Nicosia
Alfredo Nicosia, Rome IT
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20080286275 | Antigen Binding Proteins Directed Against Scavenger Receptor B1 that Inhibit Hcv Replication - The present invention features antigen binding protein that bind to a SR-BI target region identified herein as a region involved in HCV E2 binding. Identified target regions are regions bound by a single-chain antibody of SEQ ID NOs: 1, 2, 3 or 4. | 11-20-2008 |
20090035277 | Hepatitis C Virus Nucleic Acid Vaccine - The present invention features nucleic acid constructs that can be used as a HCV nucleic acid vaccine, vaccine component, or in the production of a HCV vaccine. Described constructs include those: (1) encoding for a chimeric HCV polypeptide containing a NS3-4A region based on a first HCV strain and an NS3-NS4A-NS4B-NS5A or an NS3-NS4A-NS4B-NS5A-NS5B region based on a second strain; and (2) a chimpanzee based adenovector encoding an HCV polypeptide. | 02-05-2009 |
20090233992 | HEPATITIS C VIRUS VACCINE - The present invention features Ad6 vectors and a nucleic acid encoding a Met-NS3-NS4A-NS4B-NS5A-NS5B polypeptide containing an inactive NS5B RNA-dependent RNA polymerase region. The nucleic acid is particularly useful as a component of an adenovector or DNA plasmid vaccine providing a broad range of antigens for generating an HCV specific cell mediated immune (CMI) response against HCV. | 09-17-2009 |
20110217332 | Chimpanzee Adenovirus Vaccine Carriers - The present invention provides recombinant replication-defective adenoviral vectors derived from chimpanzee adenoviruses and methods for generating recombinant adenoviruses in human E1-expressing cell lines. The invention also provides compositions and methods suitable for use for the delivery and expression of transgenes encoding immunogens against which a boosted immune response is desired. The invention further provides methods of generating clinical grade vector stocks suitable for use in humans. In a particular embodiment the invention contemplates the use of vectors comprising transgenes which encode tumor associated antigens in vaccines and pharmaceutical compositions for the prevention and treatment of cancer. | 09-08-2011 |
20120027788 | SIMIAN ADENOVIRUS NUCLEIC ACID- AND AMINO ACID-SEQUENCES, VECTORS CONTAINING SAME, AND USES THEREOF - The present invention relates to novel adenovirus strains with an improved sero-prevalence. In one aspect, the present invention relates to isolated polypeptides of adenoviral capsid proteins such as hexon, penton and fiber protein and fragments thereof and polynucleotides encoding the same. Also provided is a vector comprising the isolated polynucleotide according to the invention and adenoviruses comprising the isolated polynucleotides or polypeptides according to the invention and a pharmaceutical composition comprising said vector, adenovirus, polypeptide and/or polynucleotide. The invention also relates to the use of the isolated polynucleotides, the isolated polypeptides, the vector, the adenoviruses and/or the pharmaceutical composition for the therapy or prophylaxis of a disease. | 02-02-2012 |
20120328651 | CHIMPANZEE ADENOVIRUS VACCINE CARRIERS - The present invention provides recombinant replication-defective adenoviral vectors derived from chimpanzee adenoviruses and methods for generating recombinant adenoviruses in human E1-expressing cell lines. The invention also provides compositions and methods suitable for use for the delivery and expression of transgenes encoding immunogens against which a boosted immune response is desired. The invention further provides methods of generating clinical grade vector stocks suitable for use in humans. In a particular embodiment the invention contemplates the use of vectors comprising transgenes which encode tumor associated antigens in vaccines and pharmaceutical compositions for the prevention and treatment of cancer. | 12-27-2012 |
20130101618 | CHIMPANZEE ADENOVIRAL VECTOR-BASED FILOVIRUS VACCINES - This invention provides vaccines for inducing an immune response and protection against filovirus infection for use as a preventative vaccine in humans. In particular, the invention provides chimpanzee adenoviral vectors expressing filovirus proteins from different strains of Ebolavirus (EBOV) or Marburg virus (MARV). | 04-25-2013 |
20130150563 | LIPID-CONJUGATED ANTIBODIES - The present invention relates to novel lipid-conjugated antibodies for use in the treatment or the prevention of diseases, including but not limited to cancer, metabolic diseases including but not limited to hyperglycemia and diabetes, obesity, hypertension, hypercholesterolemia, allergy, asthma, Alzheimer's disease, and infectious diseases including but not limited to diseases caused by viruses, bacteria and fungi. | 06-13-2013 |
Alfredo Nicosia, Naples IT
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20140141042 | Expression Systems - The invention relates to an expression system comprising polynucleotides encoding proteins, wherein the expression system comprises a first polynucleotide encoding at least one protein, peptide or variant thereof, which induces a T cell response, and a second polynucleotide encoding at least one protein peptide or variant thereof, which induces an anti-pathogenic B cell response. The invention further relates to protein mixtures encoded by the expression system and cells comprising the expression system or the protein mixture and pharmaceutical compositions comprising the expression system or the protein mixture. The expression system, polynucleotides, proteins, cells, and pharmaceutical compositions are useful in the prophylaxis or treatment of infections. The invention further relates to nucleotide constructs which comprises, essentially consists or consists of a polynucleotide encoding a modified influenza hemagglutinin (HA). | 05-22-2014 |
Alfredo Nicosia, Roma IT
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20110129498 | VACCINE FOR THE PREVENTION AND THERAPY OF HCV INFECTIONS - The present invention relates to CD81-binding peptides of the hepatitis virus C(HCV) E2 glycoprotein, which are devoid of or mutated within the amino-terminal 27 amino acids of the mature E2 envelope glycoprotein, or variant thereof which retains the ability to bind to CD81. Furthermore, the present invention provides polypeptides comprising said CD81-binding peptide, polynucleotides encoding the CD81-binding peptide, and expression cassettes and vectors comprising the polynucleotide of the invention. Moreover, the present invention relates to compositions comprising the CD81-binding peptide, the polynucleotide encoding the CD81-binding peptide, the expression cassette, or the vector, and an adjuvant. Furthermore, the present invention provides a pharmaceutical composition comprising the CD81-binding peptide, the polynucleotide, the expression cassette, the vector, or the composition of the invention, and a pharmaceutically acceptable excipient, carrier, or diluent. Moreover, the present invention provides the CD81-binding peptide, the polynucleotide, the expression cassette, the vector, the composition, or the pharmaceutical composition of the invention for induction of an immune response, preferably a broad specificity immune response, against HCV in a mammal, and methods for inducing a therapeutic and/or prophylactic immune response against HCV in a mammal, preferably against HCV of various genotypes. | 06-02-2011 |
Christopher P. Nicosia, Federal Way, WA US
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20100042445 | CUSTOMIZABLE SITUATIONAL AWARENESS DASHBOARD AND ALERTS, AND ASSOCIATED SYSTEMS AND METHODS - A customizable situational awareness system is described that allows a user to customize the type of information that the user receives through a user interface, e.g., a dashboard, displayed by the system. In particular embodiments, the system can allow the user to configure alerts that are sent to the user's mobile or other device based on situational awareness events. In further embodiments, the customizable situational awareness system receives user configuration data related to flight events, maintenance events, and alerts. When the system receives situational awareness data, the system can retrieve the user's configuration data and display the situational awareness data based on the user's configuration data. Thus, aspects of the customizable situational awareness system allow the user to access information that is more relevant to the user and to filter out less relevant information. | 02-18-2010 |
Mark Nicosia, Chadds Ford, PA US
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20110264118 | Surgical Device - A wound closure device for closing a surgical wound is provided. The device includes a flexible base sheet and at least one flexible hemostatic clip for applying pressure to a patient's tissue. The flexible base sheet includes at least a first end and a second end, as well as an aperture extending through the base sheet longitudinally from proximate to the first end toward the second end. The aperture has a first and a second longitudinally extending edge. The clip has a first end, a second end, a top, a bottom, and at least a first and a second clamping member. Each clamping member has a distal edge. The clip is attachable to the base sheet. | 10-27-2011 |
Matt Nicosia, Irvine, CA US
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20100171288 | ADJUSTABLE WIDTH SKI - An adjustable width ski can comprise a top plank and two bottom planks. The relationship between the top plank and the two bottom planks can be adjusted to increase the width of the ski. The ski can further comprise a fastener to secure the top and bottom planks in the different configurations. A user can adjust the width of the ski depending on the preferences of the user. The ski can further have a mechanical or electro-mechanical adjustment mechanism. | 07-08-2010 |
Matthew Nicosia, Lacenter, WA US
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20110314971 | ONE ARMED HAMMER AND SYSTEM - The hammer system of an embodiment may allow a user to start driving a nail (e.g., into a board or the like) without having to hold the nail with their other, non-hammering hand. For example, the hammer system may accept and detachably couple to a nail. Once coupled, the hammer system may partially drive the nail, for example with a moderate strike and/or multiple taps, such that the nail is substantially secure and/or stable enough to accept subsequent driving strikes without the user having to hold the nail in place. | 12-29-2011 |
Paul Anthony Nicosia, New York, NY US
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20150008077 | PORTABLE ADJUSTABLE A-FRAME DOLLY DRYWALL CART STOP - A device that prevents an A-frame dolly drywall cart from rolling away from the operator during loading or unloading that is capable of adjusting to various wheel spans in order to accommodate a wide variety of drywall cart models. The device may be stored on the backside of the drywall cart in a position that would otherwise not be used for storage, thus enabling the device to travel with the drywall cart if desired without taking up storage space. | 01-08-2015 |
20150059189 | Drywall Corner Flush-Cutting Guide - A device capable of scoring the exterior side of drywall at a point where two drywall surfaces meet to form a corner and one of the drywall surfaces runs past the other by a distance of approximately less than two inches. The device uses the intersecting surface as a guide and includes a flat guide plate which sits above a C-shaped structure that has a cutting wheel that exists on the same plane as the intersecting surface. | 03-05-2015 |
Raymond Paul Nicosia, Troy, MI US
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20110126948 | REACTIVE PLANAR SUSPENSION FOR A WHEEL - There is described a suspension wheel comprising a substantially rigid rim, a substantially rigid hub disposed concentrically within the rim to define an annular space between the rim and the hub, the hub being adapted for connection to an axle for the wheel, and suspension members disposed in the annular space and connected to the rim and the hub to allow the rim to move in one or both of the horizontal and vertical directions relative to the hub in response to an input to the rim. | 06-02-2011 |
Santo V. Nicosia, Tampa, FL US
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20130217015 | HMGA2 AS A BIOMARKER FOR DIAGNOSIS AND PROGNOSIS OF OVARIAN CANCER - The subject invention pertains to uses of HMGA2 as a diagnostic biomarker for ovarian cancer and for prediction of a subject's resistance to cancer therapy. The methods of the subject invention are particular useful for early detection of epithelial ovarian cancer. | 08-22-2013 |
Tony Nicosia, Brookfield, WI US
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20110288722 | VEHICLE CALIBRATION USING DATA COLLECTED DURING NORMAL OPERATING CONDITIONS - Systems and methods for optimizing the performance of a vehicle under normal operating conditions. A vehicle system adjusts one or more vehicle operating parameters in a closed-loop in response to data received from sensors. A portable vehicle communication interface module is selectively attached to the vehicle without inhibiting normal operation of the vehicle. When connected to the vehicle, the vehicle communication interface module records the adjustments made by the vehicle system in closed-loop operation. These recorded values are then used to update calibration information that the vehicle system uses as default values. | 11-24-2011 |
20120259533 | VEHICLE CALIBRATION USING DATA COLLECTED DURING NORMAL OPERATING CONDITIONS - Systems and methods for optimizing the performance of a vehicle under normal operating conditions. A vehicle system adjusts one or more vehicle operating parameters in a closed-loop in response to data received from sensors. A portable vehicle communication interface module is selectively attached to the vehicle without inhibiting normal operation of the vehicle. When connected to the vehicle, the vehicle communication interface module records the adjustments made by the vehicle system in closed-loop operation. These recorded values are then used to update calibration information that the vehicle system uses as default values. | 10-11-2012 |
20130200078 | FLUSH-MOUNT FUEL CAP WITH VALVE - The present invention provides a fuel cap adapted to close an inlet of a fuel tank. The fuel cap includes a body portion adapted to engage the inlet of the fuel tank. The body portion defines a central axis. The fuel cap also includes a valve coupled to the body portion. The valve selectively allows an airflow through the body portion. The fuel cap further includes a cap cover coupled to the body portion and movable along the central axis relative to the body portion. | 08-08-2013 |
Vincent Nicosia, Phoenix, AZ US
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20140141775 | METHOD OR SYSTEM TO SEARCH WHEN MOVING OR STANDING STILL FOR 802.11 WIRELESS NETWORKS, TO THEN SEND OR RECEIVE GPS AND OTHER INFORMATION USING 802.11 WIRELESS NETWORKS TO A WEB PORTAL OR SOFTWARE APPLICATION - A method or system that when moving or standing still searches and connects to 802.11 wireless networks to then send GPS or other information and receive data or software or information from an internet web service or software application. The method or device or software searches for many types of 802.11 Wi-Fi networks, then connects to send and receive information to a web service or software application. This method or system describes four of the most common types of 802.11 network connections in claims | 05-22-2014 |
20140204934 | SYSTEM FOR CONNECTING TO WIRELESS LOCAL AREA NETWORKS WHILE IN MOTION TO SEND AND RECEIVE GPS DATA AND OTHER INFORMATION TO A WEB PORTAL OR SOFTWARE APPLICATION - A process for detecting and connecting a GPS-enabled device to available in-range wireless local area networks (WLANs), particularly while the device is in motion. Once connected, the GPS enabled device sends and receives data and other information from a web service or software application. The process includes detecting relative movement speed of the GPS device and repeatedly attempts connections with new WLAN access points when in motion, particularly in excess of five miles per hour and/or twenty-five miles per hour. | 07-24-2014 |