Patent application number | Description | Published |
20080268502 | Multiple Promoters and the Use Thereof For Gene Expression - The present invention relates to multiple promoters and to expression units comprising them; to the use thereof for regulating transcription and expression of genes; to expression cassettes which comprise multiple promoters or expression units of this kind; to vectors which comprise such expression cassettes; to genetically modified microorganisms which comprise vectors and/or expression units of this kind; and to processes for preparing biosynthetic products by culturing said genetically modified microorganisms. | 10-30-2008 |
20080274516 | Psod Expression Units - The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms. | 11-06-2008 |
20080280333 | Use of the repressor glxR for the synthesis of lysine in corynebacterium glutamicum - Isolated polypeptide sequence having the sequence of SEQ ID NO:1 or muteins thereof having the ability to bind cAMP and repress the expression of the aceB gene of | 11-13-2008 |
20080286841 | PGRO EXPRESSION UNITS - The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms. | 11-20-2008 |
20080299606 | Fermentative Production of Organic Compounds - A process for the fermentative production of at least one organic compound having at least 3 C atoms or having at least 2 C atoms and at least one 1 N atom, comprising the following steps:
| 12-04-2008 |
20090004705 | PSOD Expression Units - The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms. | 01-01-2009 |
20090029356 | Corynebacterium glutamicum genes encoding novel proteins - Isolated nucleic acid molecules, designated MCP nucleic acid molecules, which encode novel MCP proteins from | 01-29-2009 |
20090029425 | PROCESS FOR THE PRODUCTION OF BETA-LYSINE - Process for the production of -lysine by constructing a recombinant microorganism which has a deregulated lysine 2,3-aminomutase gene and at least one deregulated gene selected from the group (i) which consists of aspartokinase, aspartatesemialdehyde dehydrogenase, dihydrodipicolinate synthase, dihydrodipicolinate reductase, tetrahydrodipicolinate succinylase, succinyl-amino-ketopimelate transaminase, succinyl-diamino-pimelate desuccinylase, diaminopimelate epimerase, diamino-pimelate dehydrogenase, arginyl-tRNA synthetase, diaminopimelate decarboxylase, pyruvate carboxylase, phosphoenolpyruvate carboxylase, glucose-6-phosphate dehydrogenase, transketolase, transaldolase, 6-phosphogluconolactonase, fructose 1,6-biphosphatase, homoserine dehydrogenase, phophoenolpyruvate carboxykinase, succinyl-CoA synthetase, methylmalonyl-CoA mutase, provided that if aspartokinase is deregulated as gene (i) at least a second gene (i) other than aspartokinase has to be deregulated, and cultivating said microorganism. | 01-29-2009 |
20090053778 | Microorganisms for producing sulfur-containing compounds - The present invention relates to microorganisms and methods for producing at least one sulfur-containing compound. | 02-26-2009 |
20090081331 | Phytase - Described are DNA sequences encoding a polypeptide exhibiting phytase activity, the corresponding encoded phytase polypeptide, a process for preparing the polypeptide and the use thereof for various industrial applications. | 03-26-2009 |
20090162892 | Fermentative production of fine chemicals - The invention relates to a process for the production of at least one microbial metabolite having at least 3 carbon atoms or at least 2 carbon atoms and at least 1 nitrogen atom by means of sugar-based microbial fermentation, comprising:
| 06-25-2009 |
20090191610 | Microorganisms With Increased Efficiency for Methionine Synthesis - The present invention relates to methods for the production of microorganisms with increased efficiency for methionine synthesis, microorganisms with increased efficiency for methionine synthesis, and methods for determining the optimal metabolic flux for organisms with respect to methionine synthesis. | 07-30-2009 |
20090221027 | Use of a bacillus meti gene to improve methionine production in microorganisms - The present invention pertains to improved microorganisms and methods for the production of methionine and other sulfur containing fine chemicals using the metI gene from | 09-03-2009 |
20090246836 | Pgro expression units - The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms. | 10-01-2009 |
20090246838 | Process For The Production Of Cadaverine - Process for the production of cadaverine by constructing a recombinant microorganism which has a deregulated lysine decarboxylase gene and at least one deregulated gene selected from the group (i) which consists of aspartokinase, aspartatesemialdehyde dehydrogenase, dihydrodipicolinate synthase, dihydrodipicolinate reductase, tetrahydrodipicolinate succinylase, succinyl-amino-ketopimelate transaminase, succinyl-diamino-pimelate desuccinylase, diaminopimelate epimerase, diaminopimelate dehydrogenase, arginyl-tRNA synthetase, diaminopimelate decarboxylase, pyruvate carboxylase, phosphoenolpyruvate carboxylase, glucose-6-phosphate dehydrogenase, transketolase, transaldolase, 6-phosphogluconolactonase, fructose 1,6-biphosphatase, homoserine dehydrogenase, phophoenolpyruvate carboxykinase, succinyl-CoA synthetase, methylmalonyl-CoA mutase, provided that if aspartokinase is deregulated as gene (i) at least a second gene (i) other than aspartokinase has to be deregulated, and cultivating said microorganism. | 10-01-2009 |
20090281353 | Use of dimethyl disulfide for methionine production in microoragnisms - The present invention features improved processes and organisms for the production of methionine. The invention demonstrates that a ΔmetF organism or a ΔmetE AmetH organism, for example, mutants of | 11-12-2009 |
20090292100 | PROCESS FOR PREPARING PENTAMETHYLENE 1,5-DIISOCYANATE - The present invention relates to a process for preparing pentamethylene 1,5-diisocyanate, to pentamethylene 1,5-diisocyanate prepared in this way and to the use thereof. | 11-26-2009 |
20090298136 | Methionine producing recombinant microorganisms - This invention relates to methionine producing recombinant microorganisms. Specifically, this invention relates to recombinant strains of | 12-03-2009 |
20090298137 | MICROORGANISM AND PROCESS FOR THE PREPARATION OF L-METHIONINE - The present invention relates to microorganisms and processes for the efficient preparation of L-amino acids such as L-methionine. In particular, the present invention relates to microorganisms and processes in which the formation and/or accumulation of homolanthionine in the methionine pathway is reduced and/or prevented. | 12-03-2009 |
20090311756 | Microorganisms with a Reactivation System for cob(I)Alamin-Dependent Methionine Synthase - The present invention relates to microorganisms and methods for producing methionine by reactivation of the MetH enzyme. | 12-17-2009 |
20090325244 | METHOD OF INCREASING GENE EXPRESSION USING MODIFIED CODON USAGE - The present invention relates to a method of increasing the amount of at least one polypeptide in the host cell by expressing a modified nucleotide sequence encoding for a polypeptide in a host cell with said modified nucleotide sequence being derived from a different non-modified nucleotide sequence encoding for a polypeptide of identical amino acid sequence such that the codon usage of the modified nucleotide sequence is adjusted to the codon usage of abundant proteins in the host cell. | 12-31-2009 |
20100003727 | Coryneform Bacteria with Formate-THF-Synthetase and/or Glycine Cleavage Activity - The present invention relates to microorganisms, in particular | 01-07-2010 |
20100009416 | Process for the Preparation of L-Methionine - The present invention relates to microorganisms and processes for the efficient preparation of L-methionine. In particular, the present invention relates to processes in which the amount of serine available for the metabolism of the microorganism is increased. | 01-14-2010 |
20100015674 | Methods For The Preparation of Lysine By Fermentation Of Corynebacterium Glutamicum - The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., | 01-21-2010 |
20100035307 | Methionine Synthases with Reduced Product Inhibition - The present invention relates to nulceotide sequences encoding enzymatically active cobalamin-methionine synthase and functional fragments thereof being modified in comparison to the respective wild-type enzyme such that said enzymes show reduced product inhibition by methionine. The present invention also relates to polypeptides being encoded by such nucleotide sequences and host cells comprising such nucleotide sequences. Furthermore, the present invention relates to methods for producing methionine in host organisms by making use of such nucleotide sequences. | 02-11-2010 |
20100047881 | Microorganisms with Deregulated Vitamin B12 System - The present invention relates to microorganisms with improved efficiency of vitamin B12 utilization. | 02-25-2010 |
20100062535 | PSOD EXPRESSION UNITS - The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms. | 03-11-2010 |
20100240131 | Method of modifying the genome of gram-positive bacteria by means of a novel conditionally negative dominant marker gene - The invention relates to a novel method for modifying the genome of Gram-positive bacteria, to these bacteria and to novel vectors. The invention particularly relates to a method for modifying | 09-23-2010 |
20100292429 | Method for Fermentatively Producing 1,5-Diaminopentane - The invention relates to a method for isolating 1,5-diaminopentane (DAP) from DAP-containing fermentation broths, to a method for the fermentative production of DAP using said isolating method and to a method for producing DAP-comprising polymers by using the DAP isolated or fermatively produced DAPs according to said methods. | 11-18-2010 |
20100324258 | Process for the Production of Gamma-Aminobutyric Acid - The present invention relates to a novel method for the fermentative production of gamma-aminobutyric acid (GABA) by cultivating a recombinant micro-organism expressing an enzyme having a glutamate decarboxylase activity. The present invention also relates to corresponding recombinant hosts, recombinant vectors, expression cassettes and nucleic acids suitable for preparing such hosts as well as to a method for preparing polyamides making use of GABA as obtained fermentative production. | 12-23-2010 |
20110003963 | METHOD FOR THE PRODUCTION OF DIPICOLINATE - The present invention relates to a novel method for the fermentative production of dipicolinate by cultivating a recombinant microorganism expressing an enzyme having dipicolinate synthetase activity. The present invention also relates to corresponding recombinant hosts, recombinant vectors, expression cassettes and nucleic acids suitable for preparing such hosts as well as a method of preparing polyester or polyamide copolymers making use of dipicolinate as obtained by fermentative production. | 01-06-2011 |
20110117614 | Production Process for Methionine Using Microorganisms with Reduced Isocitrate Dehydrogenase Activity - The present invention is directed to a method utilizing a microorganism with reduced isocitrate dehydrogenase activity for the production of methionine. | 05-19-2011 |
20110129882 | GENE CODING FOR GLUCOSE-6-PHOSPHATE-DEHYDROGENASE PROTEINS - The present invention relates to isolated nucleic acid molecules encoding mutants of glucose-6-phosphate dehydrogenase, and vectors and hosts cells including such nucleic acid molecules. These nucleic acid molecules are involved in the biosynthesis of a fine chemical, e.g., an amino acid such as lysine. The present invention also relates to methods of producing and modulating the production of fine chemicals, e.g., lysine, by culturing recombinant microorganisms containing these nucleic acid molecules under conditions such that the fine chemical is produced. | 06-02-2011 |
20110207183 | Production Process for Fine Chemicals Using Microorganisms with Reduced Isocitrate Dehydrogenase Activity - The present invention is directed to a method utilizing a microorganism with reduced isocitrate dehydrogenase activity for the production of fine chemicals. Said fine chemicals may be amino acids, monomers for polymer synthesis, sugars, lipids, oils, fatty acids or vitamins and are preferably amino acids of the aspartate family, especially methionine or lysine, or derivatives of said amino acids, especially cadaverine. Furthermore, the present invention relates to a recombinant microorganism having a reduced isocitrate dehydrogenase activity in comparison to the initial microorganism and the use of such microorganisms in producing fine chemicals such as aspartate family amino acids and their derivatives. | 08-25-2011 |
20110229937 | CORYNEBACTERIUM GLUTAMICUM GENES ENCODING REGULATORY PROTEINS INVOLVED IN THE PRODUCTION OF METHIONINE - Isolated nucleic acid molecules, designated MR nucleic acid molecules, which encode novel MR proteins from | 09-22-2011 |
20120021472 | Method for the Production of Glutaconate - The present invention relates to a novel method for the biocatalytic production of unsaturated dicarboxylic acids by cultivating a recombinant microorganism co-expressing a glutaconate CoA-transferase and a 2-hydroxyglutaryl-CoA dehydratase system. The present invention also relates to corresponding recombinant hosts, recombinant vectors, expression cassettes and nucleic acids suitable for preparing such hosts as well as a method of preparing polyamide or polyester copolymers making use of said dicarboxylic acids as obtained by said biocatalytic production method. | 01-26-2012 |
20120288901 | Method of Producing Methionine in Corynebacteria by Over-Expressing Enzymes of the Pentose Phosphate Pathway - The present invention relates to a method of producing methionine in Coryneform bacteria in which enzymes of the pentose phosphate pathway are over-expressed. The present invention also relates to Coryneform bacteria for producing methionine in which at least two enzymes of the pentose phosphate pathway are over-expressed. | 11-15-2012 |
20120295315 | Nucleic acid encoding a cobalamin-dependent methionine synthase polypeptide - The present invention relates to nulceotide sequences encoding enzymatically active cobalamin-methionine synthase and functional fragments thereof being modified in comparison to the respective wild-type enzyme such that said enzymes show reduced product inhibition by methionine. The present invention also relates to polypeptides being encoded by such nucleotide sequences and host cells comprising such nucleotide sequences. Furthermore, the present invention relates to methods for producing methionine in host organisms by making use of such nucleotide sequences. | 11-22-2012 |
20120295317 | Processes and Recombinant Microorganisms for the Production of Cadaverine - The present invention relates to the use of recombinant microorganisms comprising DNA molecules in a deregulated form which improve the production of cadaverine, as well as to recombinant DNA molecules and polypeptides used to produce the microorganism, said microorganism comprising an intracellular lysine decarboxylase activity and an enhanced lysine import activity or comprising an intracellular and an extracellular lysine decarboxylase activity or comprising an intracellular and extracellular lysine decarboxylase activity and an enhanced lysine import activity. The present invention also relates to a processes for the production of cadaverine using recombinant microorganisms. | 11-22-2012 |
20140011243 | Genetically Modified Microorganisms Capable of Producing Beta-Glucans and Methods for Producing Beta-Glucans - The present invention relates to genetically modified microorganisms capable of producing beta-glucans, characterized in that said genetically modified microorganism overexpresses (i) a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity, and/or (ii) a polypeptide having 1,3-β-D-glucan synthase-activity, compared to a corresponding non-modified control microorganism of the same strain. The present invention also relates to the use of a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity or the use of such a polypeptide for producing β-glucans. Furthermore, the present invention relates to methods for producing β-glucans comprising the introduction of a promoter upstream of a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity thereby increasing the expression of said polynucleotide, or a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity into a microorganism being able to synthesize β-glucans. | 01-09-2014 |
20140141440 | Gene Cluster for Biosynthesis of Cornexistin and Hydroxycornexistin - The invention pertains to/the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides. | 05-22-2014 |
20140242704 | PEF-TS EXPRESSION UNITS - The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms. | 08-28-2014 |
20140256005 | PROCESS FOR THE PRODUCTION OF GAMMA-AMINOBUTYRIC ACID - The present invention relates to a novel method for the fermentative production of gamma-aminobutyric acid (GABA) by cultivating a recombinant microorganism expressing an enzyme having a glutamate decarboxylase activity. The present invention also relates to corresponding recombinant hosts, recombinant vectors, expression cassettes and nucleic acids suitable for preparing such hosts as well as to a method for preparing polyamides making use of GABA as obtained fermentative production. | 09-11-2014 |