an image characterizing the medium under the surface provided by a profiling system and referenced in the real environment of the user. An image of the medium under the surface is projected in front of one or both eyes of a person wearing the head-mounted display, in superimposition with the real environment of the user. The head-mounted display comprises a positioning sensor, such as an inertial positioning sensor, for determining its position and orientation in the real environment. As the user moves around the medium, the image of the medium is updated to display the medium as if it could be seen through the surface. In one embodiment of the invention, the image of the medium under surface is displayed in stereoscopy, the user thereby visualizing the medium in three dimensions. | 11-26-2009 |
20110112794 | HEAD-MOUNTED DISPLAY APPARATUS FOR PROFILING SYSTEM - The invention provides a head-mounted display to visualize a medium through a surface by displaying an image characterizing the medium under the surface provided by a profiling system and referenced in the real environment of the user. An image of the medium under the surface is projected in front of one or both eyes of a person wearing the head-mounted display, in superimposition with the real environment of the user. The head-mounted display comprises a positioning sensor, such as an inertial positioning sensor, for determining its position and orientation in the real environment. As the user moves around the medium, the image of the medium is updated to display the medium as if it could be seen through the surface. In one embodiment of the invention, the image of the medium under surface is displayed in stereoscopy, the user thereby visualizing the medium in three dimensions. | 05-12-2011 |
Patent application number | Description | Published |
20100170378 | CUTTING TOOTH ASSEMBLY WITH REVERSIBLE TOOTH - A cutting tooth assembly for a rotary cutting machine is described. The assembly includes a tooth holder adapted for mounting about the periphery of a rotating element of the rotary cutting machine, and a reversible cutting tooth, removably mounted to said tooth holder. The cutting tooth has opposed first and second cutting faces which are spaced apart along a central tooth axis extending therebetween. Each of the first and second cutting faces at least partially defines more than two cutting edges, and the cutting tooth is reversible by 180 degrees about a transverse tooth axis to dispose a selected one of the first and second cutting faces in an operable cutting position when mounted to the tooth holder. | 07-08-2010 |
20100170379 | ROTARY CUTTING MACHINE WITH REVERSIBLE TEETH - A rotary cutting machine is described and includes a circular rotatable element, a plurality of tooth holders disposed on the circular rotatable element at spaced apart locations about its periphery, and at least one reversible cutting tooth removably fastened to each tooth holder such that at least one cutting edge is disposed in a operable cutting position. Each cutting tooth includes opposed first and second cutting faces spaced apart along a central tooth axis extending therebetween. Each of the first and second cutting faces at least partially defines at least four of the cutting edges. The cutting tooth is reversible by 180 degrees about a transverse tooth axis such that it is mountable on the tooth holder in at least eight different positions, each of the positions providing a different selected one of the cutting edges in the operable cutting position. | 07-08-2010 |
20100180735 | Tooth for a circular saw or mower drum - A tooth for a circular saw or a mower drum that can be used to cut standing trees or brush and undergrowth. The tooth has four cutting edges arranged in a first pair of opposed cutting edges that are generally straight and a second pair of opposed cutting edges that are generally concave. The tooth is mounted in a holder in a first or second cutting position that orients a cutting edge of the first or second pair to physically contact and effect a cutting method to a cuttable material. In a first cutting method, a generally straight cutting edge contacts the material, resulting in a slicing action. In a second cutting method, a generally concave cutting edge contacts the material, resulting in a gouging action. Teeth in the circular saw or brush mower alternate between first and second cutting positions, allowing both cutting methods to be applied to cuttable material. | 07-22-2010 |
20140260876 | TOOTH FOR CIRCULAR SAW OR MOWER DRUM - A saw tooth for mounting onto a holder of a circular saw or of a mower drum is provided. The tooth has a mounting end for mounting against a component of the holder, a cutting end, opposite to the mounting end, the cutting end being provided with at least one cutting edge; and a plurality of sides extending from the mounting end to the cutting end. The plurality of sides include at least one holder side operatively mountable against the holder and at least one outer side opposite to the holder side the outer side being non-linear, diverging from the mounting end to the cutting end and having a contour slope which increases from the mounting end to the cutting end. The tooth thereby provides a greater clearance at its mounting end, and a greater kerf at its cutting end. | 09-18-2014 |
Patent application number | Description | Published |
20080280896 | Dipyrrole Compounds, Compositions, and Methods For Treating Cancer or Viral Diseases - The present invention relates to novel Dipyrrole Compounds, compositions comprising a Dipyrrole Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a Dipyrrole Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell, treating or preventing a viral infection, or inhibiting the replication and/or infectivity of a virus. The invention also provides screening assays for compounds that can be used in combination with Dipyrrole Compounds for the treatment of cancer or neoplastic disease, inhibition of cancer cell growth, or treatment of viral infections. | 11-13-2008 |
20080318902 | TRIHETEROCYCLIC COMPOUNDS AND COMPOSITIONS THEREOF - The present invention relates to novel Triheterocyclic Compounds, compositions comprising a Triheterocyclic Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a Triheterocyclic Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell, treating or preventing a viral infection, or inhibiting the replication and/or infectivity of a virus. | 12-25-2008 |
20100190852 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF - The present invention relates to the use of a pharmaceutically effective amount of an short-acting calcium channel blocking compound to treat ischemic heart conditions, cardiac arrhythmias, hypertensive crisis in an emergency room setting, hypertension before, during, or after surgery, no-reflow phenomenon following reperfusion, and diseases associated with decreased skeletal muscle blood flow. The invention also relates to pharmaceutical compositions formulated for use in such methods and to kits for such methods. | 07-29-2010 |
20140296335 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF - The present invention relates to the use of a pharmaceutically effective amount of an short-acting calcium channel blocking compound to treat ischemic heart conditions, cardiac arrhythmias, hypertensive crisis in an emergency room setting, hypertension before, during, or after surgery, no-reflow phenomenon following reperfusion, and diseases associated with decreased skeletal muscle blood flow. The invention also relates to pharmaceutical compositions formulated for use in such methods and to kits for such methods. | 10-02-2014 |
Patent application number | Description | Published |
20120178318 | Inlet Grate Cleaning System for a Water Jet Propulsion System - An inlet grate cleaning system for a water jet propulsion system to be used in a watercraft. The water jet propulsion system has a water passage, the water passage has an inlet and the inlet has a forward area and a rearward area with respect to the watercraft. The inlet grate cleaning system comprises a pump and at least one water intake fluidly connected to the pump. At least one water outlet is also fluidly connected to the pump. The pump is adapted for pumping water from the at least one water intake to the at least one water outlet to create at least one jet of water. The at least one water outlet is positioned so as to direct the at least one jet of water toward an inlet grate. | 07-12-2012 |
20120178561 | Driving Pulley for a Continuously Variable Transmission - A driving pulley for a CVT has a shaft, a fixed sheave mounted on the shaft, a first sleeve disposed around the shaft and being operatively connected to the shaft, a movable sheave mounted on the first sleeve, a second sleeve disposed around the first sleeve and being connected to the shaft, a spring biasing the movable sheave away from the fixed sheave, and a CVT chamber having an annular cross-section. The fixed and movable sheaves are adapted to receive a belt therebetween. The CVT chamber has at least one opening adapted for fluidly communicating the CVT chamber with a hydraulic fluid reservoir. Hydraulic pressure in the CVT chamber biases the movable sheave toward the fixed sheave. The CVT chamber has an inner wall formed by the first sleeve, an outer wall formed by the second sleeve, an outer end, and an inner end formed by the movable sheave. | 07-12-2012 |
20120178562 | Vehicle Powertrain Having a Hydraulic Continuously Variable Transmission - A vehicle powertrain has an engine, a driving shaft having a passage defined therein, a driven shaft, a pump, a hydraulic fluid reservoir, and a CVT. A driving pulley of the CVT includes a fixed sheave and a movable sheave disposed on the driving shaft for rotation therewith, a spring biasing a movable sheave away from the fixed sheave, and a CVT chamber fluidly communicating with the passage of the driving shaft. The pump supplies hydraulic fluid from the reservoir to the passage in the driving shaft. The hydraulic fluid flows from the passage to the CVT chamber to create a hydraulic pressure in the CVT chamber. The hydraulic pressure in the CVT chamber biases the movable sheave toward the fixed sheave. | 07-12-2012 |
20120179344 | Method of Controlling a Hydraulic Continuously Variable Transmission - A method of controlling a hydraulic CVT of a vehicle comprises: determining a speed of rotation of a driving shaft; determining a speed of rotation of a driven shaft; determining a ratio of the speed of rotation of the driving shaft versus the speed of rotation of the driven shaft; determining an engine torque; determining a base clamping force to be applied by the driving pulley onto the belt based on the ratio and the engine torque; determining a desired speed of rotation of the driving shaft; determining a corrective clamping force by comparing the speed of rotation of the driving shaft to the desired speed of rotation of the driving shaft; and controlling a hydraulic pressure applied to a movable sheave to apply a sum of the base and corrective clamping forces onto the belt. A vehicle having a CVT controlled by the method is also disclosed. | 07-12-2012 |
20120272885 | WATERCRAFT STEERING AND THRUST CONTROL SYSTEM - A watercraft has first and second jet propulsion units. The first jet propulsion unit includes a first inlet, a first outlet, a second outlet, and a first valve. The second jet propulsion unit includes a second inlet, a third outlet, a fourth outlet, and a second valve. The watercraft also includes first and second discharge ports disposed on opposite sides of a longitudinal centerline, a first pipe fluidly communicating the first discharge port with the second outlet, a second pipe fluidly communicating the second discharge port with the second outlet, third and a fourth discharge ports disposed on opposite sides of the longitudinal centerline, a third pipe fluidly communicating the third discharge port with the fourth outlet, and a fourth pipe fluidly communicating the fourth discharge port with the fourth outlet. | 11-01-2012 |
20120275906 | JET PROPULSION UNIT FOR A WATERCRAFT - A jet propulsion unit has a water inlet, a pump body, an impeller, and a valve assembly fluidly. The valve assembly has a valve housing having an inlet fluidly connected to the pump body, a first outlet and a second outlet. A valve body is disposed in the valve housing and is movable between first and second positions. In the first position, water from a body of water flows consecutively through the water inlet, the pump body, the inlet of the valve housing, the valve housing and the first outlet of the valve housing. In the second position, water from the body of water flows consecutively through the water inlet, the pump body, the inlet of the valve housing, the valve housing, and the second outlet of the valve housing. A watercraft having the jet propulsion unit is also disclosed. | 11-01-2012 |
20130080007 | Method of Controlling a Hydraulic Continuously Variable Transmission - A method of controlling a hydraulic CVT of a vehicle comprises: determining a speed of rotation of a driving shaft; determining a speed of rotation of a driven shaft; determining a ratio of the speed of rotation of the driving shaft versus the speed of rotation of the driven shaft; determining an engine torque; determining a base clamping force to be applied by the driving pulley onto the belt based on the ratio and the engine torque; determining a desired speed of rotation of the driving shaft; determining a corrective clamping force by comparing the speed of rotation of the driving shaft to the desired speed of rotation of the driving shaft; and controlling a hydraulic pressure applied to a movable sheave to apply a sum of the base and corrective clamping forces onto the belt. A vehicle having a CVT controlled by the method is also disclosed. | 03-28-2013 |
20130275017 | VEHICLE CLUTCH CONTROL METHOD - A vehicle has an engine having a crankshaft, a hydraulically controlled multi-plate clutch operatively connected to the crankshaft, and an output shaft operatively connected to the clutch. The clutch selectively transmits power from the crankshaft to the output shaft. A propulsion element is operatively connected to the output shaft. A hydraulic fluid supply system is fluidly connected to the clutch for supplying pressurized hydraulic fluid to the clutch. A controller is connected to the hydraulic fluid supply system. The controller receives a torque signal indicative of engine torque and controls the hydraulic fluid supply system based at least in part on the torque signal. A clutch control method and system are also disclosed. | 10-17-2013 |