Mummery
Christine L. Mummery, Leiden NL
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20150361399 | CARDIOMYOCYTE DIFFERENTIATION - This invention provides a method for testing a factor for cardiogenicity which comprises differentiating human embryonic stem (hES) cells to cardiomyocytes in the presence and absence of the factor wherein the human embryonic stem (hES) cells are cultured under a serum free condition comprising co-culture in the presence of END-2 cells or serum-free extracellular medium therefrom, and measuring the differentiation in the presence and absence of the factor. This invention also provides a method for identifying a cardiogenic factor, which comprises differentiating human embryonic stem (hES) cells to cardiomyocytes in the presence or absence of the factor wherein the human embryonic stem (hES) cells are cultured under a serum free condition comprising co-culture in the presence of END-2 cells or serum-free extracellular medium therefrom, and identifying the factor that affects the differentiation of human embryonic stem (hES) cells to cardiomyocytes in the presence or absence of the factor. | 12-17-2015 |
Christine Lindsay Mummery, Bilthoven NL
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20080254003 | Differentiation of Human Embryonic Stem Cells and Cardiomyocytes and Cardiomyocyte Progenitors Derived Therefrom - The present invention provides a method to improve current culturing methods for the differentiation of cardiomyocytes from hES cells. The method includes culturing the hES cells in the presence of ascorbic acid or a derivative thereof. Preferably the culturing is conducted in serum free conditions. The invention also includes isolated cardiomyocytes and cardiac progenitors differentiated by the methods as well as the use of these cells in methods of treating and preventing cardiac diseases and conditions. Culture media and extracellular media are also provided which include ascorbic acid for the differentiation of hES cells to cardiomyocytes. | 10-16-2008 |
20090202498 | DIRECT DIFFERENTIATION OF CARDIOMYOCYTES FROM HUMAN EMBRYONIC STEM CELLS - The present invention relates to the induction of differentiation in stem cells to cardiomyocytes and factors such as prostaglandin alone or in combination with other factors including essential minerals selected from the group including transferrin and selenium, small molecules selected from the group including a p38 MAPK inhibitor such as SB203580 and protein growth factors of the FGF, IGF and BMP families such as but not limited to IGF1, FGF2, BMP2, BMP4 and BMP6. and insulin that influence the process of differentiation to cardiomyocytes. Media that is appropriate for the induction of differentiation of cardiomyocytes from stem cells is also provided wherein the media contains these factors. The use of cardiomyocytes and cardiac progenitors produced by the directed differentiation in transplantation and screening for cardiac compounds is also provided. | 08-13-2009 |
20140287495 | Methods of Inducing Differentiation of Stem Cells - The present invention relates to methods of inducing differentiation of stem cells. In particular, the invention relates to methods of inducing differentiation of embryonic stem cells into muscle cells or vascular endothelial cells. The invention also includes cells, cell lines, testing models and culture systems used in the methods of the present invention and differentiated cells produced therefrom. The present invention also provides methods of using the differentiated cells of the present invention for therapeutic purposes. | 09-25-2014 |
Christine Lindsay Mummery, Dj Bilthoven NL
Patent application number | Description | Published |
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20120178095 | CARDIOMYOCYTE DIFFERENTIATION - This invention provides a method for testing a factor for cardiogenicity which comprises differentiating human embryonic stem (hES) cells to cardiomyocytes in the presence and absence of the factor wherein the human embryonic stem (hES) cells are cultured under a serum free condition comprising co-culture in the presence of END-2 cells or serum-free extracellular medium therefrom, and measuring the differentiation in the presence and absence of the factor. This invention also provides a method for identifying a cardiogenic factor, which comprises differentiating human embryonic stem (hES) cells to cardiomyocytes in the presence or absence of the factor wherein the human embryonic stem (hES) cells are cultured under a serum free condition comprising co-culture in the presence of END-2 cells or serum-free extracellular medium therefrom, and identifying the factor that affects the differentiation of human embryonic stem (hES) cells to cardiomyocytes in the presence or absence of the factor. | 07-12-2012 |
20140193909 | Direct Differentiation of Cardiomyocytes From Embryonic Stem Cells - The present invention relates to the induction of differentiation in human embryonic stem (hES) cells to cardiomyocytes and factors such as prostaglandin I2 (PGI2), Fgf 9, Bmp6, Bmp4, Scf, Igf2, and insulin that influence the process of differentiation to cardiomyocytes. Media that is appropriate for the induction of differentiation of cardiomyocytes from hES cells is also provided wherein the media contains these factors. Genes that are upregulated in the process of cardiomyocyte differentiation are also provided. | 07-10-2014 |
Christine Lindsay Mummery, Leiden NL
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20160115453 | DIFFERENTIATION AND EXPANSION OF ENDOTHELIAL CELLS FROM PLURIPOTENT STEM CELLS AND THE IN VITRO FORMATION OF VASCULATURE LIKE STRUCTURES - The disclosure is concerned among others with means and methods for obtaining endothelial cells and to means and methods for in vitro cell culture comprising endothelial cells and pericytes and/or smooth muscle cells derived from the pericytes. The endothelial cells or the pericytes and/or smooth muscle cells, or both, are preferably derived from in vitro differentiated pluripotent stem cells. | 04-28-2016 |
Cory Mummery, Torrance, CA US
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20160041998 | Apparatus and Methods for Personalized Video Delivery - Computer systems and methods providing personalized delivery of video files to a user's device. A computer server allows a user to create a user profile which includes information about certain user preferences, such as a favorite subject matter, favorite participant(s) and the like and, when a user connects to the computer server, the server checks a video database for video files of potential interest to the user and generates a ranking of video files of potential interest, then provides information and, if requested, the video files, to the user in order of the ranking. The ranking may be based on a variety of inputs, including both express and/or implied user preferences, the elapsed time between the publication (or creation) of a video file and the user's request therefor, the subject matter of the video file, the teams, players, and other persons included in the video file, the length of the video file, and a variety of other information about the video file. The computer server may provide this information and the video files to any one of a number of devices associated with a user, including desktop and laptop computers, tablets, phones, and the like. | 02-11-2016 |