Mellors
Darren Mellors, Fredericksburg, VA US
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20120042557 | TOP OPENING, MODULAR TOP RAIL, MULTI-RIFLE ADAPTABLE FREE FLOAT RAIL ADAPTOR SYSTEM (ARM-R) - An improved Rail Adaptor System/Rail Accessory System (RAS) which attaches to a firearm. The rail is top opening, modular, and free floats the barrel. Provided is a rigid, lightweight, strong platform for mounting firearm accessories. Heat transmission from the barrel assembly to the user is limited. The user is also protected from ventilated gases originating from the operating system. A quick detachable top rail section is provided so that that gas system may be easily accessed. This removable top section of the rail is what makes this device unique because the RAS may be installed without removing the barrel, gas system, front sight base, flash hider or the barrel nut. The herein described RAS is adaptable to a wide variety of firearms with the use of conversion parts. The top rail “returns to zero” on reinstallation allowing the remounting of various optics and electronic gun sites without the need to realign them. | 02-23-2012 |
Darren Mellors, Cambridge, MD US
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20130055613 | TOP OPENING, MODULAR TOP RAIL, MULTI-RIFLE ADAPTABLE FREE FLOAT RAIL ADAPTOR SYSTEM (ARM-R) - An improved Rail Adaptor System/Rail Accessory System (RAS) which attaches to a firearm. The rail is top opening, modular, and free floats the barrel. Provided is a rigid, lightweight, strong platform for mounting firearm accessories. Heat transmission from the barrel assembly to the user is limited. The user is also protected from ventilated gases originating from the operating system. A quick detachable top rail section is provided so that the gas system may be easily accessed. This removable top section of the rail is what makes this device unique because the RAS may be installed without removing the barrel, gas system, front sight base, flash hider or the barrel nut. The herein described RAS is adaptable to a wide variety of firearms with the use of conversion parts. The top tail “returns to zero” on reinstallation allowing the remounting of various optics and electronic gun sites without the need to realign them. | 03-07-2013 |
John Scott Mellors, Chapel Hill, NC US
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20150340219 | INTEGRATED SAMPLE PROCESSING FOR ELECTROSPRAY IONIZATION DEVICES - Methods, systems and devices that generate differential axial transport in a fluidic device having at least one fluidic sample separation flow channel and at least one ESI emitter in communication with the at least one sample separation flow channel. In response to the generated differential axial transport, the at least one target analyte contained in a sample reservoir in communication with the sample separation channel is selectively transported to the at least one ESI emitter while inhibiting transport of contaminant materials contained in the sample reservoir toward the at least one ESI emitter thereby preferentially directing analyte molecules out of the at least one ESI emitter. The methods, systems and devices are particularly suitable for use with a mass spectrometer. | 11-26-2015 |
John W. Mellors, Pittsburgh, PA US
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20100279969 | AZIDO PURINE NUCLEOSIDES FOR TREATMENT OF VIRAL INFECTIONS - The present invention is directed to compounds, compositions and methods for treating or preventing viral infections, in particular, HIV, HBV, and HCV, in human patients or other animal hosts. The compounds are 3′-azido-2′,3′-dideoxy purine nucleosides or phosphonates, and pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof. In particular, the compounds show potent antiviral activity against HIV-1 resistance mutants including HIV-1 | 11-04-2010 |
20120135951 | 3'-AZIDO PURINE NUCLEOTIDE PRODRUGS FOR TREATMENT OF VIRAL INFECTIONS - The present invention is directed to compounds, compositions and methods for treating or preventing viral infections, in particular, HIV, and HBV, in human patients or other animal hosts. The compounds are 3′-azido-2′,3′-dideoxy purine monophosphates, and pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof. In particular, the compounds show potent antiviral activity against HIV-1 and HBV. | 05-31-2012 |
Mark Mellors, Hitchin GB
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20160084443 | A PRESSURISED FLUID CONTAINER - A pressurised fluid container having a shut off valve within a valve body. The valve body contains at least one high pressure seal to seal the region around the valve. The valve body is configured such that any leakage past the or each high pressure seal enters an internal gas path which routes any fluid leakage past the or each high pressure seal to one or more discrete ports in the valve body. | 03-24-2016 |
Phillip Mellors, Manchester GB
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20090181430 | PROTEIN FOLDING - The present invention concerns a method for folding a Transforming Growth Factor Beta, or a functional analogue thereof, into a dimeric, biologically active form. The method involves adding solubilized, unfolded monomeric growth factor to a solution containing 2-(cyclohexylamino)-ethanesulfonic acid (CHES) or a functional analogue thereof and a low molecular weight sulfhydryl/disulfide redox system. The solution is then incubated under conditions suitable for generating dimeric biologically active Transforming Growth Factor Beta. | 07-16-2009 |
20090328250 | EXPRESSION OF TGF-BETA IN PLASTIDS - Provided is a method for the expression of a TGF-β in a plant. A chimeric nucleic acid sequence comprising: (1) a first nucleic acid sequence capable of regulating the transcription in a plant cell of (2) a second nucleic acid sequence, encoding a TGF-β, and adapted for expression in the plant cell; and (3) a third nucleic acid sequence encoding a termination region functional in said plant cell is introduced into a plant cell and the plant cell grown to produce TGF-β. The nucleic acid sequence may preferably be adapted for expression in a plant chloroplast. It is preferred that the TGF-β is TGF-β3, whether full length or in the form of an active fragment. | 12-31-2009 |
20110105396 | TGF-BETA3 MUTANTS - The invention provides TGF-β3s, or fragments or derivatives thereof, wherein the alpha-helix-forming domain between amino acid residues (58) and (67) of full-length wild type TGF-β3 comprises at least one alpha-helix-stabilising substitution. The invention also provides TGF-β3s, or fragments or derivatives thereof, wherein the Glycine residue at position (63) of full-length wild type TGF-β3 is replaced with Proline. Further still, the invention provides TGF-β3s, or fragments or derivatives thereof, comprising a substitution of the Glutamic acid residue at position (12) of full-length wild type TGF-β3 and/or the Arginine residue at position (52) of full-length wild type TGF-β3. The invention also provides medicaments and methods of treatment using such TGF-β3s. | 05-05-2011 |
William K. Mellors, Clinton Corners, NY US
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20080294416 | FACILITATING SIMULATION OF A MODEL WITHIN A DISTRIBUTED ENVIRONMENT - Simulation of models within a distributed environment is facilitated. A model is partitioned based on clock domains, and communication between partitions on different processors is performed on synchronous clock boundaries. Further, data is exchanged across the network on latch boundaries. Thus, management aspects of the simulation, such as management associated with the global simulation time, are simplified. | 11-27-2008 |