Paul Harris
Paul Harris, New York, NY US
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20090202428 | Use of Dtbz for Imaging Endocrine Pancreas and Beta Cell Mass In Type 1 Diabetes - The present invention provides non-invasive methods for determining the beta cell mass in the pancreas of a subject by administering to the subject an effective amount of a vesicular monoamine transporter type 2 (VMAT2)-specific radioligand; obtaining at least one computerized image of at least a portion of the pancreas of the subject; and quantitatively analyzing the computerized image in order to determine the beta cell mass in the pancreas of the subject. The present invention additionally provides methods for diagnosing a metabolic neuroendocrine disorder in a subject including insulinoma, diabetes and preclinical diabetes, as well as methods for determining the efficacy of treatment for a metabolic disorder. The present invention further provides methods for assessing the prognosis of a subject at risk for developing diabetes, and methods for managing the treatment or prevention of diabetes. The present invention also provides kits for use in determining the beta cell mass in the pancreas of a subject, as well as diagnosing metabolic or neuroendocrine disorders in a subject. | 08-13-2009 |
20100204258 | METHODS AND COMPOSITIONS FOR MODULATING INSULIN SECRETION AND GLUCOSE METABOLISM - The present invention relates to methods and compositions for treating or ameliorating the effects of diabetes. In addition, the present invention relates to methods and compositions for treating or preventing hyperglycemia, as well as modulating monoamine levels, islet β-cell insulin secretion, insulin and/or glucagon levels in a patient. In certain preferred embodiments, such methods include administering to a patient an effective amount of a vesicular monoamine transporter type 2 (VMAT2) antagonist, such as tetrabenazine (TBZ), dihydrotetrabenazine (DTBZ), tetrahydroberberine (THB), reserpine, emetine, Compound 6, or enantiomers, optical isomers, diastereomers, N-oxides, crystalline forms, hydrates, metabolites or pharmaceutically acceptable salts thereof. | 08-12-2010 |
20100209352 | SYNTHESIS AND CONJUGATION OF IRON OXIDE NANOPARTICLES TO ANTIBODIES FOR TARGETING SPECIFIC CELLS USING FLUORESCENCE AND MR IMAGING TECHNIQUES - The invention provides for methods for producing water-soluble iron oxide nanoparticles comprising encapsulating the nanoparticles in phospholipids micelles. Also provided are methods for conjugating the inventive nanoparticles via functionalized phospholipids to a target molecule, such as an antibody. The invention further provides methods for using the nanoparticle-antibody conjugate of the invention as a contrast agent to image specific cells or proteins in a subject using fluorescent and magnetic imaging techniques. | 08-19-2010 |
20110118300 | GLUCOSE METABOLISM MODULATING COMPOUNDS - The present invention provides, inter alia, dihydropyridone compounds and compositions, including analogs of a vesicular monoamine transporter type 2 (VMAT2) antagonist. The present invention also provides methods of using such compounds/analogs for modulating glucose levels, and/or preventing, treating, or ameliorating the effects of diabetes and hyper-glycemia. | 05-19-2011 |
20110294800 | HYPOGLYCEMIC DIHYDROPYRIDONES - The present invention provides, inter alia, a compound of formula I: wherein the substituent designations are indicated in the Specification. The present invention also provides pharmaceutical compositions comprising a compound of formula I, and methods of treatment or prevention of diabetes or hyperglycemia in a patient, and of normalizing blood glucose levels in a subject, by administering an effective amount of a compound of formula I. | 12-01-2011 |
Paul Harris, Auckland NZ
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20090305798 | ARTIFICIAL PLAYGROUND SURFACE WITH GRASS - A multi-layered surface suitable for a playground, including a top layer of perforated resilient mats is also provided with a bottom shock-absorbing layer having pockets or perforations capable of supporting the growth of grass or other plant material from under the mats. A middle mesh layer helps distributes forces sideways. This invention overcomes the inherent absence of resilience in grassed playgrounds and is compatible with formal tests for impact resistance. The resulting playground environment is more natural in appearance than that of an undressed plastics mat surface. | 12-10-2009 |
20090312154 | PLAYGROUND SURFACE ENHANCEMENT - If an existing playground surface is unsatisfactory (for example, has a damaged surface or is too hard), the invention provides a remediation method including repair of any localised damage, then covering the surface with previously manufactured resilient modular mats, then adhering the mats side by side so that a continuous surface is formed. Preferred mats include internal voids that improve their impact properties. An extrusion enclosing the perimeter is fastened to a substrate and receives the outer edge of the array of mats within an inwardly directed groove. The grooves serve to hold the edges of the mats down against the ground, and allow for some shrinkage or expansion. The impact performance is thereby made acceptable and can be tested according to a relevant standard method. | 12-17-2009 |
20100154997 | APPARATUS FOR CONSTRUCTION OF SAFETY MATS - An array of resilient floor tiles is assembled into a continuous sheet after being laid down. An array of included, sacrificial resistive wires is buried along the edges of the tiles and is controllably heated in order to cause welding of the edges of tiles across the paths of the wires to neighbouring tiles. Subsequently the wires may be used to give the array integral tensile strength. The welded array is provided with greater strength for resisting use, expansive and contractile forces caused by environmental heat and cold and also long-term tile contraction owing to loss of plasticiser as may be seen with PVC-based tiles. | 06-24-2010 |
20130212964 | APPARATUS FOR CONSTRUCTION OF SAFETY MATS - An array of resilient floor tiles is assembled into a continuous sheet after being laid down. An array of included, sacrificial resistive wires is buried along the edges of the tiles and is controllably heated in order to cause welding of the edges of tiles across the paths of the wires to neighboring tiles. Subsequently the wires may be used to give the array integral tensile strength. The welded array is provided with greater strength for resisting use, expansive and contractile forces caused by environmental heat and cold and also long-term tile contraction owing to loss of plasticiser as may be seen with PVC-based tiles. | 08-22-2013 |
Paul Harris, Leighton Buzzard GB
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20100108458 | Releasable Drive Arrangement - A drive arrangement comprising a drive shaft, a clutch arrangement operable, upon axial movement of the drive shaft occurring, to interrupt drive to the drive shaft, an axially movable interrupt shaft, a gear arrangement whereby the interrupt shaft is driven for rotation by the drive shaft at a speed slower than the rotary speed of the drive shaft, disconnect means operable to cause axial movement of the interrupt shaft, and transmission means for transmitting axial movement of the interrupt shaft to the drive shaft. | 05-06-2010 |
Paul Harris, London GB
Paul Harris, Redmond, WA US
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20090132308 | Solution for Managed Personal Computing - Solutions for managed personal computing (SMPC) described herein involve providing multiple services to users in a bundled fashion. In one aspect, SMPC are implemented by a system including a service delivery platform configured to deliver a plurality of services provided by a plurality of entities to a client computer. Service logic running on the service delivery platform is provided to orchestrate a plurality of service adapters. The plurality of service adapters is configured to provide an interface between the service delivery platform and at least two servers associated with at least two of the entities. In this way, the service delivery platform provides a single interface for multiple different services. | 05-21-2009 |
Paul Harris US
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20090073484 | Hospitality Digital Photo Processing - A process for providing printed photos from memory cards via network from a hotel room using a memory card reader, device to display photo(s), and a display. The on screen menu system of the photo viewer or PPV system allows for selection, processing, and billing of the photos. | 03-19-2009 |
Paul Harris, Camation, WA US
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20110136167 | Variants of glycoside hydrolases - The present invention relates to variants of a parent glycoside hydrolase, comprising a substitution at one or more positions corresponding to positions 21, 94, 157, 205, 206, 247, 337, 350, 373, 383, 438, 455, 467, and 486 of amino acids 1 to 513 of SEQ ID NO: 2, and optionally further comprising a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2 a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2, wherein the variants have glycoside hydrolase activity. The present invention also relates to nucleotide sequences encoding the variant glycoside hydrolases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences. | 06-09-2011 |
20120202266 | POLYPEPTIDES HAVING ENDOGLUCANASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME - The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. | 08-09-2012 |
20140093940 | Polypeptides Having Cellulolytic Enhancing Activity And Nucleic Acids Encoding Same - The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. | 04-03-2014 |
Paul Harris, Delta CA
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20120004519 | Motion Cancellation of Optical Input Signals for Physiological Pulse Measurement - A pulse rate sensor that includes an accelerometer for measuring periodic motion and a piezo sensor for detecting erratic motion is capable of more accurately determining pulse rate by accounting for these types of motion. The pulse rate sensor in accordance with the present invention diminishes pulse rate signal degradation due to erratic motion through a combination of algorithms that control signal boosting, waveform refinement and signal noise suppression. | 01-05-2012 |
Paul Harris, Montreal CA
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20120274042 | Replaceable and open-able dropout system enabling adjustable width and height - The invention describes a portion of a bicycle assembly that allows for a wheel hub width adjustment using replaceable dropouts of varying widths or arrangements with spacers. Alternative forms allow different arrangements for varying the wheel hub assembly without changing the dropout either by moving the dropouts relative to the mounting lugs or having extendable dropout arrangements. In addition, the dropout can have fastener holes at different locations to adjust the height of the bicycle frame relative to the ground. Moreover, the dropout can have additional fastener holes to prevent rotation of the dropout. | 11-01-2012 |
20130058706 | Unified universal rack connector - A unified bicycle rear rack connector which may comprise of two arms or strips extending from a first end securable to the rear rack, to a second end which is securable to a bike frame such that the two strips are capable of moving one over each other horizontally. Further, the two strips are joined by a fastener, such as a fastener is a nut and bolt combination, passing through overlapping holes in the two strips of the connector. Moreover, at least one of the overlapping holes is elongated to enable securing an increase or decrease of width of a connector surface parallel to the major plain of the connector that central bolt once tightened makes the assembly laterally stiff. Once the connector is fastened to the rear rack, the connector can move in a plastic fashion in a substantially vertical direction. | 03-07-2013 |
Paul Harris, Rocheport, MO US
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20140059765 | EVACUATION BLANKET AND SYSTEM - A blanket used for evacuating or transporting medical patients comprising a first side, a second side, a first outer edge, a second outer edge and a plurality of pockets disposed on one of the sides wherein the open end of the pocket is proximate a center of said second side and said closed end is proximate one of said outer edges. One or more item stored in at least one of the pockets wherein the item of information may be patient identification information, treatment instructions, medical supplies, or personal items. A system for evacuating or transporting medical patients using the blanket in coordination with one or more items of information. | 03-06-2014 |
Paul Harris, San Diego, CA US
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20140276409 | SYSTEM AND METHOD FOR DETECTING OCCLUSIONS IN AN INFUSION PUMP - Occlusions in a delivery line of an infusion pump can be detected by measuring pressure differentials in the pump over short periods of time in order to minimize the effects of long term systematic sensor changes. In a delivery mode such as basal insulin delivery where a small portion of a volume of fluid is delivered, pressure readings can be obtained before and after the motor move to deliver each portion and compared. The differentials after one or more motor moves can be compared to determine whether an occlusion is present. In a delivery mode such as bolus insulin delivery in which an entire volume of fluid is delivered, pressure differentials can be obtained for consecutive deliveries at a common point in the delivery cycle of each delivery. Comparison of these pressure values can be used to determine whether an occlusion is present. | 09-18-2014 |
Paul Harris, Livonia, MI US
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20150330274 | COMBUSTION GAS COOLING APPARATUS, DENITRATION APPARATUS INCLUDING THE COMBUSTION GAS COOLING APPARATUS, AND COMBUSTION GAS COOLING METHOD - A fuel gas cooling apparatus includes a cooling duct which causes a cooling gas to flow out into a mixing duct, and a difference of maximum dimensions in a height direction of a flow inlet and a flow outlet with respect to a passage length of the mixing duct is smaller than a difference of maximum dimensions in the height direction of a flow inlet and a flow outlet with respect to a passage length of an expanded duct, or a difference of maximum dimensions in a width direction of the flow inlet and the flow outlet with respect to the passage length of the mixing duct is smaller than a difference of maximum dimensions in the width direction of the flow inlet and the flow outlet with respect to the passage length of the expanded duct. | 11-19-2015 |
20150337700 | COMBUSTION GAS COOLING APPARATUS, DENITRATION APPARATUS HAVING THE COMBUSTION GAS COOLING APPARATUS, AND COMBUSTION GAS COOLING METHOD - A combustion gas cooling apparatus includes a cooling duct from which a cooling gas at a temperature lower than the temperature of a combustion gas flows out into a mixing duct to form a mixed gas in which the combustion gas and the cooling gas are mixed. The cooling duct has cooling gas flow inlets into which the cooling gas flows, a plurality of cooling gas outflow apertures through which the cooling gas having flowed into the cooling gas flow inlets flows out into the mixing duct, and distribution passages through which the cooling gas having flowed into the cooling gas flow inlets is distributed to the plurality of cooling gas outflow apertures. | 11-26-2015 |
Paul Harris, West Haverstraw, NY US
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20150367159 | Exercise device for utilizing an elastic band to perform exercises - An exercise device is provided. The device includes an elastic band and a pair of handle apparatuses, each having a slide adjusted locking mechanism, a handle component, and a swiveling and rotating rod mechanism. Said swiveling and rotating rod mechanism is attached by a bearing to said handle mechanism, and by a pin to said slide adjusted locking mechanism. The device is provisioned to allow a band to be replaced or adjusted in length for various workouts. | 12-24-2015 |