Mcmanus
Bruce Mcmanus, Vancouver CA
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20100317038 | GRANZYME A AND GRANZYME B DIAGNOSTICS - A method for identifying a subject being at risk for or having a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease is provided. The method may include determining the concentration of GrA and/or GrB in a blood or serum sample from said subject; and comparing the concentrations to the corresponding concentration in a control sample, wherein an elevated concentration of GrA and/or GrB may be indicative of a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease. The method may further include identifying concentrations of fibrinogen, elastin and/or fibrillin. | 12-16-2010 |
20110171645 | METHODS OF DIAGNOSING ACUTE CARDIAC ALLOGRAFT REJECTION - The present invention relates to methods of diagnosing acute rejection of a cardiac allograft using genomic expression profiling, proteomic expression profiling, metabolite profiling, or alloreactive T-cell genomic expression profiling, | 07-14-2011 |
20110189680 | Methods of Diagnosing Rejection of a Kidney Allograft Using Genomic or Proteomic Expression Profiling - A method of determining the acute allograft rejection status of a subject, the method comprising the steps of: determining the nucleic acid expression profile of one or more than one nucleic acid markers, or one or more than one proteomic markers in a biological sample from the subject; comparing the expression profile of the one or more than one nucleic acid markers to a control profile; and determining whether the expression level of the one or more than one nucleic acid markers is increased relative to the control profile, wherein the increase of the one or more than one nucleic acid markers is indicative of the acute rejection status of the subject. | 08-04-2011 |
20110190151 | METHODS OF DIAGNOSING CHRONIC CARDIAC ALLOGRAFT REJECTION - The present invention relates to methods of diagnosing chronic rejection of a cardiac allograft using genomic expression profiling, proteomic expression profiling, or a combination of genomic and proteomic expression profiling. | 08-04-2011 |
20110229546 | TREATMENT OF DISSECTION, ANEURYSM, AND ATHEROSCLEROSIS USING GRANZYME B INHIBITORS - A method of medical treatment or prevention of a vasculopathy, comprising administering a therapeutically effective amount of a granzyme B inhibitor to a subject in need thereof is provided. In other aspects uses of Granzyme B inhibitors for treatment or for preparation of medicaments for treatment of a vasculopathy are provided. | 09-22-2011 |
20130323749 | GRANZYME A AND GRANZYME B DIAGNOSTICS - A method for identifying a subject being at risk for or having a chronic Inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease is provided. The method may include determining the concentration of GrA and/or GrB in a blood or serum sample from said subject; and comparing the concentrations to the corresponding concentration in a control sample, wherein an elevated concentration of GrA and/or GrB may be indicative of a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease. The method may further include identifying concentrations of fibrinogen, elastin and/or fibrillin. | 12-05-2013 |
20140255953 | GRANZYME A AND GRANZYME B DIAGNOSTICS - A method for identifying a subject being at risk for or having a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease is provided. The method may include determining the concentration of GrA and/or GrB in a blood or serum sample from said subject; and comparing the concentrations to the corresponding concentration in a control sample, wherein an elevated concentration of GrA and/or GrB may be indicative of a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease. The method may further include identifying concentrations of fibrinogen, elastin and/or fibrillin. | 09-11-2014 |
20150133326 | BIOMARKERS FOR RECOVERED HEART FUNCTION - Disclosed herein is a method for determining recovered heart function in a subject based in the biomarker ceruloplasmin in patient samples. Also disclosed are computer systems, kits and software. | 05-14-2015 |
Colin Alexander Mcmanus, Oxford, Oxfordshire GB
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20150356357 | A METHOD OF DETECTING STRUCTURAL PARTS OF A SCENE - A method of detecting the structural elements within a scene sensed by at least one sensor within a locale, the method comprising: a) capturing data from the sensor, which data provides a first representation of the sensed scene at the current time; b) generating a second representation of the sensed scene where the second representation is generated from a prior model of the locale; and c) comparing the first and second representations with one another to determine which parts of the first representation represent structural elements of the locale. | 12-10-2015 |
David Ellis Mcmanus, Melbourne AU
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20110028427 | DIETARY FIBER AND METHOD FOR PREPARING DIETARY FIBER - The invention relates to a soluble antioxidant dietary fiber obtained from pineapple and a method of processing pineapple pulp to provide a soluble antioxidant fiber. | 02-03-2011 |
Donald Peter Mcmanus, Queensland AU
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20110158998 | HELMINTH ANTIGEN AND IMMUNOTHERAPY - A helminth protein immunogen is described. Included as the immunogen is an isolated protein comprising an immunogenic, extracellular fragment of a schistosome tegument protein selected from the group consisting of a TSP-1 protein; a TSP-2 protein; and a 7TM protein. An antibody which binds the isolated protein is also described. Additionally, an immunotherapeutic composition comprising the immunogenic protein and an immunologically acceptable carrier, diluent or excipient is described. Furthermore, a vaccine comprising the immunogenic protein is described. Also described are an isolated nucleic acid that encodes the immunogenic protein and a genetic construct comprising that isolated nucleic acid. Further, a host cell comprising the genetic construct is described. A method of immunizing against | 06-30-2011 |
Eamonn P. Mcmanus, Grenoble FR
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20110289192 | CONTROLLING A RUNNING APPLICATION FOR LIVE SCENE GRAPH EDITING - In general, in one aspect, the invention relates to a computer readable medium including software instructions for performing a method, the method including receiving, by a content server, a first request from a client for an application content file, wherein the application content file is associated with a first Java network launch protocol (JNLP) file, providing, in response to the first request, the application content file; receiving, from the client, a second request to edit the application content file, providing, in response to the second request, an application designer tool to the client; receiving, from the client, an altered application content file generated using the application designer tool, generating a second JNLP file associated with the altered application content file, and providing, to a webserver, the second JNLP file. | 11-24-2011 |
Ian Mcmanus, Queensland AU
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20110305260 | SYSTEM AND METHOD OF REFERENCE POSITION DETERMINATION - A method of reference position determination for a DGNSS base station. The base station comprises a memory, a logic controller and a GNSS receiver. Stored reference positions are stored in the memory as coordinate sets comprising components. The GNSS receiver determines a current estimate position of the base station as a coordinate set comprising components. The logic controller retrieves a stored reference position, converts the components of the stored reference position and the current estimate position to binary string format. The current estimate position is matched to the stored reference position by matching the binary string format components of the current estimate position with the binary string format components of the stored reference position. If the stored reference position is matched to the current estimate position, the base station is assigned the stored reference position as its reference position. | 12-15-2011 |
Jeff Mcmanus, Buckinghamshire GB
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20140304015 | APPARATUS AND METHOD FOR MANAGING ACCESS TO A RESOURCE - There is provided a resource access management system for managing user access to a resource having a number of resource slots, wherein each resource slot can be used by a user. The resource access management system comprises a standard access configured to allow users to access the resource, and a queue-less access configured to allow users that have a valid authorisation to access the resource. The resource access management system is configured, for each occurrence of the resource, to make a portion of the resource slots available for allocation to users that access the resource using the queue-less access, to make at least the remaining resource slots available for use by users that access the resource using the standard access, and to ensure that a number of authorisations issued for an occurrence of the resource does not exceed the number of allocable resource slots. | 10-09-2014 |
20150142481 | APPARATUS AND METHOD FOR MANAGING ACCESS TO A RESOURCE - A resource access management system and method for managing user access to a resource having a number of resource slots. Each resource slot can be used by a user. The resource access management system is provided with a primary access configured to allow a user to access the resource, the primary access having a first entry point and a first exit point. A secondary access is also provided that is configured to allow users to access the resource. The resource access management system is configured to determine an apparent wait time based on a number of users entering the primary access and the secondary access, and a predetermined resource time associated with the resource. The resource access management system is further configured to periodically determine an actual wait time of a selected user between entering the first entry point and exiting first exit point, and can then calculate a wait time for the primary access using both the apparent wait time and the actual wait time. | 05-21-2015 |
Moyra K. Mcmanus, Veldhoven NL
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20150066467 | POWER AND PERFORMANCE SORTING OF MICROPROCESSORS FROM FIRST INTERCONNECT LAYER TO WAFER FINAL TEST - A system, method and computer program product for sorting Integrated Circuits (chips), particularly microprocessor chips, and particularly that predicts chip performance or power for sorting purposes. The system and method described herein uses a combination of performance-predicting parameters that are measured early in the process, and applies a unique method to project where the part, e.g., microprocessor IC, will eventually be sorted. Sorting includes classifying the IC product to a subset of a family of products with the product satisfying certain performance characteristics or specifications, in the early stages of manufacturing, e.g., before the end product is fully fabricated. | 03-05-2015 |
Owen Ross Mcmanus, County Dublin IE
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20090297474 | Method for Detecting or Monitoring Sepsis by Analysing Cytokine mRNA Expression Levels - The present invention relates to a method for identifying patients who are likely to develop sepsis in response to infection, a method for monitoring the progress of sepsis in a patient and to an assay kit for identifying patients who are likely to develop sepsis and/or monitoring the progress of sepsis. | 12-03-2009 |
20130040299 | METHOD FOR DETECTING OR MONITORING SEPSIS BY ANALYSING CYTOKINE MRNA EXPRESSION LEVELS - The present invention relates to a method for identifying patients who are likely to develop sepsis in response to infection, a method for monitoring the progress of sepsis in a patient and to an assay kit for identifying patients who are likely to develop sepsis and/or monitoring the progress of sepsis. | 02-14-2013 |
Owen Ross Mcmanus, Co. Dublin IE
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20140051073 | METHOD OF ESTIMATING RISK OF SEVERE SEPSIS IN AN INDIVIDUAL WITH INFECTION - A method of estimating sepsis risk in an individual with infection comprises a step of assaying a biological sample from the individual for an IL-2 or IL-7 mRNA value, and correlating the mRNA value with sepsis risk. The IL-2 and IL-7 mRNA values are quantified by absolute quantification of mRNA copy number, wherein the copy numbers are normalised to a house keeping gene and corrected against a calibration curve for serial dilutions of the IL-2 and IL-7 cDNA. The method generally involves a step of assaying a biological sample from the individual for IL-2 and/or IL-7 mRNA values, optionally in combination with mRNA values for other cytokines, and correlating a sum or difference of the values with sepsis risk. | 02-20-2014 |
Owen Ross Mcmanus, Killiney IE
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20120129176 | CYTOKINES AS PROGNOSTIC MARKERS OF RESPIRATORY-TRACT INFECTION FOLLOWING MAJOR SURGERY - The invention relates to the use of a certain subset of cytokine markers as prognostic variables of infection status in an individual, and especially as prognostic markers of a patients developing severe infection such as pneumonia, and respiratory tract infection following surgery. The subset of cytokine markers consists of the interleukin cytokines IL-2, IL-7, IL-23, IL-27, and IL-IO, and Interferon-γ (INFγ) and Tissue Necrosis Factor-α (TNFα). The markers may be employed as individual prognostic variables of infection status, or they may be used in pairs or other combinations. Generally, the abundance of the markers is correlated with infection status by means of an absolute pre-operative value of biomarker abundance, ratio's of pre-operative to post-operative biomarker abundance, or ratio values for pairs of certain biomarkers within the subset. Typically, cytokine abundance is expressed in terms of mRNA copy number wherein the copy numbers are ideally normalised to a house keeping gene and quantification of mRNA copy number is determined by RT-PCR containing reference serial dilutions of cytokine specific cDNA. | 05-24-2012 |
20120149785 | METHOD OF ESTIMATING SEPSIS RISK IN AN INDIVIDUAL WITH INFECTION - A method of estimating sepsis risk in an individual with infection comprises a step of assaying a biological sample from the individual for an IL-2 or IL-7 mRNA value, and correlating the mRNA value with sepsis risk. The IL-2 and IL-7 mRNA values are quantified by absolute quantification of mRNA copy number, wherein the copy numbers are normalised to a house keeping gene and corrected against a calibration curve for serial dilutions of the IL-2 and IL-7 cDNA. The method generally involves a step of assaying a biological sample from the individual for IL-2 and/or IL-7 mRNA values, optionally in combination with mRNA values for other cytokines, and correlating a sum or difference of the values with sepsis risk using a regression analysis curve against outcome. | 06-14-2012 |
20150197808 | CYTOKINES AS PROGNOSTIC MARKERS OF RESPIRATORY-TRACT INFECTION FOLLOWING MAJOR SURGERY - The invention relates to the use of a certain subset of cytokine markers as prognostic variables of infection status in an individual, and especially as prognostic markers of a patients developing severe infection such as pneumonia, and respiratory tract infection following surgery. The subset of cytokine markers consists of the interleukin cytokines IL-2, IL-7, IL-23, IL-27, and IL-10, and Interferon-γ (INFγ) and Tissue Necrosis Factor-α (TNFα). The markers may be employed as individual prognostic variables of infection status, or they may be used in pairs or other combinations. Generally, the abundance of the markers is correlated with infection status by means of an absolute pre-operative value of biomarker abundance, ratio's of pre-operative to post-operative biomarker abundance, or ratio values for pairs of certain biomarkers within the subset. Typically, cytokine abundance is expressed in terms of mRNA copy number wherein the copy numbers are ideally normalised to a house keeping gene and quantification of mRNA copy number is determined by RT-PCR containing reference serial dilutions of cytokine specific cDNA. | 07-16-2015 |
Ronan B. Mcmanus, Bray IE
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20100204548 | Instrument Access Device - An instrument access device comprises first, second and third instrument seals for sealing around instruments extended through the device. The seals have respective connector sleeves. Each sleeve connects a base to one of the instrument seals. The device also comprises two insufflation/desufflation ports. Each of the ports comprises a connector extending from the base, a tube extending from the connector, a luer connector and a removable cap. The luer connector is used for connection to any suitable supply line for insufflation gas or for discharge if insufflation gas. In use, the insufflation/desufflation ports facilitate independent control of insufflation and desufflation as may be required during a surgical procedure. Access sleeve at the proximal end is cut-off, folded over the inner proximal ring and is held in place between the base and the inner proximal ring when the base is fitted. The proximal end of the sleeve that is generated when the sleeve is pulled upwardly to retract an incision is removed from the field of use. | 08-12-2010 |
20100217087 | INSTRUMENT ACCESS SYSTEM - An instrument access device comprises a base which is mounted to a proximal ring assembly of a retractor. A first, second and third connector sleeves connect first, second and third seal assemblies to a connector base. The connector sleeves are of a laterally flexible and longitudinally rigid material. At least some of the first, second and third seal assemblies comprise a lipseal through which an instrument is inserted and a second seal having a passageway through which the instrument is insertable. At least one of the seal assemblies has a reducer cap which has a further lipseal. To insert large diameter instruments the cap is removed. To insert smaller diameter instruments the cap is in place. The access device has two insufflation/desufflation ports. | 08-26-2010 |
20110071359 | Instrument Access Device - An instrument access device | 03-24-2011 |
20130041231 | Instrument Access Device - An instrument access device | 02-14-2013 |
Ronan B. Mcmanus, County Wicklow IE
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20140107425 | INSTRUMENT ACCESS DEVICE - An instrument access device comprises first, second and third instrument seals for sealing around instruments extended through the device. The seals have respective connector sleeves. Each sleeve connects a base to one of the instrument seals. The device also comprises two insufflation/desufflation ports. Each of the ports comprises a connector extending from the base, a tube extending from the connector, a luer connector and a removable cap. The luer connector is used for connection to any suitable supply line for insufflation gas or for discharge if insufflation gas. In use, the insufflation/desufflation ports facilitate independent control of insufflation and desufflation as may be required during a surgical procedure. Access sleeve at the proximal end is cut-off, folded over the inner proximal ring and is held in place between the base and the inner proximal ring when the base is fitted. The proximal end of the sleeve that is generated when the sleeve is pulled upwardly to retract an incision is removed from the field of use. | 04-17-2014 |
Shane Mcmanus, Vienna AT
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20130030007 | Obesity Small Molecules - The present invention relates to new therapies to treat obesity and related diseases, as well as for reducing triglyceride levels and body weight. | 01-31-2013 |
20130252924 | Compounds and Methods for Treating Pain - The present invention relates to new therapies to treat pain and related diseases, as well as pharmaceutical compounds for use in said therapies. | 09-26-2013 |
20140349969 | COMPOUNDS AND METHODS FOR TREATING PAIN - The present invention relates to new therapies to treat pain and related diseases, as well as pharmaceutical compounds for use in said therapies. | 11-27-2014 |
Soussamay Mcmanus, Waterloo CA
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20140089547 | SMART PLUG OR CRADLE - There is provided a method and apparatus for allowing a user of a mobile device to securely access a storage device of a home network of the user. The method and apparatus advantageously allow for the user to share data stored on the home network with other users, or to give full or restricted access to other computing devices. The apparatus consists of a network element residing on the home network of the user, which enables communications between the network storage and the mobile device when the mobile device is in a remote location. | 03-27-2014 |
Terry Michael Mcmanus, Mawson AU
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20110100722 | ROTARY ROLLER REAMER - A bore hole rotary reamer includes a body having cutters rotatably mounted by one or more respective spindles. A bearing region is formed on the spindle. At least one annular seal prevents ingress of contaminant to the bearing region. A circumferential void is formed adjacent the seal. At least one passageway extends in an axial direction of the spindle to the circumferential void and a piston movable in the passageway in response to supply of pressure to an outer side of the piston from the environment which surrounds the reamer. The piston transfers pressure to fluid in the cylindrical passage on an inner side of the piston to supply pressure to the circumferential void and thereby to the seal. The pressure is substantially determined by the pressure of the environment surrounding the reamer. | 05-05-2011 |
Terry Michael Mcmanus, South Australia AU
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20080202818 | Rotary Roller Reamer - A bore hole rotary reamer ( | 08-28-2008 |