Patent application number | Description | Published |
20090036648 | EGVI Endoglucanase and Nucleic Acids Encoding the Same - The present invention provides a novel endoglucanase nucleic acid sequence, designated egl6, and the corresponding EGVI amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding EGVI, recombinant EGVI proteins and methods for producing the same. | 02-05-2009 |
20090093039 | REGULATABLE GROWTH OF FILAMENTOUS FUNGI - The present invention generally relates to hyphal growth in fungi and in particular describes the modulation of genes associated with hyphal growth in filamentous fungi. The present invention provides methods and systems for the production of proteins and/or chemicals from filamentous fungi which comprise modulation of genes associated with hyphal growth. Specifically, the present invention is directed to a full length cotA gene, its gene product and methods of use. | 04-09-2009 |
20090098249 | Variant Buttiauxella sp. Phytases having altered properties - The present invention relates to variant phytase enzymes having altered properties. | 04-16-2009 |
20090130713 | TRICHODERMA PROMOTER - A promoter for use in producing proteins in filamentous fungal host cells is provided. In one embodiment, the promoter comprises SEQ ID NO:1, or a variant or a truncated form thereof that has promoter activity in a host cell. Also provided are recombinant nucleic acids, vectors containing the promoter and host cells containing a recombinant nucleic acid or vector. Methods of producing a protein using the host cells are also provided. | 05-21-2009 |
20090170181 | EGVII Endoglucanase and Nucleic Acids Encoding The Same - The present invention provides a novel endoglucanase nucleic acid sequence, designated egl7, and the corresponding EGVII amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding EGVII, recombinant EGVII proteins and methods for producing the same. | 07-02-2009 |
20090176292 | BGL7 Beta-Glucosidase and Nucleic Acids Encoding The Same - The present invention provides BGL7 polypeptides with the biological activity of a β-glucosidase and a method of producing a recombinant enzyme having β-glucosidase activity. | 07-09-2009 |
20090246856 | Trichoderma Reesei Phytase Enzymes, Nucleic Acids Encoding Such Phytase Enzymes, Vectors and Host Cells Incorporating Same and Methods of Making and Using Same - A novel DNA is provided which encodes an enzyme having phytase activity isolated from | 10-01-2009 |
20100055731 | KEX2 Cleavage Regions OF Recombinant Fusion Proteins - The invention relates to a fusion DNA construct comprising a KEX2 region comprising a KEX2 site and a KEX2 site pre-sequence immediately 5′ to the KEX2 site, a fusion polypeptide, vectors and cells comprising the fusion DNA construct, methods for producing desired proteins from filamentous fungal cells and methods for enhancing the secretion and/or cleavage of a desired protein from a cell. | 03-04-2010 |
20100144013 | OVER EXPRESSION OF FOLDASES AND CHAPERONES IMPROVES PROTEIN PRODUCTION - The present teachings provide methods for increasing protein secretion, e.g., chymosin in filamentous fungi by co-expressing certain chaperone(s) and/or foldase(s). The present teachings also provide filamentous fungi containing certain chaperone(s) and/or foldase(s) and a protein of interest for increased secretion. | 06-10-2010 |
20100184175 | BGL6 Beta-Glucosidase and Nucleic Acids Encoding the Same - The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl6, and the corresponding BGL6 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL6, recombinant BGL6 proteins and methods for producing the same. | 07-22-2010 |
20100221775 | INCREASED PRODUCTION OF SECRETED PROTEINS BY RECOMBINANT EUKARYOTIC CELLS - Described herein are methods for increasing the amount of protein secreted by a cell. In one case, a cell is provided which contains a heterologous nucleic acid encoding a protein having unfolded protein response modulating activity and a heterologous nucleic acid encoding a protein of interest to be secreted. In one case, the protein having unfolded protein response modulating activity is selected from the proteins selected from the group consisting of HAC1, PTC2 and IRE1. The protein of interest can be any secreted protein such as a therapeutic or an industrial enzyme. For example the protein can be selected from the group consisting of lipase, cellulase, endo-glucosidase H, protease, carbohydrase, reductase, oxidase, isomerase, transferase, kinase, phosphatase, alpha-amylase, glucoamylase, lignocellulose hemicellulase, pectinase and ligninase. | 09-02-2010 |
20110059507 | REGULATABLE GROWTH OF FILAMENTOUS FUNGI - The present invention generally relates to hyphal growth in fungi and in particular describes the modulation of genes associated with hyphal growth in filamentous fungi. The present invention provides methods and systems for the production of proteins and/or chemicals from filamentous fungi which comprise modulation of genes associated with hyphal growth. Specifically, the present invention is directed to a full length cotA gene, its gene product and methods of use. | 03-10-2011 |
20110086410 | BGL4 Beta-Glucosidase and Nucleic Acids Encoding the Same - The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl4, and the corresponding BGL4 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL4, recombinant BGL4 proteins and methods for producing the same. | 04-14-2011 |
20110104750 | Filamentous Fungi Having Reduced UDP-Galactofuranose Content - A filamentous fungal cell having reduced UDP-galactofuranose is provided. The fungal cell may, in certain embodiments, contain a nuclear genome comprising an inactivated UDP-galactopyranose mutase (UDP-galp mutase) gene and a recombinant nucleic acid for expression of a protein. Also provided are methods of producing a protein using the subject fungal cell, as well as methods of producing the subject fungal cell. | 05-05-2011 |
20110136197 | Expression of Catalase in Trichoderma - The invention provides methods for expression of a catalase enzyme in a | 06-09-2011 |
20110212505 | BGL3 Beta-Glucosidase and Nucleic Acids Encoding the Same - The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl3, and the corresponding BGL3 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL3, recombinant BGL3 proteins and methods for producing the same. | 09-01-2011 |
20110312031 | TRICHODERMA PROMOTER - A promoter for use in producing proteins in filamentous fungal host cells is provided. In one embodiment, the promoter comprises SEQ ID NO:1, or a variant or a truncated form thereof that has promoter activity in a host cell. Also provided are recombinant nucleic acids, vectors containing the promoter and host cells containing a recombinant nucleic acid or vector. Methods of producing a protein using the host cells are also provided. | 12-22-2011 |
20120045811 | EGVII Endoglucanase and Nucleic Acids Encoding the Same - The present invention provides a novel endoglucanase nucleic acid sequence, designated egl7, and the corresponding EGVII amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding EGVII, recombinant EGVII proteins and methods for producing the same. | 02-23-2012 |
20120100587 | BGL7 BETA-GLUCOSIDASE AND NUCLEIC ACIDS ENCODING THE SAME - The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl7, and the corresponding BGL7 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL7, recombinant BGL7 proteins and methods for producing the same. | 04-26-2012 |
20120107296 | FEED SUPPLEMENT - The present invention relates to a feed supplement comprising a phytase and a lipolytic enzyme, wherein said lipolytic enzyme has lipase activity at a pH in the range of about pH1.5 to about pH3.5. | 05-03-2012 |
20120107872 | THERMOSTABLE TRICHODERMA CELLULASE - Described are compositions and methods relating to the thermostable fungal cellulase enzyme, EGV, and | 05-03-2012 |
20120196002 | METHOD OF PRODUCING A LIPOLYTIC ENZYME - The present invention provides a transformed or transfected | 08-02-2012 |
20120225469 | ACID FUNGAL PROTEASES - The present invention is directed to novel acid proteases and more specifically to NSP24 family proteases and NSP25 family proteases including biologically active fragments thereof and to nucleic acid molecules encoding said proteases. Also provided are vectors and host cells including nucleic acid sequences coding for the proteases, methods for producing the proteases, enzyme compositions and methods employing said proteases. | 09-06-2012 |
20120301944 | BGL6 BETA-GLUCOSIDASE AND NUCLEIC ACIDS ENCODING THE SAME - The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl6, and the corresponding BGL6 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL6, recombinant BGL6 proteins and methods for producing the same. | 11-29-2012 |
20130011877 | KEX2 CLEAVAGE REGIONS OF RECOMBINANT FUSION PROTEINS - The invention relates to a fusion DNA construct comprising a KEX2 region comprising a KEX2 site and a KEX2 site pre-sequence immediately 5′ to the KEX2 site, a fusion polypeptide, vectors and cells comprising the fusion DNA construct, methods for producing desired proteins from filamentous fungal cells and methods for enhancing the secretion and/or cleavage of a desired protein from a cell. | 01-10-2013 |
20130177965 | BGL7 Beta-Glucosidase and Nucleic Acids Encoding the Same - The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl7, and the corresponding BGL7 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL7, recombinant BGL7 proteins and methods for producing the same. | 07-11-2013 |
20130224864 | FILAMENTOUS FUNGI HAVING AN ALTERED VISCOSITY PHENOTYPE - Described are compositions and methods relating variant filamentous fungi having altered growth characteristics. Such variants are well-suited for growth in submerged cultures, e.g., for the large-scale production of enzymes and other proteins for commercial applications. | 08-29-2013 |
20130230177 | Downmix Limiting - The invention relates to downmixing techniques by which output audio signals are obtained from input audio signals partitioned into subgroups. A variable common gain limiting factor is applied to all downmix coefficients that govern the contributions from the input signals in a subgroup. While preserving the proportions between signal values within a subgroup, the invention makes it possible to limit the gain of different input signal subgroups to different extents, so that relatively more perceptible signals can be limited relatively less. It then becomes possible to achieve a consistent dialogue level while transitioning in a less perceptible fashion between signal portions with and without gain limiting. Embodiments of the invention include a method, a mixing system and a computer-program product. | 09-05-2013 |
20130280228 | FEED SUPPLEMENT - The present invention relates to a feed supplement comprising a phytase and a lipolytic enzyme, wherein said lipolytic enzyme has lipase activity at a pH in the range of about pH1.5 to about pH3.5. | 10-24-2013 |
20140004587 | EGVII ENDOGLUCANASE AND NUCLEIC ACIDS ENCODING THE SAME | 01-02-2014 |
20140024067 | KEX2 Cleavage regions of recombinant fusion proteins - The invention relates to a fusion DNA construct comprising a KEX2 region comprising a KEX2 site and a KEX2 site pre-sequence immediately 5′ to the KEX2 site, a fusion polypeptide, vectors and cells comprising the fusion DNA construct, methods for producing desired proteins from filamentous fungal cells and methods for enhancing the secretion and/or cleavage of a desired protein from a cell. | 01-23-2014 |
20140024098 | EXPRESSION OF CATALASE IN TRICHODERMA - The invention provides methods for expression of a catalase enzyme in a | 01-23-2014 |
20140087443 | OVER EXPRESSION OF FOLDASES AND CHAPERONES IMPROVES PROTEIN PRODUCTION - The present teachings provide methods for increasing protein secretion, e.g., chymosin in filamentous fungi by co-expressing certain chaperone(s) and/or foldase(s). The present teachings also provide filamentous fungi containing certain chaperone(s) and/or foldase(s) and a protein of interest for increased secretion. | 03-27-2014 |
20140123404 | LACCASE VARIANTS HAVING INCREASED EXPRESSION AND/OR ACTIVITY - The present compositions, methods, and systems, relating to variant laccase enzymes that demonstrate increased expression and/or activity compared to a reference parental laccase enzyme. The variant enzymes include mutations that affect glycosylation, surface charge, or surface hydrophobicity, resulting in improved enzyme expression and/or enzyme activity. | 05-08-2014 |
20140212885 | ENDOGENOUS DNASE ACTIVITY TO REDUCE DNA CONTENT - The application provides a method of reducing the DNA content of a protein preparation or a culture broth from a filamentous fungal host cell using an endogenous filamentous fungal host DNase activity. | 07-31-2014 |
20140234931 | BGL6 Beta-Glucosidase and Nucleic Acids Encoding the Same - The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl6, and the corresponding BGL6 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL6, recombinant BGL6 proteins and methods for producing the same. | 08-21-2014 |
20140234932 | BGL7 Beta-Glucosidase and Nucleic Acids Encoding the Same - The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl7, and the corresponding BGL7 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL7, recombinant BGL7 proteins and methods for producing the same. | 08-21-2014 |
20140234933 | EGVII Endoglucanase and Nucleic Acids Encoding the Same - The present invention provides a novel endoglucanase nucleic acid sequence, designated egl7, and the corresponding EGVII amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding EGVII, recombinant EGVII proteins and methods for producing the same. | 08-21-2014 |
20140335591 | INCREASED PRODUCTION OF SECRETED PROTEINS BY RECOMBINANT EUKARYOTIC CELLS - Described herein are methods for increasing the amount of protein secreted by a cell. In one case, a cell is provided which contains a heterologous nucleic acid encoding a protein having unfolded protein response modulating activity and a heterologous nucleic acid encoding a protein of interest to be secreted. In one case, the protein having unfolded protein response modulating activity is selected from the proteins selected from the group consisting of HAC1, PTC2 and IRE1. The protein of interest can be any secreted protein such as a therapeutic or an industrial enzyme. For example the protein can be selected from the group consisting of lipase, cellulase, endo-glucosidase H, protease, carbohydrase, reductase, oxidase, isomerase, transferase, kinase, phosphatase, alpha-amylase, glucoamylase, lignocellulose hemicellulase, pectinase and ligninase. | 11-13-2014 |
20140342432 | Fungal Gene Expression Using Insulator DNA Sequences - Described are compositions and methods relating to the expression of genes of interest in fungal cells using insulator DNA sequences. | 11-20-2014 |
20140377804 | Filamentous Fungi Having Reduced UDP-Galactofuranose Content - A filamentous fungal cell having reduced UDP-galactofuranose is provided. The fungal cell may, in certain embodiments, contain a nuclear genome comprising an inactivated UDP-galactopyranose mutase (UDP-galp mutase) gene and a recombinant nucleic acid for expression of a protein. Also provided are methods of producing a protein using the subject fungal cell, as well as methods of producing the subject fungal cell. | 12-25-2014 |
20150030717 | GLYCOSYLATION AS A STABILIZER FOR PHYTASE - The present teachings provide modified enzymes, preferably phytases, which have increased stability, hypothesized to arise from increased glycosylation. The enzymes can be modified to introduce or increase the number of glycosylation sites in the amino acid sequence, or glycosylation can be increased by the use of specific host production methods, or both. The enzymes of the present teachings have an increased stability after treatment at elevated temperature, which can be measured by inactivity reversibility or percent recovery following a treatment such as heating. The enzymes of the present teachings find application for example in food, feed, and feed pelleting. | 01-29-2015 |
20150064309 | METHOD OF PRODUCING A LIPOLYTIC ENZYME - The present invention provides a transformed or transfected | 03-05-2015 |