Patent application number | Description | Published |
20090298191 | Lateral Flow and Flow-through Bioassay Devices Based On Patterned Porous Media, Methods of Making Same, and Methods of Using Same - Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region. | 12-03-2009 |
20100285606 | DENSITY-BASED METHODS FOR SEPARATION OF MATERIALS, MONITORING OF SOLID SUPPORTED REACTIONS AND MEASURING DENSITIES OF SMALL LIQUID VOLUMES AND SOLIDS - The ability to levitate, to separate, and to detect changes in density using diamagnetic particles suspended in solutions containing paramagnetic cations using an inhomogeneous magnetic field is described. The major advantages of this separation device are that: i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) it is compatible with simple optical detection (provided that transparent materials are used to fabricate the containers/channels where separation occurs; iii) it is simple to collect the separated particles for further processing; iv) it does not require magnetic labeling of the particles/materials; and v) it is small, portable. The method and kits provided provide for separation and collection of materials of different densities, diagnostics for detection of analytes of interest, monitoring of solid-supported chemical reactions and determination of densities of solid and liquid mixtures. | 11-11-2010 |
20110111517 | PAPER-BASED MICROFLUIDIC SYSTEMS - Paper-based microfluidic systems and methods of making the same are described. | 05-12-2011 |
20110123398 | THREE-DIMENSIONAL MICROFLUIDIC DEVICES - Three-dimensional microfluidic devices including by a plurality of patterned porous, hydrophilic layers and a fluid-impermeable layer disposed between every two adjacent patterned porous, hydrophilic layers are described. Each patterned porous, hydrophilic layer has a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic regions within the patterned porous, hydrophilic layer. The fluid-impermeable layer has openings which are aligned with at least part of the hydrophilic region within at least one adjacent patterned porous, hydrophilic layer. Microfluidic assay device, microfluidic mixer, microfluidic flow control device are also described. | 05-26-2011 |
20120181184 | MICROFLUIDIC, ELECTROCHEMICAL DEVICES - Microfluidic, electrochemical devices are described. The microfluidic, electrochemical device comprises one or more electrode(s) on a substrate and a patterned porous, hydrophilic layer having a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic channels within the patterned porous, hydrophilic layer, wherein the hydrophilic channel(s) comprises a hydrophilic region which is in fluidic communication with the electrode(s). In some embodiments, the electrodes comprise a working electrode, a counter electrode, and a reference electrode. In some embodiments, the microfluidic, electrochemical device further comprises a fluid sink. The method of assembling the microfluidic, electrochemical device is described. The method of using the device for electrochemical analysis of one or more analytes is also described. | 07-19-2012 |
20120198684 | METHODS OF MICROPATTERNING PAPER-BASED MICROFLUIDICS - Methods of patterning hydrophobic regions onto hydrophilic substrates are described. | 08-09-2012 |
20130034869 | DEVICES AND METHODS FOR MULTIPLEXED ASSAYS - The disclosure provides low cost, portable three-dimensional devices for performing multiplexed assays. The devices comprise at least two substantially planar layers disposed in parallel planes, wherein one of the layers is movable relative to each other parallel to the planes to permit the establishment of fluid flow communication serially between the two layers. | 02-07-2013 |
20130128036 | Lateral Flow and Flow-through Bioassay Devices Based on Patterned Porous Media, Methods of Making Same, and Methods of Using Same - Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region. | 05-23-2013 |
20140234881 | LATERAL FLOW AND FLOW-THROUGH BIOASSAY DEVICES BASED ON PATTERNED POROUS MEDIA, METHODS OF MAKING SAME, AND METHODS OF USING SAME - Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region. | 08-21-2014 |
Patent application number | Description | Published |
20080205321 | Radio frequency multicasting - A method for radio frequency multicasting and a multicast site architecture are provided. The method includes assigning a different traffic multicast Internet Protocol (IP) address to each of a plurality of groups of LMR users and encapsulating the LMR content within IP packets. The method further includes transmitting the IP packets to one of the plurality of groups of LMR users using at least one of the assigned traffic multicast IP addresses. | 08-28-2008 |
20100135197 | RADIO FREQUENCY MULTICASTING - A method for radio frequency multicasting and a multicast site architecture are provided. The method includes assigning a different traffic multicast Internet Protocol (IP) address to each of a plurality of groups of LMR users and encapsulating the LMR content within IP packets. The method further includes transmitting the IP packets to one of the plurality of groups of LMR users using at least one of the assigned traffic multicast IP addresses. | 06-03-2010 |
20110134845 | WIRELESS COMMUNICATION NETWORK PROVIDING MULTI-HOP COMMUNICATIONS - A wireless communication network is provided that includes a plurality of communication cells each defined by at least one communication coverage area and a plurality of access points each corresponding to a different one of the plurality of communication cells. Each access point is configured to communicate on a first frequency with at least one of (i) a subscriber in the at least one communication coverage area in a first communication cell and (ii) a subscriber in a second communication cell. Each access point is further configured to communicate on a second frequency with an access point in a third communication cell. | 06-09-2011 |
20120178442 | MULTIMODE LAND MOBILE RADIO - A multimode land mobile radio (LMR) and a method of communicating land mobile radio (LMR) content using an LMR device are provided. The LMR includes an LMR communication portion configured to provide communication with an LMR network and a cellular data network communication portion configured to provide communication with a cellular data network. | 07-12-2012 |
20130044710 | SYSTEM PROVIDING LAND MOBILE RADIO CONTENT USING A CELLULAR DATA NETWORK - A system and method for providing land mobile radio (LMR) content using a cellular data network is provided. The method includes communicating the LMR content via at least one of an LMR network and a cellular data network. The method further includes encapsulating the LMR content using a packet switching protocol when communicating the LMR content via the cellular data network. | 02-21-2013 |
Patent application number | Description | Published |
20080296841 | CONTAINER INCLUDING AN INTERACTIVE GAME BOARD AND BLANK FOR MAKING THE SAME - A container constructed from a blank of foldable sheet material is provided. The container includes an interactive board game. The container further includes a top wall and an opposing bottom wall, a back wall and an opposing front wall, and a pair of opposing side walls. A game board is included on at least one of the walls, and at least one game piece is removably defined within one of the walls. The game piece is removable from the wall and is movable on the game board. The container further includes a game event indicator included on one of the walls. The game event indicator indicates an event occurring within the board game. | 12-04-2008 |
20150136804 | BAG-IN-BOX CONTAINER AND METHOD OF CONSTRUCTING THE SAME - A bag-in-box container for storing and dispensing liquids is provided. The container includes an outer box including two opposing end walls, two opposing side walls, a bottom wall, a top wall, a fill opening, and a dispensing opening. The container further includes an inner, liquid-impermeable bag stored within the outer box. The bag includes a first opening, a filling fixture coupled to the first opening, a second opening, and a dispensing fixture coupled to the second opening. The filling fixture extends through the fill opening and defines a first fluid passageway extending from outside of the box to an internal cavity of the bag. The dispensing fixture extends through the dispensing opening and defines a second fluid passageway extending from the bag internal cavity to outside of the box. | 05-21-2015 |
Patent application number | Description | Published |
20160117617 | USING PREFERENTIAL STATUS INDICATORS FOR ALTERNATIVE FLIGHT RECOMMENDATIONS - Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for determining alternative travel itineraries. A method includes obtaining current flight status information; using the current flight status information to determine that a user itinerary is delayed or cancelled; determining one or more alternative flight itineraries to the user itinerary, including: determining one or more preferential status indicators from user flight itinerary information, obtaining candidate alternative flight itineraries occurring within a specified time frame that correspond to an origin and destination of the user itinerary and that are expanded to include flight itineraries and seat classes that are potentially available to the user based on the one or more preferential status indicators, ranking the candidate alternative flight itineraries, and selecting highest ranked candidates to generate a group of alternative flight itineraries; and providing the group of alternative flight itineraries for display on a user device. | 04-28-2016 |
20160117619 | USING A FLIGHT STATUS CENTRIC VIEW FOR ALTERNATIVE FLIGHT RECOMMENDATIONS - Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for determining alternative travel itineraries. A method includes obtaining current flight status information for a plurality of flights; using the current flight status information to determine that a user flight itinerary is delayed or cancelled; determining one or more alternative flight itineraries to the user itinerary, including: obtaining a collection of candidate alternative flight itineraries occurring within a specified time frame and that correspond to an origin and destination of the user itinerary, determining current flight status information for the candidate alternative flight itineraries, ranking the collection of candidate alternative flight itineraries according to one or more criteria, and selecting a specified number of the highest ranked candidate alternative flights to generate a group of alternative flight itineraries; and providing one or more of the group of alternative flight itineraries for display on a user device. | 04-28-2016 |
Patent application number | Description | Published |
20090185352 | HIGH PERFORMANCE POWER DEVICE - A printed circuit board (PCB) assembly is provided. The PCB assembly is adapted for mounting at least one heat-generating electrical device and providing integrated heat dissipating capability to dissipate heat generated by the electrical device. The PCB assembly has a top surface and a bottom surface and comprises a signal carrying layer and an insert of pyrolytic graphite (PG). The signal carrying layer, disposed between the top surface and the bottom surface, comprises a material that is both thermally conductive and electrically conductive (such as at least one of aluminum, copper, and silver and alloys thereof) and has at least a portion lying in a first plane. The insert of PG is disposed within at least a portion of the first plane of the signal carrying layer, is in thermal contact with the signal carrying layer, and is constructed and arranged to have its greatest electrical conductivity in the first plane. Optionally, a conductive via can be formed in portions of the signal carrying layer not occupied by the insert of PG, where the conductive via operably couples a first side of the signal carrying layer to a second side of the signal carrying layer. | 07-23-2009 |
20100038056 | High performance compact heat exchanger - A high performance compact heat exchanger includes a base plate with evaporator channels for cooling a heat source adjacent to the base plate. A condenser is connected to the base plate and includes fins with channels therein for the coolant. A pump delivers the coolant to the evaporator channels of the base plate after passing through the fins of the condenser. | 02-18-2010 |
20100039770 | Pneumatic presssure wedge - An electronic subsystem such as an array of radar transmit/receive microwave modules are associated with (e.g., base mounted to) spaced heat sinks. There is an electronic module on each side of each heat sink and an inflatable bladder or “pneumatic pressure wedge” between adjacent heat sinks biases a pair of electronic modules against their respective heat sinks. | 02-18-2010 |
20110075377 | Heat Sink Interface Having Three-Dimensional Tolerance Compensation - A thermal interface includes a plurality of elevated regions and a plurality of mechanical tolerance circuits coupled to the plurality of elevated regions. The thermal interface is configured to be disposed between an array of heat generating elements and a heat sink with each of the plurality of elevated regions thermally coupled to a corresponding one or more of the array of heat generating elements. In one embodiment, the thermal interface provides a thermal path between a printed wiring board having a plurality of flip-chip circuit components disposed on an external surface thereof and a heat sink disposed over the flip-chip circuit components. | 03-31-2011 |
Patent application number | Description | Published |
20110251172 | PURINE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE - The invention encompasses purine derivatives as gamma secretase modulators, useful for treating diseases associated with the deposition of beta-amyloid peptide in the brain, such as Alzheimer's disease, or of preventing or delaying the onset of dementia associated with such diseases. Pharmaceutical compositions and methods of use are included. | 10-13-2011 |
20120264735 | TYROSINE KINASE INHIBITORS - The present invention relates to pyridazin-4(1H)-one derivatives, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals. | 10-18-2012 |
20120329743 | CYCLOALKYL-FUSED TETRAHYDROQUINOLINES AS CRTH2 RECEPTOR MODULATORS - The invention provides certain cycloalkyl-fused tetrahydroquinolines of the Formula (I), | 12-27-2012 |
20130225577 | BICYCLIC DIAMINES AS JANUS KINASE INHIBITORS - The instant invention provides compounds of formula I which are Jak inhibitors, and as such are useful for the treatment of Jak-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer. | 08-29-2013 |
20140128367 | CYCLOALKYL-FUSED TETRAHYDROQUINOLINES AS CRTH2 RECEPTOR MODULATORS - The invention provides certain cycloalkyl-fused tetrahydroquinolines of the Formula (I), and their pharmaceutically acceptable salts and esters, wherein R | 05-08-2014 |
Patent application number | Description | Published |
20140179680 | Substituted Imidazopyridines as HDM2 Inhibitors - The present invention provides substituted imidazopyridines as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same. | 06-26-2014 |
20140357618 | SUBSTITUTED IMIDAZOPYRIDINES AS HDM2 INHIBITORS - The present invention provides substituted imidazopyridines as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same. | 12-04-2014 |
20150353553 | 2,6,7,8 SUBSTITUTED PURINES AS HDM2 INHIBITORS - The present invention provides 2,6,7,8 Substituted Purines as described herein or a pharmaceutically acceptable salt thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same. | 12-10-2015 |
20150368247 | 2,6,7 SUBSTITUTED PURINES AS HDM2 INHIBITORS - The present invention provides 2,6,7 substituted purines as described herein or a pharmaceutically acceptable salt thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same. | 12-24-2015 |
Patent application number | Description | Published |
20130129870 | METHOD AND APPARATUS FOR CARTRIDGE-BASED CARBONATION OF BEVERAGES - Systems, methods and cartridges for carbonating or otherwise dissolving gas in a precursor liquid, such as water, to form a beverage. A gas source can be provided in a cartridge which is used to generate gas that is dissolved into the precursor liquid. A beverage medium, such as a powdered drink mix or liquid syrup, may be provided in the same, or a separate cartridge as the gas source and mixed with the precursor liquid to form a beverage. The use of one or more cartridges for the gas source and/or beverage medium may make for an easy to use and mess-free system for making sparkling beverages, e.g., in the consumer's home. | 05-23-2013 |
20140331867 | METHOD AND APPARATUS FOR CARTRIDGE-BASED CARBONATION OF BEVERAGES - Systems, methods and cartridges for carbonating or otherwise dissolving gas in a precursor liquid, such as water, to form a beverage. A gas source can be provided in a cartridge which is used to generate gas that is dissolved into the precursor liquid. A beverage medium, such as a powdered drink mix or liquid syrup, may be provided in the same, or a separate cartridge as the gas source and mixed with the precursor liquid to form a beverage. The use of one or more cartridges for the gas source and/or beverage medium may make for an easy to use and mess-free system for making sparkling beverages, e.g., in the consumer's home. | 11-13-2014 |
20140331868 | METHOD AND APPARATUS FOR CARTRIDGE-BASED CARBONATION OF BEVERAGES - Systems, methods and cartridges for carbonating or otherwise dissolving gas in a precursor liquid, such as water, to form a beverage. A gas source can be provided in a cartridge which is used to generate gas that is dissolved into the precursor liquid. A beverage medium, such as a powdered drink mix or liquid syrup, may be provided in the same, or a separate cartridge as the gas source and mixed with the precursor liquid to form a beverage. The use of one or more cartridges for the gas source and/or beverage medium may make for an easy to use and mess-free system for making sparkling beverages, e.g., in the consumer's home. | 11-13-2014 |
20140335239 | METHOD AND APPARATUS FOR CARTRIDGE-BASED CARBONATION OF BEVERAGES - Systems, methods and cartridges for carbonating or otherwise dissolving gas in a precursor liquid, such as water, to form a beverage. A gas source can be provided in a cartridge which is used to generate gas that is dissolved into the precursor liquid. A beverage medium, such as a powdered drink mix or liquid syrup, may be provided in the same, or a separate cartridge as the gas source and mixed with the precursor liquid to form a beverage. The use of one or more cartridges for the gas source and/or beverage medium may make for an easy to use and mess-free system for making sparkling beverages, e.g., in the consumer's home. | 11-13-2014 |
Patent application number | Description | Published |
20140109560 | SOFT ROBOTIC ACTUATORS - A soft robotic device includes a flexible body having a width, a length and a thickness, wherein the thickness is at least 1 mm, the flexible body having at least one channel disposed within the flexible body, the channel defined by upper, lower and side walls, wherein at least one wall is strain limiting; and a pressurizing inlet in fluid communication with the at least one channel, the at least one channel positioned and arranged such that the wall opposite the strain limiting wall preferentially expands when the soft robotic device is pressurized through the inlet. | 04-24-2014 |
20150070904 | APPARATUS, SYSTEM, AND METHOD FOR PROVIDING FABRIC-ELASTOMER COMPOSITES AS PNEUMATIC ACTUATORS - Soft pneumatic actuators based on composites consisting of elastomers with embedded sheet or fiber structures (e.g., paper or fabric) that are flexible but not extensible are described. On pneumatic inflation, these actuators move anisotropically, based on the motions accessible by their composite structures. They are inexpensive, simple to fabricate, light in weight, and easy to actuate. This class of structure is versatile: the same principles of design lead to actuators that respond to pressurization with a wide range of motions (bending, extension, contraction, twisting, and others). Paper, when used to introduce anisotropy into elastomers, can be readily folded into three-dimensional structures following the principles of origami; these folded structures increase the stiffness and anisotropy of the elastomeric actuators, while keeping them light in weight. | 03-12-2015 |
20150132742 | Microfluidic Devices Formed From Hydrophobic Paper - Microfluidic devices fabricated from paper that has been covalently modified to increase its hydrophobicity, as well as methods of making and using thereof are provided herein. The devices are typically small, portable, flexible, and both easy and inexpensive to fabricate. Microfluidic devices contain a network of microfluidic components, including microfluidic channels, microfluidic chambers, microwells, or combinations thereof, designed to carry, store, mix, react, and/or analyze liquid samples. The microfluidic channels may be open channels, closed channels, or combinations thereof. The microfluidic devices may be used to detect and/or quantify an analyte, such as a small molecules, proteins, lipids polysaccharides, nucleic acids, prokaryotic cells, eukaryotic cells, particles, viruses, metal ions, and combinations thereof. | 05-14-2015 |
20150283699 | FLEXIBLE ROBOTIC ACTUATORS - Systems and methods for providing flexible robotic actuators are disclosed. Some embodiments of the disclosed subject matter include a soft robot capable of providing a radial deflection motions; a soft tentacle actuator capable of providing a variety of motions and providing transportation means for various types of materials; and a hybrid robotic system that retains desirable characteristics of both soft robots and hard robots. Some embodiments of the disclosed subject matter also include methods for operating the disclosed robotic systems. | 10-08-2015 |
20160052131 | Flexible and Stretchable Electronic Strain-limited Layer for Soft Actuators - A soft robot having an integrated electrical component includes an expandable or collapsible body, the body comprising an inlet that is configured to communicate with a fluid source and a flexible strain limited layer secured to a portion of the expandable or collapsible body, wherein the strain limited layer includes at least one electrical component. | 02-25-2016 |