Marvin J.
Marvin J. Antill, Sr., Houma, LA US
Patent application number | Description | Published |
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20090274520 | UNDERWATER TRENCHING APPARATUS - An underwater trenching system is mountable on a side of a barge to be propelled by the barge along a waterway, the bed of which contains a trench with a laid pipeline. To remove the excess sediment from the trench the trenching unit delivers pressurized water and air to the trench. A sparge assembly with jet nozzles directs jets of water, breaking up the formation that has built up around the pipeline. The airlift assembly creates a turbulent flow to lift the disturbed sediment and remove it from the created trench. | 11-05-2009 |
20100129158 | Underwater trenching apparatus - An underwater trenching system is mountable on a side of a barge to be propelled by the barge along a waterway, the bed of which contains a trench with a laid pipeline. To remove the excess sediment from the trench the trenching unit delivers pressurized water and air to the trench. A sparge assembly with jet nozzles directs jets of water, breaking up the formation that has built up around the pipeline. The airlift assembly creates a turbulent flow to lift the disturbed sediment and remove it from the created trench. | 05-27-2010 |
Marvin J. Grubman, Greenport, NY US
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20090269372 | Enhanced Antiviral Activity Against Foot and Mouth Disease - Previously, we showed that type I interferon (alpha/beta interferon [IFN-α/β]) can inhibit foot-and-mouth disease virus (FMDV) replication in cell culture, and swine inoculated with 10 | 10-29-2009 |
Marvin J. Grubman, Southold, NY US
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20090253185 | AVIPOX RECOMBINANTS EXPRESSING FOOT AND MOUTH DISEASE VIRUS GENES - The present invention relates to modified poxyiral vectors and to methods of making and using the same. In particular, the invention relates to recombinant avipox that expresses gene products of foot and mouth disease virus (FMDV), and to compositions or vaccines that elicit immune responses directed to FMDV gene products and which can confer protective immunity against infection by FMDV. | 10-08-2009 |
20110177123 | Recombinant Live Attenuated Foot-and-Mouth Disease (FMD) Vaccine Containing Mutations in the L Protein Coding Region - Previously we have identified a conserved domain (SAP, for SAF-A/B, Acinus, and PIAS) in the foot-and-mouth disease virus (FMDV) leader (L) protein coding region that is required for proper sub-cellular localization and function. Mutation of isoleucine 55 and leucine 58 to alanine (I55A, L58A) within the SAP domain resulted in a viable virus that displayed a mild attenuated phenotype in cell culture, along with altered sub-cellular distribution of L and failure to induce degradation of the transcription factor nuclear factor kappa-B. Here we report that inoculation of swine and cattle with this mutant virus results in the absence of clinical disease, the induction of a significant FMDV-specific neutralizing antibody response, and protection against subsequent homologous virus challenge. Remarkably, swine vaccinated with SAP mutant virus are protected against wild type virus challenge as early as two days post-vaccination suggesting that a strong innate as well as adaptive immunity is elicited. This variant could serve as the basis for construction of a live-attenuated FMD vaccine candidate. | 07-21-2011 |
20120164171 | Antiviral Activity of Bovine Type III Interferon Against Foot-and-Mouth Disease Virus - Interferons are the first line of defense against viral infections and administration of interferons as biotherapeutics has been demonstrated to be effective in controlling several viral infections. Here we report for the first time the identification and characterization of a member of the bovine type III IFN family, boIFN-λ3. We have expressed boIFN-λ3 using a recombinant replication defective human adenovirus type 5 (Ad5) and demonstrated antiviral activity against foot-and-mouth disease virus (FMDV) and vesicular stomatitis virus (VSV) in bovine cells in vitro. Furthermore, we have tested the efficacy of boIFN-λ3 against FMDV in vivo by inoculation of cattle with Ad5-boIFN-λ3 followed by intradermolingual or aerosol virus challenge. Our results demonstrate that the type III IFN family is conserved in bovines and that treatment of cattle with boIFN-λ3 alone or in combination with IFN-α is able to confer delayed and reduced severity of FMD. Furthermore inoculation with Ad5-boIFN-λ3 alone conferred full protection against aerosol challenge for at least 7 days after administration suggesting that type III IFN used in combination with FMD vaccines could fill one of the current gaps in emergency vaccination against FMDV. | 06-28-2012 |
Marvin J. Miller, Notre Dame, IN US
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20130143841 | BENZOHETEROCYCLIC ANTI-BACTERIAL AGENTS - Embodiments herein provide compounds and methods of making and using such compounds for prevention and treatment of multidrug resistant bacteria. In particular, embodiments are directed to anti-bacterial agents from benzo[d]heterocyclic scaffolds for prevention and treatment of multidrug resistant bacteria. | 06-06-2013 |
Marvin J. Slepian, Tucson, AZ US
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20100062519 | Portable organ and tissue preservation apparatus, kit and methods - An organ and tissue preservation and transport apparatus comprising a chamber, a temperature control mechanism and a system monitor. A medium bathes an organ within the chamber. The temperature control mechanism adjusts the temperature of the medium. The system monitors receiving and records the temperature of the chamber. | 03-11-2010 |
Marvin J. Zurek, Jr., Highland, MI US
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20140081516 | SYSTEMS AND METHODS FOR VIBRATION MITIGATION IN A VEHICLE - Methods and apparatus are provided for mitigating vibration in a vehicle. The apparatus can include a first sensor that generates a first signal that indicates a first phase angle of a first wheel of the vehicle and a second sensor that generates a second signal that indicates a second phase angle of a second wheel of the vehicle. The apparatus can further include a control module that based on the first signal and the second signal outputs a third signal to adjust at least one of the first phase angle and the second phase angle when the vehicle is experiencing a vibration. | 03-20-2014 |