Patent application number | Description | Published |
20080318320 | TARGETING VECTOR TO THE UROKINASE PLASMINOGEN ACTIVATOR RECEPTOR - The present invention relates to the targeted delivery of a delivery vehicle construct which specifically binds to and stimulates endocytosis into cells expressing the urokinase plasminogen activator receptor (uPAR), and particularly human airway epithelia. The delivery vehicle construct comprises a portion of uPA and a cargo linked thereto and is useful for the targeted delivery of the cargo to a cell. In one aspect of the invention, the uPA portion of the delivery vehicle construct comprises the wild-type uPA, a fragment of uPA which has the PAI-1 binding region deleted, or a uPA peptide comprising amino acids 13-19 and is useful for the targeted delivery of the cargo to cells, and in particular to airway epithelia. The present invention also provides a method for delivering the delivery vehicle construct to a cell. The method comprises the steps of (a) contacting a target cell with a delivery vehicle construct comprising a uPA portion and a cargo portion; and (b) obtaining a desired result in the target cell. | 12-25-2008 |
20090241203 | Transgenic animal models of disease - The present invention provides transgenic, large non-human animal models of diseases and conditions, as well as methods of making and using such animal models in the identification and characterization of therapies for the diseases and conditions. | 09-24-2009 |
20090241206 | METHODS FOR CLONING FERRETS AND TRANSGENIC FERRET MODELS FOR DISEASES - The invention provides a transgenic Mustelidae in which a gene associated with a human disease or condition comprises a targeted genetic modification, and uses thereof. Also provided is a method to cryopreserve Mustelidae embryos or cells, and to enhance the number of live offspring from cryopreserved Mustelidae embryos. | 09-24-2009 |
20090291150 | METHOD AND COMPOSITIONS FOR TREATING AND PREVENTING SEIZURES BY MODULATING ACID-SENSING ION CHANNEL ACTIVITY - This invention provides novel methods and compositions for treating and preventing seizures by administration of ASIC1a receptor activating compounds. A novel method of assaying ASIC1a receptor activating compounds is included in the present invention. According to the invention applicants have demonstrated that seizure duration, intensity, and progression may be modulated by administration of an ASIC1a receptor activator which acts to increase the endogenous activity of ASIC1a receptors to mediate the effects of low pH in the CNS. The inventors have also found that the ASIC1a receptor activator may prevent such seizures altogether. | 11-26-2009 |
20110054247 | METHODS FOR CLONING FERRETS AND TRANSGENIC FERRET MODELS FOR DISEASES - The invention provides a transgenic Mustelidae in which a gene associated with a human disease or condition comprises a targeted genetic modification, and uses thereof. Also provided is a method to cryopreserve Mustelidae embryos or cells, and to enhance the number of live offspring from cryopreserved Mustelidae embryos. | 03-03-2011 |
20120015396 | COMPOSITIONS AND METHODS FOR MODULATING THE ACID-SENSING ION CHANNEL (ASIC) - Novel compositions for modulating acid-sensing ion channels (ASIC) function comprising ASICĪ±, ASICĪ², and BNC1 and derivatives thereof; methods for modulating ASIC function and methods for treating cognitive disorders and for memory enhancement using the novel compositions of the invention; and a method for increasing synaptic plasticity are described. | 01-19-2012 |
20120142583 | Methods of inhibiting and treating bacterial biofilms by metal chelators - The invention presented herein provides methods and compositions for the prevention and treatment of bacterial infections. The methods are based on the discovery that depletion of bioavailable iron stimulates surface motility in bacteria thus inhibiting the ability of a bacterial population to develop into a biofilm. | 06-07-2012 |
20120180141 | Transgenic Animal Models of Disease - The present invention provides transgenic, large non-human animal models of diseases and conditions, as well as methods of making and using such animal models in the identification and characterization of therapies for the diseases and conditions. | 07-12-2012 |
20130210708 | METHODS OF INHIBITING AND TREATING BACTERIAL BIOFILMS BY METAL CHELATORS - The invention presented herein provides methods and compositions for the prevention and treatment of bacterial infections. The methods are based on the discovery that depletion of bioavailable iron stimulates surface motility in bacteria thus inhibiting the ability of a bacterial population to develop into a biofilm. | 08-15-2013 |
20130316022 | METHOD TO ENHANCE ANTIMICROBIAL ACTIVITY BY INCREASING pH - The invention provides a method to enhance antimicrobial activity, e.g., in a mammal. | 11-28-2013 |
20140255975 | TRANSGENIC PIG MODELS OF CYSTIC FIBROSIS - This invention relates to transgenic pig models of cystic fibrosis, cells that can be used to make such animals, and methods of making and using these pigs and cells. | 09-11-2014 |