Patent application number | Description | Published |
20090305276 | Method for Predicting Skin Sensitizing Activity of Compounds - The present invention provides methods for predicting the in vivo skin sensitizing activity of chemical compounds using a combination of mammalian cell models with multiple endpoint analysis, time and concentration response curves. The methods allow the determination of a predicted in vivo sensitization value of a compound—for example, a EC3 LLNA value, a GPMT value or a IVTI value—without the use of animals, with a high degree of accuracy. The methods involve detecting expression levels of genes implicated in skin sensitization, combining expression level data with concentration response data, conducting a computational analysis, and comparing test compound data to a database of known skin sensitizers. | 12-10-2009 |
20110004414 | Method for Predicting Respiratory Toxicity of Compounds - The invention provides methods for analyzing and predicting the in vivo respiratory toxicity of a compound (e.g., pharmaceutical, biological, cosmetic, or chemical compounds) or composition comprising a combination of an in vitro mammalian cell model with multiple endpoint analysis, and time and concentration response curves. The methods allow the determination of a predicted in vivo respiratory toxicity value of a compound without the use of animals, with a high degree of accuracy. The methods comprise detecting any combination of cell viability markers and expression levels of genes implicated in respiratory toxicity and/or sensitization, such as pro-inflammatory response genes, combining the viability and gene expression level data with concentration response and time response data, conducting a computational analysis, and comparing test compound data to a database of known respiratory toxicants/sensitizers to predict and/or analyze the respiratory toxicity. An indication of organ specificity is provided by a toxicity index, which is determined by comparing mean IC | 01-06-2011 |
20110008823 | TOXICITY SCREENING METHODS - The present invention provides methods of determining a level of toxicity of a given compound based on in vitro assays. The present invention provides particular methods of determining organ-specific toxicity and species-specific toxicity of a given compound based on in vitro assays. In addition, the present invention provides methods of determining a level of toxicity in normal tissue for an anti-tumor compound. The methods include providing at least one cell type and culturing the cell type in the presence of at least one concentration of the chemical compound, measuring at least one indicator of cell health at the at least one concentration of compound for the at least one cell type, and performing a concentration response analysis, from which a toxic concentration can be determined. | 01-13-2011 |
20120179381 | TOXICITY SCREENING METHODS - In vitro methods for predicting in vivo toxicity of chemical compounds, including organ-specific and multiple organ toxicity of such chemical compounds and drug-drug interactions, understanding the relative toxicity of drug candidates and identifying mechanisms of toxicity, are disclosed. | 07-12-2012 |
20130115608 | SCREENING METHODS FOR OCULAR IRRITATION AND TOXICITY - Methods of determining a level of ocular irritation and/or toxicity for a chemical compound are described. Kits for use in methods of determining a level of ocular irritation and/or toxicity for a chemical compound are also described. | 05-09-2013 |
20130252270 | TOXICITY SCREENING METHODS - Methods of evaluating an anti-tumor compound based on in vitro assays are disclosed. The methods may determine a potency/efficacy of the anti-tumor compound as well as a toxicity of the anti-tumor compound to non-cancerous cells. | 09-26-2013 |
20140147853 | Method for Predicting Respiratory Toxicity of Compounds - The invention provides methods for analyzing and predicting the in vivo respiratory toxicity of a compound (e.g., pharmaceutical, biological, cosmetic, or chemical compounds) or composition comprising a combination of an in vitro mammalian cell model with multiple endpoint analysis, and time and concentration response curves. The methods allow the determination of a predicted in vivo respiratory toxicity value of a compound without the use of animals, with a high degree of accuracy. The methods comprise detecting any combination of cell viability markers and expression levels of genes implicated in respiratory toxicity and/or sensitization, such as pro-inflammatory response genes, combining the viability and gene expression level data with concentration response and time response data, conducting a computational analysis, and comparing test compound data to a database of known respiratory toxicants/sensitizers to predict and/or analyze the respiratory toxicity. An indication of organ specificity is provided by a toxicity index, which is determined by comparing mean 10 | 05-29-2014 |
Patent application number | Description | Published |
20120247142 | Heat Pump Pool Heater Start-Up Pressure Spike Eliminator - In a heat pump pool heater, undesirable compressor-created pressure spikes resulting from start-up of the heater after extended idle periods thereof are substantially eliminated by the incorporation in the heat pump refrigerant circuit of a specially designed pressure spike eliminator structure. The spike eliminator structure includes an enclosed hollow wall structure extending around a first refrigerant tubing portion disposed between the heat pump circuit compressor and condenser and forming a cavity around the first refrigerant tubing portion, and a transfer tube directly connected to a second refrigerant tubing portion disposed between the condenser and expansion valve and intercommunicating the interiors of the cavity and the second refrigerant tubing portion. | 10-04-2012 |
20130287373 | Endothermic Base-Mounted Heat Pump Water Heater - An endothermic heat pump water heater has a water tank supported atop a hollow base, a heat pump circuit operable to provide primary heat to water in the tank, and an electric resistance heating element operable to provide secondary heat to the water. The heat pump circuit includes refrigerant tubing in which a compressor disposed within the base, a condenser in heat exchange external contact with the tank, a refrigerant expansion device, and an evaporator disposed within the base are connected in series. A vertical duct, external to the tank, has an inlet adjacent the upper tank end, and a fan is operative to sequentially flow air inwardly through the inlet, downwardly through the duct into the base, across the compressor, across the evaporator, and then outwardly from the base. | 10-31-2013 |
Patent application number | Description | Published |
20090213984 | Computed Tomography Systems and Related Methods Involving Post-Target Collimation - Computed tomography (CT) systems and related methods involving post-target collimation are provided are provided. In this regard, a representative method involving post-target collimation of X-rays includes: emitting X-rays toward a target; and collimating the X-rays downstream of the target. | 08-27-2009 |
20090213994 | Computed Tomography Systems and Related Methods Involving Forward Collimation - Computed tomography (CT) systems and related methods involving forward collimation are provided are provided. In this regard, a representative method involving forward collimation of X-rays includes: emitting X-rays from a housing in which an X-ray source is mounted; collimating the X-rays downstream of the housing; and directing the collimated X-rays at a target. | 08-27-2009 |
20090257552 | Computed Tomography Systems and Related Methods Involving Multi-Target Inspection - Computed tomography (CT) systems and related methods involving multi-target inspection are provided are provided. In this regard, a representative method includes: simultaneously directing X-rays toward multiple targets from an X-ray source; during the directing of the X-rays, independently reorienting the targets with respect to the X-ray source; and obtaining information corresponding to attenuation of the X-rays attributable to the multiple targets for producing computed tomography images of the targets. | 10-15-2009 |
20090272908 | X-Ray Detector Assemblies and Related Computed Tomography Systems - X-ray detector assemblies and related computed tomography systems are provided. In this regard, a representative X-ray detector assembly includes: a scintillator assembly having a scintillation component and an optical fiber; the scintillation component being operative to emit light responsive to X-rays being incident thereon; the optical fiber being positioned to receive light emitted from the scintillation component. | 11-05-2009 |
20100202591 | X-ray collimators, and related systems and methods involving such collimators - X-ray collimators, and related systems and methods involving such collimators are provided. In this regard, a representative X-ray collimator includes: a first member having channels located on a surface thereof; and a second member having protrusions located on a surface thereof; the first member and the second member being oriented such that the protrusions extend into the channels to define collimator apertures, each of the collimator apertures being defined by a portion of the first member and a portion of the second member. | 08-12-2010 |