Patent application number | Description | Published |
20090118814 | ENDOPROSTHESIS COATING - A method includes: providing a tubular substrate in a chamber, the tubular substrate having a lumen, an a luminal surface and a luminal surface; providing a target in the lumen; depositing a first coating onto the abluminal surface and a second coating onto the luminal surface while keeping the tubular substrate in the chamber. An endoprosthesis, such as a stent, including a first coating on at least one portion of its abluminal surface and a second coating on at least one portion of its luminal surface is also disclosed. | 05-07-2009 |
20090143856 | MEDICAL ARTICLES THAT STIMULATE ENDOTHELIAL CELL MIGRATION - A medical article that includes (a) an electronically conductive substrate having a specific conductivity of at least 1 μS/cm and (b) a galvanic couple that includes a first member and a second member arranged in sufficient proximity to each other to generate a localized electric field under physiological conditions. The first and second members are selected such that the galvanic couple exhibits an average plateau current density of at least 25 microamps/cm | 06-04-2009 |
20090281613 | Endoprostheses - An endoprosthesis includes a body defining a flow passage therethrough. The body is capable of maintaining patency in a blood vessel and includes iron or an alloy thereof. The body has a nano-structured surface comprising iron oxide in which the individual nano-structures have a height to thickness aspect ratio of at least 5:1. | 11-12-2009 |
20100030326 | Bioerodible Endoprosthesis - An endoprosthesis includes a plurality of struts defining a flow passage. At least one strut includes (a) a body comprising a bioerodible material and having a thickness and (b) a coating overlying the body. The coating includes a plurality of regions that allow physiological fluids to contact a plurality of corresponding areas of the underlying body when the endoprosthesis is implanted in a physiological environment. The plurality of regions are sized and arranged so that the contacted areas of the body erode substantially through the body in the thickness direction while the coating remains on the body when the endoprosthesis is implanted in the physiological environment. | 02-04-2010 |
20100272882 | ENDOPROSTHESE - A coating having a smooth orange peel morphology is formed on an adluminal surface of a stent, concurrently with the formation of a coating having a rough rice grain morphology on an abluminal surface of the stent. During the formation of the two coatings, a mandrel is placed adjacent to the adluminal surface of the stent but does not generally contact the adluminal surface. | 10-28-2010 |
20100318020 | ELECTROCHEMICAL THERAPEUTIC AGENT DELIVERY DEVICE - A therapeutic agent delivery device and method for eluting a therapeutic agent to a target location are disclosed. The device may comprise a first conductive element, a second conductive element, an electrochemical composition including an electrolyte and a therapeutic agent, and a permeable membrane covering the electrochemical composition. The first conductive element and the second conductive element are adapted to be connected to a voltage source. When the voltage source is connected to the first conductive element and the second conductive element, an electrochemical reaction occurs causing the therapeutic agent to pass through the permeable membrane and thereby to elute to a target location. | 12-16-2010 |
20110118826 | Bioerodible Endoprosthesis - An endoprosthesis includes a plurality of struts defining a flow passage. At least one strut includes (a) a body comprising a bioerodible material and having a thickness and (b) a coating overlying the body. The coating includes a plurality of regions that allow physiological fluids to contact a plurality of corresponding areas of the underlying body when the endoprosthesis is implanted in a physiological environment. The plurality of regions are sized and arranged so that the contacted areas of the body erode substantially through the body in the thickness direction while the coating remains on the body when the endoprosthesis is implanted in the physiological environment. | 05-19-2011 |
20110160839 | Endoprosthesis - An endoprosthesis, e.g., a bioerodable stent, that is treated by plasma immersion ion implantation on the surface and optionally in the bulk. Releasable therapeutic agent, drug, or pharmaceutically active compound may be incorporated into the treated surface of the endoprosthesis to provide desired medical benefits. | 06-30-2011 |
20110196347 | MEDICAL DEVICES EMPLOYING PIEZOELECTRIC MATERIALS FOR DELIVERY OF THERAPEUTIC AGENTS - In one aspect, the present invention provides therapeutic-agent-releasing medical devices which comprise at least one region of piezoelectric material. Therapeutic agent release is initiated or increased when the piezoelectric material is subjected to mechanical stress, which leads to the development of a voltage across the piezoelectric material. This voltage is used to initiate or increase therapeutic agent release. | 08-11-2011 |
20110238149 | ENDOPROSTHESIS - Endoprostheses and methods of making endoprostheses are disclosed. For example, endoprostheses are described that include an endoprosthesis body, a biodegradable metallic tie layer, and a polymer coating about the endoprosthesis body. The biodegradable tie layer and the polymer coating can have a high peel strength from the body. | 09-29-2011 |
20110238153 | ENDOPROSTHESES - Endoprostheses include an endoprosthesis wall that includes a surface layer that includes a metallic material and that defines a plurality of discrete pores. A porous material is disposed in one or more pores of the surface layer. The endoprostheses can, for example, deliver a therapeutic agent, such as a drug, in a controlled manner over an extended period of time. | 09-29-2011 |
20110282431 | Endoprostheses - A medical device is provided with a porous region including a reservoir zone including a polymer and a protective zone between adjacent tissue and the reservoir zone that restricts the tissue from direct contact with the polymer. | 11-17-2011 |
20110282436 | Endoprosthesis - A stent includes a MOF which adjusts pore size upon desorption or adsorption of organic molecules. | 11-17-2011 |
20120022585 | VASCULAR CLOSURE DEVICE WITH BIODEGRADABLE ANCHOR - This disclosure pertains to controllably bioabsorbable devices, particularly anchors for vascular closure plugs and to methods of use thereof. | 01-26-2012 |
20120095396 | Drug Eluting Medical Device Utilizing Bioadhesives - A medical balloon having an inner surface and an outer surface comprising a first coating composition comprising at least one therapeutic agent, the first coating composition disposed on the balloon outer surface and forming an interface between the balloon outer surface and the first coating composition and a second coating composition comprising a bioadhesive, the second coating composition disposed on the first coating composition so as to not affect the interface between the balloon outer surface and the first coating composition, the bioadhesive selected so as to adhere to body tissue, and methods of making the same. | 04-19-2012 |
20120226346 | Low Strain High Strength Stent - In at least one embodiment, a stent comprises an expandable framework comprising a plurality of serpentine bands and a plurality of connector struts. Each serpentine band comprises a plurality of alternating struts and turns. A plurality of the serpentine bands each have their proximal turns aligned on a common stent circumference and comprise first distal turns and second distal turns. The first distal turns are aligned with one another on a common stent circumference. The second distal turns aligned with one another on another common stent circumference. Each band in the plurality comprises first struts and second struts. Each first strut is attached between a proximal turn and a first distal turn, and each second strut is attached between a proximal turn and a second distal turn. The second struts are wider than said first struts. | 09-06-2012 |
20140142670 | MEDICAL ELECTRODES WITH LAYERED COATINGS - Various embodiments concern an electrode of an implantable medical device for delivering electrical stimulation to tissue. Such an electrode can include a main body formed from a substrate metal comprising one of titanium, stainless steel, a cobalt-chromium alloy, or palladium. The main body may not be radiopaque. The electrode may further include a first coating on at least one side of the main body, the first coating comprising a layer of one of tantalum or iridium metal that is at least about 2 micrometers thick. The first coating can be radiopaque and porous. The porosity of the first coating can increase the electrical performance of the electrode in delivering electrical stimulation to tissue. | 05-22-2014 |