Mendrick
Donna Mendrick, Gaithersburg, MD US
Patent application number | Description | Published |
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20090220970 | MOLECULAR TOXICOLOGY MODELING - The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes. | 09-03-2009 |
20110071767 | Hepatotoxicity Molecular Models - The present invention includes methods of predicting hepatotoxicity of test agents and methods of generating hepatotoxicity prediction models using algorithms for analyzing quantitative gene expression information. The invention also includes microarrays, computer systems comprising the toxicity prediction models, as well as methods of using the computer systems by remote users for determining the toxicity of test agents. | 03-24-2011 |
Donna Mendrick, Mount Airy, MD US
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20080274109 | Myeloid Progenitor Inhibitory Factor-1 (MPIF-1), Monocyte Colony Inhibitory Factor (M-CIF), and Macrophage Inhibitory Factor-4 (MIP-4) - There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine β8 (CKβ8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-γ and chemokine β1 (CKβ1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same. | 11-06-2008 |
Donna L. Mendrick, Gaithersburg, MD US
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20090197258 | PRIMARY RAT HEPATOCYTE TOXICITY MODELING - The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes. | 08-06-2009 |
20090202995 | MOLECULAR CARDIOTOXICOLOGY MODELING - The present invention includes methods of predicting cardiotoxicity of test agents and methods of generating cardiotoxicity prediction models using algorithms for analyzing quantitative gene expression information. The invention also includes microarrays, computer systems comprising the toxicity prediction models, as well as methods of using the computer systems by remote users for determining the toxicity of test agents. | 08-13-2009 |
Donna L. Mendrick, Mount Airy, MD US
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20080215250 | Molecular toxicology modeling - The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes. | 09-04-2008 |
Mark C. Mendrick, Albany, NY US
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20100124677 | DIRECT OXIDATION FUEL CELL SYSTEM WITH UNIFORM VAPOR DELIVERY OF FUEL - A fuel cell system which includes a fuel distribution structure that uniformly distributes vaporizing fuel to a fuel cell is provided. As the fuel travels in a flow field channel in the fuel distribution structure, it is substantially converted to a vapor by the heat of the fuel cell operation in such a manner that the resulting vapor pressure works to substantially uniformly distribute fuel evenly outwardly across substantially the entire active area of the anode aspect of one or more membrane electrode assemblies in the system, and whereby localized, uneven “hot spots” of fuel at the anode aspects are substantially prevented. A pair of enthalpy exchanger and heat spreader assemblies include a cathode current collector element that also has a heat spreader plate that collects and redirects heat in the fuel cell system, the assembly acting to manage the heat, temperature and condensation in the fuel cell system. | 05-20-2010 |
20140234740 | DIRECT OXIDATION FUEL CELL SYSTEM WITH UNIFORM VAPOR DELIVERY OF FUEL - In one embodiment, a membrane electrode assembly of a fuel cell has an anode aspect and a cathode aspect. A fuel distribution structure is disposed adjacent to the anode aspect. The fuel distribution structure has a fuel feed port configured to receive and inject liquid fuel to a flow field plate. The flow field plate has flow channels formed therein that split and spread from the fuel feed port to exit ports. The flow channels are configured to convey heat to fuel passing there through to substantially convert the liquid fuel to vaporous fuel within the flow channels. The exit ports are configured to deliver the resulting vaporous fuel to the anode aspect to substantially uniformly distribute fuel across the anode aspect. Further, an enthalpy exchanger and heat spreader assembly is in thermal contact with the fuel distribution structure and configured to provide to it heat from fuel cell operation. | 08-21-2014 |
20140264263 | PSEUDOMORPHIC ELECTRONIC AND OPTOELECTRONIC DEVICES HAVING PLANAR CONTACTS - In various embodiments, light-emitting devices incorporate smooth contact layers and polarization doping (i.e., underlying layers substantially free of dopant impurities) and exhibit high photon extraction efficiencies. | 09-18-2014 |