Nambara
Daisuke Nambara, Tokyo JP
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20120315628 | METHOD FOR IDENTIFYING ONCOGENE, METHOD FOR ESTABLISHING ONCOGENE-EXPRESSING CELL, AND METHOD OF SCREENING ONCOGENE TARGETING DRUG - The present invention provides a methodology that can develop a more excellent anti-cancer drug than conventional ones for various cancers. Specifically, the present invention provides a method for establishing an artificial cell, comprising treating a cancer cell with an expression vector for a foreign oncogene and then culturing the cancer cell treated with the expression vector under a condition which inhibits an expression or function of an oncogene that is inherent to the cancer cell, and an established artificial cell; a method of screening an anti-cancer drug, comprising evaluating whether or not a test substance inhibits a proliferation of the artificial cell; as well as a method for identifying an oncogene, comprising treating a cancer cell with an expression vector for a test gene and then culturing the cancer cell treated with the expression vector under a condition which inhibits an expression or function of an oncogene that is inherent to the cancer cell. | 12-13-2012 |
20130029357 | DIAGNOSTIC MARKER FOR EFFECT OF ANTICANCER AGENT - The present invention enables to realize a convenient determination of a therapeutic effect of an anticancer agent on a cancer. Specifically, the present invention provides a diagnostic marker for an effect of an anticancer agent on a cancer, comprising a substance having an affinity for a fragment of an extracellular domain of c-MET; a diagnostic reagent for an effect of an anticancer agent on a cancer, comprising a substance having an affinity for a fragment of an extracellular domain of c-MET and the fragment of the extracellular domain of c-MET; and a method of testing an effect of an anticancer agent on a cancer, comprising (a) measuring a concentration of a fragment of an extracellular domain of c-MET in a biological sample from a subject, and (b) comparing the measured concentration of the fragment of the extracellular domain of c-MET with an indicator which presents a relationship between a concentration of the fragment of the extracellular domain of c-MET and the effect of the anticancer agent on the cancer. | 01-31-2013 |
Masaru Nambara, Hamamatsu-Shi JP
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20150128418 | METHOD FOR MANUFACTURING FLUID POWER TRANSMISSION - A method for manufacturing a fluid power transmission includes a first step of assembling a blade/core provisional assembly having a plurality of blades movably linked to a core, involving aligning the plurality of blades on a blade alignment jig, laying the core over a group of blades while extending a projecting piece provided on each blade through a latching hole provided in the core, and bending an extremity part of the projecting piece thus preventing the projecting piece from coming out of the latching hole, a second step of setting the blade/core provisional assembly at a predetermined position on an inside face of the shell, and a third step of carrying out brazing between the projecting piece and the latching hole and between the blade and the shell. Such method provides a high quality impeller of a fluid power transmission by joining a shell, a blade, and a core. | 05-14-2015 |
Shogo Nambara, Kanagawa JP
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20130259596 | FASTENING MEMBER AND COMPRESSOR APPARATUS - The present invention provides a fastening member and a compressor apparatus capable of improving workability of assembling. A fastening member includes a bolt and a nut for attaching a compressor to a vehicle body. A non-circular relative rotation prevention portion is formed below a head portion of the bolt. A washer is non-rotatably press fitted around the relative rotation prevention portion. Before the attachment, the head portion and the washer are temporarily fixed with a space generated therebetween. An elastic body, which is attached to the compressor, is disposed between the washer and the nut. A cylindrical member is provided at an inner circumference of the elastic body. As a result, when the nut is screwed, an axial force of the nut is transmitted to the washer via the cylindrical member, and the space between the washer and the head portion reduces, completing the attachment. | 10-03-2013 |
Takahiro Nambara, Toyohashi-City JP
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20150338649 | HEAD-UP DISPLAY DEVICE AND COMBINER THEREOF - An optical display image is projected from a projector to a combiner. The combiner includes a front reflection surface, which is in a form of a curved concave surface and forms a front surface virtual image by reflecting the optical display image at a side of the combiner where an inside of a cabin is located, and a back reflection surface, which is in a form of a curved convex surface and forms a back surface virtual image by reflecting the optical display image at another side of the combiner where an outside of the cabin is located. Optical axes, which extend from the front reflection surface and the back reflection surface, respectively, to a predicted eye point of the occupant, are overlapped with each other, and a radius of curvature of the front reflection surface is smaller than a radius of curvature of the back reflection surface. | 11-26-2015 |