List, US
Alan List, Tampa, FL US
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20150343078 | TARGETED SENSITIZATION OF NON-DEL(5q) MALIGNANT CELLS - Disclosed are molecules for treating non-del(5q) MDS that mimic allelic deficiency in del5q MDS to sensitize the malignant clones of patient without del(5q). The disclosed molecule contains an inhibitor of Cdc25C, an inhibitor of PP2Acα, or a combination thereof, and a toll like receptor-9 (TLR9) targeting ligand. The molecule can also contain lenalidomide, or an analogue or derivative thereof. Also disclosed is a composition comprising the disclosed molecule in a pharmaceutically acceptable carrier. Also disclosed is a method for treating non-del(5q) meylodysplastic syndrome (MDS) in a subject by administering to the subject a therapeutically effective amount of the disclosed pharmaceutical composition. | 12-03-2015 |
20150344953 | RNF41 AS A BIOMARKER PREDICTING RESPONSE TO LENALIDOMIDE IN NON-DEL(5Q) MDS - Disclosed herein is a method of using erythroid expression levels of RNF41 as a predictive biomarker for responsiveness to lenalidomide (LEN) in patients with non-del(5q) MDS. | 12-03-2015 |
Alan F. List, Tampa, FL US
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20120316081 | Method of Identifying Myelodysplastic Syndromes - Myelodysplastic syndromes display both hematological and biological heterogeneity with variable leukemia potential. To determine whether microRNAs expression offers diagnostic discrimination or influences malignant potential in MDS, bone marrow miRNA expression was investigated from prognostically distinct MDS subsets using a microarray platform. After background subtraction and normalization, data were analyzed indicating thirteen miRNA signature with statistically significant differential expression, including down-regulation of members of a leukemia associated miRNA family. A unique signature consisting of 10 miRNAs was closely associated with International Prognostic Scoring System risk category permitting discrimination between lower and higher risk disease. Selective overexpression of miRNA-181 family members was detected in higher risk MDS, indicating pathogenetic overlap with acute myeloid leukemia. Analysis of miRNA expression profile offers diagnostic utility, and provides pathogenetic and prognostic discimination in MDS. | 12-13-2012 |
20150324543 | PATHWAYS FOR TREATING PATIENTS - Methods, systems, and apparatus, including computer programs encoded on a computer storage medium are provided, including a method for presenting information for treating patients. The method comprises presenting, in a user interface, a pathway for use in treating a patient with a disease and including a combination of therapeutic and diagnostic pathway elements including an integration of diagnostic, radiation, chemotherapy, surgical and other elements. The method further comprises augmenting the pathway including providing controls for accessing additional information associated with a given pathway element, augmenting pathway elements to include indicators for pricing, efficacy and/or toxicity of a treatment associated with a given treatment element, and augmenting the pathway with a connection to another pathway including providing a link to another pathway at a point in a given pathway that provides information for a related pathway. The method further comprises presenting an augmented pathway to a patient or treating physician. | 11-12-2015 |
Bobbie List, Mckeesport, PA US
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20090061219 | Composition for Coating Glass - A coating composition is provided that is suitable for use on glass articles. When suitably cured on a glass substrate, the coating composition provides a durable and abrasion resistant coating. The coating composition preferably includes an acrylic polymer, an optional crosslinker, and a carrier. | 03-05-2009 |
James List, Princeton, NJ US
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20120071403 | Methods for Treating Type 2 Diabetes in Patients Resistant to Previous Treatment with other Anti-Diabetic Drugs Employing an SGLT2 Inhibitor and Compositions Thereof - The invention provides methods for treating a patient having type 2 diabetes who has failed on previous regimens of one or more oral and/or injectable anti-diabetic agents, which include the step of administering a therapeutically effective amount of an SGLT2 inhibitor alone or in combination with another anti-diabetic agent and/or other therapeutic agent to such patient. A pharmaceutical composition containing dapagliflozin or dapagliflozin-S-propylene glycol solvate and one or more diabetic agents and/or other therapeutic agents for use in the methods of the invention is also provided. | 03-22-2012 |
James F. List, Princeton, NJ US
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20080234367 | Methods for Treating Obesity Employing an SGLT2 Inhibitor and Compositions Thereof - Methods are provided for treating obesity or causing weight loss in a mammalian subject or patient, wherein a therapeutically effective amount of an SGLT2 inhibitor alone or optionally in combination with another anti-obesity agent, is administered to a mammalian subject or patient. In addition, a pharmaceutical composition is provided which comprises an SGLT2 inhibitor, alone or in combination with another anti-obesity agent, and a pharmaceutically acceptable carrier thereof. | 09-25-2008 |
20090202497 | USE OF GLP-1, GLP-1 DERIVATIVES OR GLP-1 FRAGMENTS FOR SKIN REGENERATION, STIMULATION OF HAIR GROWTH, OR TREATMENT OF DIABETES - The present invention relates to the use of GLP-I, GLP-I derivatives or GLP-I fragments for skin regeneration or hair growth in mammals. As used for skin regeneration, GLP-I, GLP-I derivatives or GLP-I fragments can be applied to dermal wounds including burns, lacerations, cuts and scrapes. As used for hair growth, GLP-I, GLP-I derivatives or GLP-I fragments can be applied to humans suffering from alopecia, or baldness. GLP-I, GLP-I derivatives or GLP-I fragments can also be used to stimulate hair growth in animals raised for their pelts. GLP-I, GLP-I derivatives or GLP-I fragments can also be used in the redifferentiation of endothelial or skin cells into insulin producing cells, as a treatment for patients suffering from diabetes. | 08-13-2009 |
20120077739 | METHODS FOR TREATING OBESITY EMPLOYING AN SGLT2 INHIBITOR AND COMPOSITIONS THEREOF - Methods are provided for treating obesity or causing weight loss in a mammalian subject or patient, wherein a therapeutically effective amount of an SGLT2 inhibitor alone or optionally in combination with another anti-obesity agent, is administered to a mammalian subject or patient. In addition, a pharmaceutical composition is provided which comprises an SGLT2 inhibitor, alone or in combination with another anti-obesity agent, and a pharmaceutically acceptable carrier thereof. | 03-29-2012 |
20120101038 | USE OF GLP-1, GLP-1 DERIVATIVES OR GLP-1 FRAGMENTS FOR SKIN REGENERATION, STIMULATION OF HAIR GROWTH, OR TREATMENT OF DIABETES - The present invention relates to the use of GLP-I, GLP-I derivatives or GLP-I fragments for skin regeneration or hair growth in mammals. As used for skin regeneration, GLP-I, GLP-I derivatives or GLP-I fragments can be applied to dermal wounds including burns, lacerations, cuts and scrapes. As used for hair growth, GLP-I, GLP-I derivatives or GLP-I fragments can be applied to humans suffering from alopecia, or baldness. GLP-I, GLP-I derivatives or GLP-I fragments can also be used to stimulate hair growth in animals raised for their pelts. GLP-I, GLP-I derivatives or GLP-I fragments can also be used in the redifferentiation of endothelial or skin cells into insulin producing cells, as a treatment for patients suffering from diabetes. | 04-26-2012 |
John A. List, Albuquerque, NM US
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20130283381 | SYSTEMS AND METHODS FOR PROVIDING ANTI-MALWARE PROTECTION ON STORAGE DEVICES - Systems and methods for providing anti-malware protection on storage devices are described. In one embodiment, a storage device includes a controller, firmware, and memory. The firmware communicates with an authorized entity (e.g., external entity, operating system) to establish a secure communication channel. The system includes secure storage to securely store data. | 10-24-2013 |
John Howard List, Cincinnati, OH US
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20130149139 | DYNAMIC LOAD REDUCTION SYSTEM - Bolted together first and second flanges include bolts disposed through first bolt holes in the first flange. The bolts extend at least partially through second holes in the second flange. Bolt include bolt heads, threads, and shanks therebetween. Crushable spacers disposed around the shanks of a first plurality of the bolts and contacting and axially extending between the bolt heads and the first flange. Bushings disposed around a second plurality of the bolts and contacting and axially extending between the bolt heads and the second flange. A shank outer diameter may be smaller than a thread diameter and heat shrink tubing may be disposed around the bolt shanks of at least some of the spacers. First bolt holes may extend into an open annular slot on first flange and second holes may extend partially through a forward extending annular rail of second flange with rail received within slot. | 06-13-2013 |
Joost List, Seattle, WA US
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20100112266 | METHOD FOR PRODUCING A CONNECTION BETWEEN COMPOSITE PARTS - A method for joining together constructional parts which are made of a composite material and extend transversely to one another, such as a flange and a web of a profile, includes the steps of: | 05-06-2010 |
Matthew Jeremy List, Canton, OH US
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20120024441 | PNEUMATIC TIRE - The present invention is directed to a pneumatic tire having a rubber tread of a cap/base construction comprised of an outer rubber tread cap layer containing an outer running surface and an underlying rubber tread base layer, wherein said tread cap layer is comprised of a plurality of circumferential, longitudinal rubber tread cap zones of graduated physical properties, wherein said tread cap zones individually extend from said tread cap running surface radially inward to said tread base layer: wherein said tread cap zones are comprised of two primary tread cap zones and one central tread cap zone; | 02-02-2012 |
Michael List, Milford, OH US
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20120301645 | COATING COMPOSITIONS WITH IMPROVED ADHESION TO CONTAINERS - A coating composition comprising a resinous binder and up to 10 percent by weight of the reaction product of (i) a phosphorus acid, and (ii) a polyglycidyl ether of cyclohexane dimethanol. The compositions are useful for coating containers of all sorts, such as food and beverage containers, and the reaction product provides enhanced adhesion of the coating to the substrate. The compositions can be formulated to be substantially free of bisphenol A (BPA) and derivatives thereof such as bisphenol A diglycidyl ether (BADGE). | 11-29-2012 |
20120301646 | COATING COMPOSITIONS FOR CONTAINERS - A coating composition comprising a polyether polyol having a hydroxyl functionality of 3 to 8 and the reaction product of: | 11-29-2012 |
Michael E. List, Grand Blanc, MI US
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20090259883 | ROBUST SYNCHRONIZATION OF DIAGNOSTIC INFORMATION AMONG POWERTRAIN CONTROL MODULES - An automotive system has a primary control module, such as an engine control module (ECM) configured for connection to a malfunction indicator lamp (MIL), and a secondary control module, such as a transmission control module (TCM), each in communication with each other over a bus. Each control module includes a respective diagnostic data status record. Each record includes a pending fault field, a confirmed fault field and an MIL control status field. An improved method for synchronizing the diagnostic data contained in the respective status records includes an extended status signal set that is used to communicate over the bus. The set includes a diagnostic testing complete signal, a fault present signal and a MIL request signal indicative of a request to illuminate the MIL. Logic in the receiving control module (ECM) interprets the extended status signal set to properly synchronize its diagnostic data status record with the TCM's, including both pending and confirmed faults. | 10-15-2009 |
20090319162 | METHOD TO DETECT THE PRESENCE OF A LIQUID-COOLED ENGINE SUPPLEMENTAL HEATER - A method for detecting an engine block heater includes block heater detection logic and a data table containing calibration thresholds. The method determines a time-series of delta (Δ) engine coolant temperatures (ECT), which represent the respective differences between a start-up ECT and a plurality of operating ECT values measured thereafter. The method integrates the time-series to obtain a Δ ECT integral. The method also maintains an integrated engine speed parameter accumulated over the course of the detection period. Throughout the detection period, the method retrieves a threshold value from the table based on the integrated engine speed (Y-axis) versus an elapsed time (X-axis) since the detection period began. When the calculated Δ ECT integral value exceeds the retrieved threshold, the method determines that the block heater was operated, which can thereafter be used to suppress sensor rationality testing or reporting of results thereof. | 12-24-2009 |
20130187447 | CONTROL AND DIAGNOSTICS OF MULTIPLE ELECTRICAL GENERATING MACHINES USING AN EXTERNAL VOLTAGE REGULATOR - An electrical system for an automotive vehicle has a plurality of electrical generating machines having field windings energized by pulse width modulated drive signals generated by an external electronic voltage regulator. The pulse width modulated drive signals have a duty cycle determined by the electronic voltage regulator. A controller selects one of electrical generating machines to evaluate for failure and evaluates that electrical generating machine for failure by causing the PWM drive signal for the field windings of that electrical generating machine to be disabled. The controller then determines that this electrical generating machine has failed if the duty cycle for the PWM drive signals has then not been increased by the electronic voltage regulator by a pre-determined amount. The electrical generating machines are either generators or alternators. In an aspect, the PWM drive signals for the plurality of electrical generating machines are out of phase with each other. | 07-25-2013 |
Richard Scott List, Beaverton, OR US
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20080296731 | ENHANCED ON-CHIP DECOUPLING CAPACITORS AND METHOD OF MAKING SAME - An apparatus including a capacitor formed between metallization layers on a circuit, the capacitor including a bottom electrode coupled to a metal layer and a top electrode coupled to a metal via wherein the capacitor has a corrugated sidewall profile. A method including forming an interlayer dielectric including alternating layers of dissimilar dielectric materials in a multilayer stack over a metal layer of a device structure; forming a via having a corrugated sidewall; and forming a decoupling capacitor stack in the via that conforms to the sidewall of the via. | 12-04-2008 |
Scott List, Beaverton, OR US
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20090174070 | Three-dimensional stacked substrate arrangements - Three-dimensional stacked substrate arrangements with reliable bonding and inter-substrate protection. | 07-09-2009 |
20110260319 | THREE-DIMENSIONAL STACKED SUBSTRATE ARRANGEMENTS - Three-dimensional stacked substrate arrangements with reliable bonding and inter-substrate protection. | 10-27-2011 |
20120280387 | THREE-DIMENSIONAL STACKED SUBSTRATE ARRANGEMENTS - Three-dimensional stacked substrate arrangements with reliable bonding and inter-substrate protection. | 11-08-2012 |
Steven J. List, Bedford, MA US
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20110313094 | Carbon Blacks Having Low PAH Amounts And Methods Of Making Same - Carbon blacks, such as rubber blacks, having a low PAH concentration are described. Furthermore, elastomeric or rubber compositions containing the carbon black of the present invention are further described, as well as methods of making carbon black having a low PAH concentration. | 12-22-2011 |
Thomas Charles List, Kearney, MO US
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20100000579 | Compositions And Methods For Removing Scale And Inhibiting Formation Thereof - Compositions for removing scale and/or inhibiting formation thereof include an alkaline agent, a primary scale inhibitor, a secondary scale inhibitor and a solvent. The primary scale inhibitor may include phosphonic acid, salts of phosphonic acids and combinations thereof. Suitable secondary scale inhibitor may include aminocarboxylic acids, salts of aminocarboxylic acids, carboxylic acids, salts of carboxylic acids, polycarboxylic acids, salts of polycarboxylic acids, gluconic acids, salts of gluconic acids, steroids, tetrapyrrols, ionophores, 2,2′-bipyridine, dimercaptopropanol, ortho-phenanthroline and combinations thereof. The compositions may be prepared as a stable concentrates that have pH values greater than or equal to 11. The compositions may also be prepared on site as a use solution. Methods of using the compositions to extend system operating times and to remove scale from and/or inhibit formation of scale on an article are also disclosed. | 01-07-2010 |
Thor List, New Haven, CT US
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20090105879 | EVALUATION OF COMMUNICATION MIDDLEWARE IN A DISTRIBUTED HUMANOID ROBOT ARCHITECTURE - A publish-subscribe architecture based blackboard system for selecting and exchanging selected information among a plurality of processing modules using filters for implementing conditions described in a procedural language to reduce the amount of information transmitted between the processing modules. More than one filter may be dynamically installed in a message hub to select and collect the published information to be sent to a certain subscribing module. By using the procedural language to describe the filters, the message hub can more intelligently select the information to be sent to the subscribing module. This reduces the amount of information transmitted via communication channels. Further, the subscribing module may be relieved from the task of filtering the information received from the message hub, allowing the subscribing module to devote more resources to other operations. | 04-23-2009 |
Timothy Theodore List, Santa Cruz, CA US
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20150279387 | Voice Controlled Assistant with Coaxial Speaker and Microphone Arrangement - A voice controlled assistant has a housing to hold one or more microphones, one or more speakers, and various computing components. The housing has an elongated cylindrical body extending along a center axis between a base end and a top end. The microphone(s) are mounted in the top end and the speaker(s) are mounted proximal to the base end. The microphone(s) and speaker(s) are coaxially aligned along the center axis. The speaker(s) are oriented to output sound directionally toward the base end and opposite to the microphone(s) in the top end. The sound may then be redirected in a radial outward direction from the center axis at the base end so that the sound is output symmetric to, and equidistance from, the microphone(s). | 10-01-2015 |
Todd List, Keego Harbor, MI US
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20100187083 | Switch mechanism - A switch mechanism | 07-29-2010 |
Tom List, Kearney, MO US
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20150272198 | USE OF IODINE-CONTAINING COMPOSITIONS FOR PATHOGEN REDUCTION DURING FOOD PROCESSING - Antimicrobial compositions and methods of using the same for controlling microbial contamination on various foodstuff's during processing are provided. The antimicrobial composition includes a relatively low concentration of active iodine as the antimicrobial agent, but achieves a high efficacy when applied directly to the foodstuff being processed. The present invention can be carried out during processing of meat, poultry, fish, seafood, and even produce with little or no reduction in quality of the final edible product. | 10-01-2015 |