Nelson, MA
Andrew Nelson, Somerville, MA US
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20130209299 | COMPRESSOR WITH LIQUID INJECTION COOLING - A positive displacement rotary compressor is designed for near isothermal compression, high pressure ratios, high revolutions per minute, high efficiency, mixed gas/liquid compression, a low temperature increase, a low outlet temperature, and/or a high outlet pressure. Liquid injectors provide cooling liquid that cools the working fluid and improves the efficiency of the compressor. A gate moves within the compression chamber to either make contact with or be proximate to the rotor as it turns. | 08-15-2013 |
20140271257 | NATURAL GAS COMPRESSING AND REFUELING SYSTEM AND METHOD - A refueling system for natural gas users (e.g., natural gas vehicles) includes a two-stage compression system that compresses low-pressure gas in a natural gas supply line to compressed natural gas (CNG) pressure for use by a user. A single motor drives both a first stage rotary compressor and a rotary hydraulic pump that powers a second-stage liquid piston compressor. The motor, first stage compressor, and pump may be co-axially aligned. Booster vessels store compressed gas to augment the system's compressed gas delivery flow rate when desired. The booster vessels may be recharged with compressed gas when the system is not delivering gas to a user. Hydraulic liquid may be pumped into and out of the booster vessels during booster vessel discharge and recharge, respectively, to maintain a desired pressure within the vessels. | 09-18-2014 |
20160131138 | COMPRESSOR WITH LIQUID INJECTION COOLING - A positive displacement rotary compressor is designed for near isothermal compression, high pressure ratios, high revolutions per minute, high efficiency, mixed gas/liquid compression, a low temperature increase, a low outlet temperature, and/or a high outlet pressure. Liquid injectors provide cooling liquid that cools the working fluid and improves the efficiency of the compressor. A gate moves within the compression chamber to either make contact with or be proximate to the rotor as it turns. | 05-12-2016 |
Andrew L. Nelson, Waltham, MA US
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20140216236 | BOMB RACK LOCK - A bomb rack lock, as part of a bomb rack, comprising a plunger movable to engage a bomb rack linkage to be alternately secured and released and a solenoid body coupled to and operable to support the plunger. The plunger and the solenoid body are movable relative to each other and the bomb rack linkage and the solenoid body is movable between a first position and a second position. The bomb rack lock also includes a sensor to determine whether the solenoid body is in the first position. The plunger is movable to engage and disengage the bomb rack linkage with the solenoid body in the first position. In the second position, the solenoid body prevents engagement between the plunger and the bomb rack linkage. | 08-07-2014 |
Carl William Nelson, Charlton, MA US
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20140256519 | MULTIFUNCTION EXERCISE BELT - An exercise belt is provided. A plurality of loops attached along the length of the exercise belt. The present invention may further include a strap. The strap includes a first end that is releasably attachable to each of the plurality of loops, and a second end that is releasably attachable to each of the plurality of loops. A user may attach a weight to the strap and then attach the first end to one of the plurality of loops and the second end to one of the plurality of loops. | 09-11-2014 |
Carol A. Nelson, Westford, MA US
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20090312392 | Amino ceramide-like compounds and therapeutic methods of use - The present invention provides amino ceramide-like compounds which inhibit glucosyl ceramide (GlyCer) formation by inhibiting the enzyme GlyCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels. | 12-17-2009 |
20150238627 | PEPTIDE-LINKED MORPHOLINO ANTISENSE OLIGONUCLEOTIDES FOR TREATMENT OF MYOTONIC DYSTROPHY - Provided herein are peptide-linked morpholino (PPMO) antisense oligonucleotides that target the poly CUG repeat tract in the 3′ untranslated region of the gene encoding dystrophia myotonica-protein kinase (DMPK) and methods for systemic administration of the same for the treatment of mytonic dystrophy type I (DM1). | 08-27-2015 |
Colin Nelson, Medfield, MA US
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20130317893 | SYSTEM AND METHOD FOR COORDINATING EVENT PARTICIPATION AND PAYMENT - The invention generally relates to systems and methods for coordinating participation in, and payment for, events. In particular, the invention allows a person to initiate a group event without exposing themselves to a full cost of the event, even where full payment is traditionally collected through a single bill or prior to the event. In some aspects, the invention provides a method of organizing an event that includes broadcasting information about an event to potential participants, receiving a commitment to pay from participants, and charging each participant their share while paying a full event cost, so that no one person must pay the full cost. | 11-28-2013 |
David Charles Nelson, Princeton, MA US
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20150121664 | MULTI-PIECE PANEL FASTENER - A fastener includes a clip including a flexible head having an outer surface configured to engage and edge of a first slot in a first panel when the flexible head is inserted therein and a retainer configured to be inserted into a channel within the flexible head to impede flexing of the flexible head thereby retain the flexible head in the first slot. The clip may further include at least one member extending from the head and configured to engage a second slot in a second panel to hold the first and second panels together when the first and second slots are positioned in an opposing relationship. In some embodiments, the at least one member may include first and second spring arm members extending from the head and having outer surfaces configured to engage edges of the second slot when inserted therein. Methods using such fasteners are also discussed. | 05-07-2015 |
David Dodge Nelson, North Chelmsford, MA US
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20080202206 | EXTRACTIVE SAMPLING SYSTEM AND METHOD FOR MEASURING ONE OR MORE MOLECULAR SPECIES - A non-contact, extractive sampling system and method is provided for measuring the exhaust gas composition and fine particle composition of exhaust emissions of various types of vehicles under actual operating conditions. A portion (or sample) of an exhaust plume of a vehicle is pulled or extracted through an extraction sampling tube, via a vacuum pump, to a remote trace gas detection system where the concentration of one or more constituents present in the sample of exhaust plume may be measured. In this regard, the invention enables vehicle emissions measurements to be made at a location remote from roadway, rather than using known, “cross-path” remote emissions sensing systems. | 08-28-2008 |
Denise A. Nelson, Medway, MA US
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20080275987 | METHODS AND APPARATUS FOR INTEGRATING SERVICES FOR ACCESSING THE WORLD WIDE WEB - Web pages retrieved by a browser core are translated into user interface component definitions and page information. The definitions and page information are transmitted to a user device which recomposes the definitions and page information into a format for presentation to a user on a user device. Transmitting the definitions and page information includes translation of the definitions and page information into a format appropriate for both the particular communications media on which the information is transmitted, and the device to which the information is transmitted. The device includes a browser client which performs the recomposition. The browser client also receives user input, and may respond by altering the information locally at the user device, and sending information related to the user selection back to the browser core for further processing. The browser core also tracks user sessions, thus allowing a user to access the network from several devices, and capture session information for each access from each device. This allows users to switch devices, and start a new session at the point where a previous session ended. | 11-06-2008 |
Elizabeth Nelson, Newton, MA US
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20120222468 | ATTACHMENT DEVICE FOR IDENTIFYING CONSTITUENTS WITHIN A FLUID - An attachment device for identifying one or more constituents within a fluid includes a first end configured to selectively attach to an opening of a container of holding a fluid, and a sensor coupled to the attachment body. The sensor further includes one or more sensor elements positioned to detect and analyze a fluid within the container. The sensor is further configured to perform one or more tests on the fluid, wherein the one or more tests are useful in identifying one or more constituents within the fluid. | 09-06-2012 |
20120226446 | SYSTEMS AND METHODS FOR MONITORING THE USE OF MEDICATIONS - Systems and methods for monitoring the use of a fluid over the lifecycle of the fluid, said systems including a plurality of fluid identification stations, each station having one or more sensors to detect and identify a parameter of a fluid, wherein a each station is operably interconnected thereby permitting each station to access and verify the identity of a fluid as determined by each independent fluid identification station. | 09-06-2012 |
20120226447 | SMART MEDICATION WASTE DISPOSAL - A system for recording the wasting of fluids includes a waste disposal unit and a sensor system, having a sensor. The sensor can have one or more sensor elements in fluid communication with a fluid as it is wasted from a container into the waste disposal unit. The sensor system is configured to identify one or more drugs within the fluid and record the identity of the one or more drugs in a computer-readable medium electrically coupled to the sensor system. | 09-06-2012 |
Elizabeth Nelson, Wellesley, MA US
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20160030683 | SMART ADAPTER FOR INFUSION DEVICES - Smart sensors are employed to determine one or more of drug identification, dose, flow rate, concentration, agglomeration, and degradation and/or other characteristics of drug administration that can be detected via sensing technology. A smart sensor(s) can be coupled to or retrofitted onto injection pen injectors and/or drug delivery cartridges and/or infusion sets or cannulae, enabling infusion sets, pen injector systems or drug delivery cartridges to improve tracking of drug self-administration and stop medication errors that occur primarily through self or automated injection (e.g., due to incorrect or incomplete dosing, excessive dose or rate, incorrect drug, or drug degradation). | 02-04-2016 |
20160089056 | CANNULA INSERTION DETECTION - Sensors are disclosed that detect whether a cannula is properly inserted to its full depth in a subject's skin. The sensors may be used with a blood glucose monitor, or with a continuous insulin infusion pump, infusion set, or other system involving intermittent or continuous testing and/or drug delivery. | 03-31-2016 |
Eric Jorge Nelson, Boston, MA US
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20100247566 | CHOLERA VACCINES - The methods and compositions of the present invention are directed to a vaccine against | 09-30-2010 |
Galen C. Nelson, Boston, MA US
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20150081107 | System and Method for Crowd-Sourced Environmental System Control and Maintenance - A system and method for crowd-sourced environmental system control and building maintenance includes a server for providing selective access to building occupants and managers. Users are permitted to generate building reports in the form of (i) thermal reports using a thermal report module, and/or (ii) maintenance reports using a maintenance report module. The reports are each geo-located to locations within the building, and are then captured, stored, and aggregated at the server. The aggregated reports are sorted according to their geo-locations and comfort rules are used to (i) permit a manager at a client computer to access the server to respond, and/or (ii) automatically respond and assign a response status to particular reports. An inspection checklist interface is generated and populated to display a list of preventative maintenance tasks, each of the tasks being user-selectable to designate completion, with the updated status of the reports being stored at the server. | 03-19-2015 |
Jennifer Nelson, Boston, MA US
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20110098345 | Aptamers to Tissue Factor Pathway Inhibitor and Their Use as Bleeding Disorder Therapeutics - The invention relates generally to the field of nucleic acids and more particularly to aptamers that bind to TFPI, which are useful as therapeutics in and diagnostics of bleeding disorders and/or other diseases or disorders in which TFPI has been implicated. In addition, the TFPI aptamers may be used before, during and/or after medical procedures to reduce complications or side effects thereof. The invention further relates to materials and methods for the administration of aptamers that bind to TFPI. | 04-28-2011 |
20110281938 | APTAMERS TO TISSUE FACTOR PATHWAY INHIBITOR AND THEIR USE AS BLEEDING DISORDER THERAPEUTICS - The invention relates generally to the field of nucleic acids and more particularly to aptamers that bind to TFPI, which are useful as therapeutics in and diagnostics of bleeding disorders and/or other diseases or disorders in which TFPI has been implicated. In addition, the TFPI aptamers may be used before, during and/or after medical procedures to reduce complications or side effects thereof. The invention further relates to materials and methods for the administration of aptamers that bind to TFPI. | 11-17-2011 |
20120190834 | APTAMERS TO TISSUE FACTOR PATHWAY INHIBITOR AND THEIR USE AS BLEEDING DISORDER THEREAPEUTICS - The invention relates generally to the field of nucleic acids and more particularly to aptamers that bind to TFPI, which are useful as therapeutics in and diagnostics of bleeding disorders and/or other diseases or disorders in which TFPI has been implicated. In addition, the TFPI aptamers may be used before, during and/or after medical procedures to reduce complications or side effects thereof. The invention further relates to materials and methods for the administration of aptamers that bind to TFPI. | 07-26-2012 |
Jennifer A. Nelson, Waltham, MA US
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20110219607 | CATHODE ACTIVE MATERIALS AND METHOD OF MAKING THEREOF - A method of making a primary alkaline battery that includes a cathode including λ-MnO | 09-15-2011 |
20110220842 | ACID-TREATED MANGANESE DIOXIDE AND METHODS OF MAKING THEREOF - A primary battery includes a cathode having an acid-treated manganese dioxide, an anode, a separator between the cathode and the anode, and an alkaline electrolyte. | 09-15-2011 |
20110223477 | ALKALINE BATTERY INCLUDING LAMBDA-MANGANESE DIOXIDE AND METHOD OF MAKING THEREOF - A primary battery includes a cathode having a cathode active material including a blend or composite of λ-MnO | 09-15-2011 |
20110223493 | PRIMARY ALKALINE BATTERY - A primary battery includes a cathode having a non-stoichiometric metal oxide including transition metals Ni, Mn, Co, or a combination of metal atoms, an alkali metal, and hydrogen; an anode; a separator between the cathode and the anode; and an alkaline electrolyte. | 09-15-2011 |
20130247363 | METHODS OF MAKING METAL-DOPED NICKEL OXIDE ACTIVE MATERIALS - Methods of making high-energy cathode active materials for primary alkaline batteries are described. The primary batteries include a cathode having an alkali-deficient nickel(IV)-containing oxide including one or more metals such as Co, Mg, Al, Ca, Y, Mn, and/or non-metals such as B, Si, Ge or a combination of metal and/or non-metal atoms as dopants partially substituted for Ni and/or Li in the crystal lattice; an anode; a separator between the cathode and the anode; and an alkaline electrolyte solution. | 09-26-2013 |
20130252085 | METAL-DOPED NICKEL OXIDE ACTIVE MATERIALS - A primary battery includes a cathode having an alkali-deficient nickel oxide including metals such as Ca, Mg, Al, Co, Y, Mn, and/or non-metals such as B, Si, Ge, or a combination of metal and/or non-metal atoms; a combination of metal atoms; an anode; a separator between the cathode and the anode; and an alkaline electrolyte. | 09-26-2013 |
20130252108 | METAL-DOPED NICKEL OXIDE ACTIVE MATERIALS - A primary alkaline battery includes a cathode having an alkali-deficient nickel (IV)-containing oxide including metals such as Ni, Co, Mg, Al, Ca, Y, Mn, and/or non-metals such as B, Si, Ge or a combination of metal and/or non-metal ions as stabilizing dopants; a combination of metal ions as dopants; an anode; a separator between the cathode and the anode; and an alkaline electrolyte. The battery can be pre-discharged within one hour after assembly to decrease the open circuit voltage. | 09-26-2013 |
Jennifer Anne Nelson, Waltham, MA US
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20130036603 | PRIMARY ALKALINE BATTERY - A primary battery includes a cathode having a non-stoichiometric metal oxide including transition metals Ni, Mn, Co, or a combination of metal atoms, an alkali metal, and hydrogen; an anode; a separator between the cathode and the anode; and an alkaline electrolyte. | 02-14-2013 |
20150194666 | METHODS OF MAKING METAL-DOPED NICKEL OXIDE ACTIVE MATERIALS - Methods of making high-energy cathode active materials for primary alkaline batteries are described. The primary batteries include a cathode having an alkali-deficient nickel(IV)-containing oxide including one or more metals such as Co, Mg, Al, Ca, Y, Mn, and/or non-metals such as B, Si, Ge or a combination of metal and/or non-metal atoms as dopants partially substituted for Ni and/or Li in the crystal lattice; an anode; a separator between the cathode and the anode; and an alkaline electrolyte solution. | 07-09-2015 |
20150280234 | BETA-DELITHIATED LAYERED NICKEL OXIDE ELECTROCHEMICALLY ACTIVE CATHODE MATERIAL AND A BATTERY INCLUDING SAID MATERIAL - The invention is directed towards an electrochemically active cathode material. The electrochemically active cathode includes beta-delithiated layered nickel oxide. The beta-delithiated layered nickel oxide has an X-ray diffraction pattern. The X-ray diffraction pattern of the beta-delithiated layered nickel oxide includes a first peak from about 14.9°2θ to about 16.0°2θ; a second peak from about 21.3°2θ to about 22.7°2θ; a third peak from about 37.1°2θ to about 37.4°2θ; a fourth peak from about 43.2°2θ to about 44.0°2θ; a fifth peak from about 59.6°2θ to about 60.6°2θ; and a sixth peak from about 65.4°2θ to about 65.9°2θ. | 10-01-2015 |
20150280250 | BATTERY INCLUDING BETA-DELITHIATED LAYERED NICKEL OXIDE ELECTROCHEMICALLY ACTIVE CATHODE MATERIAL - The invention is directed towards a battery. The battery includes a cathode, an anode, a separator between the cathode and the anode, and an electrolyte. The cathode includes a conductive additive and an electrochemically active cathode material. The electrochemically active cathode material includes a beta-delithiated layered nickel oxide. The beta-delithiated layered nickel oxide has a chemical formula. The chemical formula is Li | 10-01-2015 |
Joel N. Nelson, Groton, MA US
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20130310064 | METHOD AND SYSTEM FOR SELECTING AND PROVIDING A RELEVANT SUBSET OF WI-FI LOCATION INFORMATION TO A MOBILE CLIENT DEVICE SO THE CLIENT DEVICE MAY ESTIMATE ITS POSITION WITH EFFICIENT UTILIZATION OF RESOURCES - A method of providing a relevant subset of information to a client device is based in part on scanning for Wi-Fi access points within range of the client device, using a Wi-Fi database that covers a large target region to retrieve information about these access points, using this information to estimate the position of the mobile client device, selecting a limited region in the vicinity of the estimated location of the client device, and providing information about Wi-Fi access points within this limited region to the client. For efficient transfer and maintenance of data, the target region may be divided into a hierarchy of fixed geographical tiles. | 11-21-2013 |
John Merl Nelson, Holliston, MA US
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20120185197 | Self calibrating home site fuel usage monitoring device and system - A home site fuel monitor device in conjunction with a remote central site system to provide accurate fuel usage data used in planning fuel deliveries. The fuel monitor device is U an internet based, compact, and low cost home heating site monitor device that is easily installed in the home heating site without modification to the home site's heating system. The monitor device includes a microprocessor which measures heating system run times using real time clock values. The microprocessor computes heating system fuel usage and the rate of fuel usage using heating system run times and heating burner parameters down loaded from the remote central site system. The monitor device continuously adjusts or recalibrates the rate of fuel usage defined as a burn coefficient value to coincide with the latest delivery information received from the central site system which results in increased accuracy over time. | 07-19-2012 |
Julie E. Nelson, Braintree, MA US
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20140282106 | SYSTEMS AND METHODS FOR GESTURE-BASED SHARING OF DATA BETWEEN SEPARATE ELECTRONIC DEVICES - Described herein are various embodiments of systems, methods, and apparatus that allow a user to share data, such as one or more files from within an application with one or more other (not necessarily co-located) computing devices using a gesture-based sharing function. In a particular example, systems, methods, and apparatus described herein may be used to share graphical representations of chemical structures within a chemical structure rendering application between two or more user devices. By offering a user a quick and visually intuitive option for sharing a file with other user(s) without exiting a current application, the systems, methods, and apparatus described herein provide efficient and engaging tools for sharing work product in real time between two or more users. | 09-18-2014 |
Keith A. Nelson, Newton, MA US
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20080265165 | Phase-matched terahertz emitter - Methods and apparatus are disclosed for directing optical radiation to make multiple passes across an extended region of an electro-optic material, where during each pass the electro-optic material converts a portion of the optical radiation into terahertz radiation, and where the optical radiation is directed into the electro-optic material to cause an amplitude of the terahertz radiation generated from one or more earlier passes of the optical radiation to be constructively enhanced by the terahertz radiation generated from a later pass of the optical radiation. | 10-30-2008 |
20090116009 | MULTIDIMENSIONAL PULSE SHAPER AND SPECTROMETER - Methods and apparatusare disclosed, and include: (a) separating an input electromagnetic waveform into a plurality of intermediate waveforms, each of the intermediate waveforms being spatially separated from one another; (b) dispersing frequency components of each intermediate waveform onto different regions of a spatial light modulator and modulating at least some of the dispersed frequency components with the spatial light modulator; and (c) recombining the dispersed frequency components for each of the intermediate waveforms to produce a plurality of temporally shaped output waveforms. | 05-07-2009 |
20140061469 | DETECTION OF ELECTROMAGNETIC RADIATION USING NONLINEAR MATERIALS - An apparatus for detecting electromagnetic radiation within a target frequency range is provided. The apparatus includes a substrate and one or more resonator structures disposed on the substrate. The substrate can be a dielectric or semiconductor material. Each of the one or more resonator structures has at least one dimension that is less than the wavelength of target electromagnetic radiation within the target frequency range, and each of the resonator structures includes at least two conductive structures separated by a spacing. Charge carriers are induced in the substrate near the spacing when the resonator structures are exposed to the target electromagnetic radiation. A measure of the change in conductivity of the substrate due to the induced charge carriers provides an indication of the presence of the target electromagnetic radiation. | 03-06-2014 |
20150285687 | DETECTION OF ELECTROMAGNETIC RADIATION USING NONLINEAR MATERIALS - An apparatus for detecting electromagnetic radiation within a target frequency range is provided. The apparatus includes a substrate and one or more resonator structures disposed on the substrate. The substrate can be a dielectric or semiconductor material. Each of the one or more resonator structures has at least one dimension that is less than the wavelength of target electromagnetic radiation within the target frequency range, and each of the resonator structures includes at least two conductive structures separated by a spacing. Charge carriers are induced in the substrate near the spacing when the resonator structures are exposed to the target electromagnetic radiation. A measure of the change in conductivity of the substrate due to the induced charge carriers provides an indication of the presence of the target electromagnetic radiation. | 10-08-2015 |
Keith Adam Nelson, Newton, MA US
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20160131527 | TWO-DIMENSIONAL SPECTROSCOPY SYSTEM AND TWO-DIMENSIONAL SPECTROSCOPIC ANALYSIS METHOD - A two-dimensional (2D) spectroscopy system and a 2D spectroscopic analysis method are disclosed. The 2D spectroscopy system includes: a light transmission delayer configured for forming a plurality of first light pulses from first light pulse and causing a relative time delay therebetween; a response pulse wave generator configured for generating a plurality of response pulse waves responds and having a relative time delay, and for irradiating the plurality of response pulse waves on the sample; an optical readout pulse array generator configured for forming an optical readout pulse array by splitting the second light pulse into a plurality of regions having different time delays and spatially discriminated from one another; and a reader configured for reading out by overlapping the optical readout pulse array with a signal generated from the sample. | 05-12-2016 |
Kristoff Nelson, Boston, MA US
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20130310919 | Elephant Trunk Thoracic Endograft and Delivery System - A delivery system for delivering a device within a body lumen. The delivery system includes a self-expanding stent/graft composite prosthesis and a deployment device. The deployment device includes an outer sheath which overlies the graft, and a stent retaining means for maintaining the one end of the stent in a radially compressed state. The outer sheath is retractable with respect to the graft, and the stent retaining means is removable to allow the stent end to radially expand. The deployment device may further include an inner sheath to overlie the composite and is retractable with respect to the composite. An endoluminal prosthesis including a graft attached to one stent and a second stent unattached within the graft lumen. | 11-21-2013 |
Larry G. Nelson, Webster, MA US
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20100242771 | Precision pyrotechnic display system and method having increased safety and timing accuracy - A system and method are disclosed for controlling the launch and burst of pyrotechnic projectiles in a pyrotechnic, or “fireworks”, display. | 09-30-2010 |
20150268264 | Thermistor Based Measurement System - A measurement system for monitoring ambient temperature and airspeed is disclosed. The measurement system uses a single temperature sensor, disposed in the environment under test, in communication with a controller. The controller supplies a first current to the temperature sensor to measure the ambient temperature of the environment. This first current is selected so that it results in little or no self-heating of the temperature sensor. After the ambient temperature is determined, a second, higher current is applied to the temperature sensor. This higher current serves to heat the temperature sensor be a predetermined amount. Based on the expected temperature rise, the ambient temperature and the actual monitored temperature, the airspeed may be determined. | 09-24-2015 |
Mathew A. Nelson, South Boston, MA US
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20090164598 | Program Product and System for Performing Multiple Hierarchical Tests to Verify Identity of Sender of an E-Mail Message and Assigning the Highest Confidence Value - The identity of the sender of an e-mail message is verified by performing a plurality of tests on DNS information. The DNS information is based on a client IP address or a sender address. Each test performed has a corresponding intrinsic confidence value representing the degree of confidence the test provides of the sender identity relationship. If multiple tests are successful the test result with the highest confidence value of the hierarchy of confidence values is used. The confidence value is optionally used in subsequent identity tests as specified by the subsequent test. | 06-25-2009 |
Matt Nelson, Watertown, MA US
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20150072543 | STEPPED SPRING CONTACT - In an embodiment, a stepped spring contact may have a first portion, a transition portion, and a second portion. The first portion may include a plurality of windings whose pitch may vary. The second portion may include a plurality of windings that are closely wound. A pitch of the windings contained in the second portion may be, for example, constant. The transition portion may include a winding that may make mechanical and electrical contact with a first electrical conductor (e.g., a pad contained on a printed circuit board (PCB)). The first portion may include a tip. The tip may be, for example, flat shaped or conically shaped. The tip may make electrical contact with a second electrical conductor (e.g., a terminal connector). In operation, the stepped spring contact may provide electrical continuity between the first electrical conductor and the second electrical conductor. | 03-12-2015 |
N. D. Nelson, Rowley, MA US
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20100163211 | Heat exchanger assembly - An improved heat exchanger assembly and method. First and second plates made of a predetermined thermally conductive material are configured when mated to form a hermetically sealed vapor chamber. A wick made of the same predetermined thermally conductive material resides in the vapor chamber forming a gas chamber. | 07-01-2010 |
Richard D. Nelson, Woburn, MA US
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20080214990 | Fluid Conduit Connection - A fluid conduit connector assembly includes a connector having a body with an inner surface defining a fluid channel. The connector also includes an inlet region for flow of fluid into the fluid channel, and an outlet region for flow of fluid from the fluid channel. The connector further includes an axial alignment member outward of the body, and a pair of flexible tabs arranged generally circumferentially of the alignment member and outward of the body. The connector can be configured as a day-side connector, transfer member with check valve, and/or patient-side connector. An implementation includes a day-side connector, a patient-side connector, and a transfer member, each of which has a pair of flexible tabs. The pairs of tabs are configured such that the transfer member releasably couples the day-side and patient-side connectors. A method for aseptically connecting a fluid conduit is also disclosed. | 09-04-2008 |
20110196314 | FLUID CONDUIT CONNECTION - A fluid conduit connector assembly includes a connector having a body with an inner surface defining a fluid channel. The connector also includes an inlet region for flow of fluid into the fluid channel, and an outlet region for flow of fluid from the fluid channel. The connector further includes an axial alignment member outward of the body, and a pair of flexible tabs arranged generally circumferentially of the alignment member and outward of the body. The connector can be configured as a day-side connector, transfer member with check valve, and/or patient-side connector. An implementation includes a day-side connector, a patient-side connector, and a transfer member, each of which has a pair of flexible tabs. The pairs of tabs are configured such that the transfer member releasably couples the day-side and patient-side connectors. A method for aseptically connecting a fluid conduit is also disclosed. | 08-11-2011 |
Robert Nelson, Woods Hole, MA US
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20130060477 | SYSTEMS AND METHODS FOR TOPOGRAPHIC ANALYSIS - The systems and methods described herein provide a scientific and analytical basis for the following: (a) collective interpretation of the entire spectrum of chromatographic data, e.g., GC×GC two-dimensional data, with capability of operating at multi-resolution over bigger or smaller sub-regions of the two-dimensional data, (b) given two or more samples that are from the same source, and some samples from clearly different sources, quantitatively estimate where the fingerprint of the source lies, (c) given a source signature template, an unknown sample can be compared to decide whether it is related to, and if so, to what degree, to this source, and (d) given two source signature templates, the templates can be compared to determine how related is one source to the other. | 03-07-2013 |
Robert Michael Nelson, Wellesley, MA US
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20130022980 | RNA- AND DNA-COPYING ENZYMES - The present invention is directed to DNA polymerase fusion proteins with increased processivity and nucleic acid affinity. The invention includes a fusion protein comprising a nucleic acid-binding domain fused to a polymerase domain. The nucleic acid binding domain contains at least one nucleic acid binding motif, such as a DNA-binding motif or an RNA-binding motif. The nucleic acid binding domain preferably embodies an oligonucleotide/oligosaccharide binding (OB) fold, among other conformations. The invention further includes methods of synthesizing nucleic acids using the fusion proteins described herein. | 01-24-2013 |
Sacha Nelson, Weston, MA US
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20140315211 | METHODS FOR SUPPRESSION PCR - Provided herein are approaches for the detection, identification, and/or selective amplification of specific target species or target variants of nucleic acid sequences, even within an excess of unwanted similar sequences or variants. These approaches include methods, assays, and kits for suppression PCR that require, in part, DNA polymerase that lacks 5′-3′ exonuclease activity, and a PCR primer, termed a forward selective primer or a nunchaku primer. The methods, assays, and kits provided herein are useful for a wide variety of applications, including cancer screening assays and kits, personalized screening assays, SNP (single nucleotide polymorphism) genotyping and identification, and downstream applications such as next generation high-throughput genomic sequencing and library construction. | 10-23-2014 |