Patent application number | Description | Published |
20080255033 | Metallopeptide gamma-Melanocyte Stimulating Hormone Compounds - Metallopeptides with a sequence of a biologically active gamma-melanocyte stimulating hormone sequence of length n residues, wherein a residue including a nitrogen atom and sulfur atom each available for complexation to a metal ion is inserted at any position from between the two and three position to the C-terminus side of the n position, or alternatively is substituted for the residue at any position from the three position to the n position, with a metal ion complexed thereto, with any proline (Pro) residue which is either of the two residues on the immediately adjacent N-terminus side of the inserted or substituent residue comprising a nitrogen atom and sulfur atom available for complexation to a metal ion is substituted with a homolog. | 10-16-2008 |
20090069224 | Linear and Cyclic Melanocortin Receptor-Specific Peptidomimetics - Linear and cyclic peptidomimetics which bind to one or more melanocortin receptors are provided, which peptidomimetics include at least one ring-constrained amino acid surrogate of formula I: | 03-12-2009 |
20100035821 | Amide Linkage Cyclic Natriuretic Peptide Constructs - Cyclic constructs which bind to a natriuretic peptide receptor and include a plurality of amino acid residues, at least one amino acid surrogate of formula I: | 02-11-2010 |
20100075895 | Cyclic Natriuretic Peptide Constructs - Cyclic constructs with an N-terminus and a C-terminus which bind to a natriuretic peptide receptor and include a plurality of amino acid residues, at least one amino acid surrogate of formula I: | 03-25-2010 |
20110263818 | Peptidic Constructs with Amino Acid Surrogates - Peptidic constructs including at least one ring-constrained amino acid surrogate of formula I: | 10-27-2011 |
20130045928 | Uses of Natriuretic Peptide Constructs - Use of constructs which bind to one or more natriuretic peptide receptors and include a plurality of amino acid residues and at least one amino acid surrogate of formula I: | 02-21-2013 |
20130274207 | Uses of Natriuretic Peptide Constructs - Use of constructs which bind to one or more natriuretic peptide receptors and include a plurality of amino acid residues and at least one amino acid surrogate of formula I: | 10-17-2013 |
20140134163 | COMBINATION THERAPY WITH MDM2 AND EFGR INHIBITORS - Provided is a method of treating a proliferative disease, condition, or disorder in a subject by administering a combination of an inhibitor of p53 and MDM2 binding and an EGFR inhibitor. Various embodiments of the disclosed methods provide a synergistic anti-proliferative or anti-apoptotic effect compared to administration of one agent alone. | 05-15-2014 |