Patent application number | Description | Published |
20080208326 | C3 exoenzyme-coated stents and uses thereof for treating and preventing restenosis - This invention provides a stent for implantation in a blood vessel or other tissue, wherein the stent is coated with or contains C3 exoenzyme, a chimeric version thereof or an inhibitor of RhoA. This invention also provides a method for treating or inhibiting the onset of restenosis in a subject which comprises implanting one of the instant stents in the subject's blood vessel. | 08-28-2008 |
20090004756 | METHODS FOR IDENTIFYING AGENTS THAT TARGET LEAKS IN RYANODINE RECEPTORS - The present invention provides screening methods for identifying agents that enhance binding of a ryanodine receptor and its corresponding FKBP protein, such agents to be used in treating diseases associated with ryanodine receptors. | 01-01-2009 |
20090274739 | METHODS AND COMPOSITIONS FOR TREATING NEOINTIMAL HYPERPLASIA - The present invention relates to compositions containing an mTOR inhibitor, such as rapamycin or a rapamycin derivative, in combination with a PI3 kinase inhibitor and/or a leptin inhibitor, intraluminal devices configured to release such compositions, and methods for the treatment and/or prevention of intimal hyperplasia, vascular stenosis and/or restenosis comprising delivery of such compositions or intraluminal devices to subjects in need thereof. The compositions, intraluminal devices, and methods of the invention are particularly well-suited for the treatment or prevention of vascular stenosis and restenosis in obese and diabetic subjects. | 11-05-2009 |
20140127228 | INHIBITION OF TGFBETA SIGNALING TO IMPROVE MUSCLE FUNCTION IN CANCER - Methods and compositions useful for the treatment and/or prevention of muscle weakness in cancer patients. In certain embodiments, the methods of the present invention include administering to a cancer patient a therapeutically or prophylactically effective amount of one or more inhibitors of TGFbeta signaling. | 05-08-2014 |
20140128349 | ADMINISTERING INHIBITORS OF TGFBETA SIGNALING IN COMBINATION WITH BENZOTHIAZEPINE DERIVATIVES TO IMPROVE MUSCLE FUNCTION IN CANCER PATIENTS - Methods and compositions useful for the treatment and/or prevention of muscle weakness in cancer patients. In certain embodiments, the methods of the present invention include administering to a cancer patient a therapeutically or prophylactically effective amount of one or more inhibitors of TGFbeta signaling in combination with one or more benzothiazepine derivatives. | 05-08-2014 |
Patent application number | Description | Published |
20090286591 | Method of simultaneous indication of multiple winning combinations in a symbol matrix - The present invention teaches novel methods for simultaneous indication of winning combinations in the symbol matrix. More specifically, the present invention simultaneously indicates all winning combinations formed by symbols appearing in symbol positions common to multiple pay lines. In a preferred embodiment, symbol positions common to multiple pay lines that display winning symbol combinations are simultaneously indicated to the player in a first manner. In addition, the remaining symbol positions for each of said multiple pay lines are simultaneously indicated in a second manner. | 11-19-2009 |
20120034969 | GAMING DEVICE HAVING A PLURALITY OF WILDCARD SYMBOL PATTERNS - A gaming device which includes a variety of methods to allow the player to select patterns of wildcard symbols, from a plurality of wildcard symbol patterns, and use those patterns during subsequent games. One embodiment allows the player to select a pattern of wildcard symbols and use the selected pattern during a free spin bonus game. | 02-09-2012 |
20120270634 | GAMING SYSTEM AND METHOD HAVING A PARTIAL SELECTABLE SYMBOL MATRIX - A gaming device including a plurality of symbol generators adapted to generate a plurality of symbols at a plurality of symbol positions. In one embodiment, a player selects a first symbol position, the selected symbol position is activated and the gaming device reveals whether a terminator is associated with the selected symbol position. In this embodiment, the player continues selecting symbol positions (and the gaming device continues activating the selected symbol positions) until a terminator is revealed to be associated with a selected symbol position. After a terminator is revealed, the gaming device randomly generating a symbol at each of the activated symbol positions. The gaming device determines an outcome based on the symbols or combinations of symbols generated at the activated symbol positions and provides the player the determined outcome. | 10-25-2012 |
20130095906 | GAMING DEVICE HAVING MULTIPLE SYMBOLS AT A SINGLE SYMBOL POSITION - A gaming device including a plurality of reels having a plurality of symbols including at least one replicator symbol. The replicator symbol includes at least two of the same symbols in a single symbol position on the reels. The replicator symbol may include any suitable number of the same symbols. The replicator symbol thereby increases the likelihood that a player will obtain a winning symbol combination on the reels and also an award in a game. In one embodiment, a winning symbol combination includes at least one replicator symbol and at least one other symbol at a plurality of symbol positions on a payline associated with the reels. In another embodiment, the winning symbol combination at least one replicator symbol and at least one other symbol at a plurality of symbol position in at least one symbol position on a plurality of paylines associated with the reels. | 04-18-2013 |
20130150147 | GAMING DEVICE INCLUDING PLAYER SELECTABLE WILD SYMBOLS - A gaming system configured to operate a game associated with a plurality of symbols. For a play of the game, the gaming system displays a plurality of reels, each of the reels including a plurality of the symbols and being associated with a plurality of symbol display areas. For an activation of the reels, the gaming system randomly generates and causes each of the reels to display one of the symbols on that reel at each of the symbol display areas associated with that reel. Upon an occurrence of a triggering event, the gaming system: adds one or more wild symbols to one or more of the reels and provides a plurality of additional activations of the reels. If a removal condition is satisfied prior to a final one of the additional activations of the reels, the gaming system removes a remaining wild symbol from one of the reels. | 06-13-2013 |
20130225257 | GAMING DEVICE HAVING A PLURALITY OF WILDCARD SYMBOL PATTERNS - A gaming device which includes a variety of methods to allow the player to select patterns of wildcard symbols, from a plurality of wildcard symbol patterns, and use those patterns during subsequent games. One embodiment allows the player to select a pattern of wildcard symbols and use the selected pattern during a free spin bonus game. | 08-29-2013 |
Patent application number | Description | Published |
20080207298 | SLOT MACHINE GAME HAVING A PLURALITY OF WAYS TO ISSUE A PERCENTAGE OF A PROGRESSIVE AWARD BASED UPON ANY WAGER LEVEL ("PERCENTAGE PROGRESSIVE") - A slot machine issues a percentage of one or more progressive awards based upon any wager level (“Percentage Progressive”). In a preferred embodiment of the present invention, the Percentage Progressive concept operates as follows: The game displays the total progressive award amount; The player sets the wager; The game displays a Percentage Progressive value based upon the wager level; The player presses the spin button; The reels to spin and stop; The player collects credits for any winning combinations appearing on the reels, including pay table and progressive awards. In the event of a progressive award, the player receives the Percentage Progressive value * total progressive award amount. The preferred embodiment of the present invention, therefore, allows players to participate in progressive awards at any wager level. | 08-28-2008 |
20100041462 | GAMING DEVICE HAVING FREE POTENTIAL WINNING COMBINATIONS - Methods to provide an enhanced likelihood of winning an award and to provide enhanced awards based upon the appearance of symbols on free paylines or free hands of cards. In one embodiment base paylines and the free payline are defined using the same symbol matrix and same reel strips. The free payline is an additional payline with same frequencies of wins and losses as the base paylines. The player wagers upon any number of base paylines. The player receives a free payline if a designated number of base paylines are wagered upon. A multiplier enhances the award for winning symbol combinations appearing on the free payline, with the multiplier value equal to the total wager. In another embodiment, a player wagers upon any number of displayed poker hands. The player also receives at least one free hand if a designated number of hands are wagered upon. | 02-18-2010 |
20100273550 | GAMING DEVICE INCLUDING PLAYER SELECTABLE WILD SYMBOLS - A gaming system including at least one memory device storing a plurality of instructions. The plurality of instructions, when executed by at least one processor, cause the at least one processor to operate with at least one input device and at least one display device, for a play of a game, to display a plurality of reels, each reel associated with a plurality of symbol display areas. For each reel, the gaming system randomly generates and causes the reel to display one of a plurality of different symbols on the reel at each of the plurality of symbol display areas associated with the reel. If a triggering event occurs, for one of the symbol display areas, the gaming system displays at the symbol display area two of the same symbol which is displayed at said symbol display area, evaluates the symbols displayed at each of the symbol display areas, including the symbol display area at which two of the same symbol are displayed, to determine if any winning symbol combinations are displayed and provide the player any awards associated with any displayed winning symbol combinations. | 10-28-2010 |
20120034969 | GAMING DEVICE HAVING A PLURALITY OF WILDCARD SYMBOL PATTERNS - A gaming device which includes a variety of methods to allow the player to select patterns of wildcard symbols, from a plurality of wildcard symbol patterns, and use those patterns during subsequent games. One embodiment allows the player to select a pattern of wildcard symbols and use the selected pattern during a free spin bonus game. | 02-09-2012 |
20120270634 | GAMING SYSTEM AND METHOD HAVING A PARTIAL SELECTABLE SYMBOL MATRIX - A gaming device including a plurality of symbol generators adapted to generate a plurality of symbols at a plurality of symbol positions. In one embodiment, a player selects a first symbol position, the selected symbol position is activated and the gaming device reveals whether a terminator is associated with the selected symbol position. In this embodiment, the player continues selecting symbol positions (and the gaming device continues activating the selected symbol positions) until a terminator is revealed to be associated with a selected symbol position. After a terminator is revealed, the gaming device randomly generating a symbol at each of the activated symbol positions. The gaming device determines an outcome based on the symbols or combinations of symbols generated at the activated symbol positions and provides the player the determined outcome. | 10-25-2012 |
20130095906 | GAMING DEVICE HAVING MULTIPLE SYMBOLS AT A SINGLE SYMBOL POSITION - A gaming device including a plurality of reels having a plurality of symbols including at least one replicator symbol. The replicator symbol includes at least two of the same symbols in a single symbol position on the reels. The replicator symbol may include any suitable number of the same symbols. The replicator symbol thereby increases the likelihood that a player will obtain a winning symbol combination on the reels and also an award in a game. In one embodiment, a winning symbol combination includes at least one replicator symbol and at least one other symbol at a plurality of symbol positions on a payline associated with the reels. In another embodiment, the winning symbol combination at least one replicator symbol and at least one other symbol at a plurality of symbol position in at least one symbol position on a plurality of paylines associated with the reels. | 04-18-2013 |
20130150147 | GAMING DEVICE INCLUDING PLAYER SELECTABLE WILD SYMBOLS - A gaming system configured to operate a game associated with a plurality of symbols. For a play of the game, the gaming system displays a plurality of reels, each of the reels including a plurality of the symbols and being associated with a plurality of symbol display areas. For an activation of the reels, the gaming system randomly generates and causes each of the reels to display one of the symbols on that reel at each of the symbol display areas associated with that reel. Upon an occurrence of a triggering event, the gaming system: adds one or more wild symbols to one or more of the reels and provides a plurality of additional activations of the reels. If a removal condition is satisfied prior to a final one of the additional activations of the reels, the gaming system removes a remaining wild symbol from one of the reels. | 06-13-2013 |
20130225257 | GAMING DEVICE HAVING A PLURALITY OF WILDCARD SYMBOL PATTERNS - A gaming device which includes a variety of methods to allow the player to select patterns of wildcard symbols, from a plurality of wildcard symbol patterns, and use those patterns during subsequent games. One embodiment allows the player to select a pattern of wildcard symbols and use the selected pattern during a free spin bonus game. | 08-29-2013 |
Patent application number | Description | Published |
20090041600 | BRACKETLESS MAGNETIC PUMP - A fluid pump assembly is used in combination with a container having a wall. The pump assembly comprises a first casing disposed outside the container in contact with the wall, a first magnetic assembly mounted to the first casing and operatively associated with a drive motor, a second casing disposed inside the container in contact with the wall, and a second magnetic assembly mounted to the second casing and operatively associated with an propeller. The first magnetic assembly includes a rotatable magnetic drive member drivingly coupled to the drive motor. The magnetic drive member is magnetically coupled to the magnetic driven member through the wall for imparting a rotary driving force of the drive motor to the propeller. Furthermore, the second casing is detachably connected to the second side of the wall of the container solely by magnetic attraction force between the first and second magnetic assemblies. | 02-12-2009 |
20090064406 | FOOT SPA TUB PUMP AND METHOD - A foot spa tub includes a tub basin, a first magnetic drive member rotatably coupled to a drive motor, and a first casing supporting the magnetic drive member. The first casing is disposed against an exterior surface of a sidewall of the basin. A second magnetic drive member is rotatably coupled to a blade. The first and second magnetic drive members are magnetically coupled to each other so that the blade is drivingly coupled to the drive motor. A nozzle houses the second magnetic drive member and the blade. The nozzle is detachably securable to an interior surface of the sidewall by a magnetic attraction force between the first and second magnetic drive members. A method of circulating liquid in a foot tub spa is also provided. | 03-12-2009 |
20090320202 | FOOT SPA TUB PUMP AND METHOD - A foot spa tub includes a tub basin, a first magnetic drive member rotatably coupled to a drive motor, and a first casing supporting the magnetic drive member. The first casing is disposed against an exterior surface of a sidewall of the basin. A second magnetic drive member is rotatably coupled to a blade. The first and second magnetic drive members are magnetically coupled to each other so that the blade is drivingly coupled to the drive motor. A nozzle houses the second magnetic drive member and the blade. The nozzle is detachably securable to an interior surface of the sidewall by a magnetic attraction force between the first and second magnetic drive members. The nozzle is further secured in place through a fixation assembly which prevents displacement and rotation of the nozzle during operation. | 12-31-2009 |
20100322797 | BRACKETLESS MAGNETIC PUMP - A fluid pump kit is provided. The kit includes a magnetic driven member for coupling with and rotating a propeller, and a magnetic driver for magnetically coupling to and driving the magnetic driven member by a magnetic attraction force establishable between the magnetic driver and the magnetic driven member. A motor of the kit operates the magnetic driver. First and second casings are provided for housing the magnetic driver and the magnetic driven member, respectively. The first and second casings with housed magnetic driver and magnetic driven member, respectively, are detachably securable to opposite sides of a non-magnetic spacer solely by the magnetic attraction force establishable between the magnetic driver and the magnetic driven member sufficient to support the second casing and the housed magnetic driven member in a particular position without the use of mechanical aids. | 12-23-2010 |
20110211982 | LIQUID PUMP ASSEMBLY - A fluid pump assembly is provided. The pump has a pair of units magnetically coupled to each other. The first unit contains a drive motor and a magnetic assembly. The second unit contains a magnetic assembly and a blade of a propeller/impeller for imparting movement to a fluid. As the first unit is activated by the drive motor, a magnetic flux is created which in turn rotates the magnetic assembly in the second unit, driving the blade. | 09-01-2011 |
20120251360 | BRACKETLESS MAGNETIC PUMP - A fluid pump kit is provided. The kit includes a magnetic driven member for coupling with and rotating a propeller, and a magnetic driver for magnetically coupling to and driving the magnetic driven member by a magnetic attraction force establishable between the magnetic driver and the magnetic driven member. A motor of the kit operates the magnetic driver. First and second casings are provided for housing the magnetic driver and the magnetic driven member, respectively. The first and second casings with housed magnetic driver and magnetic driven member, respectively, are detachably securable to opposite sides of a non-magnetic spacer solely by the magnetic attraction force establishable between the magnetic driver and the magnetic driven member sufficient to support the second casing and the housed magnetic driven member in a particular position without the use of mechanical aids. | 10-04-2012 |
20120272446 | FOOT SPA TUB PUMP AND METHOD - A foot spa tub includes a tub basin, a first magnetic drive member rotatably coupled to a drive motor, and a first casing supporting the magnetic drive member. The first casing is disposed against an exterior surface of a sidewall of the basin. A second magnetic drive member is rotatably coupled to a blade. The first and second magnetic drive members are magnetically coupled to each other so that the blade is drivingly coupled to the drive motor. A nozzle houses the second magnetic drive member and the blade. The nozzle is detachably securable to an interior surface of the sidewall by a magnetic attraction force between the first and second magnetic drive members. A method of circulating liquid in a foot tub spa is also provided. | 11-01-2012 |