Lutolf
Matthias Lutolf, Tolochenaz CH
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20130040357 | Hydrogel Precursor Formulation and Production Process Thereof - The present invention relates to a hydrogel precursor formulation, its process of production as well as a kit comprising said formulation and a method of production of a hydrogel using said formulation. The precursor formulation comprises at least one structural compound, preferably vinyl sulfone (acrylated branched) poly(ethylene glycol), and at least one linker compound, preferably a peptide with two cysteines, wherein said structural compound and said linker compound are polymerizable by a selective reaction between a nucleophile and a conjugated unsaturated bond or group. The precursor formulation is in the form of a powder. | 02-14-2013 |
Matthias P. Lutolf, St-Sulpice CH
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20100055733 | MANUFACTURE AND USES OF REACTIVE MICROCONTACT PRINTING OF BIOMOLECULES ON SOFT HYDROGELS - Embodiments of the present disclosure encompass microfabrication methods (“reactive microcontact printing of soft matter”) for hydrated soft polymer materials and surfaces for culture platforms suitable for the culturing of isolated single primary mammalian cells in an environment approximating the natural niches of the cells. Such culture platforms may comprise arrays of microwells, or other microscopically textured features, in which individual features can comprise desired proteins or mixtures of proteins. The microfabrication methods of the disclosure allow spatial control of surface biochemistry and topography at the micrometer scale on these hydrated soft gels. The hydrogels and methods of manufacture and use of the disclosure allow the isolation of a single stem cell and the characterizing of its interaction with cytokines and morphogens, especially with regard to modulation of the proliferative capacity of the stem cell when implanted in a recipient host. The systems for isolating or culturing a eukaryotic cell comprise a hydrogel film comprising a cross-linked polymeric composition having the characteristic of hydrating to form a hydrogel and having a topographical feature or a plurality of topographical features that may have a surface capable of receiving and immobilizing at least one biomolecule species thereon. | 03-04-2010 |
Matthias P. Lutolf, Tolochenaz CH
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20120177611 | Elastic substrates and methods of use in cell manipulation and culture - Methods are provided for the ex vivo manipulation of cells, stem cells and other reproductive cells, by manipulating the cells in a container or device comprising an elastic substrate, wherein the substrate has an elasticity that mimics the elasticity of a native microenvironment of the cell. | 07-12-2012 |
Walter Lutolf, Magden CH
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20090068261 | ORAL RAPID RELEASE PHARMACEUTICAL FORMULATION FOR PYRIDYLMETHYLSULFINYL-BENZIMIDAZOLES - The invention relates to solid oral pharmaceutical compositions in the form of pellets, mini-tablets, tablets, or capsules, comprising an optionally substituted 2-(pyridylmethylsulfinyl)-1H-benzimidazole, for example esomeprazole, and carrageenan, and optionally one or more excipients. Surprisingly, it has been found that these compositions are stable and rapidly release the active ingredient. The pellets or mini-tablets may be coated as such, or filled in capsules or pressed into tablets, with a polymer, which dissolves only at a pH value of 5 or higher, optionally over a stabilizing intermediate layer. | 03-12-2009 |