Mccafferty
Gabriel G. Mccafferty, Londonderry GB
Patent application number | Description | Published |
---|---|---|
20150131182 | MAGNETIC STACK COUPLING BUFFER LAYER - A data storage system may be configured at least with a seed lamination that is disposed between a magnetic stack and a magnetic shield. The seed lamination may be constructed and operated with a coupling buffer layer and a seed layer with the coupling buffer layer fabricated of an alloy of cobalt and a transition metal. | 05-14-2015 |
Gerard Mccafferty, Glasgow GB
Patent application number | Description | Published |
---|---|---|
20140298949 | Active Vibratory Pedal Assembly - An active vibratory pedal assembly including a pedal and means integrated with the pedal for causing the vibration of the pedal which, in one embodiment, comprises a vibration generation assembly located and mounted to the underside of the pedal plate which includes an electric motor and an eccentric coupled to and rotatable relative to the motor and adapted to generate a force that causes the vibration of the pedal plate for providing an operator with a sensory signal of a vehicular condition or event such as, for example, a vehicle's excessive speed. | 10-09-2014 |
20150130447 | Actuator and Linear Position Sensor Assembly - An actuator and sensor assembly with a housing defining a pocket and an access opening. A substrate with a sensor is located in the pocket through the access opening. A nozzle extends from the housing. A sleeve surrounds the nozzle and retains a hose on the nozzle. A connector assembly is located opposite and normal the pocket and the substrate. Compliant terminal pins extend generally normally from the connector assembly into the pocket and through-holes in the substrate. An actuator shaft gimbal includes a head located in a housing collar and a flexible neck extends through a housing aperture. A shoulder on the neck of the gimbal locks the gimbal in the collar. | 05-14-2015 |
John Mccafferty, Babraham GB
Patent application number | Description | Published |
---|---|---|
20090325815 | PRODUCTION OF ANTI-SELF ANTIBODIES FROM ANTIBODY SEGMENT REPERTOIRES AND DISPLAYED ON PHAGE - Methods are disclosed for the production of anti-self antibodies and antibody fragments, being antibodies or fragments of a particular species of mammal which bind self antigens of that species. Methods comprise providing a library of replicable genetic display packages (rgdps), such as filamentous phage, each rgdp displaying at its surface member of a specific binding pair which is an antibody or antibody fragment, and each rgdp containing nucleic acid sequence derived from a species of mammal. The nucleic acid sequence in each rgdp encodes a polypeptide chain which is a component part of the sbp member displayed at the surface of that rgdp. Anti-self antibody fragments are selected by binding with a self antigen from said species of mammal. The displayed antibody fragments may be scFv, Fd, Fab or any other fragment which has the capability of binding antigen. Nucleic acid libraries used may be derived from rearranged V-gene sequences of unimmunised mammal. Synthetic or artificial libraries are described and shown to be useful. | 12-31-2009 |
John Mccafferty, Cambridge GB
Patent application number | Description | Published |
---|---|---|
20140050738 | ANTI-TACE ANTIBODY MOLECULES AND THEIR USES - Anti-TACE (ADAM17) antibodies are disclosed that for the first time in the art are capable of binding to TACE, of acting as antagonists of one or more its biological activities, in particular by binding to TACE in a cross domain binding mode in which residues in both the catalytic domain and in the cysteine rich/disintegrin domains (Dis-Cys) are involved in antibody binding to TACE, helping to improve the specificity of the antibody binding and/or helping to improve inhibition of TACE biological activity. The therapeutic uses of the antibodies, in particular for the treatment of cancer are disclosed. | 02-20-2014 |
John Mccafferty, Cambridgeshire GB
Patent application number | Description | Published |
---|---|---|
20090155810 | METHODS FOR PRODUCING MEMBERS OF SPECIFIC BINDING PAIRS - A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a secreted recombinant genetic display package (rgdp) containing DNA encoding the sbp member or a polypeptide component thereof, by virtue of the sbp member or a polypeptide component thereof being expressed as a fusion with a capsid component of the rgdp. The displayed sbps may be selected by affinity with a complementary sbp member, and the DNA recovered from selected rgdps for expression of the selected sbp members. Antibody sbp members may be thus obtained, with the different chains thereof expressed, one fused to the capsid component and the other in free form for association with the fusion partner polypeptide. A phagemid may be used as an expression vector, with said capsid fusion helping to package the phagemid DNA. Using this method libraries of DNA encoding respective chains of such multimeric sbp members may be combined, thereby obtaining a much greater genetic diversity in the sbp members than could easily be obtained by conventional methods. | 06-18-2009 |
20100317540 | METHODS FOR PRODUCING MEMBERS OF SPECIFIC BINDING PAIRS - A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a secreted recombinant genetic display package (rgdp) containing DNA encoding the sbp member or a polypeptide component thereof, by virtue of the sbp member or a polypeptide component thereof being expressed as a fusion with a capsid component of the rgdp. The displayed sbps may be selected by affinity with a complementary sbp member, and the DNA recovered from selected rgdps for expression of the selected sbp members. Antibody sbp members may be thus obtained, with the different chains thereof expressed, one fused to the capsid component and the other in free form for association with the fusion partner polypeptide. A phagemid may be used as an expression vector, with said capsid fusion helping to package the phagemid DNA. Using this method libraries of DNA encoding respective chains of such multimeric sbp members may be combined, thereby obtaining a much greater genetic diversity in the sbp members than could easily be obtained by conventional methods. | 12-16-2010 |
20120129710 | METHODS FOR PRODUCING MEMBERS OF SPECIFIC BINDING PAIRS - A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a secreted recombinant genetic display package (rgdp) containing DNA encoding the sbp member or a polypeptide component thereof, by virtue of the sbp member or a polypeptide component thereof being expressed as a fusion with a capsid component of the rgdp. The displayed sbps may be selected by affinity with a complementary sbp member, and the DNA recovered from selected rgdps for expression of the selected sbp members. Antibody sbp members may be thus obtained, with the different chains thereof expressed, one fused to the capsid component and the other in free form for association with the fusion partner polypeptide. A phagemid may be used as an expression vector, with said capsid fusion helping to package the phagemid DNA. Using this method libraries of DNA encoding respective chains of such multimeric sbp members may be combined, thereby obtaining a much greater genetic diversity in the sbp members than could easily be obtained by conventional methods. | 05-24-2012 |
20150147274 | ANTIBODIES AGAINST HGF - RECEPTOR AND USES - Antibodies which are antagonists of the human HGF receptor (MET), wherein the antibodies specifically bind to amino acid residues 568-741 of human MET (SEQ ID No: 1) with high affinity. | 05-28-2015 |
John Mccafferty, Sawston GB
Patent application number | Description | Published |
---|---|---|
20100136660 | METHODS FOR PRODUCING MEMBERS OF SPECIFIC BINDING PAIRS - A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a secreted recombinant genetic display package (rgdp) containing DNA encoding the sbp member or a polypeptide component thereof, by virtue of the sbp member or a polypeptide component thereof being expressed as a fusion with a capsid component of the rgdp. The displayed sbps may be selected by affinity with a complementary sbp member, and the DNA recovered from selected rgdps for expression of the selected sbp members. Antibody sbp members may be thus obtained, with the different chains thereof expressed, one fused to the capsid component and the other in free form for association with the fusion partner polypeptide. A phagemid may be used as an expression vector, with said capsid fusion helping to package the phagemid DNA. Using this method libraries of DNA encoding respective chains of such multimeric sbp members may be combined, thereby obtaining a much greater genetic diversity in the sbp members than could easily be obtained by conventional methods. | 06-03-2010 |
Liam Mccafferty, Angus GB
Patent application number | Description | Published |
---|---|---|
20130320171 | DISPLAY LOCATION - A method and apparatus are disclosed for locating a display of a Self-Service Terminal (SST) at a desired viewing angle. The apparatus comprises a display support that supports a display of a Self-Service Terminal (SST) and that is pivotably mounted at an edge region thereof to the terminal; a variable length member that connects a further region of the display support to the terminal; and a motor that selectively varies the length of the member, the edge region and further region being spaced apart to tilt the display at a viewing angle responsive to the length of the variable length member. | 12-05-2013 |
20140318425 | AUTOMATED TELLER MACHINE (ATM) HAVING A SIDECAR AND METHODS OF SUPPORTING AN ATM HAVING A SIDECAR - An automated teller machine (ATM) comprises a safe enclosure in which ATM modules which require a relatively higher security level are housed. The ATM further comprises a first standard enclosure housing attached to a first side of the ATM, and in which ATM modules which require a relatively lower security level are housed. The ATM also comprises a support plate secured to bottom of the safe enclosure and to bottom of the first standard enclosure housing to structurally support both the safe enclosure and the first standard enclosure housing as a unit when the ATM is lifted and thereby to allow the ATM to be lifted without applying force to the first standard enclosure housing and thereby to prevent damage to the first standard enclosure housing. | 10-30-2014 |
20150097101 | DISPLAY LOCATION - A method and apparatus are disclosed for locating a display of a Self-Service Terminal (SST) at a desired viewing angle. The apparatus comprises a display support that supports a display of a Self-Service Terminal (SST) and that is pivotably mounted at an edge region thereof to the terminal; a variable length member that connects a further region of the display support to the terminal; and a motor that selectively varies the length of the member, the edge region and further region being spaced apart to tilt the display at a viewing angle responsive to the length of the variable length member. | 04-09-2015 |
Liam Mccafferty, Dundee GB
Patent application number | Description | Published |
---|---|---|
20150348442 | TEXTURED FILM OVERLAY FOR TOUCH-SENSITIVE DISPLAYS - An overlay for a touch-sensitive display. An example overlay includes a substrate defining a substantially smooth area and a textured area wherein the textured area corresponds to a displayed key entry area of the touch-sensitive display. | 12-03-2015 |
Shawn Patrick Mccafferty, Tananger NO
Patent application number | Description | Published |
---|---|---|
20160018548 | METHODS AND APPARATUS FOR WELLBORE EVALUATION - A wellbore tool string includes a combination of acoustic inspection tool(s) and electro-mechanical inspection tool(s). The tool string is configured to combine acoustic with electro-mechanic wellbore inspection to circumvent limitations that both technologies may be subject to in wellbore environments. Anomalous data from one or more acoustic tools can be correlated with data acquired by an electro-mechanical tool incorporated into the same tool string to determine wellbore conditions that may have adversely affected the operation of the acoustic tool(s). | 01-21-2016 |