Mackay, AU
Charles Mackay, New South Wales AU
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20080254030 | Use of Baff to Treat Th2-Mediated Conditions - Compositions and methods for treating Th2-mediated disease are provided. | 10-16-2008 |
20100143934 | Modified animal lacking functional PYY gene, monoclonal antibodies that bind PYY isoforms and uses therefor - The present invention provides transgenic animals having a reduced level of expression of peptide YY (PYY) and drug screening platforms using the transgenic animals for identifying agonists and antagonists of PYY. The present invention further provides monoclonal antibodies that bind specifically to full-length PYY[1-36] or the processed form thereof i.e., PYY[3-36] and to diagnostic and drug screening platforms using the monoclonal antibodies. The invention has particular utility for the diagnosis of a predisposition or risk of a subject becoming obese, developing one or more pathologies associated with obesity, or developing a disease/disorder of bone tissue. | 06-10-2010 |
20110044996 | NEUTRALIZING ANTIBODIES - The present invention provides antibodies that bind, interact or otherwise associate with GM-CSF or a fragment, portion or part thereof and antagonize or neutralize GM-CSF activity. In accordance with embodiments of the present invention humanized monoclonal antibodies are generated which bind to human GM-CSF with high affinity and which inhibit the activity of GM-CSF. | 02-24-2011 |
20110190477 | Humanized Anti-C5aR Antibodies - The present invention is directed to humanized antibodies which bind the human C5a receptor and their use as therapeutic and diagnostic agents. The present invention is further directed toward nucleic acid sequences which encode said humanized antibodies, and their expression in recombinant host cells. In particular, the present invention is directed towards humanized antibodies derived from murine antibody 7F3 which specifically binds to the human C5a receptor. | 08-04-2011 |
Charles Mackay, Vaucluse Nsw AU
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20140023641 | ANTIBODY WITH SPECIFICITY FOR GM-CSF (I) - The present invention relates to antibodies with specificity for granulocyte-macrophage colony stimulating factor (GM-CSF). More particularly, the invention relates to humanized monoclonal antibodies that bind specifically to human GM-CSF with high affinity. The invention also relates to nucleic acids encoding the antibodies, vectors for expression of these nucleic acids, and host cells for producing said antibodies. Further, the invention relates to the use of said antibodies in the diagnosis or treatment of autoimmune or inflammatory diseases. | 01-23-2014 |
Charles Mackay, Prahran AU
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20140065163 | ANTIBODY WITH SPECIFICITY FOR GM-CSF (II) - The present invention relates to antibodies with specificity for granulocyte-macrophage colony stimulating factor (GM-CSF). More particularly, the invention relates to humanized monoclonal antibodies that bind specifically to human GM-CSF with high affinity. The invention also relates to nucleic acids encoding the antibodies, vectors for expression of these nucleic acids, and host cells for producing said antibodies. Further, the invention relates to the use of said antibodies in the diagnosis or treatment of autoimmune or inflammatory diseases. | 03-06-2014 |
Charles R. Mackay, Vancluse AU
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20100061983 | Method of inhibiting leukocytes with human cxc chemokine receptor 3 antibody - The present invention relates to proteins or polypeptides, referred to herein as isolated and/Or recombinant mammalian (e.g., human) IP-10/Mig receptor proteins designated CXC Chemokine Receptor 3 (CXCR3) and variants thereof, including those characterized by selective binding of one or more chemokines (e.g., IP-10 and/or Mig), and/or the ability to induce a cellular response (e.g., chemotaxis, exocytosis). Antibodies reactive with CXCR3 receptors can be produced using the proteins or variants thereof or host cells comprising same as immunogen. | 03-11-2010 |
David Michael Mackay, Sydney AU
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20130200595 | GOLF BAG AND GOLF CART ASSEMBLY - A cart assembly for coupling to a golf bag, the cart assembly being moveable between a collapsed state and a deployed state and a coupling arrangement for coupling a golf bag to cart assembly, the coupling arrangement including one or more supporting collars corresponding in shape to a portion of the golf bag, the supporting collar attached to a coupling member wherein the coupling member is adapted to couple to a corresponding coupling portion located on the cart assembly. | 08-08-2013 |
Fabienne Mackay, New South Wales AU
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20080254030 | Use of Baff to Treat Th2-Mediated Conditions - Compositions and methods for treating Th2-mediated disease are provided. | 10-16-2008 |
Ian Stuart Mackay, Perth AU
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20090066535 | ALIGNING INDUCTIVE COUPLERS IN A WELL - An apparatus that is usable with a well includes a first equipment section that includes a first inductive coupler and a second equipment section that includes a second inductive coupler. The second equipment section is adapted to be run downhole into the well after the first equipment section is run downhole into the well to engage the first equipment section. A mechanism of the apparatus indicates when the first inductive coupler is substantially aligned with the second inductive coupler. | 03-12-2009 |
20120013482 | Aligning Inductive Couplers In A Well - An apparatus that is usable with a well includes a first equipment section that includes a first inductive coupler and a second equipment section that includes a second inductive coupler. The second equipment section is adapted to be run downhole into the well after the first equipment section is run downhole into the well to engage the first equipment section. A mechanism of the apparatus indicates when the first inductive coupler is substantially aligned with the second inductive coupler. | 01-19-2012 |
Joel Mackay, Newtown AU
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20130022590 | Compositions Comprising Zinc Finger Domains and Uses Therefor - The present invention relates to compositions of matter comprising zinc finger domains that bind to single-stranded RNA and are useful for modifying gene expression such as by regulating processing of messenger RNA (mRNA) or non-coding RNA (ncRNA). The invention also relates to screening, diagnostic and therapeutic methods employing such compositions of matter. | 01-24-2013 |
Joel Peter Mackay, New South Wales AU
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20090130106 | DEMIBODIES: DIMERIZATION-ACTIVATED THERAPEUTIC AGENTS - The present invention relates generally to a set of synthetic immunointeractive molecules referred to herein as “demibodies” which are useful in targeting particular cells in a subject. More particularly, the present invention provides a set of demibodies wherein at least two molecules from within the set, each specific for a different antigen on a target cell, are required to interact together at the cell surface in order to form an active complex which directs demibody-mediated cellular or complement mediated cytotoxicity and/or reporter function and/or therapeutic activity. The demibodies of the present invention are useful in the targeting of particular cells such as cancer cells including leukemic cells, pathogens including malarial, bacterial and viral agents, and stem cells including embryonic and adult stem cells and pathogen cells. The present invention provides, therefore, methods of treatment, diagnosis and undertaking research and compositions comprising demibodies useful for same. | 05-21-2009 |
Marisa Maio Mackay, South Australia AU
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20110040639 | DISTRIBUTING WEB-ACTIVATABLE CONTENT | 02-17-2011 |
William Mackay, Victoria AU
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20100222133 | Jackpot System - This invention relates to the awarding of prizes for games, such as for example, table games like card games. In one form the present invention is suitable for use in the game of Blackjack and provides a system for awarding a game prize, comprising: determining a tally corresponding to each game completed at two or more locations at which games are played; and awarding the prize to a second game upon the completion of a first game which causes the tally to reach a predetermined number. Alternatively, the present invention provides a system for awarding a game prize, comprising: determining a tally of predetermined results produced by the play of a game; and awarding the prize to a second game when a predetermined result associated with a first game causes the tally to reach a predetermined number. | 09-02-2010 |