Patent application number | Description | Published |
20090149673 | SYNTHETIC NON-FOULING AMINO ACIDS - Synthetic amino acids containing one or more non-fouling groups or moieties are described herein. In one embodiment, the amino acid has the following chemical formula: | 06-11-2009 |
20090155335 | NON-LEACHING NON-FOULING ANTIMICROBIAL COATINGS - Compositions containing one or more types of membrane-targeting antimicrobial agents immobilized on a substrate with activity in relevant biological environments, and methods of making and using thereof, are described herein. The antimicrobial agents retain their activity in the presence of blood proteins and/or in vivo due to improved molecular structures which allow for cooperative action of immobilized agents and hydrophilic chemistries which resist non-specific protein adsorption. Suitable molecular structures include branched structures, such as dendrimers and randomly branched polymers. The molecule structures may also include hydrophilic tethers which provide both flexibility and resistance to non-specific protein adsorption. The membrane targeting antimicrobial agent coatings can be applied to a variety of different types of substrates including medical implants such as vascular grafts, orthopedic devices, dialysis access grafts, and catheters; surgical tools, surgical garments; and bandages. The substrates can be composed of metallic materials, ceramics, polymers, fibers, inert materials such as silicon, and combinations thereof. The compositions described herein are substantially non-leaching, resistant to non-specific protein adsorption, and non-hemolytic. | 06-18-2009 |
20090258045 | STRUCTURES INCLUDING ANTIMICROBIAL PEPTIDES - A structure includes a substrate and a first plurality of bilayers on the substrate. The first plurality of bilayers includes a first layer including an antimicrobial peptide having a charge, and a second layer including a polyelectrolyte having a charge opposite the charge of the first layer. At least a portion of the structure is capable of degrading by sequential removal of the first layer and the second layer, and releasing the antimicrobial peptide from the structure. | 10-15-2009 |
20100076173 | SYSTEMS AND METHODS FOR GENERATING PEPTIDES - Antimicrobial peptides are small proteins used by the innate immune system to combat bacterial infection in multicellular eukaryotes. There is mounting evidence that these peptides are less susceptible to bacterial resistance than traditional antibiotics and that they may form the basis for a novel class of therapeutics. Systems and methods may treat the amino acid sequences of these peptides as a formal language and build a set of right-linear grammars that describe this language. These grammars may allow for rationally designed novel antimicrobial peptides in silico. These peptides conform to the syntax of natural antimicrobial peptides lack significant homology to any natural sequences, thus populating a previously unexplored region of protein sequence space. Synthesis of these peptides, leads to de novo AmPs. | 03-25-2010 |
20100145286 | LAYERED NON-FOULING, ANTIMICROBIAL ANTITHROMBOGENIC COATINGS - Substrates, optionally coated with an undercoating, having grafted thereto one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted to a variety of functionalized substrate materials, particularly polymeric substrates and/or polymeric undercoatings immobilized on a substrate. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted to a functionalized substrate, or optionally from an undercoating on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material | 06-10-2010 |
20100152708 | NON-FOULING, ANTI-MICROBIAL, ANTI-THROMBOGENIC GRAFT-FROM COMPOSITIONS - Substrates, optionally coated with an undercoating layer, having grafted there from one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted from a variety of substrate materials, particularly polymeric substrates and/or polymeric undercoating layers. The graft-from techniques described herein can result in higher surface densities of the non-fouling material relative to graft-to formulations. Graft-from methods can be used to produce covalently tethered polymers. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted from the substrate, or optionally from an undercoating layer on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material. | 06-17-2010 |
20110305872 | NON-FOULING, ANTI-MICROBIAL, ANTI-THROMBOGENIC GRAFT-FROM COMPOSITONS - A method for preparing and resulting articles of manufacture comprising a substrate having a surface, a bulk beneath the surface, and a grafted polymer layer on the substrate surface, the substrate surface and the grafted polymer layer, in combination, constituting a modified surface having a fibrinogen adsorption of less than about 125 ng/cm | 12-15-2011 |
20110305881 | ARTICLES HAVING NON-FOULING SURFACES AND PROCESSES FOR PREPARING THE SAME INCLUDING APPLYING A PRIMER COAT - Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve coating the substrate to conceal or reduce flaws on or in the surface of the medical device or other article substrate, and thereafter forming a grafted polymer layer on the treated substrate surface. | 12-15-2011 |
20110305895 | ARTICLES HAVING NON-FOULING SURFACES AND PROCESSES FOR PREPARING THE SAME INCLUDING PRETREATMENT OF ARTICLES - Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve treating the substrate to reduce the concentration of chemical species on the surface of or in the substrate without altering the bulk physical properties of the device or article, and thereafter forming a grafted polymer layer on the treated substrate surface. | 12-15-2011 |
20110305898 | NON-FOULING, ANTI-MICROBIAL, ANTI-THROMBOGENIC GRAFT COMPOSITIONS - The present invention generally relates to articles of manufacture, such as medical devices, having a non-fouling surface comprising a grafted polymer material. The surface resists the adhesion of biological material. | 12-15-2011 |
20110305909 | ARTICLES HAVING NON-FOULING SURFACES AND PROCESSES FOR PREPARING THE SAME WITHOUT ALTERING BULK PHYSICAL PROPERTIES - Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve treating the substrate to reduce the concentration of chemical species on the surface of or in the substrate without altering the bulk physical properties of the device or article, and thereafter forming a grafted polymer layer on the treated substrate surface. | 12-15-2011 |
20130155370 | SURFACE MODIFIED CONTACT LENSES - Medical devices having a wettable, biocompatible surface are described herein. Processes for producing such devices are also described. | 06-20-2013 |
20130158150 | MULTISTEP UV PROCESS TO CREATE SURFACE MODIFIED CONTACT LENSES - Medical devices having a wettable, biocompatible surface are described herein. Processes for producing such devices are also described. | 06-20-2013 |
20130158211 | IMBIBING PROCESS FOR CONTACT LENS SURFACE MODIFICATION - Medical devices having a wettable, biocompatible surface are described herein. Processes for producing such devices are also described. | 06-20-2013 |
20130158488 | LUMINAL MODIFICATIONS FOR CATHETERS - Catheters and a method of preparation thereof comprising a catheter body and at least one connector. The catheter body has an exterior surface and at least one lumen having an aspect ratio of at least 3:1 and an intraluminal surface comprising a hydrophilic polymer layer thereon, the hydrophilic polymer layer has an average dry thickness of at least about 50 nanometers. | 06-20-2013 |
20130158517 | SURFACE MODIFICATION FOR DIALYSIS CATHETERS - Catheters and a method of preparation thereof, the catheter comprising a catheter body, a juncture hub, extension lines and connectors, the catheter body having a proximal end, a distal end, an exterior surface, a tip region having a length of 10 cm measured from the distal end of the catheter body, and at least two lumen, each of the catheter body lumen having a proximal end, a distal end, a Lumen Aspect Ratio of at least 3:1, and an intraluminal surface, the distal ends of the at least two catheter body lumen being (i) non-coterminus or (ii) laser-cut, the exterior surface of the catheter body in the tip region or the intraluminal surface of the two catheter body lumen comprising a hydrophilic polymer layer having an Average Dry Thickness of at least about 50 nanometers. | 06-20-2013 |
20130158518 | SURFACE MODIFICATION FOR CATHETERS COMPRISED OF MULTIPLE MATERIALS - Catheters and a method for preparation thereof, the catheter comprising as component parts thereof a catheter body, a juncture hub, at least one extension line and at least one connector, each of said component parts comprising an exterior surface, at least one lumen having an intraluminal surface and a bulk polymer, wherein the intraluminal or external surface of a first of said component parts and the exterior or intraluminal surface of a second of said component parts comprise a hydrophilic polymer layer thereon having an Average Dry Thickness of at least about 50 nanometers and the first and second component parts comprise bulk polymers having different chemical compositions | 06-20-2013 |
20130176529 | SILICONE HYDROGEL CONTACT LENS MODIFIED USING LANTHANIDE OR TRANSITION METAL OXIDANTS - Medical devices having a wettable, biocompatible surface are described herein. Processes for producing such devices are also described. | 07-11-2013 |
20130188124 | HIGH IONIC STRENGTH PROCESS FOR CONTACT LENS MODIFICATION - Medical devices having a wettable, biocompatible surface are described herein. Processes for producing such devices are also described. | 07-25-2013 |
20140037967 | ARTICLES HAVING NON-FOULING SURFACES AND PROCESSES FOR PREPARING THE SAME INCLUDING PRETREATMENT OF ARTICLES - Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve treating the substrate to reduce the concentration of chemical species on the surface of or in the substrate without altering the bulk physical properties of the device or article, and thereafter forming a grafted polymer layer on the treated substrate surface. | 02-06-2014 |
20140045398 | LAYERED NON-FOULING, ANTIMICROBIAL ANTITHROMBOGENIC COATINGS - Substrates, optionally coated with an undercoating, having grafted thereto one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted to a variety of functionalized substrate materials, particularly polymeric substrates and/or polymeric undercoatings immobilized on a substrate. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted to a functionalized substrate, or optionally from an undercoating on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material | 02-13-2014 |
20150045515 | NON-FOULING, ANTI-MICROBIAL, ANTI-THROMBOGENIC GRAFT-FROM COMPOSITIONS - A method for preparing and resulting articles of manufacture comprising a substrate having a surface, a bulk beneath the surface, and a grafted polymer layer on the substrate surface, the substrate surface and the grafted polymer layer, in combination, constituting a modified surface having a fibrinogen adsorption of less than about 125 ng/cm | 02-12-2015 |
20150056411 | NON-FOULING, ANTI-MICROBIAL, ANTI-THROMBOGENIC GRAFT COMPOSITIONS - The present invention generally relates to articles of manufacture, such as medical devices, having a non-fouling surface comprising a grafted polymer material. The surface resists the adhesion of biological material. | 02-26-2015 |
Patent application number | Description | Published |
20080208483 | Sonar-Based Flow Meter Operable To Provide Product Identification - An apparatus and method for identifying one or more fluid products flowing within a pipe are provided having a flow meter mounted on the pipe and a processing unit. The flow meter has a plurality of sensors operable to detect vortical disturbances flowing with the fluid products and acoustic waves propagating through the fluid. The sensors produce signals indicative of the vortical disturbances and acoustic waves. The processing unit is operable to determine the speed of sound and volumetric flow rate of the one or more fluid products using the signals from the flow meter. The processing unit includes a database having speed of sound data for a predetermined group of products. The processing unit is operable to identify the type of each product flowing within the pipe given a temperature and pressure value of the products within the pipe. | 08-28-2008 |
20080223129 | Apparatus and method for providing a density measurement augmented for entrained gas - A flow measuring system combines a density measuring device and a device for measuring the speed of sound (SOS) propagating through the fluid flow and/or for determining the gas volume fraction (GVF) of the flow. The GVF meter measures acoustic pressures propagating through the fluids to measure the speed of sound α | 09-18-2008 |
20090044638 | VELOCITY BASED METHOD FOR DETERMINING AIR-FUEL RATIO OF A FLUID FLOW - A method for determining one or more fluid flow parameters for a fluid flowing within a pipe is provided. The fluid is a mixture of solid particles and gas. The method includes the steps of: a) providing a meter operable to determine the velocity of the fluid flow through the pipe, which meter is substantially insensitive to the particulate/gas mass ratio of the fluid flow; b) determining the velocity of the fluid flow within the pipe using the meter; and c) determining a particulate/gas mass ratio using a density value for the gas within the flow and the determined fluid flow velocity. | 02-19-2009 |
20100107727 | MEASUREMENT OF ENTRAINED AND DISSOLVED GASES IN PROCESS FLOW LINES - A device for measurement of entrained and dissolved gas has a first module arranged in relation to a process line for providing a first signal containing information about a sensed entrained air/gas in a fluid or process mixture flowing in the process line at a process line pressure. The device features a combination of a bleed line, a second module and a third module. The bleed line is coupled to the process line for bleeding a portion of the fluid or process mixture from the process line at a bleed line pressure that is lower than the process pressure. The second module is arranged in relation to the bleed line, for providing a second signal containing information about a sensed bleed line entrained air/gas in the fluid or process mixture flowing in the bleed line. The third module responds to the first signal and the second signal, for providing a third signal containing information about a dissolved air/gas flowing in the process line based on a difference between the sensed entrained air/gas and the sensed bleed line entrained air/gas. | 05-06-2010 |
20100332154 | Velocity Based Method for Determining Air-Fuel Ratio of a Fluid Flow - A method for determining one or more fluid flow parameters for a fluid flowing within a pipe is provided. The fluid is a mixture of solid particles and gas. The method includes the steps of: a) providing a meter operable to determine the velocity of the fluid flow through the pipe, which meter is substantially insensitive to the particulate/gas mass ratio of the fluid flow; b) determining the velocity of the fluid flow within the pipe using the meter; and c) determining a particulate/gas mass ratio using a density value for the gas within the flow and the determined fluid flow velocity. | 12-30-2010 |
20110118998 | APPLICATIONS OF PUMP PERFORMANCE MONITORING - The present invention provides a processor or signal processing module that features one or more modules configured to receive an input signal containing information about the unsteady pressures or acoustic emissions caused by a medium flowing through a pump, and also configured to provide of an output signal containing information about the performance of the pump. The information about the performance of the pump may include information about pump performance monitoring by a slip flow measurement, about predicting impeller wear, about pump impeller cavitation monitoring, about pump monitoring through acoustic emissions, about pump leak detection, about pump efficiency monitoring and about positive displacement pump monitoring. | 05-19-2011 |
20120017699 | APPLICATIONS FOR REAL-TIME MASS RATIO, MASS FLOW AND PARTICLE SIZE MEASUREMENT OF PARTICLE LADEN FLOWS - Techniques are provided for monitoring particle laden flows in a pipe, that include receiving signalling containing information about a parameter related to a particle laden flow in a pipe, the parameter including either (a) a sound level propagating through the particle laden flow in the pipe, or (b) a static pressure due to an acceleration of the particle laden flow in the pipe; and determining a measurement of a particle size and either a mass flow rate, or a particle-to-air mass ratio, or both the mass flow rate and the particle-to-air mass ratio, associated with the particle laden flow, based at least partly on a change in the parameter. | 01-26-2012 |
20120209550 | PERFORMANCE MONITORING OF INDIVIDUAL HYDROCYCLONES USING SONAR- BASED SLURRY FLOW MEASUREMENT - Apparatus, including a signal processor, featuring at least one module configured to respond to signals containing information about sound propagating through a slurry flowing in part, including overflow pipes, of cyclones operating in parallel on a cyclone battery, and determine the performance of individual cyclones based at least partly on the information contained in the signals. The signal process may form part of a non-invasive acoustic-based passive monitoring system, comprising: cyclones and sensors; where the cyclones are configured in parallel to form a cyclone battery in order to process a slurry, each cyclone having an overflow pipe for providing some portion of the slurry flowing in the cyclone battery, where each sensor is configured to mount on a respective overflow pipe of a respective cyclone, to respond to sound propagating through the slurry flowing in the respective overflow pipe of the respective cyclone, and to provide a respective signal containing information about the sound propagating through the slurry flowing in the respective overflow pipe of the respective cyclone; and where the signal processor is configured to respond to respective signals from the sensors and determine the performance of individual cyclones based at least partly on the information contained in the respective signals. | 08-16-2012 |
20130192351 | METHOD AND APPARATUS FOR DETERMINING GVF (GAS VOLUME FRACTION) FOR AERATED FLUIDS AND LIQUIDS IN FLOTATION TANKS, COLUMNS, DRUMS, TUBES, VATS - The invention provides a signal processor that receives a signal containing information about an acoustic signal that is generated by at least one acoustic transmitter, that travels through an aerated fluid in a container, and that is received by at least one acoustic receiver arranged in relation to the container, including inside the container; and determines the gas volume fraction of the aerated fluid based at least partly on the speed of sound measurement of the acoustic signal that travels through the aerated fluid in the container. The signal processor also sends an output signal containing information about the gas volume fraction of the aerated fluid. The signal processor may be configured together with at least one acoustic transmitter, the at least one acoustic receiver, or both. | 08-01-2013 |
20140297204 | METHOD AND APPARATUS FOR PROVIDING REAL TIME AIR MEASUREMENT APPLICATIONS IN WET CONCRETE - Apparatus is provided having an acoustic-based air probe with an acoustic source configured to provide an acoustic signal into a mixture of concrete; and an acoustic receiver configured to be substantially co-planar with the acoustic source, to respond to the acoustic signal, and to provide signaling containing information about the acoustic signal injected into the mixture of concrete. | 10-02-2014 |
20150082862 | SPEED OF SOUND AND/OR DENSITY MEASUREMENT USING ACOUSTIC IMPEDANCE - Apparatus is provided featuring a signal processor or signal processing module configured at least to: receive signaling containing information about a radiation impedance of a piston vibrating a process medium, including a fluid or slurry; and determine a speed of sound or density measurement related to the process medium, based at least partly on the signaling received. The signal processor or signal processing module may determine a speed of sound measurement related to the process medium, based on at least partly on the density of the process medium, including where the density of the process medium is known, assumed or determined by the signal processor or signal processing module, or determine a density measurement related to the process medium, based on at least partly on the speed at which sound travels in the process medium, including where the speed of sound of the process medium is known, assumed or determined by the signal processor or signal processing module. | 03-26-2015 |