Patent application number | Description | Published |
20100273210 | Biofuel manufacturing methods and systems incorporating radiocarbon analysis techniques - The systems and methods described herein are directed toward the use of radiocarbon analysis techniques in the manufacture of biofuel products. Among other things, methods and systems for using measured fossil-fuel-derived carbon content in biofuel products to guide the design and modification of biofuel manufacturing systems are disclosed. | 10-28-2010 |
20110038784 | ALKYNE-ASSISTED NANOSTRUCTURE GROWTH - The present invention relates to the formation and processing of nanostructures including nanotubes. Some embodiments provide processes for nanostructure growth using relatively mild conditions (e.g., low temperatures). In some cases, methods of the invention may improve the efficiency (e.g., catalyst efficiency) of nanostructure formation and may reduce the production of undesired byproducts during nanostructure formation, including volatile organic compounds and/or polycylic aromatic hydrocarbons. Such methods can both reduce the costs associated with nanostructure formation, as well as reduce the harmful effects of nanostructure fabrication on environmental and public health and safety. | 02-17-2011 |
20110167714 | USE OF MARINE ALGAE FOR PRODUCING HYDROCARBONS - In certain aspects, the disclosure provides methods for producing hydrocarbons from alkenone-producing algae, such as algae species of the | 07-14-2011 |
20120165490 | USE OF MARINE ALGAE FOR PRODUCING POLYMERS - In certain aspects, the disclosure provides methods for producing polymers from alkenone-producing algae, such as algae species of the Isochrysis family. | 06-28-2012 |
20130060477 | SYSTEMS AND METHODS FOR TOPOGRAPHIC ANALYSIS - The systems and methods described herein provide a scientific and analytical basis for the following: (a) collective interpretation of the entire spectrum of chromatographic data, e.g., GC×GC two-dimensional data, with capability of operating at multi-resolution over bigger or smaller sub-regions of the two-dimensional data, (b) given two or more samples that are from the same source, and some samples from clearly different sources, quantitatively estimate where the fingerprint of the source lies, (c) given a source signature template, an unknown sample can be compared to decide whether it is related to, and if so, to what degree, to this source, and (d) given two source signature templates, the templates can be compared to determine how related is one source to the other. | 03-07-2013 |
20140134093 | ALKYNE-ASSISTED NANOSTRUCTURE GROWTH - The present invention relates to the formation and processing of nanostructures including nanotubes. Some embodiments provide processes for nanostructure growth using relatively mild conditions (e.g., low temperatures). In some cases, methods of the invention may improve the efficiency (e.g., catalyst efficiency) of nanostructure formation and may reduce the production of undesired byproducts during nanostructure formation, including volatile organic compounds and/or polycylic aromatic hydrocarbons. Such methods can both reduce the costs associated with nanostructure formation, as well as reduce the harmful effects of nanostructure fabrication on environmental and public health and safety. | 05-15-2014 |
20140171608 | USE OF MARINE ALGAE FOR PRODUCING POLYMERS - In certain aspects, the disclosure provides methods for producing polymers from alkenone-producing algae, such as algae species of the | 06-19-2014 |
Patent application number | Description | Published |
20100145473 | Gradient Template for Angiogensis During Large Organ Regeneration - This invention relates to highly porous scaffolding and methods of producing the same. Specifically, the scaffolding comprises a pore volume fraction of no less than 80% (v/v) of the total volume of the scaffold and interconnecting pores forming channels in the scaffold. | 06-10-2010 |
20100221300 | Processing of Angiogenic Scaffolds for Large Organ Regeneration - This invention relates to a method for fabricating large scaffolds in a variety of shapes with an organized pore structure. The pore structure is organized such that pores are generally aligned perpendicular to the edges of the scaffold, regardless of-the particular macroscopic scaffold shape. Specifically, a freeze-drying based fabrication method for creating large, polymeric porous scaffolds for tissue engineering applications, with an organized pore structure of columnar pores extending from the scaffold periphery into the main mass of the scaffold. | 09-02-2010 |
20100303880 | Tissue scaffolding comprising surface folds for tissue engineering - The invention is directed to solid gradient scaffolds, methods of producing the same, and therapeutic applications arising from their utilization. Specifically, the gradient scaffolding includes, inter-alia, surface folds of various configuration for increasing surface area to volume of the scaffold. | 12-02-2010 |
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20140057885 | METHODS OF TREATING EPILEPSY OR STATUS EPILEPTICUS - Described herein are methods of treating epilepsy or status epilepticus, e.g., convulsive status epilepticus, e.g., early status epilepticus, established status epilepticus, refractory status epilepticus, super-refractory status epilepticus, e.g., super-refractory generalized status epilepticus; non-convulsive status epilepticus, e.g., generalized status epilepticus, complex partial status epilepticus; generalized periodic epileptiform discharges; periodic lateralized epileptiform discharges; a seizure, e.g., acute repetitive seizures, cluster seizures, the method comprising administering to the subject a neuroactive steroid. | 02-27-2014 |
20150018327 | NEUROACTIVE STEROID FORMULATIONS AND METHODS OF TREATING CNS DISORDERS - Formulations of comprising a neuroactive steroid, e.g., allopregnanolone; and optionally a cyclodextrin, e.g., a β-cyclodextrin, e.g., a sulfo butyl ether β-cyclodextrin, e.g., a β-cyclodextrin, e.g., a sulfo butyl ether β-cyclodextrin, e.g., CAPTISOL®; and methods of use in treating CNS disorders. | 01-15-2015 |
Patent application number | Description | Published |
20090010942 | NOVEL PRIMATE CHITINASES AND USES THEREFOR - Novel primate chitinases (pNC) and nucleic acids encoding these chitinases are disclosed. The pNCs of the invention are homologous to human acidic mammalian chitinases (hAMCase) and human chitotriosidase, in terms of their exon/intron genomic structure and conserved catalytic sites. The polypeptides and nucleic acids of the invention can be used to develop, and/or screen for, modulators of chitinase-activities, e.g., antisense, antibodies, RNAi. The modulators identified using methods and reagents disclosed herein can be used to reduce chitinase-associated inflammatory conditions. | 01-08-2009 |
20140286959 | Methods of Treating Inflammatory Disorders Using Anti-M-CSF Antibodies - The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to a M-CSF, preferably human M-CSF, and that function to inhibit a M-CSF. The invention also relates to human anti-M-CSF antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-M-CSF antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-M-CSF antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-M-CSF antibodies. The invention also relates to transgenic animals and transgenic plants comprising nucleic acid molecules of the present invention. | 09-25-2014 |
Patent application number | Description | Published |
20080226645 | Methods and compositions for assessment and treatment of asthma - The present invention provides methods and compositions for the assessment and treatment of asthma and other inflammatory diseases, particularly those mediated by interleukin-13 (IL-13). The present invention also provides arrays comprising markers for asthma as well as IL-13 responsiveness. The markers of the present invention can be used in methods to diagnose a patient as having asthma or an IL-13-mediated condition, to evaluate the effectiveness of potential therapeutic agents, to identify or evaluate agents capable of modulating marker expression levels, and to select a treatment for a patient suffering from asthma or an IL-13-mediated condition. | 09-18-2008 |
20090155784 | ASSESSMENT OF ASTHMA AND ALLERGEN-DEPENDENT GENE EXPRESSION - The present invention provides methods for the assessment, diagnosis, or prognosis of asthma including methods for providing an assessment, diagnosis, or prognosis comprising the step of exposing a sample derived from a patient to an allergen in vitro. The present invention also provides methods for selecting, as well as evaluating the effectiveness of, asthma treatments. The markers of the present invention can be used in methods to identify or evaluate agents capable of modulating marker expression levels in subjects with asthma | 06-18-2009 |
20090325176 | Gene Expression Profiles Associated with Asthma Exacerbation Attacks - The present invention provides methods for the assessment, diagnosis, or prognosis of asthma exacerbation, by assessing the level of expression of asthma exacerbation gene products in a sample derived from a patient. The markers of the present invention can be used in methods to identify or evaluate agents capable of modulating marker expression levels in subjects with asthma. | 12-31-2009 |
Patent application number | Description | Published |
20110212080 | UREA DERIVATIVES AS ANTIBACTERIAL AGENTS - This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which is useful for the treatment of diseases or conditions mediated by LpxC. | 09-01-2011 |
20120114739 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS - The present invention provides methods for inhibiting mTOR using pyrazolo[1,5-a]pyrimidine compounds and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with mTOR using such compounds. | 05-10-2012 |
20120328691 | ANILINOPIPERAZINE DERIVATIVES AND METHODS OF USE THEREOF - The present invention relates to novel Anilinopiperazine Derivatives of Formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, cancer, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase. | 12-27-2012 |
Patent application number | Description | Published |
20080226618 | HYDANTOIN DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS - This invention relates to compounds of the Formula (I), | 09-18-2008 |
20090175852 | IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS - In its many embodiments, the present invention provides a novel class of imidazopyrazine compounds as inhibitors of protein and/or checkpoint kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or checkpoint kinases using such compounds or pharmaceutical compositions. | 07-09-2009 |
20100179141 | NOVEL JNK INHIBITORS - Disclosed are compounds of the formula (I) wherein X is N or CH, and Y is N or CR | 07-15-2010 |
20100286135 | HETEROCYCLIC AMIDE COMPOUNDS AS PROTEIN KINASE INHIBITORS - The present invention relates to novel heterocyclic amide compounds of Formula I: as disclosed herein or a pharmaceutically acceptable salt, solvate, ester, prodrug or stereoisomer thereof. Also disclosed are compositions comprising said compounds, and methods for using said compounds for treating or preventing a proliferative disease, an anti-proliferative disorder, inflammation, arthritis, a neurological or neurodegenerative disease, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease or a fungal disease. | 11-11-2010 |
20100298314 | NOVEL JNK INHIBITORS - Disclosed are substituted imidazo[1,2-a]pyridines, imidazo[1,2-a]pyrazines, imidazo[1,2-c]pyrimidines and imidazo[1,2-d]triazines compounds of the formula: (1.0) Also disclosed are methods for treating JNK1 and ERK mediated diseases using the compounds of formula 1.0. | 11-25-2010 |
20100331313 | Thiazole Derivatives as Protein Kinase Inhibitors - The present invention relates to novel Thiazole Derivatives, compositions comprising the Thiazole Derivatives, and methods for using the Thiazole Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral infection, a fungal infection, or a disorder related to the activity of a protein kinase. | 12-30-2010 |
20110212078 | SYNTHESIS AND USE OF HETEROCYCLIC ANTIBACTERIAL AGENTS - This invention relates to compounds of the following Formula (I); or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which is useful for the treatment of diseases or conditions mediated by LpxC. | 09-01-2011 |
20120208826 | HETEROCYCLIC AMIDE COMPOUNDS AS PROTEIN KINASE INHIBITORS - The present invention relates to heterocyclic amide derivatives of Formula (I): Formula (I) wherein the variables are as defined in the specification. The present invention further relates to compositions comprising said heterocyclic amide derivatives of formula (I) and methods for using said heterocyclic amide derivatives of formula (I) for treating or preventing a disease or disorder related to the activity of a protein kinase, in particular, a proliferative disease, an anti-proliferative disorder, inflammation, arthritis, a neurological or neurodegenerative disease, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease or a fungal infection. | 08-16-2012 |
20120322791 | PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS - The present invention provides Pyrazolopyrimidine Compounds of Formula (I): | 12-20-2012 |
20130150353 | Fused Tricyclic Inhibitors of Mammalian Target of Rapamycin - This invention relates to novel fused tricyclic compounds that are inhibitors of mammalian Target of Rapamycin (mTOR) kinase, which is also known as FRAP, RAFT, RAPT or SEP, and are useful in the treatment of cellular proliferative diseases, for example cancer and other proliferative disorders. | 06-13-2013 |
20130150362 | NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS - The present invention relates to certain pyrazolo[1,5-a]pyrimidine compounds of Formula (I) as inhibitors of mammalian Target Of Rapamycin (mTOR) kinase, which is also known as FRAP, RAFT, RAPT or SEP. The compounds may be used in the treatment of cancer and other disorders where mTOR is deregulated. The present invention further provides pharmaceutical compositions comprising the pyrazolo[1,5-a]pyrimidine compounds. | 06-13-2013 |
Patent application number | Description | Published |
20090047295 | Methods and Compositions for Reducing Stemness in Oncogenesis - The invention provides methods and compositions for reducing the number of cancer stem cells in a mixed population of differentiated cells (for example, cancer cells) and cancer stem cells. The cancer stem cells, if present, can be more resistant to traditional drug-based therapies and can provide a source for new, differentiated cancer cells associated with the development of drug-resistance and more aggressive phenotypes. When combined with traditional cancer therapies, for example, drug-based therapies, the methods and compositions of the invention provide a more effective way for treating cancer and can provide a model system for developing new cancer therapies and new treatment modalities. | 02-19-2009 |
20110044895 | METHODS AND COMPOSITIONS FOR REDUCING STEMNESS IN ONCOGENESIS - The invention provides methods and compositions for reducing the number of cancer stem cells in a mixed population of differentiated cells (for example, cancer cells) and cancer stem cells. The cancer stem cells, if present, can be more resistant to traditional drug-based therapies and can provide a source for new, differentiated cancer cells associated with the development of drug-resistance and more aggressive phenotypes. When combined with traditional cancer therapies, for example, drug-based therapies, the methods and compositions of the invention provide a more effective way for treating cancer and can provide a model system for developing new cancer therapies and new treatment modalities. | 02-24-2011 |
20120269765 | CYTOKINE COMPOSITIONS AND METHODS OF USE THEREOF - Polypeptides, including non-naturally occurring and recombinantly modified polypeptides related to the p19 subunit of IL-23, methods of making such molecules and methods of using such molecules as therapeutic, prophylactic and diagnostic agents are provided. | 10-25-2012 |
Patent application number | Description | Published |
20090083811 | Unicast Delivery of Multimedia Content - Described herein are techniques, including methods and systems, including computer program products, for unicast delivery of multimedia content. A broadcast program and a video-on-demand program are ingested by a video delivery module. At least a portion of the broadcast program and at least a portion of the video-on-demand program are stored. The broadcast program, the video-on-demand program, or both are delivered as a unicast video stream to a first single subscriber through a multiplexer connected to a plurality of subscribers. | 03-26-2009 |
20090083813 | Video Delivery Module - Described herein are techniques, including methods and systems, including computer program products, for a video delivery module. A broadcast program and a video-on-demand program are ingested by a video delivery module. At least a portion of the broadcast program and at least a portion of the video-on-demand program are stored. The broadcast program, the video-on-demand program, or both are delivered as a unicast video stream to a first single subscriber through a multiplexer connected to a plurality of subscribers. | 03-26-2009 |
20090182939 | Asynchronous and Distributed Storage of Data - In one example, multimedia content is requested from a plurality of storage modules. Each storage module retrieves the requested parts, which are typically stored on a plurality of storage devices at each storage module. Each storage module determines independently when to retrieve the requested parts of the data file from storage and transmits those parts from storage to a data queue. Based on a capacity of a delivery module and/or the data rate associated with the request, each storage module transmits the parts of the data file to the delivery module. The delivery module generates a sequenced data segment from the parts of the data file received from the plurality of storage modules and transmits the sequenced data segment to the requester. | 07-16-2009 |