Patent application number | Description | Published |
20080270096 | Methods for identifying drug targets based on genomic sequence data - This invention provides a computational approach to identifying potential antibacterial drug targets based on a genomic sequence and its annotation. Starting from a fully sequenced genome, open reading frame assignments are made which determine the metabolic genotype for the organism. The metabolic genotype, and more specifically its stoichiometric matrix, are analyzed using flux balance analysis to assess the effects of genetic deletions on the fitness of the organism and its ability to produce essential biomolecules required for growth. | 10-30-2008 |
20100086984 | OPTOINJECTION METHODS - Optoinjection method for transiently permeabilizing a target cell by (a) illuminating a population of cells contained in a frame; (b) detecting at least one property of light directed from the frame; (c) locating a target cell by the property of light; and (d) irradiating the target cell with a pulse of radiation. | 04-08-2010 |
20100092954 | Method for Determining the Genetic Basis for Physiological Changes in Organisms - The present invention provides a method for discovering the basis of changes in the observable properties of organisms by subjecting an organism to selection. Individual organisms with observable differences will thus become more prevalent in a population during selection. The basis for the differences are then determined by identifying genetic differences among the individual organisms and the original organism, followed by evaluation of the effects of each genetic difference either alone or in combination by using site-directed mutagenesis followed by observation of the effects. | 04-15-2010 |
20110201075 | OPTOINJECTION METHODS - Optoinjection method for transiently permeabilizing a target cell by (a) illuminating a population of cells contained in a frame; (b) detecting at least one property of light directed from the frame; (c) locating a target cell by the property of light; and (d) irradiating the target cell with a pulse of radiation. | 08-18-2011 |
Patent application number | Description | Published |
20090175529 | METHOD AND APPARATUS FOR SELECTIVELY TARGETING SPECIFIC CELLS WITHIN A CELL POPULATION - This invention provides a method and apparatus for selectively identifying, and targeting with an energy beam, specific cells within a cell population, for the purpose of inducing a response in the targeted cells. Using the present invention, every detectable cell in a population can be identified and affected, without substantially affecting non-targeted cells within the mixture. | 07-09-2009 |
20090191619 | METHOD AND DEVICE FOR SELECTIVELY TARGETING CELLS WITHIN A THREE-DIMENSIONAL SPECIMEN - The invention provides an apparatus for electromagnetically affecting a particle of interest in a specimen. The apparatus includes (a) a stage capable of supporting the specimen; (b) a detector including at least one camera, wherein the detector is capable of resolving a particle of interest within the specimen; (c) a means for locating the particle of interest in three dimensions; (d) a means for focusing electromagnetic radiation to a focal volume within the specimen; and (e) a means for adjusting the relative positions of the stage and electromagnetic radiation focusing means, thereby positioning the particle of interest within the focal volume. | 07-30-2009 |
20100280803 | Compositions and Methods for Modeling Saccharomyces cerevisiae Metabolism - The invention provides an in silico model for determining a | 11-04-2010 |
20110010150 | METHODS AND SYSTEMS FOR GENOME-SCALE KINETIC MODELING - Embodiments of the present invention generally relate to the construction, analysis, and characterization of dynamical states of biological networks at the cellular level. Methods are provided for analyzing the dynamical states by constructing matrices using high-throughput data types, such as fluxomic, metabolomic, and proteomic data. Some embodiments relate to an individual, while others relate to a plurality of individuals. | 01-13-2011 |
20110250669 | METHOD AND APPARATUS FOR SELECTIVELY TARGETING SPECIFIC CELLS WITHIN A CELL POPULATION - This invention provides a method and apparatus for selectively identifying, and targeting with an energy beam, specific cells within a cell population, for the purpose of inducing a response in the targeted cells. Using the present invention, every detectable cell in a population can be identified and affected, without substantially affecting non-targeted cells within the mixture. | 10-13-2011 |
20120021522 | Method for the Evolutionary Design of Biochemical Reaction Networks - The present invention relates to methods for achieving an optimal function of a biochemical reaction network. The methods can be performed in silico using a reconstruction of a biochemical reaction network of a cell and iterative optimization procedures. The methods can further include laboratory culturing steps to confirm and possibly expand the determinations made using the in silico methods, and to produce a cultured cell, or population of cells, with optimal functions. The current invention includes computer systems and computer products including computer-readable program code for performing the in silico steps of the invention. | 01-26-2012 |
20130090859 | METHODS AND SYSTEMS FOR GENOME-SCALE KINETIC MODELING - Embodiments of the present invention generally relate to the construction, analysis, and characterization of dynamical states of biological networks at the cellular level. Methods are provided for analyzing the dynamical states by constructing matrices using high-throughput data types, such as fluxomic, metabolomic, and proteomic data. Some embodiments relate to an individual, while others relate to a plurality of individuals. | 04-11-2013 |
20140038296 | METABOLIC ENGINEERING OF MICROBIAL ORGANISMS - Microbial strains with desirable carbohydrate productions characteristics and methods of making and using the same are provided herein. | 02-06-2014 |