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| 20090298741 | Trophic Factor Combinations for Nervous System Treatment - The present invention relates to a composition including an effective amount of at least one of an antimicrobial peptide and a substance having an antimicrobial peptide effect and an effective amount of a neurotrophin. The composition can also include an effective amount of at least one of a growth factor and a neuropeptide. The present invention also relates a method of treating an injury to a nervous system of an animal that includes the steps of identifying the injury to the nervous system and applying to the injury an effective amount of at least one of antimicrobial peptide and a substance having an antimicrobial peptide effect. The method can also include applying an effective amount of one or more trophic factors selected from the group consisting of a growth factor, a neurotrophin, and a neuropeptide to the injury. | 12-03-2009 |
| 20100092561 | METHODS AND COMPOSITIONS USING SUBSTANCE P TO PROMOTE WOUND HEALING - Healing of wounds in mammalian tissue may be enhanced by the application of certain neuropeptides, optionally in combination with known growth promoting hormones. Exemplary neuropeptides include tachykinins, such as Substance P, Substance K, and the like, as well as calcitonin gene-related peptides. The compositions may further include a polymeric delivery carrier and are utilized by applying to the site of the wound. Wounds may be vascular or avascular wounds. The compositions promote elaboration of cellular matrices and development of cellular attachment mechanisms in addition to stimulating cellular proliferation. | 04-15-2010 |
| 20100143876 | TRANSPLANT MEDIA - The present invention relates to media containing purified antimicrobial polypeptides, such as defensins, and/or cell surface receptor binding proteins. The media may also contain buffers, macromolecular oncotic agents, energy sources, impermeant anions, ATP substrates. The media find use for the storage and preservation of internal organs prior to transplant. | 06-10-2010 |
| 20100221834 | LIQUID CRYSTALLINE SUBSTRATES FOR CULTURING CELLS - The present invention is directed to liquid crystalline substrates useful in the culture of cells and methods of their use. In certain embodiments, the invention provides methods and devices for imaging changes (e.g., reorganization) of extracellular matrix components by living cells. | 09-02-2010 |
| 20110195498 | LIQUID CRYSTALLINE SUBSTRATES FOR CULTURING CELLS - The present invention is directed to liquid crystalline substrates useful in the culture of cells and methods of their use. In certain embodiments, the invention provides methods and devices for imaging changes (e.g., reorganization) of extracellular matrix components by living cells. | 08-11-2011 |
| 20140024122 | ANALYTE DETECTION USING LIQUID CRYSTALS - Devices and methods for using changes in the defects in micrometer sized dispersed liquid crystal domains to detect or quantify analytes in a test sample, including endotoxin lipopolysaccharide (LPS), are disclosed. The dispersed liquid crystal microdomains are exposed to the test sample, and any changes in the number of defects in the liquid crystal microdomains are detected by detecting changes in the anchoring configuration of the microdomains. Such changes in anchoring configuration indicate the presence of analyte in the test sample. | 01-23-2014 |
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| 20090199626 | FUEL DELIVERY SYSTEM AND METHOD - Systems and methods for determining a plurality of characteristics of a fuel and controlling a fuel delivery system based on the characteristics of the fuel. A controller generates a plurality of control signals. The control signals are transmitted to at least one ultrasonic transducer, a capacitance sensor, and a temperature sensor. Each of the ultrasonic transducer, capacitance sensor, and temperature sensor generate at least one output signal which is transmitted back to the controller. The controller determines, based on the output signals, the plurality of characteristics of the fuel. The characteristics of the fuel can include, for example, temperature, density, dielectric constant, and the like. The controller then compares the characteristics of the fuel to a set of characteristics of a first fuel type and a second fuel type and controls a fuel delivery device based on the characteristics of the fuel. | 08-13-2009 |
| 20100262386 | IMMERSED FUEL LEVEL SENSOR - A level sensor includes a first transducer generating a first signal, a second transducer generating a second signal, and a processor configured to switch operation between a first mode and a second mode. In the first mode, the first transducer generates the first signal and the second transducer senses a reflection of the first signal from a surface. In the second mode, the second transducer generates the second signal and the first transducer senses a reflection of the second signal from a reference target. The processor determines a distance to the surface. | 10-14-2010 |
| 20120118059 | SYSTEMS AND METHODS OF DETERMINING A QUALITY AND/OR DEPTH OF DIESEL EXHAUST FLUID - A system for determining a quality and/or depth of a fluid in a tank. The system includes a controller, one or more transducers, and a temperature sensor. A fixed distance transducer transmits a sound wave toward a fixed surface. A depth transducer transmits a sound wave which reflects off a surface of the fluid. The temperature sensor senses a temperature of the fluid in the tank and provides an indication of the temperature to the controller. The controller measures the elapsed time for the sound waves to travel between the fixed distance transducer and a fixed surface and the elapsed time for the sound waves to travel between the depth transducer and the surface of the fluid held within the container. Using the elapsed times and the temperature of the fluid, the controller is able to determine a quality and the depth of the fluid. | 05-17-2012 |
| 20140196536 | THREE-MODE SENSOR FOR DETERMINING TEMPERATURE, LEVEL, AND CONCENTRATION OF A FLUID - A three-mode ultrasonic sensor for determining temperature, level, and/or concentration of a fluid. In one embodiment, the sensor includes a target positioned at a level; a controller, and a transducer electrically connected to the controller. The controller is configured to generate an ultrasonic signal, to receive a reflection of the ultrasonic signal from at least one of the target and a surface of a fluid, and generate a signal based on the reflection. The controller is further configured to receive the signal, and determine whether a level of the surface of the fluid is one of the following group: above the level of the target, below the level of the target, and substantially the same as the level of the target. | 07-17-2014 |
| 20140250986 | SYSTEMS AND METHODS OF DETERMINING A QUALITY AND A QUANTITY OF A FLUID - A system for sensing a fluid. The system including a fixed object; a first transducer generating a first sound wave in a horizontal direction and to detect a first echo of the first sound wave from the fixed object; a second transducer generating a second sound wave in a vertical direction; a temperature sensor detecting a temperature of the fluid; and a controller. The controller configured to produce a first signal to drive the first transducer to produce the first sound wave, produce a second signal to drive the second transducer to produce the second sound wave, receive a first indication of the detected first echo, receive a second indication of the detected second echo, receive a temperature indication, determine a quality of the fluid based on the first indication and the temperature indication, and determine a quantity of the fluid based on the second indication. | 09-11-2014 |
| 20150089996 | REDUCTION OF AERATION INTERFERENCE IN AN ULTRASONIC FLUID SENSING SYSTEM - A fluid sensor for sensing at least one characteristic of a fluid. The fluid sensor includes a sensing area, a sensing element and a mesh. The sensing element is configured to sense a characteristic of fluid located within the sensing area. The mesh is positioned around the sensing area. The mesh is configured to allow a liquid portion of the fluid to enter and exit the sensing area, and substantially prohibit a gas portion of the fluid to enter the channel. | 04-02-2015 |
| 20150226595 | SYSTEMS AND METHODS OF DETERMINING A QUALITY AND A QUANTITY OF A FLUID - A system for sensing a fluid. The system including a fixed object; a first transducer generating a first sound wave in a horizontal direction and to detect a first echo of the first sound wave from the fixed object; a second transducer generating a second sound wave in a vertical direction; a temperature sensor detecting a temperature of the fluid; and a controller. The controller configured to produce a first signal to drive the first transducer to produce the first sound wave, produce a second signal to drive the second transducer to produce the second sound wave, receive a first indication of the detected first echo, receive a second indication of the detected second echo, receive a temperature indication, determine a quality of the fluid based on the first indication and the temperature indication, and determine a quantity of the fluid based on the second indication. | 08-13-2015 |
| 20160041024 | THROUGH-WALL TANK ULTRASONIC TRANSDUCER - Technology is described for tank coupled to an ultrasonic sensor subassembly where the combination of the tank and ultrasonic sensor subassembly for an ultrasonic sensor. In an embodiment, ultrasonic sensor subassembly is configured to form an ultrasonic sensor upon coupling to a tank having a tank wall. The ultrasonic sensor subassembly includes a sensor subassembly housing, a planar piezoelectric element located within the sensor subassembly housing, and a circuitry electrically connected to the planar piezoelectric element, where the planar piezoelectric element includes a surface coupled to the tank wall such that the tank wall forms a matching layer of an ultrasonic sensor, and the circuitry configured to produce a signal to drive the planar piezoelectric element to generate a sound wave, and receive an indication of a detected echo from the planar piezoelectric element. Various other methods and systems are also disclosed. | 02-11-2016 |
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| 20110318394 | MULTI-LINKED STAR-SHAPED POLYMERS AND SYNTHETIC METHODS THERFOR - The invention describes new synthetic medical adhesives and antifouling coatings which exploit the key components of natural marine mussel adhesive proteins. | 12-29-2011 |
| 20120003888 | BIOADHESIVE CONSTRUCTS WITH POLYMER BLENDS - The invention describes substrates, such as prosthetics, films, nonwovens, meshes, etc. that are treated with a bioadhesive polymer blend. The bioadhesive includes polymeric substances that have phenyl moieties with at least two hydroxyl groups. The bioadhesive blend constructs can be used to treat and repair, for example, hernias and damaged tendons. | 01-05-2012 |
| 20120016390 | BIOADHESIVE COMPOUNDS AND METHODS OF SYNTHESIS AND USE - The invention describes new synthetic medical adhesives and antifouling coatings which exploit the key components of natural marine mussel adhesive proteins. | 01-19-2012 |
| 20120029559 | MULTIBRANCHED BIOADHESIVE COMPOUNDS AND SYNTHETIC METHODS THEREFOR - The invention describes new synthetic medical adhesives and antifouling coatings which exploit the key components of natural marine mussel adhesive proteins. | 02-02-2012 |
| 20120116424 | ADHESIVE COMPOUNDS AND METHODS USE FOR HERNIA REPAIR - The invention describes new synthetic medical adhesives and films which exploit the key components of natural marine mussel adhesive proteins. | 05-10-2012 |
| 20120149849 | MULTI-ARMED CATECHOL COMPOUND BLENDS - The invention describes families of compounds that utilize multihydroxyl phenyl groups to provide adhesive properties. Selection of the multihydroxy phenyl group along with linkers or linking groups and the linkages between the linkers or linking groups with polyalkylene oxides, provides materials that can be engineered to afford controllable curing time, biodegradation and/or swelling. | 06-14-2012 |
| 20120179083 | THIN FILM COMPOSITIONS AND METHODS OF SYNTHESIS AND USE THEREFOR - The invention relates generally to thin-film adhesive materials suitable for various applications. In particular, the present invention provides pliable viscoelastic thin-films configured to form strong water-resistant adhesive bonds to various surface types. | 07-12-2012 |
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| 20100113828 | MULTI-ARMED CATECHOL COMPOUND BLENDS - The invention describes families of compounds that utilize multihydroxyl phenyl groups to provide adhesive properties. Selection of the multihydroxy phenyl group along with linkers or linking groups and the linkages between the linkers or linking groups with polyalkylene oxides, provides materials that can be engineered to afford controllable curing time, biodegradation and/or swelling. | 05-06-2010 |
| 20100137902 | BIOADHESIVE CONSTRUCTS - The invention describes substrates, such as prosthetics, films, nonwovens, meshes, etc. that are treated with a bioadhesive. The bioadhesive includes polymeric substances that have phenyl moieties with at least two hydroxyl groups. The bioadhesive constructs can be used to treat and repair, for example, hernias and damaged tendons. | 06-03-2010 |
| 20100137903 | BIOADHESIVE CONSTRUCTS - The invention describes substrates, such as prosthetics, films, nonwovens, meshes, etc. that are treated with a bioadhesive. The bioadhesive includes polymeric substances that have phenyl moieties with at least two hydroxyl groups. The bioadhesive constructs can be used to treat and repair, for example, hernias and damaged tendons. | 06-03-2010 |
| 20140030944 | MONO-LAYER THIN FILM ADHESIVE COMPOUNDS AND METHODS OF SYNTHESIS AND USE - The invention relates provides synthetic medical adhesives which exploit plant derivatives to form covalent bonds with amines and thiols on tissue surfaces. | 01-30-2014 |
| 20160032047 | Peg-based adhesive phenylic derivatives and methods of synthesis and use - The invention provides compositions that use phenylic derivatives to provide adhesive properties. Selection of phenylic derivatives with linkers or linking groups, and the linkages between the linkers or linking groups with polyalkylene oxides, provided herein may be configured to control curing time, biodegradation and/or swelling. | 02-04-2016 |
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| 20140026980 | MAGNETIC DOCKING FAUCET - A faucet is provided. The faucet has a spout and a sprayhead releasably coupled to the spout. A hose having a magnetically responsive collar thereon provides fluid through the spout to the sprayhead. A magnet is located in the faucet such that when the sprayhead is coupled to the spout, the collar magnetically couples to the magnet, thereby applying sufficient magnetic force to the hose to retain the sprayhead against the spout. | 01-30-2014 |
| 20140069520 | MAGNETIC DOCKING FAUCET - A faucet includes a spout and a sprayhead movable between a docked position, in which the sprayhead is in contact with the spout, and an undocked position, in which the sprayhead is spaced apart from the spout. The faucet also includes a hose that includes a tubular portion having an inlet end and an outlet end and configured to provide fluid through the spout to the sprayhead and a magnetically responsive end portion coupled to the outlet end and configured to be freely and rotatably received within a portion of the sprayhead. A magnet is located in the spout such that when the sprayhead is in the docked position, the magnet magnetically attracts the magnetically responsive end portion of the hose so as to retain the sprayhead against the spout. | 03-13-2014 |
| 20140189947 | DAMPER LOCKING MECHANISM FOR TOILET SEAT - A toilet includes a seat, a bowl and a damper locking mechanism that allows the seat to rotate relative to the bowl with an influenced inertia. The damper locking mechanism includes a hinge base having a biasing member and an interior surface that defines a bore and a damper having an exterior surface that engages the interior surface. When the damper is disposed in the bore, the biasing member imparts a radial force to bias the damper into the hinge base and remove a looseness between the seat and the bowl. | 07-10-2014 |
| 20140201895 | BUMPERLESS TOILET LID - A lid for a toilet including a bottom surface that faces a top surface of a seat for the toilet when the seat is in a lowered position proximate to a bowl of the toilet. The bottom surface of the lid has a sweeping profile that extends along at least a portion of the bottom surface of the lid and is configured to engage the top surface of the seat. A uniform gap between the seat and lid is defined by the sweeping profile of the lid and the material thickness of the lid when both the lid and the seat are in a lowered position. | 07-24-2014 |
| 20140250578 | TOILET WITH LIGHTED SEAT HINGE - Various disclosed systems relate to fixtures, such as toilets, that include a lighting mechanism for illuminating portions of the fixture. One embodiment relates to a toilet. The seat assembly of the toilet includes a hinge assembly having a hinge housing and a lighting mechanism. The lighting mechanism is at least partially encapsulated by the hinge housing. The lighting mechanism including a first light source and a power source. The seat assembly further includes a lid pivotally connected to the hinge assembly. The seat assembly includes a ring pivotally connected to the hinge assembly. The lighting mechanism is configured to direct light at the tank and to direct light into the bowl such that light is reflected off of the tank and off of an interior of the bowl. | 09-11-2014 |
| 20150368887 | MAGNETIC DOCKING FAUCET - A faucet is provided. The faucet has a spout and a sprayhead releasably coupled to the spout. A hose having a magnetically responsive collar thereon provides fluid through the spout to the sprayhead. A magnet is located in the faucet such that when the sprayhead is coupled to the spout, the collar magnetically couples to the magnet, thereby applying sufficient magnetic force to the hose to retain the sprayhead against the spout. | 12-24-2015 |
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| 20100025279 | STACKABLE CONTAINER - A container adapted to be stacked on top of a second container is provided. The container includes a first end wall and a sidewall having a first end and a second end. The container includes a first seam coupling the first end wall to the first end of the sidewall, the first seam including a shoulder extending inwardly from an outer surface of the first seam. The container includes an alignment feature extending from the shoulder away from the first end wall. The alignment feature is adapted to align the container relative to the second container and to resist lateral movement of the container relative to the second container when the container is stacked on top of the second container. | 02-04-2010 |
| 20100025281 | STACKABLE CONTAINER - A container configured to be stacked adjacent to a second container is provided. The container includes a sidewall having a first end, an end wall having a peripheral edge, a seam coupling the peripheral edge of the end wall to the first end of the sidewall, and an alignment feature coupled to the seam. The alignment feature includes an inner surface. The alignment feature is positioned relative to the seam such that, when the container is stacked adjacent to the second container, the inner surface of the alignment feature contacts an outer surface of a seam of the second container, the contact resisting lateral movement of the container relative to the second container. | 02-04-2010 |
| 20130306657 | STACKABLE CONTAINER - A container configured to be stacked adjacent to a second container is provided. The container includes a sidewall having a first end, an end wall having a peripheral edge, a seam coupling the peripheral edge of the end wall to the first end of the sidewall, and an alignment feature coupled to the seam. The alignment feature includes an inner surface. The alignment feature is positioned relative to the seam such that, when the container is stacked adjacent to the second container, the inner surface of the alignment feature contacts an outer surface of a seam of the second container, the contact resisting lateral movement of the container relative to the second container. | 11-21-2013 |
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| 20080215093 | Degradable Cage Coated With Mineral Layers For Spinal Interbody Fusion - A cage for facilitating fusion of bones, such as vertebrae, or fusion of adjacent bone surfaces is disclosed. In one form, the cage includes a plurality of spaced apart walls comprising a biodegradable polymeric material (e.g., polycaprolactone); an osteoconductive mineral coating (e.g., a calcium compound) on at least a portion of the walls; and a bioactive agent (e.g., a bone morphogenetic protein) associated with the polymeric material and/or the coating. The bioactive agent is present in amount that induces ossification between the bones or adjacent bone surfaces. The cage may also include a fixation plate connected to at least one of the walls. | 09-04-2008 |
| 20090087472 | CONTROLLED RELEASE OF BIOPHARMACEUTICAL GROWTH FACTORS FROM HYDROXYAPATITE COATING ON BIORESORBABLE INTERFERENCE SCREWS USED IN CRUCIATE LIGAMENT RECONSTRUCTION SURGERY - Controlled release of biopharmaceutical growth factors from a hydroxyapatite coating on a bioresorbable interference screw used in cruciate ligament reconstruction surgery on a human. Biologically active scaffolds, such as interference bone screws used for ligament fixation, made by growing calcium phosphate-based hydroxyapatite coatings on bioresorbable poly(α-hydroxy ester) scaffolds that provide controlled mineral dissolution and controlled release of bone morphogenetic protein-2. The biologically active scaffold provides improved bioavailability of BMP-2 growth factor that in turn provides enhanced graft-bone healing in the tibial bone tunnel. The coating method uses surface hydrolysis and modified simulated body fluid incubation which does not require solvent or heat and is conducted at room temperature. | 04-02-2009 |
| 20110022085 | BIOLOGICALLY ACTIVE SUTURES FOR REGENERATIVE MEDICINE - The present disclosure generally relates to biodegradable and bioresorbable materials having a mineral layer on the surface of the material. More particularly, the disclosure relates to biodegradable and bioresorbable orthopedic devices having a degradable mineral layer on the surface thereof that can be used as a delivery vehicle for biological substances. Also provided are various methods of using the mineralized devices in tissue regeneration, including bone tissue engineering, and methods for producing the mineralized devices. | 01-27-2011 |
| 20110129611 | DECORATING HYDROXYAPATITE BIOMATERIALS WITH MODULAR BIOLOGICALLY ACTIVE MOLECULES - A modular peptide design strategy wherein the modular peptide has two functional units separated by a spacer portion is disclosed. More particularly, the design strategy combines a hydroxyapatite-binding portion and a biomolecule-derived portion. The modular peptides have improved non-covalent binding to the surface of the HA-based materials, and are capable of initiating osteogenesis, angiogenesis, and/or osteogenic differentiation. | 06-02-2011 |
| 20110305760 | TISSUE REGENERATION SYSTEM - A system for growing tissue based upon layers of an inorganic extracellular matrix, wherein each layer of the inorganic matrix is designed to dissolve at a separate rate and result in sequential growth factor delivery upon its dissolution. | 12-15-2011 |
| 20120330423 | Engineered Scaffolds for Intervertebral Disc Repair and Regeneration and for Articulating Joint Repair and Regeneration - Methods for the engineering and preparation of intervertebral disc repair scaffolds and articulating joint repair scaffolds are disclosed. The methodology utilizes either magnetic resonance images or combined magnetic resonance and computed tomography images as a template for creating either the intervertebral scaffold or the joint repair scaffold (e.g., osteochondral scaffold) with fixation to the underlying bone. The disc scaffold design may include an outer annulus that may contain desired structures and a central nucleus pulposus region that could either contain a designed microstructure or a contained hydrogel. The osteochondral scaffold may include a bone compartment interface with a cartilage compartment. The bone compartment may interface with a cutout portion of the bone through fixation components. Different microstructure designs may be created for the bone and cartilage compartment to represent desired mechanical and mass transport properties. The microstructure controls elastic and permeability property distribution within the scaffold. | 12-27-2012 |
| 20150238655 | MINERAL COATED SCAFFOLDS - Provided is a composition for a scaffold having a mineral coating similar to bone. Also provided is a method for mineral coating a scaffold so as to promote mineral coating of the scaffold with a plate-like nanostructure and a carbonate-substituted, calcium-deficient hydroxyapatite phase. | 08-27-2015 |
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| 20110269231 | PROTEOGLYCAN-BINDING PEPTIDES THAT MODULATE STEM CELL BEHAVIOR - Biomaterials presenting synthetic peptides and methods of preparing biomaterials are disclosed. More particularly, the disclosure is directed to biomaterials including a substrate including a synthetic peptide thereon, wherein the synthetic peptide is selected from synthetic proteoglycan-binding peptides, synthetic glycosaminoglycan-binding peptides, and combinations thereof. The present disclosure is further directed to methods of preparing the biomaterials for use in sequestering endogenous proteoglycans and endogenous glycosaminoglycans, increasing stem cell proliferation, reducing spontaneous stem cell differentiation, and enhancing induced osteogenic differentiation of mesenchymal stem cells. | 11-03-2011 |
| 20110282392 | DEGRADABLE CAGE FOR BONE FUSION - A cage for facilitating fusion of bones, such as vertebrae, or fusion of adjacent bone surfaces is disclosed. In one form, the cage includes a plurality of spaced apart walls comprising a biodegradable polymeric material (e.g., polycaprolactone); an osteoconductive mineral coating (e.g., a calcium compound) on at least a portion of the walls; and a bioactive agent (e.g., a bone morphogenetic protein) associated with the polymeric material and/or the coating. The bioactive agent is present in amount that induces ossification between the bones or adjacent bone surfaces. The cage may also include a fixation plate connected to at least one of the walls. | 11-17-2011 |
| 20120271418 | MODULAR TISSUE SCAFFOLDS - Provided are biocompatible and implantable scaffolds for treating a tissue defect, such as a bone gap. The scaffolds can have a modular design comprising a tissue scaffold rack designed to accommodate one or more modules. Also provided are methods for fabrication and use of such scaffolds. | 10-25-2012 |
| 20130149457 | METHODS OF DECORATING HYDROXYAPATITE BIOMATERIALS WITH MODULAR BIOLOGICALLY ACTIVE MOLECULES - A modular peptide design strategy wherein the modular peptide has two functional units separated by a spacer portion is disclosed. More particularly, the design strategy combines a hydroxyapatite-binding portion and a biomolecule-derived portion. The modular peptides have improved non-covalent binding to the surface of the HA-based materials, and are capable of initiating osteogenesis, angiogenesis, and/or osteogenic differentiation. | 06-13-2013 |
| 20130296177 | CHEMICALLY-DEFINED ARRAYS FOR SCREENING CELL-SUBSTRATE INTERACTIONS - Patterned SAM arrays and methods of preparing patterned SAM arrays are disclosed. Advantageously, the methods used to prepare the patterned SAM arrays allow for controlling SAM spot-to-spot conditions such as ligand identity and ligand density, which allows for preparing a wide range of SAM spots in a single array format. Additionally, the patterned SAM arrays of the present disclosure support the culture of a range of cell types. The patterned SAM arrays offer the ability to rapidly screen substrate components for influencing cell attachment, spreading, proliferation, migration, and differentiation. | 11-07-2013 |
| 20140113835 | CHEMICALLY-DEFINED ARRAYS FOR SCREENING CELL-SUBSTRATE INTERACTIONS - Patterned SAM arrays and methods of preparing patterned SAM arrays are disclosed. Advantageously, the methods used to prepare the patterned SAM arrays allow for controlling SAM spot-to-spot conditions such as ligand identity and ligand density, which allows for preparing a wide range of SAM spots in a single array format. Additionally, the patterned SAM arrays of the present disclosure support the culture of a range of cell types. The patterned SAM arrays offer the ability to rapidly screen substrate components for influencing cell attachment, spreading, proliferation, migration, and differentiation. | 04-24-2014 |
| 20140141047 | SELECTION OF PLATELET RICH PLASMA COMPONENTS VIA MINERAL BINDING - Mineral coated devices and methods for delivering an autologous biological molecule using the mineral coated devices are disclosed. The mineral coated devices allow for the isolation and delivery of a biological molecule obtained from the same subject to avoid the safety concerns of current biological therapies obtained by recombinant methods and purification from animal sources. Methods for selectively isolating and eluting a biological molecule using the mineral coated devices are also disclosed. | 05-22-2014 |
| 20140161886 | MINERAL-COATED MICROSPHERES - Provided is a microsphere comprising a bead coated with a first calcium-containing mineral. Also provided is a method of producing a microsphere. Additionally, a method of administering a compound to a vertebrate is provided. | 06-12-2014 |
| 20140235498 | ENHANCED THROUGHPUT MINERAL COATINGS FOR OPTIMIZATION OF STEM CELL BEHAVIOR - Disclosed are methods for cell transfection and regulating cellular behavior. More particularly, the present disclosure relates to methods of non-viral cell transfection and regulating cellular behavior using mineral coatings that allow for the enhanced transfection of cells. The mineral coatings bind polynucleotides and provide a source of calcium and phosphate ions to enhance transfection. The present disclosure also provides a high throughput platform for screening non-viral transfection of cells. The methods of the present disclosure also provide an advantageous polynucleotide delivery platform because the mineral coatings may be deposited on various medical device materials after being specifically developed using the high throughput screening platform. | 08-21-2014 |
| 20140235542 | MODULAR, BIOACTIVE PEPTIDES FOR BINDING NATIVE BONE AND IMPROVING BONE GRAFT OSTEOINDUCTIVITY - A modular peptide design strategy wherein the modular peptide has two functional units separated by a spacer portion is disclosed. More particularly, the design strategy combines a bone-binding portion and a biomolecule-derived portion. The modular peptides have improved non-covalent binding to the surface of native bone, and are capable of initiating osteogenesis, angiogenesis, and/or osteogenic differentiation. | 08-21-2014 |
| 20140273221 | SUBSTRATES FOR GENERATION OF CONTROLLED HUMAN PLURIPOTENT STEM CELL COLONY SIZE AND SHAPE - Methods of cell culture using patterned SAM arrays are disclosed. Advantageously, the disclosed methods use SAM arrays presenting adhesion peptides to grow confluent monolayers that can invaginate to form an embryoid body. | 09-18-2014 |
| 20150024490 | CHEMICALLY LABILE PEPTIDE-PRESENTING SURFACES FOR CELLULAR SELF-ASSEMBLY - Methods of cell culture using patterned SAM arrays are disclosed. Advantageously, the disclosed methods use SAM arrays presenting adhesion peptides to grow confluent monolayers that can invaginate to form an embryoid body. | 01-22-2015 |
| 20150291929 | HYDROGEL COMPOSITIONS FOR USE IN PROMOTING TUBULOGENESIS - Hydrogel Compositions and methods of using hydrogel compositions are disclosed. Advantageously, the hydrogel compositions offer the ability to rapidly screen substrate components for influencing cell attachment, spreading, proliferation, migration, and differentiation. In particularly suitable embodiments, the hydrogel compositions of the present disclosure may be used to promote tubulogenesis of endothelial cells. | 10-15-2015 |
| 20150291930 | HYDROGEL COMPOSITIONS FOR USE IN CELL EXPANSION AND DIFFERENTIATION - Hydrogel compositions and methods of using hydrogel compositions are disclosed. Advantageously, the hydrogel compositions offer the ability to promote cellular expansion and/or cellular differentiation of various cells. | 10-15-2015 |
| 20150293073 | NOVEL METHOD FOR FORMING HYDROGEL ARRAYS USING SURFACES WITH DIFFERENTIAL WETTABILITY - Patterned hydrogel arrays and methods of preparing patterned hydrogel arrays are disclosed. Advantageously, the methods used to prepare the patterned hydrogel arrays allow for controlling individual hydrogel spot conditions such as hydrogel spot modulus, hydrogel spot ligand identity and hydrogel spot ligand density, which allows for preparing a wide range of hydrogel spots in a single array format. Patterned hydrogel arrays can also be formed to include hydrogel-free pools surrounded by hydrogel. Additionally, the patterned hydrogel arrays of the present disclosure support the culture of a range of cell types. The patterned hydrogel arrays offer the ability to rapidly screen substrate components for influencing cell attachment, spreading, proliferation, migration, and differentiation. | 10-15-2015 |
