Lucie
Lucie Bednarova, Livermore, CA US
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20080213638 | ENGINE BLOCK FOR USE IN A FUEL CELL SYSTEM - In one embodiment, an engine block may comprise an interconnect having: a first manifold section, a second manifold section perpendicular to the first manifold section, the first manifold section and the second manifold section having a plurality of conduits to receive a gas flow, wherein the first manifold section and the second manifold section are formed from a single manifold device; a fuel cell stack housing coupled to the second manifold section to receive a fuel cell stack; and a fuel processor coupled to the first manifold section, wherein the fuel cell processor and the fuel cell stack operate at substantially the same temperature. | 09-04-2008 |
Lucie Brocher, Sion CH
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20150301502 | RESONATOR WITH REDUCED SENSITIVITY TO CLIMATIC VARIATIONS - A compensating balance spring for a thermally compensated sprung balance resonator including a core formed from at least one non-metallic material. The core is entirely coated with a layer which is moisture proof to render the balance spring less sensitive to climatic variations. The compensating balance spring can be applied to timepieces. | 10-22-2015 |
20150355600 | RESONATOR WITH REDUCED SENSITIVITY TO CLIMATIC VARIATIONS - A compensating balance spring for a thermally compensated sprung balance resonator including a core formed from at least one non-metallic material. The core is partially coated with at least one layer which is moisture proof to render the balance spring less sensitive to climatic variations. | 12-10-2015 |
Lucie Campora US
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20140154758 | BIOMASS DERIVED METHYL METHACRYLATE AND CORRESPONDING MANUFACURING METHOD, USES AND POLYMERS - The invention relates to methyl methacrylate characterized in that at least one portion of the carbons thereof is biologically sourced and, more specifically, in that it contains between 0.2×10 | 06-05-2014 |
Lucie Campora, Diesen FR
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20110318515 | BIOMASS-DERIVED METHYL METHACRYLATE AND CORRESPONDING MANUFACTURING METHOD, USES AND POLYMERS - The invention relates to methyl methacrylate characterized in that at least one portion of the carbons thereof is biologically sourced and, more specifically, in that it contains between 0.2×10 | 12-29-2011 |
Lucie Casaban, Malakoff FR
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20150182617 | GLYCOPROTEINS FOR PSEUDOTYPING LENTIVECTORS - The invention relates to compositions and methods based on the use of viral G proteins to pseudotype vectors. The viral G proteins can be expressed by expression vectors and can be used to pseudotype lentiviral vectors. The viral G proteins can be included in a combination of compounds for sequential administration to a mammalian host. | 07-02-2015 |
Lucie Castens, Neuchatel CH
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20110240107 | LARGE-AREA THIN-FILM-SILICON PHOTOVOLTAIC MODULES - Micromorph tandem cells with stabilized efficiencies of 11.0% have been achieved on as-grown LPCVD ZnO front TCO at bottom cell thickness of just 1.3 μm in combination with an antireflection concept. Applying an advanced LPCVD ZnO front TCO stabilized tandem cells of 10.6% have been realized at a bottom cell thickness of only 0.8 μm. Implementing intermediate reflectors in Micromorph tandem cell devices allow for, compared to commercial SnO | 10-06-2011 |
Lucie Chandernagor, Caen FR
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20150091630 | RF POWER DETECTOR AND DETECTION METHOD - The invention provides an RF detection circuit and method using an envelope detector having an output connected to a first input of a differential amplifier and a reference storage capacitor to a second input of the differential amplifier. In a preferred implementation of the calibration mode, there is initial discharging of a reference storage capacitor, high speed charging of the reference storage capacitor until the differential amplifier output toggles, then slower discharging of the reference storage capacitor until the differential amplifier output toggles again. The resulting voltage is stored on the reference storage capacitor for use in a subsequent detection mode. This provides storage of an offset voltage which calibrates both the envelope detector differential amplifier functions. | 04-02-2015 |
Lucie Charissou, Fougeres FR
Lucie Degraeve, Lyon FR
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20110179463 | SELECTION OF A DATA STREAM - In order to assist the selection of a data stream to be played back on a receiver device from a plurality of data streams received by the receiver device, a plurality of data streams are received in a processor unit simultaneously with auxiliary data respectively associated with said data streams. Then, on the basis of the received auxiliary data, information for assisting selection of what is to be displayed for each data stream is determined. Thereafter, the data streams are linked with the respectively determined selection assistance information. These linked data streams are then transmitted to the receiver device. | 07-21-2011 |
Lucie Fraichard, Toulouse FR
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20150318073 | TALC COMPOSITION - An electrically conducting talc composition may include synthetic talc particulate coated with an electrically conducting coating agent, wherein the coating agent may include carbon nanotubes or an electrically conductive polymeric material, such as a nanocarbon material, such as, for example, carbon nanotubes. A method of making an electrically conducting talc composition may include forming electrically conducting coating agent on or about particles of the talc particle. | 11-05-2015 |
Lucie Galons, Paris FR
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20110058942 | BALANCING DEVICE AND METHOD - The invention relates to a balancing device comprising a nut | 03-10-2011 |
20140248155 | ONE-BLOCK BLADED DISK PROVIDED WITH BLADES WITH ADAPTED FOOT PROFILE - A one-block bladed disk includes blades, a leading edges of which has sweep and dihedral angles, both strongly variable and increasingly large upon approaching a connection to a hub to improve mechanical strength of the whole and obtain good distribution of gas flow over the height of the blade. | 09-04-2014 |
20150198221 | BALANCING DEVICE AND METHOD - A balancing device including a nut having an internal thread, and a countersunk collar is disclosed. The countersunk collar has a through-hole with a diameter greater than the diameter of the internal thread of the nut. The countersunk collar includes a balancing weight. | 07-16-2015 |
Lucie Hoffmannová, Pribor CZ
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20100204460 | NATURAL BRASSINOSTEROIDS FOR USE FOR TREATING HYPERPROLIFERATION, TREATING PROLIFERATIVE DISEASES AND REDUCING ADVERSE EFFECTS OF STEROID DYSFUNCTION IN MAMMALS, PHARMACEUTICAL COMPOSITION AND ITS USE - The present invention relates to natural brassinosteroids of general formula (I), wherein R is CH | 08-12-2010 |
20110311652 | Novel Saponin Compounds, Methods of Preparation Thereof, Use Thereof and Pharmaceutical Compositions - This invention relates to novel saponin compounds of formula II wherein MBz denotes p-methoxybenzoyl, and R is selected from the group comprising C | 12-22-2011 |
Lucie Hoffmannová, Pribor CZ
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20100204460 | NATURAL BRASSINOSTEROIDS FOR USE FOR TREATING HYPERPROLIFERATION, TREATING PROLIFERATIVE DISEASES AND REDUCING ADVERSE EFFECTS OF STEROID DYSFUNCTION IN MAMMALS, PHARMACEUTICAL COMPOSITION AND ITS USE - The present invention relates to natural brassinosteroids of general formula (I), wherein R is CH | 08-12-2010 |
Lucie Jodin, Nancy FR
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20080305399 | ELECTROLYTIC ORGANIC GLASS, ITS MANUFACTURING PROCESS AND DEVICE COMPRISING IT - The invention relates to a solid electrolyte, to a process for its manufacture and also to devices comprising it. | 12-11-2008 |
20090068529 | SILICIFIED ELECTROLYTE MATERIAL FOR FUEL CELL, METHOD FOR ITS PREPARATION AND FUEL CELL USING SAME - This material suitable for constituting an electrolyte for a fuel cell has a hydrophobic matrix comprising carbon, fluorine, oxygen and hydrogen, and silicon. | 03-12-2009 |
20100028526 | THIN FILM COATING METHOD - The invention relates to a thin film coating method using a thin film having minimal adhesion in relation to biological species, of the type comprising the deposition of a thin film with —COOH function. The invention is characterised in that the method includes a step involving the vapour phase chemical decomposition of a carbonaceous precursor containing neither a carboxyl group nor a carbonyl group, in the presence of water. The invention is particularly suitable for use in the field of thin films. | 02-04-2010 |
20130260024 | METHOD FOR PRODUCING LITHIUM-BASED LAYERS BY CVD - A method for forming by CVD a lithium-based layer, according to which the lithium precursor is in liquid form in a mixture containing a solvent and a Lewis base. | 10-03-2013 |
20130323621 | SILICIFIED ELECTROLYTE MATERIAL FOR FUEL CELL, METHOD FOR ITS PREPARATION AND FUEL CELL USING SAME - This material suitable for constituting an electrolyte for a fuel cell has a hydrophobic matrix comprising carbon, fluorine, oxygen and hydrogen, and silicon. | 12-05-2013 |
Lucie Kotalova, Hradec Kralove CZ
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20110087336 | SELF-EXPANDING PLASTIC STENT - The self-expanding plastic stent is a resilient plastic stent with such expansional strength that a small diameter delivery system may be used to implant the stent, thereby minimizing possible complications for the patient. The stent is made from a braided monofilament, which may be polyetheretherketone (PEEK), polyetherketone (PEK), polyetherketoneketone (PEKK), polyaryletherketone (PAEK), polyetherketoneether-ketoneketone (PEKEKK), or any blends and alloys of these particular resins. The plastic stent may or may not be covered with polymer film. When used, the polymer film includes materials based on polyurethanes, silicones, or materials that biodegrade or erode in the body. Specifically the biodegradable materials might include poly-L-lactide, poly-D-lactide, polyglycolide, ε-caprolactone (epsilon-caprolactone), starch, and collagen or its polymer blends, alloys or copolymers. This material is heat-treated. The monofilament preferably has a diameter of 0.2-0.7 mm. The self-expanding plastic stent demonstrates better mechanical features, processibility, and shape memory. | 04-14-2011 |
Lucie Landouar-Arsivaud, Montils FR
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20090276917 | Gene Promotors Which Can be Used in Plants - The present invention relates to nucleic acid sequences which have a transcriptional promoter activity preferentially in the phloem of plants under conditions of stress, or in the roots, to derived sequences, to constructs containing such sequences, and also to cells transformed with said constructs and to transgenic plants. The present invention makes it possible to place any transgene under the transcriptional control of a promoter, the activity of which is tissue-specific, organ-specific and/or inducible by environmental factors, such as biotic or abiotic stresses. | 11-05-2009 |
Lucie Lebosse, Guidel-Plages FR
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20130020808 | UNDERWATER ELECTRICITY GENERATION MODULE PROVIDED WITH A BASE - The invention relates to an underwater electricity generation module provided with a base. The electricity generation module is of the type that comprises an elongate cylindrical casing ( | 01-24-2013 |
Lucie Le Van-Jodin, Nancy FR
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20150311562 | SOLID ELECTROLYTE FOR A MICROBATTERY - A solid electrolyte including a layer of Li | 10-29-2015 |
Lucie Le Van-Jodin, Grenoble FR
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20100326814 | METHOD FOR ELIMINATING METALLIC LITHIUM - The method for eliminating metallic lithium on a support comprises a plasma application step. The plasma is formed from a carbon source and an oxygen source with a power comprised between 50 and 400 W. It transforms the metallic lithium into lithium carbonate. The method then comprises a dissolution step of the lithium carbonate in an aqueous solution. | 12-30-2010 |
20150194700 | Method For Producing A Lithium-Based Electrolyte For A Solid Microbattery - A method for producing a solid lithium-based electrolyte for a solid microbattery implements the cathode sputtering of a lithium-based target material on an object supported by a substrate holder. A grid made of lithium-free electrically conductive material is interposed between the object and the lithium-based target material, the grid being electrically connected to the substrate holder. | 07-09-2015 |
Lucie Lorrain, Champlain CA
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20100279420 | BIOSENSORS, AND METHOD AND KITS FOR USING SAME - A stabilised thylakoid membrane formulation comprising thylakoid membranes in a buffered solution and liposomes, wherein the formulation has a ratio of chlorophyll/liposomes of at least about 10:1. The invention further comprises a method for detecting or quantifying the presence of toxic molecules in a fluid sample, comprising obtaining a stabilised thylakoids membranes formulation; and assessing the photosynthetic efficiency of the thylakoid membranes formulation in the presence of said sample, whereby the molecules are detected when the photosynthetic efficiency is measurably different in the presence versus in the absence of the sample. The present invention also comprises kits using the stabilised thylakoid membranes formulation for detecting and/or quantifying the toxic molecule in a fluid sample. | 11-04-2010 |
20110177546 | METHOD OF DETECTING BIOACTIVE MOLECULES IN A FLUID SAMPLE - A method of detecting the presence of bioactive molecules in a fluid sample, comprising contacting a solution of a microorganism selected from the group consisting of a monocellular algae and a cyanobacteria with the fluid sample so as to obtain a formulation having a microorganism concentration of 200 000-1×10 | 07-21-2011 |
Lucie Malosse, Tours FR
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20080200729 | Preparation of Aryl Phosphines - A method of making an aryl phosphine is provided. The method comprises reacting an organophosphine of general formula (1): HPXY with a substituted aryl compound in the presence of a catalyst, a base, a ligand and an iodine containing co-catalyst. In formula (1) X and Y can be the same or different and are cycloalkyl; substituted alkyl; primary, secondary and tertiary alkyl; and heterocyclic moieties; and one of X and Y can optionally be hydrogen. | 08-21-2008 |
Lucie Malosse, Clermont-Ferrand FR
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20120178172 | FLUORESCENT POLYMERS OF 7-HYDROXYCOUMARIN COMPOUNDS, CHEMICAL SENSORS COMPRISING THEM, AND POLYMERIZABLE FLUORESCENT COMPOUND OF 7-HYDROXYCOUMARIN - Polymers and copolymers of polymerizable fluorescent compounds of 7-hydroxycoumarin such as Ethyl-2-methacrylate Umbelliferone-4-acetate are provided. In addition, a sensor comprising this polymer notably for detecting and/or assaying nitrated and organophosphorus compounds, explosives, and toxic compounds is provided. | 07-12-2012 |
20150253245 | FLUORESCENT POLYMERS OF 7-HYDROXYCOUMARIN COMPOUNDS, CHEMICAL SENSORS COMPRISING THEM, AND POLYMERIZABLE FLUORESCENT COMPOUND OF 7-HYDROXYCOUMARIN - A polymer is obtained by polymerization of a polymerizable fluorescent monomer compound of 7-hydroxycoumarin having the following formula (I): | 09-10-2015 |
Lucie Mondoulet, Chatillon FR
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20120064144 | METHOD OF TREATING ECZEMA - The present invention relates to the treatment of eczema. More specifically, the invention relates to a new method of treating eczema through the epicutaneous route. In particular, the method of the invention comprises applying to a non eczematous area of the skin of the subject a skin patch device, comprising a composition, under conditions allowing a contact between said composition and the skin. The present invention also relates to the skin patch device. | 03-15-2012 |
20120207815 | METHOD OF TREATING EOSINOPHILIC ESOPHAGITIS - The present invention relates to the treatment of EE. More specifically, the invention relates to a new method of treating EE through the epicutaneous route. In particular, the method of the invention comprises applying to the skin of the subject a skin patch device, comprising a composition, under conditions allowing a contact between said composition and the skin. The present invention also relates to the skin patch device and to a use of the skin patch device in the manufacture of a composition for treating eosinophilic esophagitis in a subject. | 08-16-2012 |
20130039958 | METHOD OF VACCINATION - The present invention relates to improved methods for vaccination of a subject. Particularly, the present invention discloses the use of skin antigen application to amplify and improve a pre-existing immunity against a selected pathogen in a subject. The present invention discloses the use of skin application in combination with conventional vaccination or priming for improved immunization or vaccination of a subject against a selected pathogen. | 02-14-2013 |
20140377311 | METHOD OF PREVENTING ALLERGIES - The present invention relates to compositions and methods for preventing allergy in a subject. Particularly, the present invention relates to epicutaneous prevention of allergies in children. The invention also relates to compositions for use in such methods, as well as their manufacture. The invention may be used to cause protection against any allergy, particularly food or respiratory allergies. | 12-25-2014 |
Lucie Mondoulet, Chatilon FR
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20100136093 | Immunotherapeutic Method For Increasing Groundnut Tolerance In A Subject - The present invention describes a new method for progressive desensitization of a subject to groundnut. More specifically, the invention relates to the immunotherapeutic method for increasing groundnut tolerance in an allergic subject using epicutaneous administration. The present invention is also relative to the use of a skin patch device for progressive desensitization of a subject to groundnut. | 06-03-2010 |
Lucie Parenicova, Den Haag NL
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20090176219 | DNA BINDING SITE OF A TRANSCRIPTIONAL ACTIVATOR USEFUL IN GENE EXPRESSION - We have discovered DNA binding sites which are specifically recognized by PrtT, a transcriptional activator for protease genes. The DNA binding site can be defined structurally by a consensus nucleotide sequence and functionally by PrtT's ability to regulate transcriptional activation through that sequence. Both PrtT and its cognate DNA binding site (i.e., the nucleotide sequence in each promoter that is recognized by PrtT) can be used in a gene expression system. Possession of only a PrtT transcriptional activator is insufficient, its cognate DNA binding site is necessary for recognition by PrtT (i.e., binding to the site and activating transcription under appropriate conditions). A functional site, such as one obtained from a wild-type fungal gene, will confer PrtT-dependent transcriptional activation on 3′-downstream sequences. A mutation of a wild-type promoter that results in a non-functional site will abolish PrtT-dependent transcriptional activation of 3′-downstream sequences. A mutation of a wild-type promoter that results in a more functional site will enhance PrtT-dependent transcriptional activation of 3′-downstream sequences. | 07-09-2009 |
20110165656 | Fungal transcriptional activators useful in methods for producing a polypeptide - The present invention relates to functional cDNA and genomic sequences encoding PrtT proteins, which have transcriptional activity on a protease promoter, to PrtT proteins and to their use. The invention further relates to two distinct types of filamentous fungal cells. Filamentous fungal cells are transformed to over-express these PrtT proteins: this type of filamentous fungus will be highly suited as protease producer. Alternatively, the endogenous prtT genes of filamentous fungal cells are inactivated: this type of filamentous fungus is highly suited for the production of any polypeptide native or not which is highly sensitive for protease degradation. The PrtT proteins of the invention provide means for identification of functional homologues in other species. | 07-07-2011 |
20110311679 | PREGASTRIC ESTERASE AND DERIVATIVES THEREOF - The present invention relates to novel lipase polynucleotide sequences, their corresponding proteins as well as ways of manufacturing said sequences and said proteins and use of the proteins in the preparation of food compositions. The invention further relates to methods for releasing proteins from the exterior of a host cell as well as to a method for killing micro-organisms. | 12-22-2011 |
20110318752 | METHOD FOR IMPROVING THE YEILD OF A POLYPEPTIDE - The present invention relates to a method for improving protein yield. The method comprises modifying the value of a set of relevant protein features to fall within an optimal range or to become more close to an optimal value for one or more protein features in the eukaryotic host. | 12-29-2011 |
Lucie Parenicova, Echt NL
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20140186494 | Pregastric Esterase and Derivatives Thereof - The present invention relates to novel lipase polynucleotide sequences, their corresponding proteins as well as ways of manufacturing said sequences and said proteins and use of the proteins in the preparation of food compositions. The invention further relates to methods for releasing proteins from the exterior of a host cell as well as to a method for killing micro-organisms. | 07-03-2014 |
20140377407 | ALPHA-AMYLASE - This invention relates to a novel alpha-amylase, a process for its preparation and the use of the amylase. | 12-25-2014 |
Lucie Podevin, Henin-Beaumont FR
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20150150251 | BIOSOLUBILIZER - Composition containing at least one substance that is not water-soluble and is solubilised in a sophorolipid, and at least water, and use thereof for cleaning hard surfaces and laundry, for killing plants, for combating insect pests, for combating fungus and mould proliferation, for combating gastropods, for combating moss, algae and lichen proliferation, for the cosmetics industry and for skin and hair care. | 06-04-2015 |
Lucie Pospisilova, Svitavy CZ
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20120095205 | Method of Modification of Hyaluronic Acid by Means of (O-ACYL-O'-ALKYL Carbonate-Substituted Pyridine) Complex - This invention relates to a novel method of preparation of hyaluronic acid derivatives by means of a reaction of the hyaluronic acid with the complex (O-acyl-O′-alkyl carbonate-substituted pyridine) of the general formula R—CO—O—CO—O—R1 and R25C5N. The reaction takes place in DMSO in the presence of an external base, forming O-acylated products. The method leads to higher substitution degrees and shorter reaction times compared to the known analogues, hi case the agent comprises two or more functional groups R(CO—O—CO—O—R1)n, crosslinked hyaluronic acid derivatives are formed. | 04-19-2012 |
20120245323 | OXIDIZED DERIVATIVE OF HYALURONIC ACID, A METHOD OF PREPARATION THEREOF AND A METHOD OF MODIFICATION THEREOF - The invention relates to a hyaluronic acid derivative and methods of preparation and modification of a hyaluronan derivative with an aldehydic group in the position (6) of the polysaccharide glucosamine part. The oxidation of the hyaluronic acid can be performed by means of Dess-Martin periodinane (DMP) agent. The prepared aldehyde can be used for binding amine, diamine, amino acid, peptide and other compounds containing an amino group, e.g. by means of the reductive amination with NaBH | 09-27-2012 |
20120264913 | METHOD OF PREPARATION OF AN OXIDIZED DERIVATIVE OF HYALURONIC ACID AND A METHOD OF MODIFICATION THEREOF - The invention relates to a new method of preparation of a hyaluronan derivative with an aldehydic group in the position (6) of the polysaccharide glucosamine part. The hyaluronic acid oxidation can be performed by means of TEMPO/NaCIO or TEMPO/TCC systems in a protic environment with or without the presence of anorganic salts. Thus prepared aldehyde can be used for binding amines, diamines, amino acids, peptides and other compounds containing an amino group, e.g. by means of the reductive amination with NaBH | 10-18-2012 |
Lucie Potucka, Brezova CZ
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20120149907 | PROCESS FOR PREPARING TRICHLOROAMMINEPLATINATE SALT AND THE PRODUCTS OBTAINED THEREIN - The present invention relates to a process for preparing a trichloroammineplatinate salt by reacting a tetrachloroplatinate salt in aqueous solution in the presence of ammonium chloride and an alkali chloride with one or more carbonate salts selected from the group consisting of potassium, sodium and ammonium carbonate while keeping the pH value below 7 during the reaction; the product obtained therein and a use thereof. | 06-14-2012 |
Lucie Rarova, Pribor CZ
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20150368248 | 2-SUBSTITUTED-6-BIARYLMETHYLAMINO-9-CYCLOPENTYL-9H-PURINE DERIVATIVES, USE THEREOF AS MEDICAMENTS, AND PHARMACEUTICAL COMPOSITIONS - This invention relates to novel 2-substituted-6-biarylmethylamino-9-cyclopentyl-9H-purine derivatives, showing activity as specific inhibitors of growth and angiogenesis of hepatocellular carcinoma. The invention further includes pharmaceutical compositions containing the 2-substituted-6-biarylmethylamino-9-cyclopentylpurines. | 12-24-2015 |
Lucie Rousseville, Waldolwisheim FR
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20100253372 | SEMICONDUCTOR DEVICE AND WAFER WITH A TEST STRUCTURE AND METHOD FOR ASSESSING ADHESION OF UNDER-BUMP METALLIZATION - Semiconductor device with a patterned pad metal layer and a patterned under-bump metallization layer being mutually electrically connected in a common contact area | 10-07-2010 |
Lucie Routaboul, Strasbourg FR
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20130193426 | USE OF ZWITTERIONIC MOLECULES FOR FORMING A HOLE OR ELECTRON TRANSPORT LAYER - The invention relates to the use of zwitterionic molecules for forming a hole or electron transport layer. The preferred zwitterionic molecules of the invention are derivatives of p-benzoquinonemonoimines. The invention is useful in the field of electronic devices in particular. | 08-01-2013 |
Lucie Szucova, Velke Kunetice CZ
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20090170879 | 6,9-Disubstituted Purine Derivatives and Their Use as Cosmetics and Cosmetic Compositions - Certain 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are provided. These 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are useful in compositions for treating mammalian cells, and especially human skin cells, in order to ameliorate the adverse effects of aging, treat skin disease states, treat immunological responses resulting from or associated with inflammation, and the like. | 07-02-2009 |
20100234401 | 6,9-Disubstituted Purine Derivatives and Their Use For Treating Skin - The present invention provides methods and compositions for countering the adverse effects of aging on mammalian cells in vitro and in vivo, especially human skin cells and human skin, and treatment of hyperproliferative and related skin diseases in mammals by administering compositions containing 6,9-disubstituted purine derivatives. | 09-16-2010 |
20110224238 | 6, 9-Disubstituted Purine Derivatives and Their Use for Treating Skin - The present invention provides methods and compositions for countering the adverse effects of aging on mammalian cells in vitro and in vivo, especially human skin cells and human skin, and treatment of hyperproliferative and related skin diseases in mammals by administering compositions containing 6,9-disubstituted purine derivatives. | 09-15-2011 |
20110230503 | 6, 9-Disubstituted Purine Derivatives and Their Use as Cosmetics and Cosmetic Compositions - Certain 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are provided. These 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are useful in compositions for treating mammalian cells, and especially human skin cells, in order to ameliorate the adverse effects of aging, treat skin disease states, treat immunological responses resulting from or associated with inflammation, and the like. | 09-22-2011 |
20130072505 | 6,9-Disubstituted Purine Derivatives and Their Use for Treating Skin - The present invention provides methods and compositions for countering the adverse effects of aging on mammalian cells in vitro and in vivo, especially human skin cells and human skin, and treatment of hyperproliferative and related skin diseases in mammals by administering compositions containing 6,9-disubstituted purine derivatives. | 03-21-2013 |
Lucie Szucova, Olomouc CZ
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20120071433 | Substituted 6-(Benzylamino) Purine Riboside Derivatives, Use Thereof and Compositions Containing These Derivatives - The invention relates to 2-substituted-6-(substituted benzylamino)purine riboside derivatives of the general formula I. These compounds possess antiapoptotic, anti-inflammatory and differentiating activities. The invention relates also to the compositions, which contain these derivatives as active ingredients. | 03-22-2012 |
20130210632 | USE OF 6- SUBSTITUTED 9 - HALOGENALKYL PURINES FOR REGULATION OF GROWTH AND DEVELOPMENT OF WHOLE PLANTS, PLANT CELLS AND PLANT ORGANS; NOVEL 6 - SUBSTITUTED 9 - HALOGENALKYL PURINES - The invention relates to 6-substituted 9-halogenalkyl purine derivatives of the general formula I wherein R6 is selected from the group comprising —NH-furfuryl, —NH-(4-hydroxy-3-methylbut-2-en-1-yl), —NH-(3-methylbut-2-en-1-yl), —NH-(4-hydroxy-3-methylbutyl), —NH-(4-hydroxy-1,3-dimethylbut-2-en-1-yl), —NH-(4-hydroxy-1,3-dimethylbutyl), —NH-benzyl, —NH-phenyl, wherein benzyl, furfuryl and phenyl can be unsubstituted or optionally substituted with 1 to 3 substituents selected from the group comprising hydroxy, halogen, methyl and methoxy, and R9 is selected from the group comprising C | 08-15-2013 |
20140066394 | Substituted 6-(Benzylamino) Purine Riboside Derivatives, Use Thereof and Compositions Containing These Derivatives - A method of treatment using 2-substituted-6-(substituted benzylamino)purine riboside derivatives of the general formula I. These compounds possess antiapoptotic, anti-inflammatory and differentiating activities. | 03-06-2014 |
Lucie Tisovska, Melnik CZ
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20100145064 | METHOD FOR THE PREPARATION OF ZOLMITRIPTAN - A method for the preparation of zolmitriptan or its pharmaceutically acceptable salts, comprising isolation of a crystalline salt of zolmitriptan, its optional re-purification and conversion to the substance of formula (III). Zolmitriptan hydrochloride in the crystalline state. | 06-10-2010 |
Lucie Vistejnova, Kralovice CZ
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20150299911 | Endless Fibres on the Basis of Hyaluronan Selectively Oxidized in the Position 6 of the N-Acetyl-D-Glucosamine Group, Preparation and Use Thereof, Threads, Staples, Yarns, Fabrics Made Thereof and Method for Modifying the Same - The present invention relates to the preparation of textile processable endless monofilaments and multifilaments on the basis of hyaluronan which has been selectively oxidized to aldehyde in the position 6 of its/V-acetyl-D-glucosamine group and to the subsequent modification of such filaments with low molecular dihydrazides. The fibres as well as the fabrics, which are subsequently prepared from the former, exhibit a time-varying solubility in saline depending on the external modification of the fibres. After having been externally modified, the fibres as well as the fabrics exhibit a prolong period of transition into an evenly distributed gel layer. The externally modified fibrous materials retain their full biocompatibility. | 10-22-2015 |
20150320873 | C6-C18-Acylated Derivative of Hyaluronic Acid, Method of Preparation Thereof, Nanomicellar Composition on its Basis, Method of Preparation Thereof and Method of Preparation Stabilized Nanomicellar Composition, and Use Thereof - The invention relates to a method of preparation hydrophobized hyaluronic acid (Formula I) and further to a method of encapsulating biologically active substances into the nanomicelles of hydrophobized hyaluronan serving as carriers of biologically active hydrophobic substances. The hydrophobization of hyaluronan is carried out through an esterification reaction of hyaluronan with long-chain carboxylic acids, the latter being activated by a halogenide derivative of 2,4,6-trichlorobenzoic acid or by another organic chloride. In an aqueous environment, water-soluble hydrophobized derivatives can form nanomicelles in which nonpolar substances can be bound by means of non-covalent physical interactions. The core of a nanomicelle is formed by hydrophobic acyl functional groups while the shell of a nanomicelle is formed by hyaluronic acid. The encapsulation of the substances into nanomicelles can be performed by means of the solvent exchange method or by means of sonication. Hyaluronic nanomicelles support the penetration of bound substances in topical applications and enable the bound substances to be transferred into the individual cells. The nanomicelles obtained from hydrophobized hyaluronan derivatives are usable in cosmetic and pharmaceutical applications. | 11-12-2015 |
Lucie Wolfova, Opava CZ
Patent application number | Description | Published |
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20150175717 | Hyaluronic Acid Derivative, Method of Preparation Thereof, Method of Modification Thereof and Use Thereof - The invention relates to the preparation and use of α,β-unsaturated aldehyde of hyaluronan having a double bond in the positions 4 and 5 and an aldehydic group in the position 6 of the glucosamine part of the polysaccharide. The method of preparation is based on dehydration of hyaluronan having an aldehydic group in the position 6 of the glucosamine part of the polysaccharide. Two methods have been described, which are dehydration in a solution or heating in solid state in absence of solvents, bases or other additives. This derivative allows stabilization of conjugates of hyaluronan with amino compounds by means of a multiple bond from the aldehyde side, and therefore, it is possible to effectively immobilize practically any compound containing an amino group to such modified hyaluronan in physiological conditions. In case of using a diamine or compounds or polymers containing three or more amino groups, it is possible to prepare crosslinked hyaluronan derivatives. The described solution brings along a significant advantage not only in the field of carriers of biologically active substances, but also in tissue engineering where crosslinking with biologically acceptable amino compounds in physiological conditions is very much demanded. | 06-25-2015 |
20150308016 | Fibres Based on Hydrophobized Derivatives of Hyaluronan, Method of Their Preparation and Use, Textiles on Base Thereof and Use Thereof - The invention relates to the biodegradable fibres which are based on hydrophobic derivatives of hylauronan, specifically on the base of the hyaluronan derivative C | 10-29-2015 |