Patent application number | Description | Published |
20080312840 | Method for Affinity Scoring of Peptide/Protein Complexes - The present invention is related to a quantitative structure-based affinity scoring method for peptide/protein complexes. More specifically, the present invention comprises a method that operates on the basis of a highly specific force field function (e.g. CHARMM) that is applied to all-atom structural representations of peptide/receptor complexes. Peptide side-chain contributions to total affinity are scored after detailed rotameric sampling followed by controlled energy refinement. The method of the invention further comprises a de novo approach to estimate dehydration energies from the simulation of individual amino acids in a solvent box filled with explicit water molecules and applying the same force field function as used to evaluate peptide/receptor complex interactions. | 12-18-2008 |
20120278054 | METHOD FOR AFFINITY SCORING OF PEPTIDE/PROTEIN COMPLEXES - The present invention is related to a quantitative structure-based affinity scoring method for peptide/protein complexes. More specifically, the present invention comprises a method that operates on the basis of a highly specific force field function (e.g. CHARMM) that is applied to all-atom structural representations of peptide/receptor complexes. Peptide side-chain contributions to total affinity are scored after detailed rotameric sampling followed by controlled energy refinement. The method of the invention further comprises a de novo approach to estimate dehydration energies from the simulation of individual amino acids in a solvent box filled with explicit water molecules and applying the same force field function as used to evaluate peptide/receptor complex interactions. | 11-01-2012 |
20130261049 | ALPHABODIES SPECIFICALLY BINDING TO CLASS-I VIRAL FUSION PROTEINS AND METHODS FOR PRODUCING THE SAME - Single-chain Alphabodies that comprise an alpha-helical binding region which mediates binding to a first fusion-driving region of a class-1 viral fusion protein and which structurally mimics a second fusion-driving region of said class-1 viral fusion protein, wherein said first and second fusion-driving regions of said class-1 viral fusion protein are regions which interact to drive the fusion between a virus displaying said class-1 viral fusion protein and a target cell. | 10-03-2013 |
20140057830 | ALPHABODIES SPECIFICALLY BINDING TO CYTOKINES OR GROWTH FACTORS AND/OR CYTOKINE OR GROWTH FACTOR RECEPTORS - Alphabodies that specifically bind to cytokines or growth factor and/or their receptors, as well as polypeptides that comprise or essentially consist of such Alphabodies. Further nucleic acids encoding such Alphabodies; methods for preparing such Alphabodies and polypeptides; host cells expressing or capable of expressing such Alphabodies and polypeptides; compositions, and in particular pharmaceutical compositions, that comprise such Alphabodies, polypeptides, nucleic acids and/or host cells; and uses of such Alphabodies or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes. | 02-27-2014 |
20140294828 | ALPHABODIES SPECIFICALLY BINDING TO VIRAL PROTEINS AND METHODS FOR PRODUCING THE SAME - The invention provides methods for the production of single-chain Alphabody polypeptides having detectable binding affinity for, or detectable in vitro activity on, a viral protein of interest, which comprising the step of producing a single-chain Alphabody library comprising at least 100 different-sequence single-chain Alphabody polypeptides, wherein said Alphabody polypeptides differ from each other in at least one of a defined set of 5 to 20 variegated amino acid residue positions, and wherein said variegated amino acid residue positions are located at specific positions in one or more of the alpha-helices of the Alphabody or the linker fragment connecting two consecutive alpha-helices of the Alphabody polypeptides. The invention further provides Alphabodies obtainable by the methods of the invention and uses thereof. | 10-02-2014 |
Patent application number | Description | Published |
20090305009 | PRINTED SUBSTRATE, METHOD FOR MANUFACTURING FLOOR PANELS AND METHOD FOR MANUFACTURING PRINTED SUBSTRATES - A printed substrate may be used for manufacturing floor panels that have at least a basic panel and provided thereon a top layer with a printed decor. The printed substrate may include a print. The print may include the printed decors of a plurality of the floor panels. The printed decors in the print may be grouped in stripes of similar tint. | 12-10-2009 |
20100242391 | FLOOR PANEL, AS WELL AS METHOD, DEVICE AND ACCESSORIES FOR MANUFACTURING SUCH FLOOR PANEL - Floor panel, more particularly a laminate floor panel, wherein this floor panel comprises a decor, a top layer on the basis of synthetic material, and an underlying substrate ( | 09-30-2010 |
20110120634 | METHOD FOR MANUFACTURING A LAMINATE PRODUCT, LAMINATE PRODUCTS OBTAINED THEREBY AND DEVICE FOR REALIZING THE METHOD - Method for manufacturing a laminate product comprising at least a laminate layer with a decor sheet, wherein, for forming the laminate layer, at least a decor sheet is formed by providing in a decor application process a decor in the form of a motif on a decor carrier, wherein this decor carrier consists of a continuous material web, wherein the decor is applied by means of one or more digital printers and wherein the global decor during the processing of the material web is controlled in a varying manner, by means of controlling the one or more printers, as a function of varying external data. | 05-26-2011 |
20110200750 | METHODS FOR MANUFACTURING PANELS AND PANEL OBTAINED HEREWITH - Method for manufacturing panels of the type which is composed at least of a substrate and a top layer with a printed decor, wherein the top layer comprises at least two material layers, and wherein for manufacturing, one starts from larger boards, wherein the method consists at least of providing said two material layers and performing a print directly on the substrate material, wherein at least a first of said two material layers is provided on the surface of the larger board before it is subdivided, whereas at least a second of said two material layers is provided on the surface of one or more of the smaller panels obtained by subdividing. | 08-18-2011 |
20110311806 | METHOD FOR MANUFACTURING PANELS AND PANELS OBTAINED HEREBY - A method for manufacturing panels including a substrate on the basis of a pressed material mass, whereby it is started from a material mass to be densified, wherein the density of this material mass, in one or more densifying steps, is at least doubled. Prior to one or more of these densifying steps, a colorant is added to the material mass. | 12-22-2011 |
20110318507 | METHOD FOR MANUFACTURING PANELS AND PANELS OBTAINED THEREBY - A method for manufacturing coated panels of the type including at least a substrate and a top layer, provided on the substrate, with a motif, may involve providing a synthetic material layer on the substrate, and providing a relief on the surface of the synthetic material layer. The relief may show a pattern of recesses and/or protrusions. The pattern may be at least partially determined using a light-projection technique. | 12-29-2011 |
20130062006 | PANEL AND METHODS FOR MANUFACTURING PANELS - A panel may include at least a substrate and a top layer provided on the substrate. The top layer may include a vinyl-based synthetic material layer. The substrate may be a wood-based substrate. A primer may be provided between the substrate and the vinyl-based synthetic material layer. | 03-14-2013 |
20130067842 | FLOOR PANEL AND METHODS FOR MANUFACTURING FLOOR PANELS - In a method for manufacturing floor panels that have at least a substrate and a top layer provided on the substrate, the top layer including a thermoplastic layer that is translucent or transparent, the method may involve providing the top layer, including the thermoplastic layer, on the substrate. The method may also involve heating at least the thermoplastic layer, and structuring the thermoplastic layer using a mechanical press element. | 03-21-2013 |
20130104478 | PANEL FOR FORMING A FLOOR COVERING | 05-02-2013 |
20130104485 | FLOOR PANEL | 05-02-2013 |
20130295352 | Method for Manufacturing a Laminate Product, Laminate Products Obtained Thereby and Device for Realizing the Method - Method for manufacturing a laminate product comprising at least a laminate layer with a decor sheet, wherein, for forming the laminate layer, at least a decor sheet is formed by providing in a decor application process a decor in the form of a motif on a decor carrier, wherein this decor carrier consists of a continuous material web, wherein the decor is applied by means of one or more digital printers and wherein the global decor during the processing of the material web is controlled in a varying manner, by means of controlling the one or more printers, as a function of varying external data. | 11-07-2013 |
20140020820 | METHODS FOR MANUFACTURING FLOOR PANELS - In a method for manufacturing floor panels that have at least a substrate and a top layer provided on the substrate, the top layer including a thermoplastic layer that is translucent or transparent, the method may involve providing the top layer, including the thermoplastic layer, on the substrate. The method may also involve heating at least the thermoplastic layer, and structuring the thermoplastic layer using a mechanical press element. | 01-23-2014 |
20140290158 | FLOOR PANEL - In a method for manufacturing floor panels that have at least a substrate and a top layer provided on the substrate, the top layer including a thermoplastic layer that is translucent or transparent, the method may involve providing the top layer, including the thermoplastic layer, on the substrate. The method may also involve heating at least the thermoplastic layer, and structuring the thermoplastic layer using a mechanical press element. | 10-02-2014 |
20140332431 | PACKAGED SET OF PANELS - Packaged set of panels, such as furniture, floor, ceiling and/or wall panels, consisting of a package, wherein this package is at least composed of, on the one hand, one or more panels, which, at least on one pair of opposite panel edges, comprise coupling parts, or tiles of a stone-like material, whether or not comprising coupling parts, and, on the other hand, a packaging, consisting of one or more packaging parts, wherein the package comprises at least one crumple zone. | 11-13-2014 |