Patent application number | Description | Published |
20080249101 | BENZOIMIDAZOLE, TETRAHYDRO-QUINOXALINE, BENZOTRIAZOLE, DIHYDRO-IMIDAZO[4,5-c] PYRIDINONE AND DIHYDRO-ISOINDOLONE DERIVATIVES - This invention relates to compounds of the formula | 10-09-2008 |
20080293756 | 4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES - This invention relates to 4,4-disubstituted piperidine derivatives of the formula | 11-27-2008 |
20080306116 | ARYLOXAZOLE, ARYLOXADIAZOLE AND BENZIMIDAZOLE DERIVATIVES - This invention relates to compounds of the formula | 12-11-2008 |
20090029976 | BENZOFURAN AND BENZOTHIOPHENE-2-CARBOXYLIC ACID AMIDE DERIVATIVES - The present invention relates to compounds of formula I | 01-29-2009 |
20090143439 | NEW PYRIDINES AS FBPASE INHIBITORS FOR TREATMENT OF DIABETES - Compounds of formula (I) | 06-04-2009 |
20090143448 | NEW AMINOTHIAZOLES AS FBPASE INHIBITORS FOR DIABETES - Compounds of formula (I) | 06-04-2009 |
20090163517 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES - This invention is concerned with compounds of the formula | 06-25-2009 |
20100035953 | Pyrazole Phenyl Derivatives - The invention relates to compounds of the formula I: | 02-11-2010 |
20110207799 | Compositions for Targeted Delivery of siRNA - The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers. | 08-25-2011 |
20110237640 | PYRAZOLE PHENYL DERIVATIVES - The invention relates to compounds of the formula I: | 09-29-2011 |
20120157509 | GALACTOSE CLUSTER-PHARMACOKINETIC MODULATOR TARGETING MOIETY FOR siRNA - The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cell in vivo. The pharmacokinetic modulator improve in vivo targeting compared to the targeting ligand alone. Targeting ligand-pharmacokinetic modulator targeting moiety targeted RNAi polynucleotides can be administered in vivo alone or together with co-targeted delivery polymers. | 06-21-2012 |
20120165393 | Peptide-Based In Vivo siRNA Delivery System - The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted melittin delivery peptides. Delivery peptides provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides. | 06-28-2012 |
20120172412 | In Vivo Polynucleotide Delivery Conjugates Having Enzyme Sensitive Linkages - The present invention is directed compositions for delivery of RNA interference (RNAi) polynucleotides to cells in vivo. The compositions comprise amphipathic membrane active polyamines reversibly modified with enzyme cleavable dipeptide-amidobenzyl-carbonate masking agents. Modification masks membrane activity of the polymer while reversibility provides physiological responsiveness. The reversibly modified polyamines (dynamic polyconjugate or DPC) are further covalently linked to an RNAi polynucleotide or co-administered with a targeted RNAi polynucleotide-targeting molecule conjugate. | 07-05-2012 |
20130065876 | 3-PYRIDINE CARBOXYLIC ACID HYDRAZIDES - The present invention relates to compounds of formula I, | 03-14-2013 |
20130072679 | DIHYDROQUINOLINE-2-ONE DERIVATIVES - The invention provides novel compounds having the general formula (I) | 03-21-2013 |
20130079365 | NEW BICYCLIC DIHYDROQUINOLINE-2-ONE DERIVATIVES - The invention provides novel compounds having the general formula (I) | 03-28-2013 |
20130143863 | NEW BICYCLIC DIHYDROISOQUINOLINE-1-ONE DERIVATIVES - The invention provides novel compounds having the general formula (I) | 06-06-2013 |
20130190484 | In Vivo Polynucleotide Delivery Conjugates Having Enzyme Sensitive Linkages - The present invention is directed compositions for delivery of RNA interference (RNAi) polynucleotides to cells in vivo. The compositions comprise amphipathic membrane active polyamines reversibly modified with enzyme cleavable dipeptide-amidobenzyl-carbonate masking agents. Modification masks membrane activity of the polymer while reversibility provides physiological responsiveness. The reversibly modified polyamines (dynamic polyconjugate or DPC) are further covalently linked to an RNAi polynucleotide or co-administered with a targeted RNAi polynucleotide-targeting molecule conjugate. | 07-25-2013 |
20130245091 | Compositions for Targeted Delivery of siRNA - The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers. | 09-19-2013 |
20130274287 | PHENYL-TETRAHYDROISOQUINOLINE DERIVATIVES - The invention provides novel compounds having the general formula (I) | 10-17-2013 |
20130281658 | Peptide-Based In Vivo siRNA Delivery System - The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted melittin delivery peptides. Delivery peptides provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides. | 10-24-2013 |
20140128429 | NEW IMIDAZOLYLKETONE DERIVATIVES - The invention provides novel compounds having the general formula (I) | 05-08-2014 |
20140135380 | Small molecule conjugates for intracellular delivery of nucleic acids - The invention provides use of novel compounds for delivery of nucleic acids, and conjugates of these compounds with nucleic acids. Further novel design criteria for chemically stabilized siRNA particular useful when covalently attached to said compounds and co-administered with a delivery polymer to achieve mRNA knock down in vivo are disclosed therein. | 05-15-2014 |
20140135381 | Small molecule conjugates for intracellular delivery of biologically active compounds - The invention provides novel compounds and conjugates of these compounds useful for the delivery of biologically active substances. Further novel design criteria for chemically stabilized siRNA particular useful when covalently attached to a delivery polymer to achieve in vivo mRNA knock down are disclosed therein. | 05-15-2014 |