Patent application number | Description | Published |
20090238802 | Intraperitoneal Delivery Of Genetically Engineered Mesenchymal Stem Cells - A method of expressing at least one protein in an animal by intraperitoneal administration of mesenchymal stem cells genetically engineered with at least one polynucleotide encoding the at least one protein. The method may be employed in treating lysosomal storage disorders, such as Fabry Disease, or arthritic disorders, or hemophilia, for example. | 09-24-2009 |
20090257989 | Intraperitoneal Delivery Of Genetically Engineered Mesenchymal Stem Cells - A method of expressing at least one protein in an animal by intraperitoneal administration of mesenchymal stem cells genetically engineered with at least one polynucleotide encoding the at least one protein. The method may be employed in treating lysosomal storage disorders, such as Fabry Disease, or arthritic disorders, or hemophilia, for example. | 10-15-2009 |
20100015597 | PRODUCTION OF BIOLOGICAL CARRIERS FOR INDUCTION OF IMMUNE RESPONSE AND INHIBITION OF VIRAL REPLICATION - This application provides a method to form non-infectious Biological Carrier that may be used to deliver signals to cells either in vitro or in vivo. The Biological Carriers are inactivated virus particles that have been specifically modified to give biological properties different from the virus particles deriving from an unmodified host cell that (i) expresses at least one co-stimulatory molecule and (iia) at least one antigen that can initiate an immune response, and/or (iib) express surface molecules that suppress viral replication. | 01-21-2010 |
20100178302 | CHRONIC PATHOGEN-EXPRESSING CELL LINES - This application provides a method to establish and construct cell lines expressing pathogens without destruction of the host cells. The invention allows for the formation of cell lines for the purpose of continuous expression, release, and harvesting of the pathogen and maintaining the consistency of the final biological product. Although the invention is intended for pathogen antigen expression, the invention allows for the production of any antigen by the described methods. The establishment of a chronically infected cell line can be used for reagent, diagnostic, quantification, or vaccine purposes. We have used the procedure to select for a host cell line that naturally adapts to HIV-1 replication without affecting the host cell's ability to survive. This allowed for the establishment of a chronic HIV-1 expressing cell line that continuously expresses HIV-1 particles. | 07-15-2010 |
20100255111 | Intraperitoneal Delivery of Genetically Engineered Mesenchymal Stem Cells - A method of expressing at least one protein in an animal by intraperitoneal administration of mesenchymal stem cells (or genetically engineered mesenchymal stem cells) with at least one polynucleotide encoding at least one protein. The method may be employed, for example, in treating lysosomal storage disorders, such as Fabry Disease, or arthritic disorders, or hemophilia, or diabetes. | 10-07-2010 |
20110027237 | Intraperitoneal Delivery of Genetically Engineered Mesenchymal Stem Cells - A method of expressing at least one protein in an animal by intraperitoneal administration of mesenchymal stem cells genetically engineered with at least one polynucleotide encoding the at least one protein. The method may be employed in treating lysosomal storage disorders, such as Fabry Disease, or arthritic disorders, or hemophilia, for example. | 02-03-2011 |
20110027241 | Intraperitoneal Delivery of Genetically Engineered Mesenchymal Stem Cells - A method of expressing at least one protein in an animal by intraperitoneal administration of mesenchymal stem cells genetically engineered with at least one polynucleotide encoding the at least one protein. The method may be employed in treating lysosomal storage disorders, such as Fabry Disease, or arthritic disorders, or hemophilia, for example. | 02-03-2011 |
20110262389 | Tumor-derived Biological Antigen Presenting Particles - Disclosed is a biological anti-tumor approach that delivers specific antigen stimulation in the presence of co-stimulatory signals to the immune system. Tumor cells are engineered such that processed antigens and co-stimulatory molecules are incorporated into virus-like particles capable of modulating immune responses without cellular entry and nucleic acid genomic host cell integration. The invention describes constructing antigen presenting particles that will themselves present tumor antigens in an immunogenic fashion to therapeutically activate anti-tumor immunity within a mammalian host. | 10-27-2011 |
Patent application number | Description | Published |
20090043827 | DYNAMIC LEGAL DATABASE PROVIDING HISTORICAL AND CURRENT VERSIONS OF BODIES OF LAW - Information collections defining a common subject such as a codified or uncodified body of law are stored on a computer readable medium in association with temporal information indicating the state or status with respect to time of parts of the information collection, including different versions of the same part. Parts that are different versions of each other have different temporal information associated therewith and can be accessed based on the temporal information. Thus, the temporal information may be used to control access to and display of parts of the subject in a computer system based on time as a search or request parameter. Parts of the common subject may be organized and stored according to various schemes, including hierarchical schemes such as topic trees, a relational database, a file system or a structured document system (e.g., using XML). Parts of the common subject and temporal and other information may be associated in various ways, including linking (e.g., hyperlinking), with pointers, or by including them in the same file, record or document. A hierarchical arrangement of hyperlinked, structured documents collectively provide a table of contents (TOC) to the subject. In the preferred embodiment, the subject is a statutory body of law such as the United States Code. Sections of the Code are stored in associated with temporal information such as date of enactment, effective date and termination date. A researcher can then access the version of the code in effect at any particular time. For example, historical and current versions of a section of the United States Code can be viewed, as accessed hierarchically or directly by identification of the section and a date. Other information, stored in association with a part of a body of law may include historical information, commentary, annotations, descriptive information, legislative history, references, and/or links to laws, judicial decisions and other information. | 02-12-2009 |