Nagle, US
Advait Nagle, San Diego, CA US
Patent application number | Description | Published |
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20090118273 | Compounds and Compositions as Protein Kinase Inhibitors - The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of Abl, Bcr-Abl, Bmx, BTK, b-RAF, c RAF, CSK, cSRC, Fes, FGFR3, Flt3, IKKα, IKKβ, JNK1α1, JNK2α2, Lck, Met, MKK4, MKK6, p70S6K, PAK2, PDGFRα, PKA, PKCα, PKD2, ROCK-II, Ros, Rsk1, SAPK2α, SAPK2β, SAPK3, SAPK4, SGK, Syk, Tie2 and TrkB kinases. | 05-07-2009 |
20100324062 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS - The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, Aurora-A, Axl, BMX, CHK2, c-RAF, cSRC, Fes, FGFR3, Flt3, IKKα, IR, JNK2α2, Lck, Met, MKK6, MST2, p70S6K, PDGFRα, PKA, PKD2, ROCK-II, Ros, Rsk1, SAPK2α, SAPK2β, SAPK3, SAPK4, Syk, Tie2 and TrkB kinases. | 12-23-2010 |
20110144107 | COMPOUNDS AND COMPOSITIONS USEFUL FOR THE TREATMENT OF MALARIA - The invention provides a class of compounds of formula I, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent malaria. | 06-16-2011 |
Advait S. Nagle, San Diego, CA US
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20110059934 | COMPOUNDS AND COMPOSITIONS USEFUL FOR THE TREATMENT OF PARASITIC DISEASES - The invention provides a class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent malaria. | 03-10-2011 |
20130281403 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES - The invention provides a class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent malaria. | 10-24-2013 |
Advait Suresh Nagle US
Patent application number | Description | Published |
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20150344471 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES - The present invention provides compounds of formula I: | 12-03-2015 |
Advait Suresh Nagle, San Diego, CA US
Patent application number | Description | Published |
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20140155367 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES - The present invention provides compounds of formula I: | 06-05-2014 |
20140274926 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES - The present invention provides compounds of Formula I: | 09-18-2014 |
20140275013 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES - The present invention provides compounds of formula I: | 09-18-2014 |
20140275119 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES - The present invention provides compounds of formula I: | 09-18-2014 |
20150011522 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES - The present invention provides compounds of formula I: | 01-08-2015 |
20150175613 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES - The present invention provides compounds of Formula A: | 06-25-2015 |
20150291598 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES - The present invention provides compounds of formula I: [INSERT FORMULA HERE] or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease, such as malaria, caused by a | 10-15-2015 |
20150344471 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES - The present invention provides compounds of formula I: | 12-03-2015 |
Allen J. Nagle, Woodbury, MN US
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20090032114 | EXTERNAL WATER SHUTOFF - The present subject matter relates to controlling water sources external to a structure and more particularly to an external water shutoff. One embodiment of the present subject matter includes an apparatus having an electrically operable valve placed on a water supply line internal to a structure between a location where the water supply line enters the structure and a location where the water supply line exits the structure, an auto-drain valve, and means for controlling the electrically operable valve, wherein the means for controlling is external to the structure, further wherein the means for controlling the electrically operable valve is communicatively connected to the electrically operable valve external to the structure. | 02-05-2009 |
Barry Nagle, Carmel, IN US
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20140289896 | HYBRID CORN PLANT AND SEED A7610 - This invention provides hybrid maize plant designated A7610. This invention further provides hybrid seed of A7610, hybrid plants produced from such seed, and variants, mutants, and trivial modifications to hybrid A7610, as well as methods of using the hybrid and products produced from the hybrid. | 09-25-2014 |
Barry J. Nagle, Bridgewater, NJ US
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20100011459 | HYBRID CORN PLANT AND SEED PPVO1864 - This invention provides hybrid maize plant designated PPVO1864. This invention further provides hybrid seed of PPVO1864, hybrid plants produced from such seed, and variants, mutants, and trivial modifications to hybrid PPVO1864, as well as methods of using the hybrid and products produced from the hybrid. | 01-14-2010 |
Barry J. Nagle, Carmel, IN US
Patent application number | Description | Published |
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20090291190 | HYBRID CORN PLANT AND SEED PP79702 - This invention provides hybrid maize plant designated PP79702. This invention further provides hybrid seed of PP79702, hybrid plants produced from such seed, and variants, mutants, and trivial modifications to hybrid PP79702, as well as methods of using the hybrid and products produced from the hybrid. | 11-26-2009 |
20090317534 | HYBRID CORN PLANT AND SEED PP59601 - This invention provides hybrid maize plant designated PP59601. This invention further provides hybrid seed of PP59601, hybrid plants produced from such seed, and variants, mutants, and trivial modifications to hybrid PP59601, as well as methods of using the hybrid and products produced from the hybrid. | 12-24-2009 |
20100009061 | HYBRID CORN PLANT AND SEED PP88602 - This invention provides hybrid maize plant designated PP88602. This invention further provides hybrid seed of PP88602, hybrid plants produced from such seed, and variants, mutants, and trivial modifications to hybrid PP88602, as well as methods of using the hybrid and products produced from the hybrid. | 01-14-2010 |
20140083417 | HIGH TDF STARCH MADE BY HIGH TEMPERATURE STEEPING OF GRAIN - The application relates to a starch comprising greater than 70% by weight of total dietary fiber as determined by the OAOC 991.43 test method and wherein the starch has not been chemically modified. | 03-27-2014 |
20140083418 | HIGH TEMPERATURE METHODS OF STEEPING GRAIN - The application relates to a process comprising: a) steeping high amylose corn kernels at a temperature from about 71° C. to about 93° C. for a time from about 24 hours to about 72 hours; b) subjecting the high-temperature steep corn kernels to conventional wet milling; c) recovering starch with a total dietary fiber (TDF) content from about 33% to about 45% (w/w); and d) wherein the recovered starch has not been chemically modified. | 03-27-2014 |
Brian C. Nagle, Aurora, IL US
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20100315950 | METHOD AND APPARATUS FOR TRAFFIC MANAGEMENT IN A WIRELESS NETWORK - Currently, network utilization and performance are diminished due to capacity issues, which may be resolved by adding hardware/software to spread traffic uniformly according to network element usage information. Disclosed is a method of and corresponding apparatus for resolving network element capacity issues in a wireless network by inspecting data traffic content for information about wireless network elements and data traffic content, collecting said information, and managing (e.g., shaping and steering) the incoming traffic based on the information. Examples of said information include radio bearer resource information for network elements and traffic associated with a wireless access portion of the wireless network and radio access bearer information for network elements and traffic associated with a backhaul portion of the wireless network. By employing embodiments of the invention, network utilization and performance may be increased using existing wireless network elements in a manner overlaid on existing network optimization techniques (e.g., load balancing). | 12-16-2010 |
Carl Joseph Nagle, Holly Springs, NC US
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20100318971 | Systems And Methods For Identifying Graphic User-Interface Components - Systems and methods for identifying a target position on a computer display are provided. A system receives computer display data indicative of contents of a computer display and identifies a first area of interest within the computer display. Identifying the area of interest includes receiving a first image and searching the computer display for the first image. Upon finding a match for the first image, a location of the match for the first image is identified as a first point. A second image is received and searched for on the computer display. Upon finding a match for the second image, the location of the match is identified as a second point. The first point and the second point are used in defining an area of interest. A target position is located within the area of interest. | 12-16-2010 |
Cheryl Nagle, Bradenton, FL US
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20090175995 | CONTROL OF FLAVOR CHARACTERISTICS OF AND INDICATOR OF FRESHNESS IN FRUIT JUICE - Control of flavor characteristics of and fresh taste in fruit juice, particularly citrus fruit juice, and especially orange juice. | 07-09-2009 |
Dale G. Nagle, Oxford, MS US
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20090137664 | SAURURUS CERNUUS COMPOUNDS THAT INHIBIT CELLULAR RESPONSES TO HYPOXIA - Compounds and compositions that effectively block hypoxia-inducible factor-1 function, and methods of use thereof. The compounds and compositions of the present invention are useful in the prevention and treatment of cancer, stroke, heart disease, ocular neovascular diseases, and arthritis. | 05-28-2009 |
David P. Nagle, Westfield, MA US
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20130136614 | PROPELLER BLADE HAVING COMPLIANT ADHESIVE AT SPAR INTERFACE - A propeller blade includes a foam core, an adhesive layer formed on the core and a structural layer that covers at least a portion of the adhesive layer and that surrounds at least a portion of the foam core. | 05-30-2013 |
20130136615 | PROPELLER BLADE WITH LIGHTWEIGHT INSERT - A propeller blade includes a foam core and a structural layer that surrounds at least a portion of the foam core and includes a face side and a camber side is disclosed. The propeller blade also includes an insert disposed in the foam core in operable contact with the face side and the camber side of the structural layer. | 05-30-2013 |
20130280079 | PROPELLER BLADE WITH METALLIC FOAM SPAR CORE - According to one embodiment, a propeller blade includes a metallic foam core and a structural layer that surrounds at least a portion of the metallic foam core. | 10-24-2013 |
20130280084 | PROPELLER BLADE WITH INTERNAL STIFFENER - A propeller blade includes a foam core having a slot formed through it from a camber side to a face side, an internal stiffener disposed through the slot and including flanges in contact with both the camber and face sides and a structural layer that surrounds at least a portion of the foam core and in contact with the flanges on both the camber and face sides. | 10-24-2013 |
20130287584 | PROPELLER BLADE WITH MODIFIED SPAR LAYUP - According to one embodiment, a propeller blade includes a foam core and a structural layer formed of multiple layers that surrounds at least a portion of the foam core. The structural layer includes a mid-thickness location defined between the foam core and an outer edge of the structural layer and the multiple layers include at least one unidirectional layer and at least one biased layer disposed asymmetrically about the mid-thickness location. | 10-31-2013 |
20130343898 | PROPELLER BLADE WITH CARBON FOAM SPAR CORE - According to one embodiment, a propeller blade includes a carbon foam core and a structural layer that surrounds at least a portion of the carbon foam core. | 12-26-2013 |
20140133995 | PROPELLER BLADE WITH MODIFIED SPAR STIFFNESS - A propeller blade includes a foam core, a structural layer formed of multiple layers that surrounds at least a portion of the foam core and at least one section of fibers formed separately from the structural layer located between two of the multiple layers. | 05-15-2014 |
20150110630 | RETENTION ASSEMBLY FOR A PROPELLER BLADE - A retention assembly for a propeller blade includes an inner ring that is conformally shaped to a bore of an annular loop, the annular loop being associated with a root portion of the propeller blade; a base that is configured to be immediately adjacent the annular loop; an outer ring that includes an extended tapered portion which decreases in radial thickness from an inboard end to an outboard end; and an adhesive that adhesively connects complementary surfaces of the outer ring and the annular loop. Also, a propeller blade assembly includes a propeller blade having a blade portion and a root portion and the retention assembly configured to be attached to the propeller blade. | 04-23-2015 |
20150110633 | RETENTION ASSEMBLY WITH A CONICAL INTERFACE FOR A PROPELLER BLADE - A retention assembly for a propeller blade includes an inner ring that is conformally shaped to a bore of an annular loop, the annular loop being associated with a root portion of the propeller blade; a base that is configured to be immediately adjacent the annular loop; an annular outer ring including a bearing race interface that is conical in shape and includes a radially inner surface that conforms to a radially outer surface of the annular loop; and an adhesive that adhesively connects complementary surfaces of the outer ring and the annular loop. Also, a propeller blade assembly includes a propeller blade having a blade portion and a root portion; and the retention assembly that is configured to attach to the propeller blade. | 04-23-2015 |
20150233249 | PROPELLER BLADE AND METHOD - A propeller blade includes an inner spar structure surrounding an inner spar foam core. Also included is a leading edge foam structure disposed proximate a leading edge of the inner spar structure. Further included is a trailing edge foam structure disposed proximate a trailing edge of the inner spar structure. Yet further included is an outer spar structure surrounding the inner spar structure, the leading edge foam structure and the trailing edge foam structure. Also included is a blade shell, a leading edge foam core located between the outer spar structure and the blade shell, and a trailing edge foam core located between the outer spar structure and the blade shell. | 08-20-2015 |
20150266572 | PROPELLER BLADE HAVING COMPLIANT SPAR CORE - A propeller blade includes a foam core formed of a combination of polyuria and polyvinyl chloride (pvc), an adhesive layer formed on the core and a structural layer that covers at least a portion of the adhesive layer and that surrounds at least a portion of the foam core. | 09-24-2015 |
Deborah Nagle, Arlington, MA US
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20160000550 | METHODS FOR TREATING DISEASES OF THE COLON - Methods for treating diseases of the rectum or colon are provided. The methods can comprise accessing the rectal mucosa through a trans-anal approach; performing a mucosectomy to remove mucosal tissue from at least a portion of the rectal or colonic wall; and securing a flexible scaffold material to a region of the rectal or colonic wall from which mucosa has been removed, wherein the scaffold material is selected to facilitate cellular ingrowth and formation of new mucosal tissue. | 01-07-2016 |
Dennis Nagle, Peabody, MA US
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20120221312 | METHOD AND SYSTEM FOR POWER DELIVERY NETWORK ANALYSIS - The subject application relates to a method and system for power delivery network analysis. The present disclosure is directed towards a computer-implemented method for analyzing a power delivery network (PDN) system. The method may include receiving at least one of a chip power model, a package power model and a board power model at the computing device and co-simulating at least two of the chip power model, the package power model, and the board power model. Numerous other features are also within the scope of the present disclosure. | 08-30-2012 |
20120221988 | METHOD AND SYSTEM FOR POWER DELIVERY NETWORK ANALYSIS - The subject application relates to a method and system for power delivery network analysis. The present disclosure is directed towards a computer-implemented method for analyzing a power delivery network (PDN) associated with an electronic circuit design. Embodiments may include extracting, using at least one processor, an electromagnetic (EM) model for each of one or more discontinuity structures associated with the circuit design and generating a three dimensional adaptive mesh model that is based upon, at least in part, the extracted EM model. Numerous other features are also within the scope of the present disclosure. | 08-30-2012 |
20120221990 | METHOD AND SYSTEM FOR POWER DELIVERY NETWORK ANALYSIS - The subject application relates to a method and system for power delivery network analysis. The present disclosure is directed towards a computer-implemented method for displaying one or more results of a power delivery network (PDN) analysis associated with an electronic circuit design. The method may include extracting, using at least one processor, an electromagnetic (EM) model for each of one or more discontinuity structures associated with the electronic circuit design. The method may further include performing a power delivery network analysis of the electronic circuit design, the PDN analysis including a Method of Moments (MoM) calculation. The method may also include displaying a three dimensional image depicting one or more results of the PDN analysis. Numerous other features are also within the scope of the present disclosure. | 08-30-2012 |
Greg A. Nagle, Portland, OR US
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20090281655 | CONTROL SYSTEM FOR A LOAD HANDLING CLAMP - A control system for a load-handling clamp includes first and second load-engaging surfaces for selectively gripping and releasing a load disposed between said surfaces. At least one of said surfaces is selectively movable toward the other by a hydraulic actuator. At least one fluid valve assembly variably regulates a maximum hydraulic clamping pressure capable of causing the actuator to move one of the surfaces toward the other in a load clamping movement. Preferably, a load geometry sensor produces an electrical effect that varies as a function of the geometric profile of the load. A data receiver preferably also obtains load identification information related to at least one characteristic of the load, other than the load's geometry. A controller, in response to the data receiver and load geometry sensor, operates to control the valve assembly's regulation of the maximum hydraulic clamping pressure. In order to prepare for the load clamping movement, the controller is preferably also capable of enabling the actuator to move one of said surfaces toward the other in an initial clamp closing movement at a maximum hydraulic closing pressure greater than the maximum hydraulic clamping pressure. Thereafter the controller enables the load clamping movement at a pressure level substantially no greater than the maximum hydraulic clamping pressure. | 11-12-2009 |
Gregory A. Nagle, Portland, OR US
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20130277584 | FLUID POWER CONTROL SYSTEM FOR MOBILE LOAD HANDLING EQUIPMENT - A fluid power control system for load handling mobile equipment includes a pair of hydraulic actuators for moving respective cooperating load-engaging members selectively toward or away from each other, or in a common direction, at respective asynchronous speeds to selectively attain either synchronous or asynchronous respective positions of the actuators. The actuators have sensors enabling a controller to monitor their respective movements and correct unintended differences in the actuators' respective movements, such as unintended differences in relative intended positions, speeds, or rates of change of speeds. Respective hydraulic valves responsive to the controller separately and nonsimultaneously decrease respective flows through the respective actuators to more accurately and rapidly correct differences from the intended relative movements of the actuators. | 10-24-2013 |
20140121823 | INTERACTIVE CLAMP FORCE CONTROL SYSTEM FOR LOAD HANDLING CLAMPS - Improvements are disclosed for a load-clamping system with variable clamping force control by which a wide variety of different load types in a wide variety of different load geometric configurations can be accurately clamped at respective variable optimal clamping force settings dependent on each load's respective load type and geometric configuration in combination. An operator display and input terminal cooperates with a controller to translate assortments of possible load variables into a form easily discernible visually by a clamp operator and preferably easily comparable by the operator, from his visual observation, to each particular load which he is about to engage, so that the operator can interactively guide the controller in its selection of an optimal clamping force setting for each particular load. | 05-01-2014 |
20140121824 | INTERACTIVE CLAMP FORCE CONTROL SYSTEM FOR LOAD HANDLING CLAMPS - Improvements are disclosed for a load-clamping system with variable clamping force control by which a wide variety of dissimilar loads of different types, geometric configurations and/or other parameters can be accurately clamped at respective variable optimal clamping force settings. An operator terminal cooperates with a controller to translate one or more possible load parameters into a form easily discernible visually by a clamp operator and preferably easily comparable by the clamp operator, from his visual observation, to each particular load which he is about to engage, so that the clamp operator can interactively guide the controller in its selection of an optimal clamping force setting for each particular load. | 05-01-2014 |
20140121825 | INTERACTIVE CLAMP FORCE CONTROL SYSTEM FOR LOAD HANDLING CLAMPS - Improvements are disclosed for a load-clamping system with variable clamping force control by which a wide variety of dissimilar loads of different types, geometric configurations and/or other parameters can be accurately clamped at respective variable optimal clamping force settings. An operator terminal cooperates with a controller to translate one or more possible load parameters into a form easily discernible visually by a clamp operator and preferably easily comparable by the clamp operator, from his visual observation, to each particular load which he is about to engage, so that the clamp operator can interactively guide the controller in its selection of an optimal clamping force setting for each particular load. | 05-01-2014 |
20140240117 | CLAMPING SURFACE POSITIONING SYSTEM FOR MOBILE LOAD-HANDLING CLAMPS - A control system is provided for a load-handling clamp mountable on a vehicle, the clamp having a pair of opposed load-engagement clamping surfaces capable of clamping opposite sides of different types and configurations of loads. At least one of the clamping surfaces is closeable toward the other clamping surface along a direction which extends substantially laterally across a direction of forward approach of the clamp toward the load. The control system is capable of generating a variable signal indicating a desired forward, vertical and/or lateral pre-engagement position of the clamp from which the clamping surfaces can correctly engage the load. | 08-28-2014 |
20140244025 | INTERACTIVE CLAMP FORCE CONTROL SYSTEM FOR LOAD HANDLING CLAMPS - Improvements are disclosed for a load-clamping system with variable clamping force control by which a wide variety of dissimilar loads of different types, geometric configurations and/or other parameters can be accurately clamped at respective variable optimal clamping force settings. An operator terminal cooperates with a controller to translate one or more possible load parameters into a form easily discernible visually by a clamp operator and preferably easily comparable by the clamp operator, from his visual observation, to each particular load which he is about to engage, so that the clamp operator can interactively guide the controller in its selection of an optimal clamping force setting for each particular load. | 08-28-2014 |
20150368080 | SIDE-SHIFT LIMITER - A side shift limiting attachment for a material handing vehicle alerts the vehicles operator and restricts side shifting, lifting, tilting and/or rotation of the attachment when the side shift displacement is approaching or has reached a limit for a lift height. | 12-24-2015 |
H. Troy Nagle, Durham, NC US
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20090286055 | Methods and Devices for Providing Flexible Electronics - Methods and devices for providing flexible electronics are described. In an exemplary embodiment of the present invention, a conductive ink is applied to a nonwoven substrate. More particularly, the exemplary embodiment provides a nonwoven substrate with a general depth in the z-direction and a conductive ink carried by the nonwoven substrate on the surface of the substrate and at least partially but no more than 50% within the nonwoven substrate in the z-direction. | 11-19-2009 |
20100261983 | IMPLANTABLE DEVICES FOR DYNAMIC MONITORING OF PHYSIOLOGICAL AND BIOLOGICAL PROPERTIES OF TUMORS - Biocompatible sensors configured for implantation include a first body in communication with a plurality of remote sensor bodies to detect physiological parameters in vivo. | 10-14-2010 |
20100268078 | METHODS AND SYSTEMS FOR MONITORING PATIENTS UNDERGOING TREATMENT FOR CANCER - Oncology monitoring systems include: (a) a first plurality of radiation sensors configured to reside proximate a target tumor treatment site of a patient, the sensors being configured to provide radiation data associated with the tumor treatment site; and (b) a first portable receiver in communication with the plurality of sensors. The receiver is configured to obtain radiation data from the sensors at a plurality of different times. The receiver is in communication with a local and/or remote computer that tracks variation in the radiation data to provide dynamic tumor site information. | 10-21-2010 |
James C. Nagle, Austin, TX US
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20110087468 | Approximating a System Using an Abstract Geometrical Space - System and method for approximating a system. A multi-parameter representation of a family of systems is stored. An embedding of the family into an abstract geometrical continuous space with a metric and defined by the parameters is determined. Coordinates of the space specify values for the parameters of systems of the family. The space includes a grid of points representing respective discrete approximations of the systems. A first point corresponding to a desired instance of a system is determined. The first point's coordinates specify values for the parameters of the instance. The space is sampled using a mapping of a well-distributed point set from a Euclidean space of the parameters to the abstract space. A nearest discrete point to the first point is determined which specifies values for parameters for an optimal discrete approximation of the desired instance, which are useable to implement the discrete approximation of the desired instance. | 04-14-2011 |
20130196330 | Identifying Microparticles in a Plurality of Images to Perform Polynucleotide Sequencing - Performing sequencing of a polynucleotide. A first image of microparticles that are distributed in a random fashion on a substrate may be received. Each of the microparticles may include a plurality of similar oligonucleotides of the polynucleotide. A second image of the microparticles may be received. A plurality of first subportions of the first image may be determined. Each subportion may include a respective plurality of microparticles distributed in a random fashion. The second image may be analyzed to identify a plurality of second subportions in the second image. Each of the plurality of second subportions may correspond to a respective one of the plurality of first subportions. A plurality of the microparticles may be matched from the first and second images based on said analyzing. At least a portion of the sequence of nucleotides of the polynucleotide may be determined based on said matching. | 08-01-2013 |
20140359589 | Graphical Development and Deployment of Parallel Floating-Point Math Functionality on a System with Heterogeneous Hardware Components - System and method for configuring a system of heterogeneous hardware components, including at least one: programmable hardware element (PHE), digital signal processor (DSP) core, and programmable communication element (PCE). A program, e.g., a graphical program (GP), which includes floating point math functionality and which is targeted for distributed deployment on the system is created. Respective portions of the program for deployment to respective ones of the hardware components are automatically determined. Program code implementing communication functionality between the at least one PHE and the at least one DSP core and targeted for deployment to the at least one PCE is automatically generated. At least one hardware configuration program (HCP) is generated from the program and the code, including compiling the respective portions of the program and the program code for deployment to respective hardware components. The HCP is deployable to the system for concurrent execution of the program. | 12-04-2014 |
20140359590 | Development and Deployment of Parallel Floating-Point Math Functionality on a System with Heterogeneous Hardware Components - System and method for configuring a system of heterogeneous hardware components, including at least one: programmable hardware element (PHE), digital signal processor (DSP) core, and programmable communication element (PCE). A program, e.g., a graphical program (GP), which includes floating point math functionality and which is targeted for distributed deployment on the system is created. Respective portions of the program for deployment to respective ones of the hardware components are automatically determined. Program code implementing communication functionality between the at least one PHE and the at least one DSP core and targeted for deployment to the at least one PCE is automatically generated. At least one hardware configuration program (HCP) is generated from the program and the code, including compiling the respective portions of the program and the program code for deployment to respective hardware components. The HCP is deployable to the system for concurrent execution of the program. | 12-04-2014 |
John Nagle, Menlo Park, CA US
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20100121835 | System and method for improving integrity of internet search - A system and method are provided to receive a search query from a user, typically via a web browser, the Internet, and a web server. A search engine obtains a set of potential search results based on the search query. For each Internet domain or web site mentioned in the search results, a set of data sources is accessed to obtain information concerning the legitimacy of the business associated with the Internet domain or web site. The legitimacy information is used to reorder or to change or to augment the appearance or presentation of the search result for the Internet domain or web site. The processed search results are returned to the user. | 05-13-2010 |
20120005170 | System and method for improving integrity of internet search - A system and method are provided to receive a search query from a user, typically via a web browser, the Internet, and a web server. A search engine obtains a set of potential search results based on the search query. For each Internet domain or web site mentioned in the search results, a set of data sources is accessed to obtain information concerning the legitimacy of the business associated with the Internet domain or web site. The legitimacy information is used to reorder or to change or to augment the appearance or presentation of the search result for the Internet domain or web site. The processed search results are returned to the user. | 01-05-2012 |
John T. Nagle, Willowick, OH US
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20080255814 | APPARATUS AND METHOD FOR MODEL-BASED CONTROL - Various methods and systems for the parametric control of a process include representing the process with a process model used to generate future predictions of a process variable. In one embodiment, the process exhibits integrating behavior that is represented by a non-integrating process model. In another embodiment, an inverse of the model is filtered using a filter that includes a lead time constant that is selected to minimize a steady state error of the predicted process variable. In yet another embodiment, an array of output model values is revised or reindexed in response to a change in a time-varying parameter related to the process. | 10-16-2008 |
Lee V. Nagle, Coral Springs, FL US
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20100134184 | HYBRID POWER CONTROL FOR A POWER AMPLIFIER - A hybrid power control system ( | 06-03-2010 |
Ray Nagle, Tucson, AZ US
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20120220672 | Presence of ERG Gene Rearrangements and Protein Over-expression in Low Grade PIN (LG-PIN) in Prostate Biopsies - The present disclosure relates to methods for the early detection of ERG over-expression, gene rearrangements, and diagnosis and/or prognosis of prostate cancer using a combined ERG IHC-FISH assay. | 08-30-2012 |
Ray B. Nagle, Tucson, AZ US
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20100196902 | PROSTATE CANCER BIOMARKERS - Disclosed are biomarkers, at least, useful for the diagnosis and/or prognosis of cancer and for making treatment decisions in cancer, for example prostate cancer. | 08-05-2010 |
20120200694 | MULTI-MODALITY CONTRAST AND BRIGHTFIELD CONTEXT RENDERING FOR ENHANCED PATHOLOGY DETERMINATION AND MULTI-ANALYTE DETECTION IN TISSUE - Multiple modality contrast can be used to produce images that can be combined and rendered to produce images similar to those produced with wavelength absorbing stains viewed under transmitted white light illumination. Images obtained with other complementary contrast modalities can be presented using engineered color schemes based on classical contrast methods used to reveal the same anatomical structures and histochemistry, thereby providing relevance to medical training and experience. Dark-field contrast images derived from refractive index and fluorescent DAPI counterstain images are combined to produce images similar to those obtained with conventional H&E staining for pathology interpretation. Such multi-modal image data can be streamed for live navigation of histological samples, and can be combined with molecular localizations of genetic DNA probes (FISH), sites of mRNA expression (mRNA-ISH), and immunohistochemical (IHC) probes localized on the same tissue sections, used to evaluate and map tissue sections prepared for imaging mass spectrometry. | 08-09-2012 |
20130196866 | EXPRESSION OF ETS RELATED GENE (ERG) AND PHOSPHATASE AND TENSIN HOMOLOG (PTEN) CORRELATES WITH PROSTATE CANCER CAPSULAR PENETRATION - The disclosure provides methods for characterizing a prostate cancer sample by detecting expression of ERG, PTEN or both, changes in which relative to a normal control are shown herein to be correlated with prostate cancer capsular penetration and more aggressive forms of prostate cancer. Such methods are useful for the prognosis of prostate cancer capsular penetration and for making treatment decisions in patients with prostate cancer that has penetrated the capsule. Also provided are kits that can be used with such methods. | 08-01-2013 |
20140296088 | Spectral Imaging for Measurement of Nuclear Pathology Features in Cancer Cells Prepared for In Situ Analysis - In general, the presently disclosed technology relates to identification of cancer subtypes. More specifically, the technology relates to methods for determining molecular drivers of cancer and/or progression using a multivariate image data and statistical analysis of in-situ molecular markers and morphological characteristics in the same cells of a biological sample suspected of b cancer. This analysis takes place after a single acquisition that obtains the molecular and anatomic morphology data in parallel. The analysis compares specific morphological and molecular markers to known samples exhibiting particular genetic drivers of the cancer. This method provides statistical information that allows for an increased confidence in the identification of specific molecular drivers of the cancer. | 10-02-2014 |
20150197811 | Spectral Imaging for Measurement of Nuclear Pathology Features in Cancer Cells Prepared for In Situ Analysis - In general, the presently disclosed technology relates to identification of cancer subtypes. More specifically, the technology relates to methods for determining molecular drivers of cancer and/or progression using a multivariate image data and statistical analysis of in-situ molecular markers and morphological characteristics in the same cells of a biological sample suspected of b cancer. This analysis takes place after a single acquisition that obtains the molecular and anatomic morphology data in parallel. The analysis compares specific morphological and molecular markers to known samples exhibiting particular genetic drivers of the cancer. This method provides statistical information that allows for an increased confidence in the identification of specific molecular drivers of the cancer. | 07-16-2015 |
Rick A. Nagle, Phoenix, AZ US
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20080231067 | Retractable Tailgate Barrier and Accessory Systems - A tailgate barrier system designed to maintain cargo within the cargo bed of a transport vehicle when the tailgate of the vehicle's cargo bed is lowered. The barrier stores within a storage compartment in or on the tailgate of a vehicle, and extends linearly upward from the storage compartment for use. An arrangement of extendable supports, pivotally coupled to the tailgate and top rail of the barrier system, enable the preferred upward movement. The system further comprises electrical connections. Groups of accessories mountable to the tailgate barrier system are also disclosed. | 09-25-2008 |
Rob Nagle, Hackettstown, NJ US
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20140193545 | CARAMEL, CONFECTION COMPRISING THE CARAMEL AND METHOD OF MAKING THE CONFECTION - A caramel is provided comprising a solid plant fat and an amount of water less than 10 wt %. The caramel exhibits a chewy texture when consumed but is yet depositable. The caramel is thus advantageously used in a confection. In addition to the caramel, the confection may comprise a crisp component. Methods of making the confection are also provided. | 07-10-2014 |
Robert Nagle, Mountain View, CA US
Robert Nagle, Hackettstown, NJ US
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20150044338 | ULTRASONIC ROTARY MOLDING - The present disclosure describes an ultrasonic rotary molding system that is used to form edible compositions or food products as they move along a conveyor belt. The food products are formed by an ultrasonic rotary wheel that includes one or more cutting tools that cut, and perhaps three dimensionally mold, food product strips. The system may include a movable backing plate that is located below the point where the ultrasonic rotary wheel cuts the food product strips. The movable backing plate may be spring loaded and it may exert force upwards against the conveyor belt and in turn against the food product. | 02-12-2015 |
Russell J. Nagle, Lancaster, MA US
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20120039173 | Traffic Management In A Multi-Channel System - A method, system and computer program product in a downstream line card of a Cable Modem Termination System (CMTS) for managing downstream traffic for channels and bonded channel groups is provided herein. The method comprises the step of receiving packets for transmission to cable modems and classifying each packet to a flow based on class of service associated with the packet. The method further includes the step of storing the packets in flow queues based, wherein a flow queue is selected based on a flow a packet is associated with and wherein each flow corresponds to a single flow queue. The method also includes transmitting the packets from the flow queues to channel queues or bonded channel queues using corresponding channel nodes or bonded channel nodes at a rate that is determined based on feedback data and scheduling downstream transmission of packets on a single downstream channel if the packet is stored in a channel queue and on multiple downstream channels that are bonded together to form a bonded channel group if the packet is stored in a bonded channel queue. The feedback data is adjusted for each channel node or bonded channel node based on a queue depth for a corresponding channel queue or bonded channel queue. | 02-16-2012 |
20150215217 | TRAFFIC MANAGEMENT IN A MULTI-CHANNEL SYSTEM - A method, system and computer program product in a downstream line card of a Cable Modem Termination System (CMTS) for managing downstream traffic for channels and bonded channel groups is provided herein. The method comprises the step of receiving packets for transmission to cable modems and classifying each packet to a flow based on class of service associated with the packet. The method further includes the step of storing the packets in flow queues based, wherein a flow queue is selected based on a flow a packet is associated with and wherein each flow corresponds to a single flow queue. The method also includes transmitting the packets from the flow queues to channel queues or bonded channel queues using corresponding channel nodes or bonded channel nodes at a rate that is determined based on feedback data and scheduling downstream transmission of packets on a single downstream channel if the packet is stored in a channel queue and on multiple downstream channels that are bonded together to form a bonded channel group if the packet is stored in a bonded channel queue. The feedback data is adjusted for each channel node or bonded channel node based on a queue depth for a corresponding channel queue or bonded channel queue. | 07-30-2015 |
Samantha Nagle, Dupont, WA US
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20080213215 | Concentrated Protein Lyophilates, Methods, and Uses - The invention provides, among other things, lyophilized compositions of high surface area that comprise a protein and that reconstitute quickly and efficiently to solution of high protein concentration with minimal formation, if any, of foam, effervescence, bubbles, turbidity, or particulates that might be deleterious. The invention also provides, among other things, methods for making the lyophilized compositions. The invention in additional aspects also provides Raman Imaging Spectrographic methods for real time analyses of polymorphs in a sample using PLS algorithms. By way of particular example, the use of the method for the analysis of mannitol polymorphs is described, and the use of the analysis to determine optimum compositions and lyophilization methods for producing lyophilates of pharmaceutical proteins having a predefined distribution of mannitol polymorphs and having the aforementioned reconstitution properties is also described. | 09-04-2008 |
20120116054 | CONCENTRATED PROTEIN LYOPHILATES, METHODS, AND USES - The invention provides, among other things, lyophilized compositions of high surface area that comprise a protein and that reconstitute quickly and efficiently to solution of high protein concentration with minimal formation, if any, of foam, effervescence, bubbles, turbidity, or particulates that might be deleterious. The invention also provides, among other things, methods for making the lyophilized compositions. The invention in additional aspects also provides Raman Imaging Spectrographic methods for real time analyses of polymorphs in a sample using PLS algorithms. By way of particular example, the use of the method for the analysis of mannitol polymorphs is described, and the use of the analysis to determine optimum compositions and lyophilization methods for producing lyophilates of pharmaceutical proteins having a predefined distribution of mannitol polymorphs and having the aforementioned reconstitution properties is also described. | 05-10-2012 |
Shahnaz Nagle, Austin, TX US
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20150194208 | SRAM WORDLINE DRIVER SUPPLY BLOCK WITH MULTIPLE MODES - A wordline driver supply block supporting multiple operation modes of a memory of a microprocessor in a device for reducing power consumption thereof. | 07-09-2015 |
Steven Nagle, Santa Barbara, CA US
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20090205092 | METHOD OF FABRICATING A PROBE DEVICE FOR A METROLOGY INSTRUMENT AND A PROBE DEVICE PRODUCED THEREBY - A method of producing a probe device for a metrology instrument such as an AFM includes providing a substrate and forming a tip stock extending upwardly from the substrate. The tip stock is preferably FIB milled to form a tip of the probe device. The tip preferably has a high aspect ratio, with a height that is at least about 1 micron for performing critical dimension (e.g., deep trench) atomic force microscopy. The stock is preferably pedestal shaped having a distal end that is substantially planar which can be machined into a tip in at least less than about 2 minutes. With the preferred embodiments, the FIB milling step can be completed in substantially fewer and less complicated steps than known techniques to produce a high aspect ratio tip suitable for DT-AFM in less than about one minute. | 08-13-2009 |
Steven F. Nagle, Santa Barbara, CA US
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20090031792 | Probe Device for a Metrology Instrument and Method of Fabricating the Same - A method of producing a probe device for a metrology instrument such as an AFM includes providing a substrate having front and back surfaces and then forming an array of tip height structures on the first surface of the substrate, the structures having varying depths corresponding to selectable tip heights. The back surface of the substrate is etched until a thickness of the substrate substantially corresponds to a selected tip height, preferably by monitoring this etch visually and/or monitoring the etch rate. The tips are patterned from the front side of the wafer relative to fixed ends of the cantilevers, and then etched using an anisotropic etch. As a result, probe devices having sharp tips and short cantilevers exhibit fundamental resonant frequencies greater than 700 kHz or more. | 02-05-2009 |
20090032706 | Fast-Scanning SPM and Method of Operating Same - A method and apparatus are provided that have the capability of rapidly scanning a large sample of arbitrary characteristics under force control feedback so has to obtain a high resolution image. The method includes generating relative scanning movement between a probe of the SPM and a sample to scan the probe through a scan range of at least 4 microns at a rate of at least 30 lines/sec and controlling probe-sample interaction with a force control slew rate of at least 1 mm/sec. A preferred SPM capable of achieving these results has a force controller having a force control bandwidth of at least closed loop bandwidth of at least 10 kHz. | 02-05-2009 |
Thomas K. Nagle, Grand Rapids, MI US
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20120084991 | TRIGGER ASSEMBLY FOR PARTS CHECKING JIGS AND THE LIKE - A trigger assembly for parts checking jigs and the like has a pivoting trigger arm with a central bearing aperture. A universal base is supported on the jig, and has two pairs of pivot pin apertures located adjacent opposite ends, a U-shaped central channel in the bottom face in which the trigger arm is received, and two laterally spaced gauge bushing apertures in the upper face. A pivot pin extends through the bearing aperture in the trigger arm and one pair of the pivot pin apertures in the base. A spring is mounted in the base and biases the trigger arm to an extended position. A gauge bushing is received in one of the two bushing apertures, such that the trigger arm assembly can be readily reconfigured for placement at various locations on the jig by selective mounting of the trigger arm and the gauge bushing in selected ones of the associated base apertures. | 04-12-2012 |
20130168364 | GO/NO GO BALL FEELER GAUGE FOR PARTS CHECKING JIGS AND METHOD - A go/no go ball feeler gauge includes a ball that is laser-welded to a rod. The rod is preferably cut utilizing an EDM process to provide a flat end to which the metal ball is laser-welded. Also, the metal ball is selected to have an initial size that is about 2 microns less than a final required size, and the laser welding process causes the ball to expand to the required diameter. | 07-04-2013 |
Timothy J. Nagle, Campbell, CA US
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20150083212 | THIN-FILM PHOTOVOLTAIC DEVICES WITH DISCONTINUOUS PASSIVATION LAYERS - In various embodiments, photovoltaic devices incorporate discontinuous passivation layers (i) disposed between a thin-film absorber layer and a partner layer, (ii) disposed between the partner layer and a front contact layer, and/or (iii) disposed between a back contact layer and the thin-film absorber layer. | 03-26-2015 |
20150087106 | METHODS OF FORMING THIN-FILM PHOTOVOLTAIC DEVICES WITH DISCONTINUOUS PASSIVATION LAYERS - In various embodiments, photovoltaic devices incorporate discontinuous passivation layers (i) disposed between a thin-film absorber layer and a partner layer, (ii) disposed between the partner layer and a front contact layer, and/or (iii) disposed between a back contact layer and the thin-film absorber layer. | 03-26-2015 |
William A. Nagle, Laureldale, PA US
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20100194109 | Method of Using A Coupling Having an Angularly Oriented Cavity - A method for joining pipe elements in end to end relation uses a coupling that includes interconnectable coupling segments having connection members at opposite ends. The connection members are tightenable for drawing the segments toward one another and into engagement with the pipe elements. Each segment has a concavity positioned between inwardly projecting arcuate surfaces that engage grooves in the pipe elements. The concavities house a sealing member that extends circumferentially around the pipe elements. Angularly oriented surfaces are positioned adjacent to the connection members. The surfaces on facing segments engage one another and cause the segments to rotate in opposite directions about an axis perpendicular to the pipe elements. The concavities are angularly oriented with respect to the axis so that when the segments rotate, the concavities are oriented substantially parallel to the seal. | 08-05-2010 |