Patent application number | Description | Published |
20110063573 | RNFL MEASUREMENT ANALYSIS - One embodiment of the present invention accounts for individual anatomical variation when evaluating optical nerve fiber measurements. In one aspect, contextual information is used to compensate or correct measurement data. In another aspect, reference coordinates are remapped for improved comparison or visualization. In one embodiment of this latter aspect, the method uses measurements of nerve fiber capacity and maps of nerve fiber retinal service to improve sensitivity and specificity in eye function metrics. In one instance, we use the birefringence of nerve fibers to determine the orientation of the fibers within the RNFL. Orientation of the fibers about the ONH is indicative of the service provided by the fibers and is used to improve the interpretation of thickness measurements of the nerve fiber layer. Normalized nerve fiber measurements about the optic nerve head improve specificity and sensitivity as compared to the standard model. These improvements are a result of partitioning the normative database or modifying the measurement data prior to comparison. Statistics on normalized measurements of nerve fiber bundles also show improvements in specificity and sensitivity. | 03-17-2011 |
20130120757 | METHODS, SYSTEMS AND APPLICATIONS OF VARIABLE IMAGING DEPTH IN FOURIER DOMAIN OPTICAL COHERENCE TOMOGRAPHY - Systems, methods and applications for adjusting the imaging depth of a Fourier Domain optical coherence tomography system without impacting the axial resolution of the system are presented. One embodiment of the invention involves changing the sweep rate of a swept-source OCT system while maintaining the same data acquisition rate and spectral bandwidth of the source. Another embodiment involves changing the data acquisition rate of a SS-OCT system while maintaining the same sweep rate over the same spectral bandwidth. Several applications of variable imaging depth in the field of ophthalmic imaging are described. | 05-16-2013 |
20130218927 | METHOD FOR SCALING OPHTHALMIC IMAGING MEASUREMENTS TO REFLECT FUNCTIONAL DISABILITY RISK - Methods for relating ophthalmic structural measurements to ophthalmic function are presented. The central idea is that each value for a given structural measurement can be empirically associated with a certain likelihood of disability or reduced function by measuring relevant patient populations in which some subjects have those disabilities This method is intended as an aid to doctors who manage glaucoma, or for the study of glaucoma or glaucoma therapy in clinical trials. The method could also be used in other progressive diseases where more than one method is used to diagnose and manage disease, and it is desirable to use a structural method to predict the risk of further functional loss. | 08-22-2013 |
20130286354 | ASSESSMENT OF RETINAL DISRUPTION - Systems and methods for improving the assessment of disruption or abnormalities to retinal layers are presented. The disruptions are detected by analyzing at least one segmented boundary of optical coherence tomography data. Several different types of analysis can be used alone or in combination to make an assessment of the level of disruption to the particular boundary or layer defined by the boundary. The results can be presented as an end face image and quantified to report an amount of disruption. In one embodiment, a method for determining the disruption to the photoreceptor outer segment is described. | 10-31-2013 |
20130301008 | ANALYSIS AND VISUALIZATION OF OCT ANGIOGRAPHY DATA - Methods for analyzing and visualizing OCT angiography data are presented. In one embodiment, an automated method for identifying the foveal avascular zone in a two dimensional en face image generated from motion contrast data is presented. Several 3D visualization techniques are presented including one in which a particular vessel is selected in a motion contrast image and all connected vessels are highlighted. A further embodiment includes a stereoscopic visualization method. In addition, a variety of metrics for characterizing OCT angiography image data are described. | 11-14-2013 |
20140276025 | MULTIMODAL INTEGRATION OF OCULAR DATA ACQUISITION AND ANALYSIS - Regions-of-interest discovered from analyses of images obtained from one imaging modality can be further observed, analyzed, supplemented, and further analyzed by one or more additional imaging modalities and in an automated way. In addition, one or more pathologies identified from analyses of these regions-of-interest, and a metric of the likelihood of the presence of disease, and/or a metric of risk of disease progression can be derived therefrom. | 09-18-2014 |
20140307933 | METHODS TO REDUCE VARIANCE IN OCT ANALYSIS OF THE MACULA - Methods for analyzing optical coherence tomography (OCT) images of the macula to reduce variance and improve disease diagnosis are presented. One embodiment of the invention is directed towards selecting analysis locations and data segmentation techniques to take advantage of structural homogeneities. Another embodiment is directed towards reducing the variance in a collection of normative data by transforming the individual members of the database to correspond to a Standard Macula. Variations in foveal size are corrected by radial transformation. Variations in layer thickness are corrected by axial shifting. Diagnosis is performed by comparing OCT images from a patient to the improved normative database. | 10-16-2014 |
20150305614 | METHODS AND SYSTEMS FOR AUTOMATIC DETECTION AND CLASSIFICATION OF OCULAR INFLAMMATION - Systems and methods to improve the detection and classification of inflammation in the eye are presented. The inflammatory markers in image data can be graded by comparing identified and extracted characteristics from the images with characteristics derived from a set of images of eyes from a general population of subjects. The image data can be divided into sub-regions for analysis to better isolate the true inflammatory markers from the impacts of cataracts or other opacities. In another embodiment, the location of an imaging beam can be controlled to minimize the impact of lens opacities from the collected data used to analyze the inflammation state of an eye. | 10-29-2015 |