Perrin, CA
Andre' Perrin, Newbury Park, CA US
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20100122602 | Parallel kinematic positioning system - A parallel kinematic positioning system | 05-20-2010 |
Marilyn Perrin, La Jolla, CA US
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20090117649 | ISOLATED SOLUBLE CORTICOTROPIN RELEASING FACTOR RECEPTOR TYPE 2 (SCRFR2) - The present invention is directed to compositions and methods related to soluble G-protein coupled receptors (sGPCR). In certain aspects the invention includes compositions and methods related to a soluble corticotropin releasing factor receptor related protein, sCRFR2, as well as its effects on CRFR signaling and interaction between CRF family ligand and CRFR receptors, including but not limited to CRFR2, CRFR1 and functional or signaling capable variants thereof. | 05-07-2009 |
Marilyn H. Perrin, La Jolla, CA US
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20090149629 | CRFR1 SELECTIVE LIGANDS - CRF peptide analogs that bind to CRFR1 with an affinity far greater than they bind to CRFR2. Some of these analogs exhibit CRF agonist activity. One exemplary analog that may be made by solid-phase synthesis is: | 06-11-2009 |
20090156493 | UROCORTIN-III AND USES THEREOF - A search of the public human genome database identified a human EST, GenBank accession number AW293249, which has high homology to known pufferfish urocortin sequences. The full length sequence was amplified from human genomic DNA and sequenced. Sequence homology comparisons of the novel sequence with human urocortin I and urocortin II revealed that the sequence encoded a novel human urocortin, which was designated urocortin III (UcnIII). While urocortin III does not have high affinity for either CRF-R1 or CRF-R2, the affinity for CRF-R2 is greater than the affinity for CRF-R1. Urocortin III is capable stimulating cyclic AMP production in cells expressing CRF-R2α or β. Thus, the affinity is high enough that urocortin III could act as a native agonist of CRF-R2. However, it is also likely that urocortin III is a stronger agonist of a yet to be identified receptor. | 06-18-2009 |
20100168021 | UROCORTIN PROTEINS AND USES THEREOF - A human urocortin-related peptide with significant sequence homology to the CRF neuropeptide family was identified. A mouse cDNA was isolated from whole brain poly (A+) RNA that encodes a predicted 38 amino acid peptide protein designated herein as urocortin II. Both human URP and mouse Ucn II are structurally related to the other known mammalian family members, CRF and urocortin (Ucn). These peptides are involved in the regulation of the hypothalamic-pituitary-adrenal axis under basal and stress conditions, suggesting a similar role for URP and Ucn IL Synthesized Ucn-II and URP peptide binds with higher affinity to CRF-R2 than to CRF-R1 Ucn II and human URP appear to be involved in the regulation of body temperature and appetite and may play a role in other stress related phenomenon. These findings identify Ucn II and human URP as a new members of the CRF family of neuropeptides, which are expressed centrally and bind to CRF-R2. | 07-01-2010 |
20120270792 | UROCORTIN-III AND USES THEREOF - A search of the public human genome database identified a human EST, GenBank accession number AW293249, which has high homology to known pufferfish urocortin sequences. The full length sequence was amplified from human genomic DNA and sequenced. Sequence homology comparisons of the novel sequence with human urocortin I and urocortin II revealed that the sequence encoded a novel human urocortin, which was designated urocortin III (UcnIII). While urocortin III does not have high affinity for either CRF-R1 or CRF-R2, the affinity for CRF-R2 is greater than the affinity for CRF-R1. Urocortin III is capable stimulating cyclic AMP production in cells expressing CRF-R2α or β. Thus, the affinity is high enough that urocortin III could act as a native agonist of CRF-R2. However, it is also likely that urocortin III is a stronger agonist of a yet to be identified receptor. | 10-25-2012 |
20140004603 | UROCORTIN-III AND USES THEREOF | 01-02-2014 |
20140288161 | UROCORTIN-III AND USES THEREOF - A search of the public human genome database identified a human EST, GenBank accession number AW293249, which has high homology to known pufferfish urocortin sequences. The full length sequence was amplified from human genomic DNA and sequenced. Sequence homology comparisons of the novel sequence with human urocortin I and urocortin II revealed that the sequence encoded a novel human urocortin, which was designated urocortin III (UcnIII). While urocortin III does not have high affinity for either CRF-R1 or CRF-R2, the affinity for CRF-R2 is greater than the affinity for CRF-R1. Urocortin III is capable stimulating cyclic AMP production in cells expressing CRF-R2α or β. Thus, the affinity is high enough that urocortin III could act as a native agonist of CRF-R2. However, it is also likely that urocortin III is a stronger agonist of a yet to be identified receptor. | 09-25-2014 |
Mark A. Perrin, San Jose, CA US
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20100155223 | Electromagnet array in a sputter reactor - A multi-step process performed in a plasma sputter chamber including sputter deposition from the target and argon sputter etching of the substrate. The chamber includes a quadruple electromagnetic coil array coaxially arranged in a rectangular array about a chamber axis outside the sidewalls of a plasma sputter reactor in back of an RF coil within the chamber. The coil currents can be separately controlled to produce different magnetic field distributions, for example, between a sputter deposition mode in which the sputter target is powered to sputter target material onto a wafer and a sputter etch mode in which the RF coil supports the argon sputtering plasma. A TaN/Ta barrier is first sputter deposited with high target power and wafer bias. Argon etching is performed with even higher wafer bias. A flash step is applied with reduced target power and wafer bias. | 06-24-2010 |
Michael R. Perrin, West Hills, CA US
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20140277022 | SUTURE TRACKING DILATORS AND RELATED METHODS - Suture tracking dilators and methods for removing implanted medical devices such as microstimulators or microsensors from living tissue are described. A suture tracking dilator has a slit running along its axial length. The slit can have a curved portion. A suture is attached to a medical device prior to its implantation. To remove the implanted medical device, the free end of the suture is exposed and inserted in the slit in the suture tracking dilator. The suture is held under tension at its free end, the dilator is inserted in the living tissue and the dilator follows the suture to the implanted medical device. The medical device is removed by pulling on the free end of the suture. | 09-18-2014 |
Patrick C. Perrin, Rancho Palos Verdes, CA US
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20100102101 | Paper toweling dispenser apparatus - Toweling dispenser apparatus including a toweling support roller carrying a movable cutter blade. A switch is actuated after a user pulls on toweling to rotate the toweling support roller and transport the toweling. After some rotation of the roller has occurred, an electric switch is closed and energizes an electric motor to drive the roller and reduce the force required by the user to rotate the roller and actuate the cutter blade to sever a towel from the toweling. | 04-29-2010 |
Ronald D. Perrin, Huntington Beach, CA US
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20090236955 | HANGING FILE BAR AND METHOD FOR USING SAME - A bar for suspending a document between two parallel rails includes a substantially rectangular body having an upper edge, a lower edge, and a plurality of spaced apart holes centered about a midpoint of said body, said lower edge defining first and second integral hook members disposed at opposite ends of said body portion including a downwardly directed leg member on respective distal sides of the hook members. | 09-24-2009 |
Scott Perrin, Santa Clara, CA US
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20140276747 | SYSTEM AND METHOD FOR DENERVATION - A catheter apparatus for treatment of a human patient is described, the catheter apparatus having a central axis and comprising a shaping structure moveable between a delivery state having a first helical shape, and a deployed state having a second helical shape. The shaping structure is configured to have a reverse taper with a structural diameter that varies over the length of the shaping structure such that the structural diameter of the shaping structure at the proximal end is smaller than the structural diameter of the shaping structure at the distal end. | 09-18-2014 |
Scott H. Perrin, Temecula, CA US
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20120010565 | BALLOON CATHETER WITH IMPROVED TAPER SUPPORT - A catheter balloon having improved steerability is disclosed having a transition between a soft distal tip and a relatively stiffer working portion of a balloon carrying a stent, in the form of a support sleeve on the inner member. The support sleeve provides stiffness to the taper portion of the balloon and also allows precise location of a radio opaque marker. The support sleeve can have a varying thickness or be made of a combination of materials to yield an increasing or decreasing stiffness along the support sleeve to provide an even smoother transition along the balloon's length. | 01-12-2012 |