Osborne, GB
Andrew J. Osborne, Eastleigh GB
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20130160022 | TRANSACTION MANAGER FOR NEGOTIATING LARGE TRANSACTIONS - A computer receives a transaction request that includes information identifying computer resource requirements for the transaction, a resource policy, and a transaction failure policy. The computer determines if sufficient computer resources are available to complete the transaction request based on the received information identifying resource requirements for the transaction. If there are not sufficient computer resources available to complete the transaction request, the computer applies the resource policy to the transaction request and processes the transaction request. If the processed transaction request fails to complete successfully, the computer applies the transaction failure policy to the processed transaction request. | 06-20-2013 |
20140096110 | MANAGING A SET OF SOFTWARE MODULES IN A SOFTWARE RUNTIME ENVIRONMENT - A method, system, and/or computer program product manages a set of software modules in a software runtime environment, where the set of software modules has one or more dynamic dependencies and one or more static dependencies. Each software module having a static dependency on another software module in a set of software modules is identified. Each subset of the set of software modules that is interdependent with another subset due to static dependencies between subsets is identified. In response to a change in state of a module in an identified subset, the change in state is applied to all modules in the identified subset. | 04-03-2014 |
Anthony Osborne, Romford GB
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20150323017 | VEHICLE CLUTCH SYSTEM INCLUDING THRUST BEARING LOAD CELL - A clutch system according to an exemplary aspect of the present disclosure includes, among other things, a thrust bearing and a load sensor positioned relative to the thrust bearing and configured to measure a load exerted against the thrust bearing. | 11-12-2015 |
David Osborne, Bristol GB
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20100018119 | MONITOR AND A METHOD FOR MEASURING OXYGEN CONCENTRATION - A monitor for monitoring the concentration of oxygen in a fuel or in an ullage over a fuel comprises (i) a sensing element comprising a luminescent substance comprising a luminophore and a support in which the luminophore is covalently bound to the support, (ii) a light source arranged to irradiate the sensing element with light, and (iii) a photosensor arranged to detect light emitted from the luminescent substance. The luminescent substance may be, for example, a platinum porphyrin covalently bound to silica. | 01-28-2010 |
Gareth Osborne, Hampshire GB
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20100149761 | Apparatus and method for use in assembly of a portable apparatus - An apparatus including: a first interconnector portion configured to fasten to a side part of a first housing portion of a portable apparatus, and a second interconnector portion rigidly connected to the first interconnector portion and configured to fasten to a second housing portion of the portable apparatus. | 06-17-2010 |
20110000774 | APPARATUS FOR KEY ACTUATION AND ASSOCIATED METHODS - An apparatus for key actuation of an electronic device comprising a linear bearing configured for transmitting user actuation, and a complementary guide portion, wherein the linear bearing and the guide portion are arranged to allow the linear bearing to move reciprocally relative to the guide portion for key activation, and wherein both the linear bearing and the guide portion comprise a material with a hardness substantially between 6 Mohrs and 10 Mohrs. | 01-06-2011 |
20120236518 | Apparatus and method for use in assembly of a portable apparatus - An apparatus comprising: a first interconnector portion configured to fasten to a side part of a first housing portion of a portable apparatus, and a second interconnector portion rigidly connected to the first interconnector portion and configured to fasten to a second housing portion of the portable apparatus. | 09-20-2012 |
Gary Osborne, Bedfordshire GB
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20110095577 | MEAL TRAY WITH ADVERTISING DISPLAY - A meal tray assembly for being carried by an aft-facing side of a seat back for use by a person seated aft of the seat back is provided. The assembly includes a tray mountable to the seat back and including a first shell having a forward facing surface when in the stowed position and a second shell for mating with the first shell and having a rearward facing surface towards the aft-seated person when in the stowed position. A major recess is defined in the rearward facing surface of the second shell and an inwardly facing elongate flanged is carried by the rearward facing surface of the second shell and extending towards the major recess. A flexible screen is provided for being positioned in the recess by an interference fit between the inwardly facing flange and an engaging surface of the major recess. | 04-28-2011 |
Graham William Osborne, North Walsham GB
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20130192221 | HEAT MACHINES - A heat machine having an external heat source and an external heat sink may be configured as a Stirling engine having a hot pair of cylinder-and-displacer combinations | 08-01-2013 |
Howard George Osborne, Isle Of Man GB
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20080201965 | Saw Guide - A saw guide intended for guiding the blade of a saw during cutting of a workpiece ( | 08-28-2008 |
20110064531 | CUTTING APPARATUS AND METHOD - An apparatus for use in cutting a mortice pocket in a leading edge of a door in-situ, the apparatus comprising: at least one elongate guide means; clamping means for clamping the elongate guide means to a door or other workpiece; a drill guide means mounted on the elongate guide means; and translating means; wherein the drill guide means comprises a bearing block and a saddle member, the saddle member having a bearing block aperture formed therethrough arranged to releasably receive the bearing block therein, the bearing block having a hole therethrough adapted snugly to receive a drill shaft such that the drill shaft is supported, directly or indirectly, by the bearings of the bearing block and is rotatable therein, and wherein at least one of the bearing block aperture and the bearing block is tapered. | 03-17-2011 |
James Osborne, Saffron Walden GB
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20150126471 | 5-[[4-[[MORPHOLIN-2-YL]METHYLAMINO]-5-(TRIFLUOROMETHYL)-2-PYRIDYL]AMINO]PY- RAZINE-2-CARBONITRILE AND THERAPEUTIC USES THEREOF - The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to 5-[[4-[[morpholin-2-yl]methylamino]-5-(trifluoromethyl)-2-pyridyl]amino]pyrazine-2-carbonitrile compounds (referred to herein as “TFM compounds”) which, inter alia, inhibit Checkpoint Kinase 1 (CHK1) kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit CHK1 kinase function, and in the treatment of diseases and conditions that are mediated by CHK1, that are ameliorated by the inhibition of CHK1 kinase function, etc., including proliferative conditions such as cancer, etc., optionally in combination with another agent, for example, (a) a DNA topoisomerase I or II inhibitor; (b) a DNA damaging agent; (c) an antimetabolite or a thymidylate synthase (TS) inhibitor; (d) a microtubule targeted agent; (e) ionising radiation; (f) an inhibitor of a mitosis regulator or a mitotic checkpoint regulator; (g) an inhibitor of a DNA damage signal transducer; or (h) an inhibitor of a DNA damage repair enzyme. | 05-07-2015 |
Kenneth Osborne, Glasgow GB
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20130179625 | Security System Storage of Persistent Data - A security system including devices generating persistent data, a local control system (LCS) including a microprocessor and non-volatile memory and receiving persistent data from the devices, and a server remote from the LCS. The remote server is in communication with the LCS microprocessor which periodically transmits logical portions of persistent data (each including a timestamp) to the remote server where it is saved. The microprocessor also periodically saves the persistent data portions in LCS non-volatile memory less frequently than the persistent data portions are periodically saved in the remote data storage, and saves the timestamp in the local data storage for each persistent data portion saved only at the remote server. When rebooting the LCS, the microprocessor retrieves from the remote data storage only the persistent data portions having timestamps subsequent to the timestamp saved in the local data control system non-volatile memory. | 07-11-2013 |
Mark Osborne, Hampshire GB
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20110102767 | LIGHTNING DETECTION - A device for detecting lightning currents in a wind turbine comprises an inductive loop ( | 05-05-2011 |
Mark Osborne, Little Chesterford GB
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20090237670 | Prism design for scanning applications and illumination of microscopy sample - There is disclosed a prism for use in scanning applications such as total internal reflection microscopy in which the prism is translated relative to an incident light beam. A geometry is disclosed which cancels walk of the beam footprint at the base of the prism. Walk of the beam footprint due to irregularities in a largely planar sample surface located at the prism base are cancelled by coupling movement of the incident light beam to movement of the sample in the field of view of an objective lens, for example as part of an autofocus arrangement. | 09-24-2009 |
Mark Osborne, Abingdon GB
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20130229284 | GAS SAFETY MONITOR - A dangerous level of gas safety monitor for indicating a level of a target gas in an atmosphere comprising: a sol-gel layer comprising a first phosphorescent material, exposed to the atmosphere; a light source enabled to stimulate the phosphorescent material; a detector enabled to detect light emitted by the phosphorescent material; a pressure sensor to determine the pressure of the atmosphere; a processor enabled to determine relative phase shift or time delay between the detected light emitted by the phosphorescent material and the emitted light of the light source, wherein the monitor is configured to provide an output indicative of a dangerous level of the target gas in the atmosphere, the output based on the determined pressure and relative phase shift or time delay. | 09-05-2013 |
Mark Allen Osborne, Nr. Saffron Walden GB
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20100130368 | Method and system for sequencing polynucleotides - Provided herein is a method of determining a sequence of a target polynucleotide. The method can include the steps of a) providing a device including an array of relatively short polynucleotides and relatively long polynucleotides immobilised on a surface of a solid support, wherein the relatively long polynucleotides are fragments of the target polynucleotide and wherein the relatively long polynucleotides are separated by a distance of at least 10 nm, whereby parts of the relatively long polynucleotides that extend beyond the relatively short polynucleotides can be individually optically resolved; and b) determining the sequence of the target polynucleotide by detecting incorporation of nucleotides into strands complementary to the relatively long polynucleotide fragments using fluorescent labels associated with the incorporated nucleotides. Also provided is system for determining a sequence of a target polynucleotide. The system can include means for carrying out steps a) and b) of the above method. | 05-27-2010 |
Mark James Osborne, Middlesex GB
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20150212235 | SYSTEM AND METHOD FOR DETERMINING RETAINED HYDROCARBON FLUID - A computer-implemented method for determining an amount of hydrocarbon fluid present in a rock of a hydrocarbon-producing reservoir is provided. The rock comprises organic matter and porous and permeable inorganic matter. The method comprises the steps of receiving data relating to chemical and kinetic properties of the organic matter, rock lithology data, rock thickness and reservoir temperature and pressure data, inputting the received data into a computer-implemented model, and operating the model. The model operates to a) simulate hydrocarbon fluid generation in the rock based on the input data and thereby determine an amount of generated hydrocarbon fluid, b) generate predicted data, and c) determine a total amount of hydrocarbon fluid present in the rock based on the predicted data. The generated predicted data is indicative of i) an amount of the generated hydrocarbon fluid adsorbed onto a surface of the organic matter within the rock, ii) an amount of the generated hydrocarbon fluid present in the pores of the organic matter by determining the porosity of the organic matter, based on the chemical and kinetic properties of the organic matter, and iii) an amount of the generated hydrocarbon fluid present in the pores of the inorganic matter by determining the porosity of the inorganic matter, based on the rock lithology data. A corresponding system, a computer program and a computer readable medium are also provided. | 07-30-2015 |
Matthew Osborne, Macclesfield GB
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20140357661 | CHEMICAL COMPOUNDS - The invention concerns compounds of Formula (I) | 12-04-2014 |
Matthew David Osborne, Kent GB
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20130183714 | MYELOMA CELL CULTURE IN TRANSFERRIN-FREE LOW IRON MEDIUM - The present invention relates to a method for culturing mammalian cells in a culture medium which is transferrin free and which contains no lipophilic or synthetic nitrogen-containing chelators. Also provided is the use of the medium and a process for providing a mammalian product by culturing cells capable of producing the product in the medium. | 07-18-2013 |
Nigel Osborne, Surrey GB
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20140307878 | METHOD AND SYSTEM FOR ANALYSING SOUND - The present invention relates to a method and system for analysing audio (eg. music) tracks. A predictive model of the neuro-physiological functioning and response to sounds by one or more of the human lower cortical, limbic and subcortical regions in the brain is described. Sounds are analysed so that appropriate sounds can be selected and played to a listener in order to stimulate and/or manipulate neuro-physiological arousal in that listener. The method and system are particularly applicable to applications harnessing a biofeedback resource. | 10-16-2014 |
Paul Ronald Osborne, Dorset GB
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20110308288 | ROLLING MILL TEMPERATURE CONTROL - For controlling the flatness of the strip during the rolling of aluminium strip or foil, the system consists of a full width bank of cryogenic roll cooling devices acting on the roll(s) and a full width bank of roll heating devices also acting the roll(s). Both or either of the cooling and heating banks are divided into individually controllable zones. A process automation system controls the action of the cooling and heating banks via feedback from a strip shape meter and/or a predictive process model, in order, by thermal growth/contraction, to create the best roll profile for rolling flat strip. | 12-22-2011 |
Richard Osborne, Bristol GB
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20110131559 | COMPILING AND LINKING - A method of generating a computer program, the method comprising: independently compiling a plurality of source code modules to generate a plurality of respective object modules comprising a plurality of respective threads explicitly designated by a user to be executed in parallel; in each of the object modules, inserting at least one symbol indicative of a property of the object module's thread potentially conflicting with a corresponding property of a thread of another of said object module as a result of parallel execution of those threads; executing a linker to perform a linking process on said object modules, the linking process comprising: assessing the symbols in conjunction with one another to determine whether a conflict exists between the threads of two or more of the respective object modules; and linking the object modules to generate a computer program in which said threads are executable in parallel, wherein the linking is performed in dependence on said assessment. | 06-02-2011 |
Richard Osborne, St. Andrew Bristol GB
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20110131558 | LINK-TIME RESOURCE ALLOCATION FOR A MULTI-THREADED PROCESSOR ARCHITECTURE - A method comprising: independently compiling a plurality of modules of source code to generate a plurality of respective object modules comprising a plurality of respective parallel threads explicitly designated by a user to be executed in parallel on a target platform; in each of the object modules, inserting at least one symbol indicative of a usage of a resource of the target platform associated with the respective thread; executing a linker to perform a linking process for linking the object modules, wherein the linking process comprises assessing the symbols in conjunction with one another, and based on the assessment generating an indication relating to a usage of the resource required for execution of the threads in parallel. | 06-02-2011 |
Richard William Osborne, Bristol GB
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20130220024 | TEST APPARATUS FOR PROVIDING AXIAL STRESSES IN A STRUCTURE - The invention provides a test apparatus for providing axial stresses in a structure, comprising a first set of formations for abutting a first surface of the structure at a first plurality of locations, a second set of formations for abutting a second surface of the structure at a second plurality of locations, and a force actuator, and wherein each set of formations comprises at least three formations and wherein at least two formations in each set of formations are aligned with a notional alignment line along the structure and at least one formation in each set of formations is out of alignment along the structure with said notional alignment line, such that when the force actuator applies a force, loads are applied at different locations, causing the structure to bend biaxially and thereby providing biaxial stresses in the structure. | 08-29-2013 |
Robert Osborne, Great Chesterford GB
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20110319299 | METHODS AND COMPOSITIONS FOR POLYNUCLEOTIDE LIBRARY PRODUCTION, IMMORTALIZATION AND REGION OF INTEREST EXTRACTION - Aspects of the present invention are drawn to methods and compositions for the genetic analysis of regions of interest (ROI) from one or more starting polynucleotide sample(s). In certain aspects, adapter tagged polynucleotide fragments from a plurality of initial polynucleotide samples are pooled, circularized and amplified to produce an immortalized library. Multiple ROI's from this immortalized library are amplified (e.g., in independent iPCR reactions) to generate amplicons, and, in some embodiments, pooled to form a pooled ROI amplicon sample. In certain embodiments, the amplicons for each ROI amplicon in the pooled ROI amplicon sample are present at known molar or mass ratios. The pooled ROI amplicon sample can be analyzed/processed as desired, e.g., sequenced using next generation sequencing technology. | 12-29-2011 |
20120071331 | INCREASING CONFIDENCE OF ALLELE CALLS WITH MOLECULAR COUNTING - Aspects of the present invention include methods and compositions for determining the number of individual polynucleotide molecules originating from the same genomic region of the same original sample that have been sequenced in a particular sequence analysis configuration or process. In these aspects of the invention, a degenerate base region (DBR) is attached to the starting polynucleotide molecules that are subsequently sequenced (e.g., after certain process steps are performed, e.g., amplification and/or enrichment). The number of different DBR sequences present in a sequencing run can be used to determine/estimate the number of different starting polynucleotides that have been sequenced. DBRs can be used to enhance numerous different nucleic acid sequence analysis applications, including allowing higher confidence allele call determinations in genotyping applications. | 03-22-2012 |
20120122161 | Sorting Asymmetrically Tagged Nucleic Acids by Selective Primer Extension - The present invention provides methods and compositions for amplifying and sorting adapter tagged nucleic acid fragments using selective primer extension. Immortalized pooled polynucleotide samples and method of producing the same are also provided. | 05-17-2012 |
20130203047 | Increasing Confidence of Allele Calls with Molecular Counting - Aspects of the present invention include methods and compositions for determining the number of individual polynucleotide molecules originating from the same genomic region of the same original sample that have been sequenced in a particular sequence analysis configuration or process. In these aspects of the invention, a degenerate base region (DBR) is attached to the starting polynucleotide molecules that are subsequently sequenced (e.g., after certain process steps are performed, e.g., amplification and/or enrichment). The number of different DBR sequences present in a sequencing run can be used to determine/estimate the number of different starting polynucleotides that have been sequenced. DBRs can be used to enhance numerous different nucleic acid sequence analysis applications, including allowing higher confidence allele call determinations in genotyping applications. | 08-08-2013 |
20130267424 | Method of tagging using a split DBR - Aspects of the present invention include methods and compositions for determining the number of individual polynucleotide molecules originating from the same genomic region of the same original sample that have been sequenced in a particular sequence analysis configuration or process. In these aspects of the invention, a degenerate base region (DBR) is attached to the starting polynucleotide molecules that are subsequently sequenced (e.g., after certain process steps are performed, e.g., amplification and/or enrichment). The number of different DBR sequences present in a sequencing run can be used to determine/estimate the number of different starting polynucleotides that have been sequenced. DBRs can be used to enhance numerous different nucleic acid sequence analysis applications, including allowing higher confidence allele call determinations in genotyping applications. | 10-10-2013 |
20140073512 | Compositions and Methods for Intramolecular Nucleic Acid Rearrangement - Aspects of the present invention are drawn to processes for moving a region of interest in a polynucleotide from a first position to a second position with regard to a domain within the polynucleotide, also referred to as a “reflex method”. In certain embodiments, the reflex method results in moving a region of interest into functional proximity to specific domain elements present in the polynucleotide (e.g., primer sites and/or MID). Compositions, kits and systems that find use in carrying out the reflex processes described herein are also provided. | 03-13-2014 |
20140272985 | Compositions and Methods for Intramolecular Nucleic Acid Rearrangement - Aspects of the present invention are drawn to processes for moving a region of interest in a polynucleotide from a first position to a second position with regard to a domain within the polynucleotide, also referred to as a “reflex method”. In certain embodiments, the reflex method results in moving a region of interest into functional proximity to specific domain elements present in the polynucleotide (e.g., primer sites and/or MID). Compositions, kits and systems that find use in carrying out the reflex processes described herein are also provided. | 09-18-2014 |
20150031559 | Increased Confidence of Allele Calls with Molecular Counting - Aspects of the present invention include methods and compositions for determining the number of individual polynucleotide molecules originating from the same genomic region of the same original sample that have been sequenced in a particular sequence analysis configuration or process. In these aspects of the invention, a degenerate base region (DBR) is attached to the starting polynucleotide molecules that are subsequently sequenced (e.g., after certain process steps are performed, e.g., amplification and/or enrichment). The number of different DBR sequences present in a sequencing run can be used to determine/estimate the number of different starting polynucleotides that have been sequenced. DBRs can be used to enhance numerous different nucleic acid sequence analysis applications, including allowing higher confidence allele call determinations in genotyping applications. | 01-29-2015 |
Robert Osborne, Essex GB
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20130059310 | Compositions and Methods for Intramolecular Nucleic Acid Rearrangement - Aspects of the present invention are drawn to processes for moving a region of interest in a polynucleotide from a first position to a second position with regard to a domain within the polynucleotide, also referred to as a “reflex method”. In certain embodiments, the reflex method results in moving a region of interest into functional proximity to specific domain elements present in the polynucleotide (e.g., primer sites and/or MID). Compositions, kits and systems that find use in carrying out the reflex processes described herein are also provided. | 03-07-2013 |
20130210643 | Method for preparing a counter-tagged population of nucleic acid molecules. - Aspects of the present invention include methods and compositions for determining the number of individual polynucleotide molecules originating from the same genomic region of the same original sample that have been sequenced in a particular sequence analysis configuration or process. In these aspects of the invention, a degenerate base region (DBR) is attached to the starting polynucleotide molecules that are subsequently sequenced (e.g., after certain process steps are performed, e.g., amplification and/or enrichment). The number of different DBR sequences present in a sequencing run can be used to determine/estimate the number of different starting polynucleotides that have been sequenced. DBRs can be used to enhance numerous different nucleic acid sequence analysis applications, including allowing higher confidence allele call determinations in genotyping applications. | 08-15-2013 |
20130220812 | Compositions and Methods for Intramolecular Nucleic Acid Rearrangement - Aspects of the present invention are drawn to processes for moving a region of interest in a polynucleotide from a first position to a second position with regard to a domain within the polynucleotide, also referred to as a “reflex method”. In certain embodiments, the reflex method results in moving a region of interest into functional proximity to specific domain elements present in the polynucleotide (e.g., primer sites and/or MID). Compositions, kits and systems that find use in carrying out the reflex processes described herein are also provided. | 08-29-2013 |
20130224743 | Method for accurately counting starting molecules - Aspects of the present invention include methods and compositions for determining the number of individual polynucleotide molecules originating from the same genomic region of the same original sample that have been sequenced in a particular sequence analysis configuration or process. In these aspects of the invention, a degenerate base region (DBR) is attached to the starting polynucleotide molecules that are subsequently sequenced (e.g., after certain process steps are performed, e.g., amplification and/or enrichment). The number of different DBR sequences present in a sequencing run can be used to determine/estimate the number of different starting polynucleotides that have been sequenced. DBRs can be used to enhance numerous different nucleic acid sequence analysis applications, including allowing higher confidence allele call determinations in genotyping applications. | 08-29-2013 |
20130237458 | Method of adding a DBR by primer extension - Aspects of the present invention include methods and compositions for determining the number of individual polynucleotide molecules originating from the same genomic region of the same original sample that have been sequenced in a particular sequence analysis configuration or process. In these aspects of the invention, a degenerate base region (DBR) is attached to the starting polynucleotide molecules that are subsequently sequenced (e.g., after certain process steps are performed, e.g., amplification and/or enrichment). The number of different DBR sequences present in a sequencing run can be used to determine/estimate the number of different starting polynucleotides that have been sequenced. DBRs can be used to enhance numerous different nucleic acid sequence analysis applications, including allowing higher confidence allele call determinations in genotyping applications. | 09-12-2013 |
20150080452 | Compositions and Methods Related to Protein Displacement Therapy for Myotonic Distrophy - Disclosed are compositions and methods related to the interaction of polyCUG and polyCCUG repeat RNA and proteins that bind to these repetitive RNA sequences. Also disclosed are methods of treating DM1 or DM2 comprising inhibiting the interaction of poly(CUG) | 03-19-2015 |
Robert Osborne, Great Chesterford, Saifron, Walden GB
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20150197786 | Method for Attaching a Counter Sequence to a Nucleic Acid Sample - Described herein is a method for adding a counter sequence to the individual polynucleotide molecules of an initial nucleic acid sample. After addition of the counter sequence, the sample may be amplified and the number of initial target molecules in the sample can be estimated by counting the number of counter sequences associated with the amplified target molecules. | 07-16-2015 |
Robert Osborne, Saffron GB
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20120135407 | Compositions and Methods for Intramolecular Nucleic Acid Rearrangement - Aspects of the present invention are drawn to processes for moving a region of interest in a polynucleotide from a first position to a second position with regard to a domain within the polynucleotide, also referred to as a “reflex method”. In certain embodiments, the reflex method results in moving a region of interest into functional proximity to specific domain elements present in the polynucleotide (e.g., primer sites and/or MID). Compositions, kits and systems that find use in carrying out the reflex processes described herein are also provided. | 05-31-2012 |
Simon Osborne, Redhill GB
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20100005174 | SERVICE ASSEMBLY AND DELIVERY - A system for assembling and delivering a communications service or product is described which is flexible to accommodate the rapid introduction of new product/service offerings on a frequent basis. The method involves receiving data relating to a number of communication service components and creating and storing a data structure for each communication service component. Data component is also received relating to a communication service, the data identifying at least one of the communication service components and a data structure for the communications service is created and stored. In response to receiving an input requesting provisioning of the communications service, an end-to-end process flow for delivering the communications service is automatically created based on the data structure for the communications service and the data structure for the identified communication service components. | 01-07-2010 |