Patent application number | Description | Published |
20130035285 | NOVEL GLUCAGON ANALOGUES - The present invention relates to novel peptide compounds which have a protracted profile of action and improved solubility and stability, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in the manufacture of medicaments. The compounds of the invention are of particular interest in relation to the treatment of hyperglycemia, diabetes and obesity, as well as a variety of diseases or conditions associated with hyperglycemia, diabetes and obesity. | 02-07-2013 |
20130143798 | NOVEL GLUCAGON ANALOGUES - The present invention relates to novel peptide compounds which have an improved physical stability in solution and improved solubility at neutral pH, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in the manufacture of medicaments. The compounds of the invention are of particular interest in relation to the treatment of hyperglycemia, diabetes and obesity, as well as a variety of diseases or conditions associated with hyperglycemia, diabetes and obesity. | 06-06-2013 |
20130288960 | Double-Acylated GLP-1 Derivatives - The invention relates to a derivative of a GLP-1 analogue, which analogue comprises a first K residue at a position corresponding to position 18 of GLP-1 (7-37) (SEQ ID NO: 1), a second K residue at another position, and a maximum of twelve amino acid changes as compared to GLP-1 (7-37); which derivative comprises two protracting moieties attached to said first and second K residue, respectively, via a linker, wherein the protracting moiety is selected from Chem. 1, Chem. 2, and Chem. 3: Chem.: HOOC—(CH | 10-31-2013 |
20130338068 | DOUBLE-ACYLATED GLP-1 DERIVATIVES WITH A LINKER - The invention relates to a derivative of a GLP-1 analogue, which analogue comprises a first K residue at a position corresponding to position 18 of GLP-1(7-37) (SEQ ID NO: 1), a second K residue at another position, and a maximum of twelve amino acid changes as compared to GLP-1(7-37); which derivative comprises two protracting moieties attached to said first and second K residue, respectively, via a linker, wherein the protracting moiety is selected from | 12-19-2013 |
20140088005 | DOUBLE-ACYLATED GLP-1 DERIVATIVES - The invention relates to a derivative of a GLP-1 analogue, which analogue comprises a first K residue at a position corresponding to position 27 of GLP-1(7-37) (SEQ ID NO: 1); a second K residue at a position corresponding to position T of GLP-1(7-37), where T is an integer in the range of 7-37 except 18 and 27; and a maximum of ten amino acid changes as compared to GLP-1(7-37); wherein the first K residue is designated K | 03-27-2014 |
20140179899 | DOUBLE-ACYLATED GLP-1 DERIVATIVES - The invention relates to a derivative of a GLP-1 analogue, which analogue comprises a first K residue at a position corresponding to position 37 of GLP-1(7-37) (SEQ ID NO: 1), a second K residue at a position corresponding to position 26 of GLP-1(7-37), and a maximum of ten amino acid modifications as compared to GLP-1(7-37), wherein the first K residue is designated K | 06-26-2014 |
Patent application number | Description | Published |
20090257435 | MODIFICATION OF LIVE STREAMS - Mechanisms are provided for generating and modifying live media streams. A device establishes a session and requests a media stream from a content server. The content server provides the media stream to the device. The content server also obtains an insertion stream for inclusion in the media stream. Packets are removed from the media stream to allow inclusion of the insertion stream. Timestamp information and sequence number information is maintained to allow uninterrupted delivery of the modified media stream. | 10-15-2009 |
20090257447 | BIT RATE CONTROL - Mechanisms are provided to smooth bandwidth usage rates associated with a media stream. A content server analyzes a buffered media stream to determine timing and sequence number information. Packets designated for transmission at a bandwidth usage peak are transmitted earlier in time, with earlier packets shifted even earlier as sequence numbers allow. This evens out bandwidth usage rates and allows improved transmission to devices without requiring modified device operation. | 10-15-2009 |
20090259756 | TRANSMITTING MEDIA STREAM BURSTS - Mechanisms are provided to transmit media stream bursts upon recognizing that a device buffer is low or empty. In particular examples, a content server transmits 6 seconds of video in 2 seconds in order to quickly replenish a device buffer so that the device can start playback sooner. Content server buffers for particular channels can be prefilled even before any stream is requested for that channel. The content server can transmit at a higher bit rate for a short period of time or alternatively can switch to transmitting a lower quality stream for a short period of time. A media stream burst can be provided without disrupting system operation or requiring client rebuffering. | 10-15-2009 |
20090259764 | INTRO OUTRO MERGER WITH BIT RATE VARIATION SUPPORT - Mechanisms are provided to support intro stream merger and outro stream merger into a live stream without disrupting application operation. An intro merger stream corresponding to a requested live stream including multiple packets is obtained. The intro merger stream is transmitted to a device. Time and sequence number information is maintained during transmission of the intro merger stream to allow modification of the live stream using time and sequence number information. The device receives both the intro merger stream and the live stream in a single session. | 10-15-2009 |
20090260030 | DYNAMIC ADVERTISEMENT STREAM REPLACEMENT - Mechanisms are provided for replacing default advertisement streams in a media stream with replacement advertisement streams. User profile information is obtained for a particular user and/or device. A default advertisement stream is identified and replaced with advertisement streams selected using the user profile information. Timestamp information and sequence number information is maintained to allow uninterrupted delivery of the modified media stream while customizing media streams for particular users. | 10-15-2009 |
20090260045 | NETWORK OPTIMIZED DISTRIBUTION - A content server is configured to buffer and transmit numerous live media streams to individual devices. The content server analyzes characteristics associated with the live media streams to determine timing and sequence number information. Other characteristics such as network congestion metrics, device buffer usage metrics, etc., can also be evaluated. Combined peak transmission times are determined to allow packets designated for transmission at a bandwidth usage peak to be transmitted earlier in time. Earlier packets are shifted even earlier as sequence numbers allow. This evens out bandwidth usage rates and allows improved live media stream transmission. | 10-15-2009 |
20140013004 | MODIFICATION OF LIVE STREAMS - Mechanisms are provided for generating and modifying live media streams. A device establishes a session and requests a media stream from a content server. The content server provides the media stream to the device. The content server also obtains an insertion stream for inclusion in the media stream. Packets are removed from the media stream to allow inclusion of the insertion stream. Timestamp information and sequence number information is maintained to allow uninterrupted delivery of the modified media stream. | 01-09-2014 |
20140351389 | MODIFICATION OF LIVE STREAMS - Mechanisms are provided for generating and modifying live media streams. A device establishes a session and requests a media stream from a content server. The content server provides the media stream to the device. The content server also obtains an insertion stream for inclusion in the media stream. Packets are removed from the media stream to allow inclusion of the insertion stream. Timestamp information and sequence number information is maintained to allow uninterrupted delivery of the modified media stream. | 11-27-2014 |