Patent application number | Description | Published |
20130316679 | SYSTEMS AND METHODS FOR MANAGING CONCURRENT AUDIO MESSAGES - A system for receiving multiple conversations or messages and for playing the multiple conversations or messages with a mobile device and wireless earpieces. The system may determine various presentation parameters based on various characteristics of the received messages and may play the messages such that audio appears at distinguishing locations around the user. The system may change how messages and/or conversations are played in response to recognize a change in the focus of the user based on detected user inputs, such as body movement gestures. | 11-28-2013 |
20130316746 | PERSONAL HUB PRESENCE AND RESPONSE - Methods, devices, and systems for transmitting convenient messages to a recipient for rendering based on the recipient's device availabilities. A recipient's mobile device may be connected to a personal hub and/or earpiece devices configured to render various incoming communications, such as audio messages and visual messages. The incoming messages may be delivered to the recipient's mobile device and other connected devices that may render the contents of the incoming messages. A delivery confirmation message that describes the receipt and use of incoming messages may be generated and returned to a sender's computing device. In an embodiment, the recipient's devices may generate status information for describing the status of devices to a sender's computing device. In an embodiment, the sender's computing device may generate and transmit outgoing messages formatted based on the received status information and including metadata that instructs the recipient's devices to render message content in particular manners. | 11-28-2013 |
20140029701 | FRAME SYNC ACROSS MULTIPLE CHANNELS - Systems, methods, and devices synchronize data streams by hashing received data frames to generate a sequence of hash values, comparing the generated hash value sequence to a hash value sequence received in a control stream, and processing data frames when the hash value sequences match. A source device and multiple receiver devices may synchronize audio data encoded in data frames, applying a hash function to each data frame to generate a first sequence of hash values, transmitting the data frames on a first channel and the first sequence of hash values on a control channel, receiving the data frames and the first sequence of hash values in the receiver devices, applying the hash algorithm to received data frames to generate a second sequence of hash values, comparing the first and second sequences of hash values, and processing data frames when the first and second sequences of hash values match. | 01-30-2014 |
20140073256 | METHOD OF PROVIDING CALL CONTROL INFORMATION FROM A MOBILE PHONE TO A PERIPHERAL DEVICE - The systems, methods, and devices of the various embodiments provide call control information from a mobile phone to another device by moving the functionality enabling the separation of call control commands from audio data off the mobile phone. The various embodiments handle the separation of call control commands from audio data at an ear piece or other peripheral device, such as a personal hub, which is part of a multiple subscriber device system. The various embodiments enable the standard Bluetooth® Hands-Free Profile to be used by a multiple subscriber device system to interact with a mobile phone. | 03-13-2014 |
20140119407 | APPARATUS AND METHOD FOR EXTENDING BLUETOOTH DEVICE RANGE - An apparatus for extending Bluetooth device range includes a Bluetooth range extender device implementing at least two Bluetooth communication profiles such that the Bluetooth range extender device implements a first role to a first standard Bluetooth communication device and implements a second role to a second standard Bluetooth communication device. | 05-01-2014 |
Patent application number | Description | Published |
20090048122 | Stabilized polypeptide compositions - The invention is based, at least in part, on the development of stabilized binding molecules that consist of or comprise a stabilized scFv and methods for making such stabilized molecules. | 02-19-2009 |
20090130105 | COMPOSITIONS THAT BIND MULTIPLE EPITOPES OF IGF-1R - The instant invention is based, at least in part on the finding that binding molecules which bind to different epitopes within IGF-1R result in improved IGF-1 and/or IGF-2 blocking capabilities when compared to binding molecules that bind to a single IGF-1R epitope. The instant invention provides compositions that bind to multiple epitopes of IGF-1R, for example, combinations of monospecific binding molecules or multispecific binding molecules (e.g., bispecific molecules). Methods of making the subject binding molecules and methods of using the binding molecules of the invention to antagonize IGF-1R signaling are also provided. | 05-21-2009 |
20090155255 | CD23 BINDING MOLECULES AND METHODS OF USE THEREOF - The invention is based, at least in part, on the development of multivalent and stabilized forms of CD23 binding molecules and methods of use thereof for the treatment of immune cell disorders, including leukemias or lymphomas such as CLL. | 06-18-2009 |
20110301331 | Stabilized polypeptide compositions - The invention is based, at least in part, on the development of stabilized binding molecules that consist of or comprise a stabilized scFv and methods for making such stabilized molecules. | 12-08-2011 |
20120100140 | STABILIZED FC POLYPEPTIDES WITH REDUCED EFFECTOR FUNCTION AND METHODS OF USE - A method of producing Fc-containing polypeptides, such as antibodies, having stabilized Fc regions is provided, together with stabilized Fc polypeptides produced according to these methods as well as methods of using such antibodies as therapeutics. | 04-26-2012 |
20140079701 | LINKER PEPTIDES AND POLYPEPTIDES COMPRISING SAME - The invention is based, at least in part, on the finding that linker peptides which lack the amino acid sequence GSG reduce or eliminate the addition of posttranslational modifications to the polypeptides which comprise them. More specifically, the novel linker peptides disclosed herein reduce the ability of enzymes to link carbohydrate adducts to polypeptides comprising these linker peptides, e.g., reduce the ability of xylosyltransferase to link xylose to polypeptides. These novel linker peptides, molecules comprising same, and methods of their use are described. | 03-20-2014 |
Patent application number | Description | Published |
20100144798 | Modulators of ATP-Binding Cassette Transporters - The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators. | 06-10-2010 |
20110144123 | Thiazoles and Oxazoles Useful as Modulators of ATP-Binding Cassette Transporters - The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators. | 06-16-2011 |
20110306607 | HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS - The invention relates to heterocyclic chromene-spirocyclic piperidine amides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. | 12-15-2011 |
20110306637 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS - The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators. | 12-15-2011 |
20120184583 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS - The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators. | 07-19-2012 |
20120196869 | PYRROLOPYRAZINE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS - The invention relates to pyrrolopyrazine-spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. | 08-02-2012 |
20120245136 | CHROMAN-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS - The invention relates to chroman spirocyclic piperidine amide derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. | 09-27-2012 |
20120264749 | MORPHOLINE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS - The invention relates to morpholine spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. | 10-18-2012 |
20130178471 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS - Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention. | 07-11-2013 |
20140080825 | Modulators of ATP-binding cassette transporters - The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators. | 03-20-2014 |
20140080826 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS - Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention. | 03-20-2014 |
20140171427 | Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels - The invention relates to heterocyclic chromene-spirocyclic piperidine amides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. | 06-19-2014 |
20140309220 | BENZOXAZINES AS MODULATORS OF ION CHANNELS - The invention relates to benzoxazines useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. | 10-16-2014 |
20150025073 | MORPHOLINE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS - The invention relates to morpholine spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. | 01-22-2015 |
20150094304 | Modulators of ATP-Binding Cassette Transporters - Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention. | 04-02-2015 |
20150174098 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS - Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention. | 06-25-2015 |
20150174127 | Pyrrolopyrazine-Spirocyclic piperidine amides as modulators of ion channels - The invention relates to pyrrolopyrazine-spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. | 06-25-2015 |
20160095858 | Modulators of Cystic Fibrosis Transmembrane Conductance Regulator - The present invention features a compound of formula I: | 04-07-2016 |
Patent application number | Description | Published |
20080235391 | Method and apparatus for transferring files to clients using a peer-to-peer file transfer model and a client-server transfer model - A method and apparatus is provided for delivering a content file to a client over a packet-switched network. The method begins by determining a suitable throughput required to deliver the content file to the client. Next, the throughput available in a peer-to-peer network for delivering the content file to the client is determined. The required throughput is compared to the available throughput. If the available throughput is less than the required throughput, the available throughput is supplemented with additional throughput. The content is then delivered to the client over the packet-switched network using the available throughput of the peer-to-peer network and the additional throughput. | 09-25-2008 |
20110191419 | METHOD AND APPARATUS FOR TRANSFERRING FILES TO CLIENTS USING A PEER-TO-PEER FILE TRANSFER MODEL AND A CLIENT-SERVER TRANSFER MODEL - A method and apparatus is provided for delivering a content file to a client over a packet-switched network. The method begins by determining a suitable throughput required to deliver the content file to the client. Next, the throughput available in a peer-to-peer network for delivering the content file to the client is determined. The required throughput is compared to the available throughput. If the available throughput is less than the required throughput, the available throughput is supplemented with additional throughput. The content is then delivered to the client over the packet-switched network using the available throughput of the peer-to-peer network and the additional throughput. | 08-04-2011 |
20110191420 | METHOD AND APPARATUS FOR TRANSFERRING FILES TO CLIENTS USING A PEER-TO-PEER FILE TRANSFER MODEL AND A CLIENT-SERVER TRANSFER MODEL - A method and apparatus is provided for delivering a content file to a client over a packet-switched network. The method begins by determining a suitable throughput required to deliver the content file to the client. Next, the throughput available in a peer-to-peer network for delivering the content file to the client is determined. The required throughput is compared to the available throughput. If the available throughput is less than the required throughput, the available throughput is supplemented with additional throughput. The content is then delivered to the client over the packet-switched network using the available throughput of the peer-to-peer network and the additional throughput. | 08-04-2011 |
20140115106 | METHOD AND APPARATUS FOR TRANSFERRING FILES TO CLIENTS USING A PEER-TO-PEER FILE TRANSFER MODEL AND A CLIENT-SERVER TRANSFER MODEL - A method and apparatus is provided for delivering a content file to a client over a packet-switched network. The method begins by determining a suitable throughput required to deliver the content file to the client. Next, the throughput available in a peer-to-peer network for delivering the content file to the client is determined. The required throughput is compared to the available throughput. If the available throughput is less than the required throughput, the available throughput is supplemented with additional throughput. The content is then delivered to the client over the packet-switched network using the available throughput of the peer-to-peer network and the additional throughput. | 04-24-2014 |
Patent application number | Description | Published |
20120264967 | PROCESS FOR MAKING (R) -3-(2,3-DIHYDROXYPROPYL)-6-FLUORO-5-(2-FLOURO-4-IODOPHENYLAMINO)-8-METHYL- PYRIDO[2,3-d]PYRIMIDINE-4,7(3H,8H)-DIONE AND INTERMEDIATES THEREOF - The present invention relates generally to processes of making (R)-3-(2,3-Dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione, intermediates thereof, and a process for making a particular polymorph of (R)-3-(2,3-Dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione. | 10-18-2012 |
20130225813 | PROCESS FOR MAKING (R) -3-(2,3-DIHYDROXYPROPYL)-6-FLUORO-5-(2-FLOURO-4-IODOPHENYLAMINO)-8-METHYL- PYRIDO[2,3-d]PYRIMIDINE-4,7(3H,8H)-DIONE AND INTERMEDIATES THEREOF - The present invention relates generally intermediates for making (R)-3-(2,3-Dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione. | 08-29-2013 |