Meining
Alexander Meining, Howenbrunn DE
Patent application number | Description | Published |
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20090240143 | METHOD AND AN OPTICAL PROBE FOR IN VIVO IMAGING OF A MUCOSA IN A BILIARY OR PANCREATIC SYSTEM AND A METHOD FOR SELECTIVELY OPERATING A TISSUE SAMPLING OF A MUCOSA IN A BILIARY OR PANCREATIC SYSTEM - A method for observing a mucosa of a biliary or pancreatic system in a subject includes positioning a optical probe in contact with said mucosa, wherein the optical probe accesses the biliary or pancreatic system using a working channel of an endoscope inserted orally in the subject. An optical probe to be used with a fiber optic microscope for in vivo observation includes an optical fiber bundle, a miniaturized objective connected coaxially at a distal tip of the optical fiber bundle, wherein the optical fiber bundle and the miniaturized objective each have a diameter of less than 1.2 mm such that said optical probe can access a biliary or pancreatic system using a working channel of an endoscope inserted orally. | 09-24-2009 |
Stefan Meining, Uslar DE
Patent application number | Description | Published |
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20120212830 | NONPOLARIZING BEAM SPLITTER - Nonpolarizing beam splitter has at least one substrate, to which a partially reflective coating having a plurality of layers is applied. The layer sequence of the coating includes at least one metal layer, at least two first refractive layers made of a high or medium refractive index dielectric material, and at least two second refractive layers made of a low or medium refractive index dielectric material. | 08-23-2012 |
Winfried Meining, Zolling DE
Patent application number | Description | Published |
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20150031618 | MUTEINS OF A1M LIPOCALIN AND METHOD OF PRODUCTION THEREFOR - The present disclosure relates to a collection of novel muteins derived from human α1m (or a1m) polypeptide or a functional homologue thereof. The disclosure further refers to a α1m mutein capable of specifically binding to one or more targets other than a target to which wild-type α1m binds. The disclosure also relates to a method for producing such collection of muteins and a method for isolating a mutein capable of binding one or more such non-natural targets of wild-type α1m polypeptide. These aspects are made possible due to, e.g, the structural elucidation of α1m disclosed herein by the present inventors, an appreciation of ligand-binding sights thereof and, hence, an understanding of which amino acid positions are most suitable for mutagenesis for re-engineering specificity and affinity for any given target while maintaining the secondary and/or tertiary structure of α1m. | 01-29-2015 |