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| 20100035867 | Inhibitors of Cyclic Nucleotide Synthesis and Their Use for Therapy of Various Diseases - We disclose a method of inhibiting activity of adenylyl cyclase or guanylyl cyclase in a mammal by administering to the mammal an amount of a composition effective to inhibit the activity, wherein the composition contains at least one compound selected from the group consisting of structural formulae (Ia) and (Ib) and salts thereof, wherein R1 is —H or has the structure —C(═O)R8; R2 is ═O or has the structure —OC(═O)R9; and R3, R4, R5, R6, and R7 are each independently selected from the group consisting of —H, —NO | 02-11-2010 |
| 20100144675 | Regulation of sGC Function by Corrin Derivatives - We disclose a method of activating soluble guanylyl cyclase (sGC) in a patient, comprising administering to the patient a composition comprising a corrin and a pharmaceutically-acceptable carrier. We also disclose a composition, comprising a corrin, an NO-independent sGC activator selected from the group consisting of BAY 41-2272, BAY 58-2667, HMR1766, YC-I, and S3448, and a pharmaceutically-acceptable carrier. | 06-10-2010 |
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| 20090027460 | SYSTEM FOR ALIGNING A CHARGE TUNNEL OF AN INK JET PRINTER - A system and method for aligning a charge tunnel of an inkjet printer. The system may include a charge tunnel unit and a charge tunnel base. The charge tunnel unit includes a slot, and is configured to impart an electrical charge on ink droplets passing through the slot. The charge tunnel unit may be at least partially pivoted about the base through the tightening or loosening of an adjustment screw. The system may also include a charge tunnel cradle that is operably connected to the charge tunnel base and the printhead deck. The charge tunnel base and the charge tunnel cradle may be operably connected to a adjustment fastener. The tightening or loosening of the adjustment fastener may linearly move the charge tunnel base, and attached charge tunnel unit, towards or away from the charge tunnel cradle, thereby allowing for the adjustment of the linear position of the slot. | 01-29-2009 |
| 20100085401 | ADJUSTABLE PRINT HEAD - An adjustable print head assembly for an ink jet printer includes a first member and a second member. The first member includes an outer wall and an inner passage. The second member includes an outer wall and an inner passage, the outer wall including an angled surface complementary to the angled surface of the first member. A print head is connected to the second member. At least one ink line runs from the umbilical to the print head, and is disposed through the inner passages of the first and second members. The print head assembly is adjustable from a first configuration to a second configuration, wherein in the first configuration, the print head axis is oriented generally parallel to the umbilical axis, and in the second configuration, the print head axis is oriented at a predetermined angle with respect to the umbilical axis. | 04-08-2010 |
| 20140152743 | ADJUSTABLE PRINT HEAD - An adjustable print head assembly for an ink jet printer includes a first member and a second member. The first member includes an outer wall and an inner passage. The second member includes an outer wall and an inner passage, the outer wall including an angled surface complementary to the angled surface of the first member. A print head is connected to the second member. At least one ink line runs from the umbilical to the print head, and is disposed through the inner passages of the first and second members. The print head assembly is adjustable from a first configuration to a second configuration, wherein in the first configuration, the print head axis is oriented generally parallel to the umbilical axis, and in the second configuration, the print head axis is oriented at a predetermined angle with respect to the umbilical axis. | 06-05-2014 |
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| 20090069638 | Diagnostic and Treatment Regimen for Achieving Body Water Homeostasis - A method for achieving and maintaining an optimized cellular water homeostasis and good connective tissue health in humans, where cellular water homeostasis is expressed as the ratio of intercellular water (“ICW”) content to extracellular water (“ECW”) content homeostasis comprising the steps of (i) taking a first set of measurements of two or more of ICW, ECW and total body water (“TBW”) contend; (ii) comparing the first set of measurements against a predetermined set of values associated with a population of people; (iii) administering an initial dosing of a first composition comprising a therapeutically-effective amount of an amino acid/phospholipid pairing (“AAPP”); (iv) taking a follow-up set of measurements of two or more of TBW, ICW and/or ECW after the initial dosing; (v) comparing the follow-up set of measurements against the predetermined set of population values; (vi) administering a follow-up dosing of a follow-up composition comprising a therapeutically-effective amount of an AAPP; (vii) repeating steps (iv) through (vi) until the desired values of TBW, ICW and/or ECW are achieved. | 03-12-2009 |
| 20090093440 | Fragranced Therapeutic Delivery System - The present invention relates to multi-functional topical delivery systems for providing long-lasting delivery of fragrance as. well as skin-supporting and/or pharmaceutically active ingredients comprising (i) an oil phase; (ii) an aqueous phase; (iii) phenoxyethanol at a concentration of from about 2.0% to about 2.7% based on the total weight of the composition; (iv) an effective exfoliating amount of a hydrophobic hydroxycarboxylic acid selected from the group consisting of orthohydroxybenzoic acid, hydroxycarboxylic acids containing a C12-C24 fatty acid esterified to the alpha carbon hydroxyl group, hydroxycarboxylic acids containing a C12-C24 fatty alcohol esterified to a carboxyl group; (v) a non-ionic emulsifier having an HLB of from about 7 to about 10; (vi) a fragrance composition; and (vii) at least one skin-supporting or dermatopharmaceutically active agent. | 04-09-2009 |
| 20090105191 | Pharmaceutical and Dermatocosmetic Compositions Comprising Extract of Durio Zibenthinus - The present invention relates to dermatocosmetic and pharmaceutical compositions comprising compounds obtained from | 04-23-2009 |
| 20100278759 | Topical Therapeutic Delivery System - The present invention relates to an oil-in-water emulsion topical delivery system comprising an oil phase; an aqueous phase; phenoxyethanol; an effective exfoliatingamount of a hydrophobic hydroxycarboxylic acid; a non-ionic emulsifier having an HLB of from about 7 to about 10; and at least one skin-supporting ordermatopharmaceutically active agent. | 11-04-2010 |
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| 20120136434 | ERGONOMIC MITRAL HEART VALVE HOLDERS - A holder for a prosthetic mitral heart valve that attaches to an inflow end of the valve and includes a simple tensioning mechanism that flexes the heart valve commissure posts inward to help prevent suture looping. The tensioning mechanism may include relatively movable rings of the holder or a generally unitary holder with a tensor, or rotatable knob. Connecting sutures thread through internal passages in the holder and travel in the outflow direction along valve commissure posts, emerging at the post tips and mutually crossing over the outflow side of the valve. A handle attaches off-center on the holder to increase visualization of and access to the heart valve through a central window. The holder is constructed of non-metallic materials so as to avoid interfering with imaging devices, and the handle is ergonomically curved and shaped to facilitate manipulation. The holder may be shaped as a ring with an open inner diameter for enhanced access to the commissure posts and leaflets. | 05-31-2012 |
| 20120290079 | MITRAL HEART VALVE HOLDER AND STORAGE SYSTEM - An improved holder and storage system for a tissue-type prosthetic mitral heart valve that constricts the commissure posts of the valve and prevents suture looping. A rod axially movable relative to the holder tensions lengths of attachment sutures that extend between the commissure post tips to create a tent and flex the tips inward, thus helping to prevent looping of any of an array of pre-implanted sutures around the leading tips during delivery of the valve. The holder has a safety mechanism that prevents valve delivery before the rod is deployed. One embodiment automatically deploys the rod upon opening a storage jar. One embodiment permits a delivery handle to directly deploy the rod, while another uses a separate worm screw and coupling. A holder clip that attaches to a packaging sleeve may be formed of flexible members meshed together from which the heart valve and holder are easily pulled free to eliminate a step of decoupling the clip from the sleeve. | 11-15-2012 |
| 20150196394 | MITRAL HEART VALVE HOLDER AND STORAGE SYSTEM - An improved holder and storage system for a tissue-type prosthetic mitral heart valve that constricts the commissure posts of the valve and prevents suture looping. A rod axially movable relative to the holder tensions lengths of attachment sutures that extend between the commissure post tips to create a tent and flex the tips inward, thus helping to prevent looping of any of an array of pre-implanted sutures around the leading tips during delivery of the valve. The holder has a safety mechanism that prevents valve delivery before the rod is deployed. One embodiment automatically deploys the rod upon opening a storage jar. One embodiment permits a delivery handle to directly deploy the rod, while another uses a separate worm screw and coupling. A holder clip that attaches to a packaging sleeve may be formed of flexible members meshed together from which the heart valve and holder are easily pulled free to eliminate a step of decoupling the clip from the sleeve. | 07-16-2015 |
| 20150313712 | ERGONOMIC MITRAL HEART VALVE HOLDERS - A holder for a prosthetic mitral heart valve that attaches to an inflow end of the valve and includes a simple tensioning mechanism that flexes the heart valve commissure posts inward to help prevent suture looping. The tensioning mechanism may include relatively movable rings of the holder or a generally unitary holder with a tensor, or rotatable knob. Connecting sutures thread through internal passages in the holder and travel in the outflow direction along valve commissure posts, emerging at the post tips and mutually crossing over the outflow side of the valve. A handle attaches off-center on the holder to increase visualization of and access to the heart valve through a central window for enhanced access to the commissure posts and leaflets. The holder is constructed of non-metallic materials so as to avoid interfering with imaging devices, and the handle is ergonomically curved and shaped to facilitate manipulation. | 11-05-2015 |
| 20160067042 | VALVED AORTIC CONDUITS - A valved conduit including a bioprosthetic aortic heart valve connected to a tubular conduit graft forming an ascending aorta. The conduit graft may attach to the heart valve in a manner that facilitates a redo operation in which the valve is replaced with another valve. A sewing ring may be pre-attached to the inflow end of the graft, and then the valve connected to a delivery holder advanced into the graft and secured to the sewing ring. Dry bioprosthetic valves coupled with conduit grafts sealed with a bioresorbable medium can be stored with the delivery holder. | 03-10-2016 |
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| 20110198244 | PROSTHETIC HEART VALVE PACKAGING SYSTEM - Packaging for prosthetic heart valves including an assembly for securely retaining a heart valve within a sterile jar and facilitating retrieval therefrom. The assembly includes a packaging sleeve that fits closely within the jar and has a clip structure for securing a valve holder. A delivery handle on the end of a shaft couples with the valve holder while the packaging sleeve engages the jar to prevent rotation. The assembly of the packaging sleeve, valve, and holder can then easily be removed from the jar. | 08-18-2011 |
| 20130165953 | SUTURE CLIP DEPLOYMENT DEVICES - Suture clip deployment devices for applying suture clips to sutures are described. Some embodiments can include a generally tubular main body and a vacuum port located at the distal end, a hollow inner body longitudinally slidable within the main body and extending from the main body at its distal end, and a suture recess located in the generally tubular main body. At least one suture clip configured to frictionally fit on an outer surface of the inner body is deployed during use. Clip deployment can occur after a vacuum source is applied to the device so as to draw the suture into the device. The suture lines can be retrieved through the suture recess, and the device can be actuated so as to deliver the suture clip off the delivery device and onto the suture, locking the suture in place. | 06-27-2013 |
| 20140121764 | AORTIC VALVE AND CONDUIT GRAFT IMPLANT TOOL - A sizing tool for use in implanting a composite valved conduit having a prosthetic heart valve on a distal end attached to a conduit graft that extends to a proximal end. The tool includes a proximal handle and a distal shaft, a prosthetic heart valve sizer having an axis affixed to a distal end of the shaft, and a conduit graft replica having an axis mounted on the shaft proximal to the heart valve sizer. A method of securing a composite valved conduit includes introducing to an excised ascending aorta the sizing tool, measuring the aortic annulus with the prosthetic heart valve sizer, and determining whether the coronary arteries have sufficient length or whether an additional tubular coronary extension segment is required to add to one or both of the ends of the coronary arteries by extending the coronary arteries toward the conduit graft replica. | 05-01-2014 |
| 20140303652 | SUTURE CLIP DEPLOYMENT DEVICES - Suture clip deployment devices for applying suture clips to sutures are described. Some embodiments can include a generally tubular main body and a vacuum port located at the distal end, a hollow inner body longitudinally slidable within the main body and extending from the main body at its distal end, and a suture recess located in the generally tubular main body. At least one suture clip configured to frictionally fit on an outer surface of the inner body is deployed during use. Clip deployment can occur after a vacuum source is applied to the device so as to draw the suture into the device. The suture lines can be retrieved through the suture recess, and the device can be actuated so as to deliver the suture clip off the delivery device and onto the suture, locking the suture in place. | 10-09-2014 |
| 20150182217 | SUTURE CLIP DEPLOYMENT DEVICES - Suture clip deployment devices for applying suture clips to sutures are described. Some embodiments can include a generally tubular main body and a vacuum port located at the distal end, a hollow inner body longitudinally slidable within the main body and extending from the main body at its distal end, and a suture recess located in the generally tubular main body. At least one suture clip configured to frictionally fit on an outer surface of the inner body is deployed during use. Clip deployment can occur after a vacuum source is applied to the device so as to draw the suture into the device. The suture lines can be retrieved through the suture recess, and the device can be actuated so as to deliver the suture clip off the delivery device and onto the suture, locking the suture in place. | 07-02-2015 |
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| 20110140504 | SYSTEM AND METHOD FOR SEAT BELT CONTROL - A system is provided for utilizing belt movement information in a motorized seat belt (MSB) control system algorithm to achieve better levels of comfort and safety. The MSB control system algorithm controls execution of multiple modes including a no friction mode, a stowage mode, a slack reduction mode, an out of position warning mode, a medium pull-back mode, and a high pull-back mode. The MSB control system algorithm also controls execution of a low power mode initiated after the other vehicle modules are put to sleep to provide the ability to stow the seat belt after the vehicle has been turned off for some period of time. The MSB control system algorithm also controls belt monitoring functions defined based on a buckle switch state that indicates the buckled or unbuckled state of the seat belt. Belt monitoring consists of belt movement being converted to counts based on a resolution provided by a belt movement sensor. | 06-16-2011 |
| 20110148176 | SYSTEM AND METHOD FOR SEAT BELT CONTROL - A system is provided for utilizing belt movement information in a motorized seat belt (MSB) control system algorithm to achieve better levels of comfort and safety. The MSB control system algorithm controls execution of multiple modes including a no friction mode, a stowage mode, a slack reduction mode, an out of position warning mode, a medium pull-back mode, and a high pull-back mode. The MSB control system algorithm also controls execution of a low power mode initiated after the other vehicle modules are put to sleep to provide the ability to stow the seat belt after the vehicle has been turned off for some period of time. The MSB control system algorithm also controls belt monitoring functions defined based on a buckle switch state that indicates the buckled or unbuckled state of the seat belt. Belt monitoring consists of belt movement being converted to counts based on a resolution provided by a belt movement sensor. | 06-23-2011 |
| 20110153165 | SYSTEM AND METHOD FOR SEAT BELT CONTROL - A system is provided for utilizing belt movement information in a motorized seat belt (MSB) control system algorithm to achieve better levels of comfort and safety. The MSB control system algorithm controls execution of multiple modes including a no friction mode, a stowage mode, a slack reduction mode, an out of position warning mode, a medium pull-back mode, and a high pull-back mode. The MSB control system algorithm also controls execution of a low power mode initiated after the other vehicle modules are put to sleep to provide the ability to stow the seat belt after the vehicle has been turned off for some period of time. The MSB control system algorithm also controls belt monitoring functions defined based on a buckle switch state that indicates the buckled or unbuckled state of the seat belt. Belt monitoring consists of belt movement being converted to counts based on a resolution provided by a belt movement sensor. | 06-23-2011 |
| 20140071282 | ALERT SYSTEMS AND METHODS USING REAL-TIME LANE INFORMATION - Methods and systems are provided for alerting a driver of a vehicle. In one embodiment, a method includes: receiving sensor data that is generated by an image sensor that senses conditions in proximity of the vehicle; determining real-time lane information from the sensor data, wherein the real-time lane information includes at least one of a lane width, a lane type, and a lane curvature; selectively performing an alert method that evaluates the presence of objects in proximity to the vehicle based on the real-time lane information; and selectively generating an alert signal to alert the driver based on the alert method. | 03-13-2014 |
| 20150198711 | OBJECT FUSION SYSTEM OF MULTIPLE RADAR IMAGING SENSORS - A method of detecting and tracking objects using multiple radar sensors. Objects relative to a host vehicle are detected from radar data generated by a sensing device. The radar data includes Doppler measurement data. Clusters are formed, by a processor, as a function of the radar data. Each cluster represents a respective object. Each respective object is classified, by the processor, as stationary or non-stationary based on the Doppler measurement data of each object and a vehicle speed of the host vehicle. Target tracking is applied, by the processor, on an object using Doppler measurement data over time in response to the object classified as a non-stationary object; otherwise, updating an occupancy grid in response to classifying the object as a stationary object. | 07-16-2015 |
