Patent application number | Description | Published |
20090203616 | METHODS FOR TREATING PAIN AND SCREENING ANALGESIC COMPOUNDS - The present invention relates to the use of compounds that block the α9α10 subtype of the nicotinic acetylcholine receptor (nAChR) for treating pain, such as neuropathic pain and inflammatory pain, and inflammatory disorders, such as arthritis. The present invention also relates to screening compounds to identify analgesic agents that block the α9α10 subtype of the nAChR. | 08-13-2009 |
20100093620 | TYROSINE-RICH CONOPEPTIDES - The invention relates to relatively short peptides (termed Conopeptide-Y family peptides or CPY family peptides or CPY peptides herein), about 30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which are rich in the amino acid tyrosine. | 04-15-2010 |
20100145011 | ALPHA-CONOTOXIN PEPTIDES - The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. | 06-10-2010 |
20110064668 | J-SUPERFAMILY CONOTOXIN PEPTIDES - The invention relates to relatively short peptides (termed J-Superfamily conotoxin peptides, J-conotoxins or J-conotoxin peptides herein), about 25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. The J-conotoxins are useful for treating disorders involving voltage gated ion channels and/or receptors. | 03-17-2011 |
20110166322 | ALPHA-CONOTOXIN PEPTIDES - The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. | 07-07-2011 |
20110304329 | LABELED PEPTIDES AND METHODS OF USE THEREOF FOR IMPROVED OXIDATION AND MAPPING OF DISULFIDE BRIDGES - Described herein are labeled proteins and methods of use thereof for identifying the position of multiple disulfide bridges present in the peptide. The methods combine the use of diselenide bridges and NMR-based mapping of the disulfide bridges. Also described herein are labeled proteins described above that contain fluorous bridges and spacers that facilitate oxidative folding of the protein. The resulting biorthogonal oxidation strategy for studying disulfide-rich peptides both improves oxidative folding and provides simultaneous determination of the disulfide crosslink connectivity in the peptide. The methods permit routine and facile production of disulfide-rich peptides. | 12-15-2011 |
20120149869 | ALPHA-CONOTOXIN PEPTIDES - The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. | 06-14-2012 |
20120220539 | CONOTOXIN PEPTIDES - The present invention relates conotoxin peptides that are analogs of the α-contoxin peptide RgIA. These conotoxin peptides block the α9α10 subtype of the nicotinic acetylcholine receptor (nAChR) and can be used for treating pain, such as neuropathic pain and inflammatory pain, inflammatory disorders, such as rheumatic diseases, and in the treatment of breast cancer. | 08-30-2012 |
20130338338 | ALPHA-CONOTOXIN PEPTIDES - The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. | 12-19-2013 |
20140018400 | METHODS AND COMPOSITIONS RELATED TO NEUROACTIVE THIAZOLINE COMPOUNDS - In one aspect, the invention relates to compounds having a general structure: and methods of using same to modulate calcium release. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 01-16-2014 |
20140121168 | ANTAGONISTS OF TRPV1 RECEPTOR - TRPV1 antagonists and associated methods are provided. A TRPV1 channel antagonist can have the structure: Formula (I) wherein R | 05-01-2014 |
20140350218 | ALPHA-CONOTOXIN PEPTIDES - The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. | 11-27-2014 |
20150225466 | COMPOSITIONS AND METHODS FOR PEPTIDE EXPRESSION AND PURIFICATION USING A TYPE III SECRETION SYSTEM - Disclosed are compositions and methods for expressing and purifying a peptide of interest using a Flagellar Type III secretion system. Disclosed are nucleic acid sequences that contain a FlgM nucleic acid sequence, a cleavage site, and a nucleic acid sequence of interest. Also disclosed are polypeptides that contain FlgM, a cleavage site and a peptide of interest. Methods of producing polypeptides that have FlgM, a cleavage site and a peptide of interest are provided. | 08-13-2015 |
Patent application number | Description | Published |
20090041200 | Radiation therapy imaging and delivery utilizing coordinated motion of jaws, gantry, and couch - A method of delivering a radiation therapy treatment plan to a treatment area of a patient. The treatment plan is delivered using a radiation therapy system including a moveable support for supporting a patient, and a gantry moveable relative to the support. The gantry supports a radiation source, a set of jaws having a jaw width and a multi-leaf collimator for modulating the radiation during delivery of the treatment plan. The support is moved during delivery of the treatment plan to the treatment area, and the width of the jaws is dynamically adjusted during delivery of the treatment plan to the treatment area. | 02-12-2009 |
20090110145 | METHOD FOR ADAPTING FRACTIONATION OF A RADIATION THERAPY DOSE - A system and method of adapting a radiation therapy treatment plan for a patient by varying the fraction size delivered to the patient on any individual day, based at least partially on the use of daily patient registration (i.e., taking images of the patient before each fraction is delivered to see the position and size of the tumor on that day). The fraction size can be dynamically altered based upon the biology of the tumor. | 04-30-2009 |
20090116616 | SYSTEM AND METHOD FOR MOTION ADAPTIVE OPTIMIZATION FOR RADIATION THERAPY DELIVERY - A system and method of optimizing delivery of a radiation therapy treatment. The system optimizes treatment delivery in real-time to take into account a variety of factors, such as patient anatomical and physiological changes (e.g., respiration and other movement, etc.), and machine configuration changes (e.g., beam output factors, couch error, leaf error, etc.). | 05-07-2009 |
20090252291 | SYSTEM AND METHOD FOR MOTION ADAPTIVE OPTIMIZATION FOR RADIATION THERAPY DELIVERY - A system and method of optimizing delivery of a radiation therapy treatment. The system optimizes treatment delivery in real-time to take into account a variety of factors, such as patient anatomical and physiological changes (e.g., respiration and other movement, etc.), and machine configuration changes (e.g., beam output factors, couch error, leaf error, etc.). | 10-08-2009 |
Patent application number | Description | Published |
20130084771 | Autonomous Bobble Head Toy - An apparatus includes a base, a drive mechanism attached to the base for causing the base to move across a support surface, a bobble head rotatably coupled to the base and rotatable about at least one axis, and a vibrating mechanism adapted to cause the bobble head to oscillate about at least one axis. | 04-04-2013 |
20130084773 | Autonomous Bobble Head Toy - An apparatus includes a base, a drive mechanism attached to the base for causing the base to move across a support surface, a bobble head rotatably coupled to the base and rotatable about at least one axis, and a vibrating mechanism adapted to cause the bobble head to oscillate about at least one axis. | 04-04-2013 |
20130084774 | AUTONOMOUS VEHICLE SYSTEM - An apparatus includes a housing, a rotational motor situated within the housing, an eccentric load adapted to be rotated by the rotational motor, and a plurality of legs each having a leg base and a leg tip at a distal end relative to the leg base. The legs are coupled to the housing at the leg base and include at least one driving leg constructed from a flexible material and configured to cause the apparatus to move in a direction generally defined by an offset between the leg base and the leg tip as the rotational motor rotates the eccentric load. | 04-04-2013 |
20130084775 | Autonomous Vehicle System - An apparatus includes a housing, a rotational motor situated within the housing, an eccentric load adapted to be rotated by the rotational motor, and a plurality of legs each having a leg base and a leg tip at a distal end relative to the leg base. The legs are coupled to the housing at the leg base and include at least one driving leg constructed from a flexible material and configured to cause the apparatus to move in a direction generally defined by an offset between the leg base and the leg tip as the rotational motor rotates the eccentric load. | 04-04-2013 |
20140057525 | Ambulatory Toy - An ambulatory toy includes a body; a drive mechanism coupled to the body; a plurality of leg members coupled to the drive mechanism, each of the leg members having a distal end disposed downwardly in a first position and adapted to contact a support surface; and a self-righting member coupled to at least one of the legs. The self-righting member adapted to move the distal ends of the legs of the toy from a second position to the first downwardly disposed position. The method of self-righting using the self-righting member coupled to the leg. | 02-27-2014 |
20140094088 | Imitating Serpentine Motion In A Mechanical Figure - In one embodiment there is provided a mechanical device capable of mimicking a serpentine motion. The mechanical device includes a plurality of segmented portions interconnected consecutively at pivoted junctions. A rotational motor and an eccentric weight are secured about one segmented portion and at least one pair of legs extends from a segmented portion towards a contact surface and causes the segmented portion to move in a direction defined as the rotational motor rotates the eccentric weight. The additional segmented portions following the segmented leg portion follow in a serpentine motion as these portions rock and pivot to counter-balance the undulation caused by the segmented leg portion. | 04-03-2014 |
20150224413 | Aquatic Toy - In one embodiment there is provided an aquatic toy configured for movement under water. The aquatic toy employs sensors to automatically turn on when placed in water and further employs a timing circuit to automatically turn the toy off after a predetermined amount of time. The aquatic toy further includes a shock sensor to monitor movement of the toy when in water and after the timer expires. Movement such as tapping on the tank, splashing the water, or physical movement of the toy will turn on the toy and re-activate the timer. However, the sensors can further detect when the toy is dry to ensure the shock sensor is only active when the sensor is wet. | 08-13-2015 |
Patent application number | Description | Published |
20100082012 | DOUBLE BALLOON CATHETER AND METHODS FOR HOMOGENEOUS DRUG DELIVERY USING THE SAME - The invention, in one embodiment, is directed to a catheter for site-specific delivery of a therapeutic agent to a blood vessel of a patient. The catheter further includes an elongated shaft having at least one inner lumen, a distal end and a proximal end and proximal and distal vessel-conforming balloons where each is separately positionable and inflatable, and when inflated, substantially restricts blood flow in the vessel and creates a treatment window of a defined but variable length for delivery of the therapeutic agent. The catheter optionally includes at least one marker band adjacent to the proximal balloon and at least one marker band adjacent to the distal balloon. At least one lateral aperture positioned in the window is in fluid communication with a drug delivery conduit located within either the inner shaft or the outer shaft to provide a homogeneous concentration of the therapeutic agent to the window. | 04-01-2010 |
20100130996 | DEVICES AND METHODS FOR MANIPULATING A CATHETER SHAFT - A catheter for performing a procedure at a treatment site in the lumen of a blood vessel. The catheter includes an elongate tubular shaft having a proximal bend, a distal bend and a hinge element. A distal portion of the shaft includes a window extending through the sidewall of the shaft between the hinge element and the distal end of the elongate tubular shaft. A working element is disposed within the lumen of the elongate tubular shaft and is configured for performing the procedure through the window at the treatment site. The bends and hinge element are configured to urge the window against a wall of the vessel at the treatment site. | 05-27-2010 |
20140052105 | DOUBLE BALLOON CATHETER AND METHODS FOR HOMOGENEOUS DRUG DELIVERY USING THE SAME - The present disclosure is directed to a catheter for site-specific delivery of a therapeutic agent to a blood vessel of a patient. The catheter further includes an elongated shaft having at least one inner lumen, a distal end and a proximal end and proximal and distal vessel-conforming balloons where each is separately positionable and inflatable, and when inflated, substantially restricts blood flow in the vessel and creates a treatment window of a defined but variable length for delivery of the therapeutic agent. The catheter optionally includes at least one marker band adjacent to the proximal balloon and at least one marker band adjacent to the distal balloon. At least one lateral aperture positioned in the window is in fluid communication with a drug delivery conduit located within either the inner shaft or the outer shaft to provide a homogeneous concentration of the therapeutic agent to the window. | 02-20-2014 |
20140107679 | METHOD FOR MANIPULATING CATHETER SHAFT - A catheter for performing a procedure at a treatment site in the lumen of a blood vessel. The catheter includes an elongate tubular shaft having a proximal bend, a distal bend and a hinge element. A distal portion of the shaft includes a window extending through the sidewall of the shaft between the hinge element and the distal end of the elongate tubular shaft. A working element is disposed within the lumen of the elongate tubular shaft and is configured for performing the procedure through the window at the treatment site. The bends and hinge element are configured to urge the window against a wall of the vessel at the treatment site. | 04-17-2014 |
Patent application number | Description | Published |
20090241964 | METHODS AND DEVICES FOR PASSIVE RESIDUAL LUNG VOLUME REDUCTION AND FUNCTIONAL LUNG VOLUME EXPANSION - The volume of a hyperinflated lung compartment is reduced by sealing a distal end of the catheter in an airway feeding the lung compartment. Air passes out of the lung compartment through a passage in the catheter while the patient exhales. A one-way flow element associated with the catheter prevents air from re-entering the lung compartment as the patient inhales. Over time, the pressure of regions surrounding the lung compartment cause it to collapse as the volume of air diminishes. Residual volume reduction effectively results in functional lung volume expansion. Optionally, the lung compartment may be sealed in order to permanently prevent air from re-entering the lung compartment. The invention further discloses a catheter with a transparent occlusion element at its tip that enables examination of the lung passageway through a viewing scope. | 10-01-2009 |
20110295141 | METHODS AND SYSTEMS FOR ENDOBRONCHIAL DIAGNOSTICS - A method for assessing lung function in a patient is disclosed. The method comprises isolating a lung compartment. Thereafter, in one embodiment, an inhaled gas of known composition is introduced into the lung and compared to the composition of the exhaled gas. Alternatively, accumulated CO | 12-01-2011 |
20110313307 | MEASURING LUNG FUNCTION AND LUNG DISEASE PROGRESSION AT A LOBAR/SEGMENTAL LEVEL - A method for determining lung function in a patient is disclosed, in which a multi-lumen catheter with an expandable occluding element at its end is used to isolate a targeted lung compartment, and respiratory characteristics at the targeted lung compartment are measured over multiple respiratory cycles. The relation between various characteristics of the respiratory cycle is used to determine compliance of lung tissue within the targeted lung compartment. | 12-22-2011 |
20120149978 | DEVICES AND SYSTEMS FOR LUNG TREATMENT - Devices, systems, and methods for measuring the diameter of an airway in a human or animal subject are disclosed. The device comprises a flexible catheter body having a proximal end and a distal end. Flexible sizing elements are disposed along and extend approximately orthogonally from the catheter body. The sizing elements have different heights from one another and are configured to fit through the working channel of a bronchoscope. Devices, systems, and methods for redirecting airflow through a lung airway are also disclosed. The method comprises introducing into the airway a catheter comprising a distal end, a proximal end and an elongated portion therebetween, wherein the distal end comprises an airway closing mechanism, and wherein the proximal end comprises an actuator to actuate the airway closing mechanism; and actuating the airway closing mechanism to at least partially close the airway. | 06-14-2012 |
20130023919 | IMPLANT LOADING DEVICE AND SYSTEM - Devices, methods, and systems are provided for loading an implantable device into a container. One aspect of the loading system contains a loader element with a loading tunnel that is configured to gradually contract an implantable device into a compressed state of reduced size relative to an expanded state as the implantable device travels through the loading tunnel. | 01-24-2013 |
20130317293 | DEVICES, METHODS, AND SYSTEMS FOR DELIVERING IMPLANTS TO A LUNG REGION - Devices, methods, and systems for accessing a lung region are provided. The system includes a delivery catheter having a proximal section, a distal section, and a body disposed in-between, wherein the distal region comprises at least one curved section; and a bronchoscope having a proximal section, a distal section, and a body disposed in-between, wherein the bronchoscope is configured to receive the delivery catheter; wherein the delivery catheter is configured to affect a curvature of the distal section of the bronchoscope when the distal section of the delivery catheter is advanced at least partially through the distal end of the bronchoscope. | 11-28-2013 |
20140315175 | SYSTEM FOR SIMULATING LUNG FUNCTION - A system for simulating a breathing lung is disclosed. The system comprises a lung model contained within an enclosure, wherein a main bronchus of the lung model is open to ambient air. In one embodiment, the system also comprises a vacuum pump connected to the enclosure, a first normally closed 2-way valve connected to the enclosure, a flow controller connected to both the vacuum pump and the enclosure, and a timer connected to the first normally closed 2-way valve. In alternative embodiments, the system comprises a first pump connected to the enclosure and a second pump connected to the enclosure, wherein the first and second pumps work independently of each other, and wherein the first pump is a vacuum pump, and the second pump is either a peristaltic pump or a piston pump. | 10-23-2014 |
20150231353 | METHODS AND DEVICES FOR PASSIVE RESIDUAL LUNG VOLUME REDUCTION AND FUNCTIONAL LUNG VOLUME EXPANSION - The volume of a hyperinflated lung compartment is reduced by sealing a distal end of the catheter in an airway feeding the lung compartment. Air passes out of the lung compartment through a passage in the catheter while the patient exhales. A one-way flow element associated with the catheter prevents air from re-entering the lung compartment as the patient inhales. Over time, the pressure of regions surrounding the lung compartment cause it to collapse as the volume of air diminishes. Residual volume reduction effectively results in functional lung volume expansion. Optionally, the lung compartment may be sealed in order to permanently prevent air from re-entering the lung compartment. The invention further discloses a catheter with a transparent occlusion element at its tip that enables examination of the lung passageway through a viewing scope. | 08-20-2015 |