Patent application number | Description | Published |
20110275535 | Yeast Display Systems - The present invention relates to the field of protein display libraries and library screening. In preferred embodiments, the present invention provides a three component system for display comprising a cell surface molecule, an adapter molecule and a display molecule. | 11-10-2011 |
20140271635 | TREATMENT OF CANCER USING HUMANIZED ANTI-CD19 CHIMERIC ANTIGEN RECEPTOR - The invention provides compositions and methods for treating diseases associated with expression of CD19. The invention also relates to chimeric antigen receptor (CAR) specific to CD19, vectors encoding the same, and recombinant T cells comprising the CD19 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD19 binding domain. | 09-18-2014 |
20140322212 | EFFECTIVE TARGETING OF PRIMARY HUMAN LEUKEMIA USING ANTI-CD123 CHIMERIC ANTIGEN RECEPTOR ENGINEERED T CELLS - The invention provides compositions and methods for treating leukemia, for example, acute myeloid leukemia (AML) and B-cell acute lymphoid leukemia (B-ALL). The invention also relates to at least one chimeric antigen receptor (CAR) specific to CD123, vectors comprising the same, and recombinant T cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD123 binding domain. The invention also includes methods of bone marrow ablation for use in treatments necessitating bone marrow reconditioning or transplant. | 10-30-2014 |
20140322275 | TREATMENT OF CANCER USING HUMANIZED ANTI-EGFRvIII CHIMERIC ANTIGEN RECEPTOR - The invention provides compositions and methods for treating diseases associated with expression of EGFRvIII. The invention also relates to chimeric antigen receptor (CAR) specific to EGFRvIII, vectors encoding the same, and recombinant T cells comprising the anti-EGFRvIII CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an anti-EGFRvIII binding domain. | 10-30-2014 |
Patent application number | Description | Published |
20110038866 | IMPROVED FIBRONECTIN-BASED BINDING MOLECULES AND USES THEREOF - The invention provides fibronectin type III (Fn3)-based binding molecules that bind to a specific target antigen. The invention further provides bispecific Fn3-based binding molecules that bind to two or more targets simultaneously. The Fn3-based binding molecules of the invention can also be linked together to form multispecific Fn3-based binding molecules, and/or can be conjugated to a non-Fn3 moiety, such as, Human Serum Albumin (HSA), for improved half life and stability. The invention also provides methods for generating, screening and using Fn3-based binding molecules in a variety of therapeutic and diagnostic applications. | 02-17-2011 |
20120129766 | METHODS OF TREATING FGF21-ASSOCIATED DISORDERS - The invention relates to the identification of new polypeptide and protein variants of fibroblast growth factor 21 (FGF21) that have improved pharmaceutical properties. Also disclosed are methods for treating FGF21-associated disorders, including metabolic conditions. | 05-24-2012 |
20120208704 | UNIVERSAL FIBRONECTIN TYPE III BOTTOM-SIDE BINDING DOMAIN LIBRARIES - The invention pertains to a natural-variant combinatorial library of fibronectin Type 3 domain (Fn3) polypeptides useful in screening for the presence of one or more polypeptides having a selected binding or enzymatic activity. The library polypeptides include (a) regions A, AB, B, C, CD, D, E, EF, F, and G having wildtype amino acid sequences of a selected native fibronectin Type 3 polypeptide or polypeptides, and (b) loop regions AB, CD, and EF having selected lengths (Bottom Loops). The Fn3 may also have loop regions BC, DE, and FG having wildtype amino acid sequences, having selected lengths, or mutagenized amino acid sequences (Top Loops). | 08-16-2012 |
20130064823 | COMPOSITIONS AND METHODS OF USE FOR THERAPEUTIC LOW DENSITY LIPOPROTEIN - RELATED PROTEIN 6 (LRP6) MULTIVALENT ANTIBODIES - The present disclosure relates to an antibody or antigen binding fragment having at least two receptor binding do mains for two different binding sites of LRP6 and compositions and methods of use thereof. | 03-14-2013 |
20130129724 | DUAL FUNCTION PROTEINS FOR TREATING METABOLIC DISORDERS - The present invention relates to the identification of new proteins comprising fibroblast growth factor 21 (FGF21) and other metabolic regulators, including variants thereof, known to improve metabolic profiles in subjects to whom they are administered. Also disclosed are methods for treating FGF21-associated disorders, GLP-1-associated disorders, and Exendin-4-associated disorders, including metabolic conditions. | 05-23-2013 |
20140050725 | LOW DENSITY LIPOPROTEIN - RELATED PROTEIN 6 (LRP6) - HALF LIFE EXTENDER CONSTRUCTS - The present invention relates to LRP6 constructs that bind to LRP6 receptor. The LRP6 constructs comprise at least one LRP6 binding moiety and a half-life extender molecule such that the LRP6 construct inhibit the Wnt signaling pathway without potentiation of the Wnt signal. The LRP6 constructs also have an increased half-life to provide more time for the therapeutic benefit. | 02-20-2014 |
20140057807 | FIBRONECTIN CRADLE MOLECULES AND LIBRARIES THEREOF - The here described invention discloses a combination of a top and bottom loop binder library using the CD and the FG loops of a number of FnIII domains (FnIII) (e.g., FnIII | 02-27-2014 |
20140161796 | SINGLE CHAIN PROTEINS WITH C-TERMINAL MODIFICATIONS - The invention pertains to an isolated V | 06-12-2014 |
20150030617 | LOW DENSITY LIPOPROTEIN - RELATED PROTEIN 6 (LRP6) - HALF LIFE EXTENDER CONSTRUCTS - The present invention relates to LRP6 constructs that bind to LRP6 receptor. The LRP6 constructs comprise at least one LRP6 binding moiety and a half-life extender molecule such that the LRP6 construct inhibit the Wnt signaling pathway without potentiation of the Wnt signal. The LRP6 constructs also have an increased half-life to provide more time for the therapeutic benefit. | 01-29-2015 |
Patent application number | Description | Published |
20100160952 | Expandable Guide Sheath and Apparatus and Methods for Making Them - An apparatus for providing access to a body lumen includes a tubular proximal portion and an expandable distal portion, which extends distally from a distal end of the proximal portion. The expandable distal portion includes an expandable sheath and a stiffening member. The proximal portion has a first lumen extending from a proximal end to a distal end thereof, and the expandable sheath defines a second lumen that is in fluid communication with the first lumen and extends distally from the proximal portion to a distal terminal opening of the second lumen. The stiffening member is attached directly to the expandable sheath so as to extend alongside the second lumen, and the distal terminal opening of the second lumen is defined by a portion of a perimeter of a distal terminal end of the expandable sheath that becomes spaced apart from the stiffening member when the sheath is expanded. | 06-24-2010 |
20110196365 | Systems, Apparatus, Methods, and Procedures for the Non-Invasive Treatment of Tissue Using Microwave Energy - A system applies, in a non-invasive manner, energy to a targeted tissue region employing a controlled source of energy, a multiple use applicator, and a single use, applicator-tissue interface carried by the applicator. The system can generate and apply energy in a controlled fashion to form a predefined pattern of lesions that provide therapeutic benefit, e.g., to moderate or interrupt function of the sweat glands in the underarm (axilla). | 08-11-2011 |
20110215023 | DUAL COMPARTMENT SANDWICH CONTAINER AND METHOD OF MAKING SAME - A sandwich container includes an outer housing. The outer housing includes a tray compartment body and a lid compartment body. The tray compartment body is hingedly connected to the lid compartment body. The tray compartment body defines a tray compartment and the lid compartment body defines a lid compartment. The sandwich container also includes a divider hingedly connected to the outer housing. The divider is rotatable from an unseated position to a seated position. The divider is configured to separate the tray compartment from the lid compartment when the divider is in the seated position. | 09-08-2011 |
20110215097 | DUAL COMPARTMENT SANDWICH CONTAINER AND METHOD OF MAKING SAME - A flexible divider for separating a lower compartment of a container from an upper compartment of the container includes a transverse member and a rim defining an outer perimeter of the divider. The flexible divider also includes a flexible wall connecting the transverse member to the rim. The flexible wall is configured to facilitate movement of the transverse member from an upper stable position to a lower stable position. | 09-08-2011 |
20110313412 | TISSUE INTERFACE SYSTEM AND METHOD - An applicator-tissue interface is disclosed for use in connection with medical device treatment applicators. The interface provides a cover to protect applicator components against contamination and may be disposable or reusable. Also included are tissue acquisition features including a tissue receiving chamber defined by a bio-barrier with vacuum ports or channels for tissue acquisition. Vacuum balancing is provided to prevent contamination on the applicator side of the bio-barrier. Locking mechanisms are disclosed for ensuring secure attachment between the interface and applicator. Methods of using the applicator-tissue interface in connection with an applicator are also disclosed. | 12-22-2011 |
20120298675 | BEVERAGE CONTAINER WITH HEATING OR COOLING INSERT AND METHOD OF MAKING SAME - A container assembly for maintaining a temperature of a liquid includes an outer wall defining an interior cavity for storing the liquid. The container assembly also includes an inner wall indirectly connected to the outer wall. The inner wall defines an external cavity configured to receive a thermal cartridge for maintaining the temperature of the material within the inner cavity. The thermal cartridge includes a base portion configured to couple the thermal cartridge to the container assembly. The thermal cartridge also includes an insert portion configured to be received by the external cavity. The base portion and the insert portion unitarily form the thermal cartridge. | 11-29-2012 |
20130007967 | Oral-care device and system - A device with two or more regions configured to clean or treat a working surface is disclosed. Preferably, the device is an oral-care device with a power cleaning head. The power cleaning head comprises two or more regions, wherein at least one of the regions is configured to move and wherein at least one of the regions comprises a squeegee element. Preferably, the regions are configured to independently rotate, oscillate, vibrate or otherwise move while cleaning teeth and gums and can each include bristles, nodules, squeegee elements, or any combination thereof. | 01-10-2013 |
20140041137 | Multi-directional wiping elements and device using the same - Multi-directional wiping elements are disclosed. The wiping elements comprise intersecting squeegee segments that provide top wiping squeegee edges and side wiping squeegee edges. Devices utilizing the multi-directional wiping elements of the present invention can include bristles that are configured to simultaneously wipe a working surface with the wiping elements. In accordance with the embodiments of the invention, the multi-directional wiping elements are utilized in a toothbrush cleaning head that is configured to be operated manually or, alternatively, is motorized and is configured to rotate, oscillate, vibrate and/or move according to a combination thereof. | 02-13-2014 |
20140201932 | Oral-care device and system - A device with two or more regions configured to clean or treat a working surface is disclosed. Preferably, the device is an oral-care device with a power cleaning head. The power cleaning head comprises two or more regions, wherein at least one of the regions is configured to move and wherein at least one of the regions comprises a squeegee element. Preferably, the regions are configured to independently rotate, oscillate, vibrate or otherwise move while cleaning teeth and gums and can each include bristles, nodules, squeegee elements, or any combination thereof. | 07-24-2014 |
20150148792 | SYSTEMS, APPARATUS, METHODS, AND PROCEDURES FOR THE NON-INVASIVE TREATMENT OF TISSUE USING MICROWAVE ENERGY - A system applies, in a non-invasive manner, energy to a targeted tissue region employing a controlled source of energy, a multiple use applicator, and a single use, applicator-tissue interface carried by the applicator. The system can generate and apply energy in a controlled fashion to form a predefined pattern of lesions that provide therapeutic benefit, e.g., to moderate or interrupt function of the sweat glands in the underarm (axilla). | 05-28-2015 |
Patent application number | Description | Published |
20130046810 | METHOD, SYSTEM, AND APPARATUS FOR FUTURE DELIVERY OF DIGITAL CONTENT OVER A NETWORK - According to embodiments of the invention, there are provided a system and method for future delivery of digital content over a data network. Digital content may be obtained at a server over a data network from a client device or from a third party vendor server, the digital content being intended for future delivery to one or more recipients, on or after a designated delivery date. The delivery metadata may include at least one recipient and a delivery date. The digital content may be stored and inaccessible to the recipient user, until the delivery date, at which time, the content may be delivered to the at least one recipient. | 02-21-2013 |
20150142877 | METHOD, SYSTEM, AND APPARATUS IN SUPPORT OF POTENTIAL FUTURE DELIVERY OF DIGITAL CONTENT OVER A NETWORK - A method in support of potential future delivery of digital content items over a data network includes obtaining at a server over the data network at least one digital content item for potential future delivery and delivery metadata pertaining to potential future delivery of the digital content item. The delivery metadata includes at least one recipient and a monitoring interval. The digital content item is stored by a processor of the server, and, during the monitoring interval, a user account associated with the digital content item is monitored by the processor for an occurrence of an inactivity benchmark. Upon a lapse of the monitoring interval without an occurrence of the inactivity benchmark, the digital content item is delivered to the at least one recipient. A system can be constructed to implement the method described herein. | 05-21-2015 |
Patent application number | Description | Published |
20090042227 | AMINO(OLIGO)THIOPHENE DYES, PREPARATION THEREOF, AND OPTICAL METHODS OF USE - Amino(oligo)thiophene dyes useful for studying the electrophysiology of organelles, cells, and tissues are described. Compared to previously known dyes, the amino(oligo)thiophene dyes exhibit improved (faster) response to membrane potential changes, as well as the ability to be excited by 1064 nanometer femtosecond pulses. Methods of preparing the amino(oligo)thiophene dyes are also described. | 02-12-2009 |
20120196893 | COMPOSITION, METHOD, SYSTEM AND KIT FOR OPTICAL ELECTROPHYSIOLOGY - The present invention provides a method of optical electrophysiological probing, including: providing a fluorescing chemical probe; contacting a thick portion of tissue with the fluorescing chemical probe to create a thick portion of treated tissue; applying a first range of wavelengths of electromagnetic radiation to the treated portion of tissue; and detecting a plurality of depth-specific emission wavelengths emitted from the thick portion of treated tissue. | 08-02-2012 |
20130330762 | FLUORINATED VOLTAGE SENSITIVE DYES, PREPARATION THEREOF, AND OPTICAL METHODS OF USE - A fluorinated voltage sensitive dye has the structure | 12-12-2013 |
Patent application number | Description | Published |
20130136570 | DIPPER BAIL - The invention provides a bail for a rope shovel having a hoist rope and a dipper. The bail includes a pair of arms coupled to the dipper; and a cross-member extending between the pair of arms and being pivotably coupled to each of the arms. The cross-member includes a mounting block for coupling the hoist rope to the bail. | 05-30-2013 |
20130261904 | EXTENDED REACH CROWD CONTROL FOR A SHOVEL - An industrial machine and a method of controlling an industrial machine, the industrial machine including a dipper supported by a dipper handle. The method may include determining an operating phase of the industrial machine, in a first operating phase of the industrial machine, limiting, with at least one controller, a reach of the dipper handle, and in a second operating phase of the industrial machine, enabling, with the at least one controller, an extended reach of the dipper handle greater than the reach in the first operating phase. The industrial machine may include at least one controller configured to determine an operating phase of the industrial machine, in a first operating phase of the industrial machine, limit a reach of the dipper handle, and, in a second operating phase of the industrial machine, enable an extended reach of the dipper handle greater than the reach in the first operating phase. | 10-03-2013 |