Patent application number | Description | Published |
20110229981 | DETECTION OF SHED CD31, DIAGNOSIS OF ATHEROTHROMBOSIS AND AUTOIMMUNE DISORDERS, AND METHODS FOR ANALYZING SIGNALING PATHWAYS - The present invention stems from the finding that the extracellular domain of CD31 proteins present on blood leukocytes is shed and released in the circulation as a soluble form of CD31. A method for detecting shed CD31 is further disclosed. The invention therefore relates to a method for detecting a shed ectodomain of a transmembrane protein such as CD31 and to the use of such a method as a diagnostic tool. The invention further provides methods for determining whether a candidate protein is part of a molecular complex. | 09-22-2011 |
20120010136 | USE OF CD31 PEPTIDES IN THE TREATMENT OF THROMBOTIC AND AUTOIMMUNE DISORDERS - The present invention stems from the finding that the extracellular domain of CD31 proteins present on blood leukocytes is shed and released in the circulation as a soluble form of CD31. The invention relates to peptides corresponding to fragments of CD31 that inhibit T-cell response, and to their use in the treatment of thrombotic disorders such as atherothrombosis and autoimmune disorders. | 01-12-2012 |
20150065374 | Detection of Platelet-Derived Shed CD31 - The present invention relates to various soluble forms of CD31, including a novel form which is shed by activated platelets and released into the circulation. Methods for detecting said soluble forms of CD31 are disclosed, as are methods of specifically 1 detecting said platelet-derived shed CD31 and the use of such methods as a diagnostic tool. | 03-05-2015 |
20150203536 | CD31 PEPTIDES - The present invention provides peptides corresponding to fragments of CD31 that inhibit platelet and leukocyte activation, and to their use in the treatment of thrombotic disease. These peptides find use as therapeutic agents in the treatment of inflammatory diseases and thrombotic diseases such as atherothrombosis, in particular when immobilised onto solid supports. | 07-23-2015 |
Patent application number | Description | Published |
20090042959 | COMPOUNDS HAVING IMMUNOMODULATOR ACTIVITY - Compounds of formula I | 02-12-2009 |
20100305176 | (S,R.)-3-PHENYL-4,5 DIHYDRO-5-ISOXAZOLE ACETIC ACID-NITRIC OXIDE AND USE THEREOF AS ANTI-CANCER AND ANTIVIRAL AGENT - The present invention relates to an isoxazole derivative, the compound of formula (I) | 12-02-2010 |
20110195939 | ANTITUMOR PROPERTIES OF NO MODIFIED PROTEASE INHIBITORS - HIV-protease inhibitors, particularly saquinavir, showed strong anticancer activity but numerous side effects limited its application. In order to overcome its toxicity original compounds were modified by covalent attachment of NO. The efficacy of parental and NO-modified drug was compared in vitro and in vivo. Anticancer activities of NO-modified saquinavir (Saq-NO) was monitored in vitro using assay for cell viability, proliferation, necrotic, autophagic and apoptotic cell death, differentiation, expression of intracellular molecules such as cyclin D3, p53 and Akt. Antitumor properties and toxicity of the compound was estimated in vivo. Saq-NO abrogated the viability of large spectrum of human and rodent tumor cell lines with IC50 significantly lower than parental drug and expressed strong antimelanoma action in vivo. In contrast to saquinavir, there was no detectable toxicity against primary cells in vitro and in vivo. Saq-NO permanently diminished cell proliferation by induction of cell cycle block accompanied with minor presence of tumor cell death. Repressed proliferation was coordinated with strong activation of p53 and differentiation of C6 and B16 cells into oligodendrocytes or “Schwan” like cells, respectively. Oppositely to general characteristic of saquinavir to inhibit Akt signalling, Saq-NO treatment resulted in transient and intensive upregulation of Akt. This antagonism between parental and modified compound could be the crucial for switch of saquinavir from toxic to completely untoxic drug. | 08-11-2011 |
Patent application number | Description | Published |
20090190269 | SELF-ALIGNED COPLANAR STRUCTURE FOR NARROW-TRACK EMR DEVICES AND A METHOD FOR PRODUCING THE SAME - An extraordinary magnetoresistive sensor (EMR sensor) having a lead structure that is self aligned with a magnetic shunt structure. To form an EMR sensor according to an embodiment of the invention, a plurality of layers are deposited to form quantum well structure such as a two dimensional electron gas structure (2DEG). A first mask structure is deposited having two openings, and a material removal process is performed to remove portions of the sensor material from areas exposed by the openings. The distance between the two openings in the first mask defines a distance between a set of leads and the shunt structure. A non-magnetic metal is then deposited. A second mask structure is then formed to define shape of the leads. | 07-30-2009 |
20110063416 | 3D IMAGING DEVICE AND METHOD FOR MANUFACTURING SAME - The invention concerns a 3D imaging device comprising a photodetector ( | 03-17-2011 |
20110088453 | PHOTOACOUSTIC GAS DETECTOR - A photoacoustic detection device including a nanophotonic circuit including a plurality of semiconductor lasers capable of emitting a different frequencies; input couplers connected to optical waveguides; a multiplexer; an output optical waveguide, emerging into a recess; a tuning fork having its free arms arranged at the output of the output optical waveguide; and means for detecting the vibration of the tuning fork, all these elements being assembled in a monolithic component. | 04-21-2011 |
20120112387 | MOLD FOR THERMAL NANOIMPRINT LITHOGRAPHY, PROCESS FOR FABRICATING THE SAME, AND NANOIMPRINT PROCESS USING THE SAME - A heating mold for thermal nanoimprint lithography comprising resistive heating means and collecting means for collecting the electromagnetic energy of a variable electromagnetic field emitted by a source located outside the mold, said collecting means being connected to said resistive heating means (34) in which said energy is dissipated. | 05-10-2012 |
20120266655 | PHOTOACOUSTIC GAS SENSOR WITH A HELMHOLTZ CELL - A photoacoustic detection device including a nanophotonic circuit including a first chip on which is formed at least one optical waveguide and in which is formed a set of cavities defining a Helmholtz resonator; at least one optical source capable of emitting an optical signal in a given wavelength range, capable of being modulated at an acoustic modulation frequency, this source being attached to the first chip; a second chip forming a cap for said cavities and including acoustic sensors; and electronic circuits for processing the output of the acoustic sensors formed in the first or the second chip. | 10-25-2012 |
20130120749 | Particle Detector and Method for Producing Such A Detector - The invention relates to a particle detector including a substrate ( | 05-16-2013 |
20130315547 | OPTICAL WAVEGUIDE HAVING A VARYING INDEX GRADIENT - A photoacoustic detection device including a nanophotonic circuit including a first chip on which is formed at least one optical waveguide and in which is formed a set of cavities defining a Helmholtz resonator; at least one optical source capable of emitting an optical signal in a given wavelength range, capable of being modulated at an acoustic modulation frequency, this source being attached to the first chip; a second chip forming a cap for said cavities and including acoustic sensors; and electronic circuits for processing the output of the acoustic sensors formed in the first or the second chip. Further, an optical waveguide comprising, on a silicon substrate, a silicon germanium core with a variable germanium concentration along a direction perpendicular to the substrate, said core being covered with a cladding silicon layer. | 11-28-2013 |
20140078504 | Optical Gas Detector - A gas detector including: an assembly of two coaxial parabolic reflective caps having opposite concavities, and a wafer arranged in the focal plane of the two caps, at the center of this focal plane, comprising, back-to-back: a diverging light emitter directed towards the first cap and a light receiver directed towards the second cap, wherein the two caps are distant substantially by the sum of their focal distances plus the thickness of the wafer. | 03-20-2014 |
20140097343 | Spectroscopic Detector And Corresponding Method - The invention relates to a spectroscopic detector, including: at least one waveguide ( | 04-10-2014 |
20140376854 | DEVICE FOR NON-LINEAR SIGNAL CONVERSION BY FOUR-WAVE MIXING - A device for non-linear conversion of first infrared signal into a second infrared signal with a wavelength that is less than that of the first infrared signal by means of four-wave mixing, which includes at least one portion of SiGe arranged on at least one first layer of material with a refractive index which is less than that of silicon, a germanium concentration in the portion of SiGe which varies continuously between a first value and a second value which is greater than the first value, in a direction which is approximately perpendicular to a face of the first layer on which the portion of SiGe is arranged, and in which a summital part of the portion of SiGe where the germanium concentration is equal to the second value is in contact with a gas and/or a material with a refractive index which is less than that of the silicon. | 12-25-2014 |
20150116710 | Particle Detector and Method for Producing Such a Detector - The invention relates to a particle detector including a substrate made of a semiconductor material, in which at least one through-cavity is formed, defined by an input section and an output section, wherein the input section thereof is to be connected to an airflow source, the substrate supporting: an optical means including at least one laser source, and at least one waveguide connected to the at least one laser source and leading into the vicinity of the output section of the cavity; and a photodetector located near the output section of the cavity and offset relative to the optical axis of the optical means. | 04-30-2015 |
20150192513 | OPTICAL GAS DETECTOR - A gas detector including a planar mirror; a concave spherical mirror facing the planar mirror, having an optical axis orthogonal to the planar mirror, the distance between the planar and spherical being equal to 0.75 times the radius of curvature of the spherical mirror, to within 10%; a radiation emitter/receiver arranged at the point of intersection of the spherical mirror and of the optical axis; and a radiation receiver/emitter arranged at the point of intersection of the planar mirror and of the optical axis. | 07-09-2015 |