Macauley
Andrew Sean Macauley, Bitterley GB
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20150274389 | Waterproof Closure System - A waterproof closure system | 10-01-2015 |
Matthew Macauley, Burnaby CA
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20100016386 | SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF - The invention provides compounds of formula (I) for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc | 01-21-2010 |
20120316207 | SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF - The invention provides compounds of formula (I) for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc. | 12-13-2012 |
Matthew S. Macauley, Port Alberni CA
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20080287375 | Selective Glycosidase Inhibitors, Methods of Making Inhibitors, and Uses Thereof - The invention comprises compounds for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions containing the compounds or prodrugs of the compounds. The invention also comprises animal models and methods of making the animal models for studying diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc, and treatment of such diseases and disorders. The invention also comprises methods of treating such diseases and disorders. The invention also comprises methods of making the compounds, and methods of making selective glycosidase inhibitors. | 11-20-2008 |
Nicola Macauley, York GB
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20120095463 | FRACTURE FIXATION SYSTEMS - Systems for bone fracture repair are disclosed. One system includes a biocompatible putty that may be packed about a bone fracture to provide full loadbearing capabilities within days. The disclosed putties create an osteoconductive scaffold for bone regeneration and degrade over time to harmless resorbable byproducts. Fixation devices for contacting an endosteal wall of an intramedullary (IM) canal of a fractured bone are also disclosed. One such fixation device includes a woven elongated structure fabricated from resorbable polymer filaments. The woven elongated structure has resilient properties that allow the woven structure to be radially compressed and delivered to the IM canal using an insertion tube. When the insertion tube is removed, the woven structure expands towards its relaxed cross-sectional width to engage the endosteal wall. The woven elongated structure is impregnated with a resorbable polymer resin that cures in situ, or in the IM canal. | 04-19-2012 |
Nicola Macauley, Yorkshire GB
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20100137491 | FIBER REINFORCED COMPOSITE MATERIAL - The present disclosure relates to a fiber reinforced composite material. In an embodiment, the composite material includes a PLLA fiber material and a matrix material that does not have the same chemical element composition as the fiber material. Other fiber reinforced composite materials are also disclosed. | 06-03-2010 |
Nicola Macauley, Haxby GB
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20140235754 | FIBER REINFORCED COMPOSITE MATERIAL - The present disclosure relates to a fiber reinforced composite material. In an embodiment, the composite material includes a PLLA fiber material and a matrix material that does not have the same chemical element composition as the fiber material. Other fiber reinforced composite materials are also disclosed. | 08-21-2014 |
Nicola Jayne Macauley, York GB
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20140128990 | BONE PUTTY - The present invention relates to a macroporous material for filling bone voids. In particular, we describe an implant material comprising bioresorbable polymer granules and a biocompatible water-miscible solvent, wherein the solvent at least partially dissolves and/or softens the polymer granules to form a mouldable mass that can be used to fill a bone defect but hardens when water is added and/or the implant material is placed in an aqueous environment, and wherein the implant material has macroporosity suitable for bone in-growth. | 05-08-2014 |