Patent application number | Description | Published |
20110065698 | NOVEL PROTEIN KINASE MODULATORS - The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate protein kinase CK2 activity, Pim kinase activity and/or FMS-like tyrosine kinase (Flt) activity. The invention also relates in part to methods for using such molecules. | 03-17-2011 |
20110152240 | PYRAZOLOPYRIMIDINES AND RELATED HETEROCYCLES AS CK2 INHIBITORS - The invention provides compounds that inhibit protein kinase CK2 activity (CK2 activity), and compositions containing such compounds. These compounds and compositions are useful for treating proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation, pain, and certain immunological disorders, and have the following general formula: | 06-23-2011 |
20140094448 | PYRAZOLOPYRIMIDINES AND RELATED HETEROCYCLES AS CK2 INHIBITORS - The invention provides compounds that inhibit protein kinase CK2 activity (CK2 activity), and compositions containing such compounds. These compounds and compositions are useful for treating proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation, pain, and certain immunological disorders, and have the following general formula: | 04-03-2014 |
Patent application number | Description | Published |
20080225695 | FAILURE PROTECTION IN A PROVIDER BACKBONE BRIDGE NETWORK USING FORCED MAC FLUSHING - A technique for operating a network involves controlling the black-holing of traffic by forcing customer source MAC address (CMAC)-to-backbone source MAC address (BMAC) associations at provider backbone bridge (PBB) provider edge (PE) devices to be flushed from their corresponding forwarding information bases (FIBs) in response to a service failure so that new CMAC-to-BMAC associations, which are reflective of a secondary traffic path, are learned faster than they would otherwise be learned if the network had relied on native functionality to learn new CMAC-to-BMAC associations that are reflective of the secondary traffic path. | 09-18-2008 |
20080228943 | FAILURE PROTECTION IN A PROVIDER BACKBONE BRIDGE NETWORK USING SELECTIVE REDIRECTION - A technique for operating a network involves controlling the black-holing of traffic by selectively redirecting unicast traffic destined for a dual-homed customer equipment (CE) device from a first provider backbone bridge (PBB) provider edge (PE) device to a second PBB PE device in response to a service failure. Unicast traffic is selectively redirected from the first PBB PE device to the second PBB PE device for a time interval that is long enough to enable the customer source MAC address (CMAC)-to-backbone MAC address (BMAC) association of the second PBB PE device to be learned by other PBB PE devices. | 09-18-2008 |
20090116396 | OAM echo messaging to verify a service-based network distribution path - Echo messaging for operation, administration, and management of a service-based distribution path and associated services are disclosed. Service-based distribution paths or transport tunnels include services mapped or bound to a path associated with the transport tunnel. Echo messaging provides OAM capabilities to monitor the operational state of a service-based distribution path, including determining configuration, connectivity, and other characteristics of the path and associated services that transport data. OAM functions provided by echo messaging enable OAM functions despite service volume along a core network, path or set of paths. | 05-07-2009 |
20090129384 | Data mirroring in a service - Data mirroring in a service such as a virtual private LAN service is disclosed. Data packets, segments, frames, or other forms of encapsulation may be mirrored off of a core network (e.g., IP, TCP) to one or more mirroring destinations without using a parallel network. Encapsulation techniques are provided that enable packets to be mirrored and transmitted across services such as VPLS, MPLS, and others to a mirror destination. Once received at the mirror destination, mirrored packets may be used for troubleshooting in a more efficient and less resource and time-consuming manner. | 05-21-2009 |
20100228842 | Injecting addresses to enable OAM functions - Inserting an address used for performing such OAM functions in an efficient way that is transparent to a customer or service using the network path is disclosed. An indication is received that a source address reserved for OAM use should be inserted into a forwarding database associated with a provider network node, such as a provider edge device, that receives the indication. The address is inserted into a forwarding database as an address that is owned by the provider network node and reserved for OAM use. One or more other nodes associated with a service with which the OAM address is associated may be notified that the OAM address is associated with the provider network node that owns the OAM address. | 09-09-2010 |
Patent application number | Description | Published |
20140162266 | METHODS FOR POLYMERASE CHAIN REACTION COPY NUMBER VARIATION ASSAYS - This disclosure provides methods for measuring the copy number for highly amplified and/or abundant genomic loci. Recognized herein is a need for methods for determining nucleic acid copy number, particularly in instances where one locus to be quantified (i.e., the target) is relatively more abundant than a locus of known abundance (i.e., the reference). In some cases, the method involves combining a query nucleic acid sample with a diluting nucleic acid sample and measuring the relative copy number of a target sequence compared with a reference sequence in the combined sample. | 06-12-2014 |
20140309128 | DIGITAL ASSAYS FOR MUTATION DETECTION - Provided herein are methods, compositions, and kits for detecting alleles using a single probe or a single primer set. Also, provided herein are methods, compositions, and kits for detecting allelic variants using a single probe or a single primer set. Also, provided herein are methods, compositions, and kits for determining a polymerization error rate. | 10-16-2014 |
Patent application number | Description | Published |
20140221238 | MULTIPLEXED DIGITAL ASSAY WITH SPECIFIC AND GENERIC REPORTERS - Digital assay system, including methods, apparatus, and compositions, for performing target assays in partitions each containing a generic reporter and a specific reporter for target amplification. | 08-07-2014 |
20150148250 | AMPLIFICATION REPORTER WITH BASE-PAIRING OLIGOMERS - System, including methods, apparatus, and compositions, for performing amplification assays with an amplification reporter including a first oligomer and a second oligomer capable of base-pairing with one another below a melting temperature of the reporter. The reporter may have a detectable photoluminescence that is affected, such as reduced, by base-pairing of the first and second oligomers with one another. A target, such as a nucleic acid target sequence, may be amplified in at least one volume, such as a plurality of partitions, above the melting temperature, and photoluminescence of the reporter may be detected from the at least one volume below the melting temperature. A property of the target, such as a concentration of the target, may be determined based on the photoluminescence detected. | 05-28-2015 |
20160076099 | ANALYSIS OF NUCLEIC ACIDS - Provided herein are improved methods, compositions, and kits for analysis of nucleic acids. The improved methods, compositions, and kits can enable copy number estimation of a nucleic acid in a sample. Also provided herein are methods, compositions, and kits for determining the linkage of two or more copies of a target nucleic acid in a sample (e.g. whether the two or more copies are on the same chromosome or different chromosomes) or for phasing alleles. | 03-17-2016 |
20160102346 | MULTIPLEXED DIGITAL ASSAY WITH SPECIFIC AND GENERIC REPORTERS - Digital assay system, including methods, apparatus, and compositions, for performing target assays in partitions each containing a generic reporter and a specific reporter for target amplification. | 04-14-2016 |
Patent application number | Description | Published |
20080213872 | Disposable and Removable Nucleic Acid Extraction and Purification Cartridges For Automated Flow-Through Systems - Removable cartridges are used on automated flow-through systems for the purpose of extracting and purifying genetic material from complex matrices. Different types of cartridges are paired with specific automated protocols to concentrate, extract, and purifying pathogenic or human genetic material. Their flow-through nature allows large quantities sample to be processed. Matrices may be filtered using size exclusion and/or affinity filters to concentrate the pathogen of interest. Lysed material is ultimately passed through a filter to remove the insoluble material before the soluble genetic material is delivered past a silica-like membrane that binds the genetic material, where it is washed, dried, and eluted. Cartridges are inserted into the housing areas of flow-through automated instruments, which are equipped with sensors to ensure proper placement and usage of the cartridges. Properly inserted cartridges create fluid- and air-tight seals with the flow lines of an automated instrument. | 09-04-2008 |
20080254467 | Automated High-Throughput Flow-Through Real-Time Diagnostic System - An automated real-time flow-through system capable of processing multiple samples in an asynchronous, simultaneous, and parallel fashion for nucleic acid extraction and purification, followed by assay assembly, genetic amplification, multiplex detection, analysis, and decontamination. The system is able to hold and access an unlimited number of fluorescent reagents that may be used to screen samples for the presence of specific sequences. The apparatus works by associating extracted and purified sample with a series of reagent plugs that have been formed in a flow channel and delivered to a flow-through real-time amplification detector that has a multiplicity of optical windows, to which the sample-reagent plugs are placed in an operative position. The diagnostic apparatus includes sample multi-position valves, a master sample multi-position valve, a master reagent multi-position valve, reagent multi-position valves, and an optical amplification/detection system. | 10-16-2008 |
20090137047 | Automated Diagnostic Kiosk for Diagnosing Diseases - An automated and autonomous diagnostic apparatus that is capable of dispensing collection vials and collections kits to users interesting in collecting a biological sample and submitting their collected sample contained within a collection vial into the apparatus for automated diagnostic services. The user communicates with the apparatus through a touch-screen monitor. A user is able to enter personnel information into the apparatus including medical history, insurance information, co-payment, and answer a series of questions regarding their illness, which is used to determine the assay most likely to yield a positive result. Remotely-located physicians can communicate with users of the apparatus using video tele-medicine and request specific assays to be performed. The apparatus archives submitted samples for additional testing. Users may receive their assay results electronically. Users may allow the uploading of their diagnoses into a central databank for disease surveillance purposes. | 05-28-2009 |
20100152885 | AUTOMATED DIAGNOSTIC KIOSK FOR DIAGNOSING DISEASES - An automated and autonomous diagnostic apparatus that is capable of dispensing collection vials and collections kits to users interesting in collecting a biological sample and submitting their collected sample contained within a collection vial into the apparatus for automated diagnostic services. The user communicates with the apparatus through a touch-screen monitor. A user is able to enter personnel information into the apparatus including medical history, insurance information, co-payment, and answer a series of questions regarding their illness, which is used to determine the assay most likely to yield a positive result. Remotely-located physicians can communicate with users of the apparatus using video tele-medicine and request specific assays to be performed. The apparatus archives submitted samples for additional testing. Users may receive their assay results electronically. Users may allow the uploading of their diagnoses into a central databank for disease surveillance purposes. | 06-17-2010 |
20120322058 | Analysis of nucleic acids - Provided herein are improved methods, compositions, and kits for analysis of nucleic acids. The improved methods, compositions, and kits can enable copy number estimation of a nucleic acid in a sample. Also provided herein are methods, compositions, and kits for determining the linkage of two or more copies of a target nucleic acid in a sample (e.g., whether the two or more copies are on the same chromosome or different chromosomes) or for phasing alleles. | 12-20-2012 |
20130005587 | AUTOMATED HIGH-THROUGHPUT FLOW-THROUGH REAL-TIME DIAGNOSTIC SYSTEM - An automated real-time flow-through system capable of processing multiple samples in an asynchronous, simultaneous, and parallel fashion for nucleic acid extraction and purification, followed by assay assembly, genetic amplification, multiplex detection, analysis, and decontamination. The system is able to hold and access an unlimited number of fluorescent reagents that may be used to screen samples for the presence of specific sequences. The apparatus works by associating extracted and purified sample with a series of reagent plugs that have been formed in a flow channel and delivered to a flow-through real-time amplification detector that has a multiplicity of optical windows, to which the sample-reagent plugs are placed in an operative position. The diagnostic apparatus includes sample multi-position valves, a master sample multi-position valve, a master reagent multi-position valve, reagent multi-position valves, and an optical amplification/detection system. | 01-03-2013 |
20130040841 | DIGITAL ASSAYS WITH MULTIPLEXED DETECTION OF TWO OR MORE TARGETS IN THE SAME OPTICAL CHANNEL - System, including methods and apparatus, for performing a digital assay with multiplexed detection of two or more distinct targets in the same optical channel. | 02-14-2013 |
20140171341 | MULTIPLEXED DIGITAL ASSAYS - System, including methods and apparatus, for performing a multiplexed digital assay. | 06-19-2014 |
Patent application number | Description | Published |
20110211448 | PER-CLASS SCHEDULING WITH RATE LIMITING - Providing network access is disclosed. Use of a provider equipment port via which network access is provided to two or more downstream nodes, each having one or more classes of network traffic associated with it, is scheduled on a per class basis, across the downstream nodes. The respective network traffic sent to each of at least a subset of the two or more downstream nodes is limited, on a per downstream node basis, to a corresponding rate determined at least in part by a capacity of a communication path associated with the downstream node. | 09-01-2011 |
20140119173 | MULTIPATH VIRTUAL ROUTER REDUNDANCY - Providing gateway redundancy is disclosed. On each of a master and a standby gateway a single IP routing redundancy protocol instance is associated with a plurality of subscriber subnets. On each gateway, the respective single IP routing redundancy protocol instance is used to provide gateway redundancy for the plurality of subscriber subnets. | 05-01-2014 |
20150029857 | PER-CLASS SCHEDULING WITH RATE LIMITING - Providing network access is disclosed. Use of a provider equipment port via which network access is provided to two or more downstream nodes, each having one or more classes of network traffic associated with it, is scheduled on a per class basis, across the downstream nodes. The respective network traffic sent to each of at least a subset of the two or more downstream nodes is limited, on a per downstream node basis, to a corresponding rate determined at least in part by a capacity of a communication path associated with the downstream node. | 01-29-2015 |