Patent application number | Description | Published |
20140302469 | Systems and Methods for Providing a Multi-Modal Evaluation of a Presentation - Systems and methods are described for providing a multi-modal evaluation of a presentation. A system includes a motion capture device configured to detect motion an examinee giving a presentation and an audio recording device configured to capture audio of the examinee giving the presentation. One or more data processors are configured to extract a non-verbal feature of the presentation based on data collected by the motion capture device and an audio feature of the presentation based on data collected by the audio recording device. The one or more data processors are further configured to generate a presentation score based on the non-verbal feature and the audio feature. | 10-09-2014 |
20150254565 | Systems and Methods for Constructed Response Scoring Using Metaphor Detection - Systems and methods described herein utilize supervised machine learning to generate a figure-of-speech prediction model for classify content words in a running text as either being figurative (e.g., as a metaphor, simile, etc.) or non-figurative (i.e., literal). The prediction model may extract and analyze any number of features in making its prediction, including a topic model feature, unigram feature, part-of-speech feature, concreteness feature, concreteness difference feature, literal context feature, non-literal context feature, and off-topic feature, each of which are described in detail herein. Since uses of figure of speech in writings may signal content sophistication, the figure-of-speech prediction model allows scoring engines to further take into consideration a text's use of figure of speech when generating a score. | 09-10-2015 |
20150269529 | Systems and Methods for Assessing Structured Interview Responses - Systems and methods described herein utilize supervised machine learning to generate a model for scoring interview responses. The system may access a training response, which in one embodiment is an audiovisual recording of a person responding to an interview question. The training response may have an assigned human-determined score. The system may extract at least one delivery feature and at least one content feature from the audiovisual recording of the training response, and use the extracted features and the human-determined score to train a response scoring model for scoring interview responses. The response scoring model may be configured based on the training to automatically assign scores to audiovisual recordings of interview responses. The scores for interview responses may be used by interviewers to assess candidates. | 09-24-2015 |
Patent application number | Description | Published |
20150062156 | Method to Visualize Semantic Data in Contextual Window - A method for displaying contextual semantic data in a graphical overlay includes activating a first lens corresponding to a first domain, and activating at least one first domain context within the first lens. The method also includes, responsive to activating the at least one first domain context within the first lens, displaying the first domain context within the first lens. At least one second domain context is activated and displayed throughout the entire graphical overlay while simultaneously displaying the at least one first domain context within the first lens. Alternatively, the at least one second domain context is displayed within an activated second lens, which corresponds to a second domain, while simultaneously displaying the at least one first domain context within the first lens. By simultaneously displaying the first and second domain contexts, a cross-domain interaction between the first and second domains is identified. | 03-05-2015 |
20150062173 | Method to Visualize Semantic Data in Contextual Window - A system and a computer program product for displaying contextual semantic data in a graphical overlay includes a processor activating a first lens corresponding to a first domain, activating at least one first domain context within the first lens, and responsive to activating the at least one first domain context within the first lens, displaying the first domain context within the first lens. At least one second domain context is activated and displayed throughout the entire graphical overlay while simultaneously displaying the at least one first domain context within the first lens. Alternatively, the at least one second domain context is displayed within an activated second lens, which corresponds to a second domain, while simultaneously displaying the at least one first domain context within the first lens. By simultaneously displaying the first and second domain contexts, a cross-domain interaction between the first and second domains is identified. | 03-05-2015 |
20150062174 | Method of Presenting Data in a Graphical Overlay - A method for displaying data in a graphical overlay includes overlaying a first lens, including a first dataset, on a first region of the graphical overlay while a second lens, including a second dataset, overlaps the first lens. The first and second datasets are simultaneously displayed, and a correlation between the datasets is determined. Separation of the first and second lenses preserves a circumscribed region within each lens. The first dataset corresponds to first orientation position of the first lens. Rotation of the first lens to a second orientation position reconfigures the first dataset to provide a modified first dataset which corresponds to the second position. A rotational position may also be associated with points in time, a first position corresponding to a first point in time and the first dataset representing the first dataset at the first point in time. | 03-05-2015 |
20150062176 | Method of Presenting Data in a Graphical Overlay - A system and a computer program product for displaying data in a graphical overlay. The method includes overlaying a first lens, including a first dataset, on a first region of the graphical overlay while a second lens, including a second dataset, overlaps the first lens. The first and second datasets are simultaneously displayed, and a correlation between the datasets is determined. Separation of the first and second lenses preserves a circumscribed region within each lens. The first dataset corresponds to first orientation position of the first lens. Rotation of the first lens to a second orientation position reconfigures the first dataset to provide a modified first dataset which corresponds to the second position. A rotational position may also be associated with points in time, a first position corresponding to a first point in time and the first dataset representing the first dataset at the first point in time. | 03-05-2015 |
20150067587 | Visual Domain Navigation - A method, a system and a computer program product for visually navigating contextual semantic data in a graphical overlay. The method includes overlaying a first lens, corresponding to a first domain and oriented in a first position, on the graphical overlay. A set of semantic data is displayed within the first lens. Rotation of the first lens to a second position reconfigures the semantic data such that a modified set of semantic data is displayed within the first lens. The modified semantic data and a ghosted image of the set of semantic data may be simultaneously displayed. A rotational position of the first lens is associated with various context aspects. A second lens, corresponding to a second domain, fully overlaps the first lens. Responsive to separating the first and second lenses, a circumscribed region is preserved within each of the first and second lenses while concealing a non-circumscribed region. | 03-05-2015 |
Patent application number | Description | Published |
20130117206 | DYNAMIC TRAINING AND TAGGING OF COMPUTER CODE - System, method, device and article of manufacture are provided wherein software code is sorted between optional pools using attributes of software in the target pools. Training for subsequent sorts can take place when attributes of already sorted code is considered and used when sorting previously unclassified code. Manual intervention may also be used to sort code and to verify the accuracy of previous sorts. | 05-09-2013 |
20140101655 | Enforcing Machine Deployment Zoning Rules in an Automatic Provisioning Environment - A mechanism is provided for enforcing machine deployment zoning rules in an automatic provisioning system. Responsive to receiving a machine specification from a user for deployment of a virtual machine in a computing environment, the automatic provisioning system applies machine deployment zone rules to the machine specification. Responsive to the machine specification not meeting the machine deployment zone rules, the automatic provisioning system generates a failure notification. The automatic provisioning system presents the failure notification to the user. | 04-10-2014 |
20140157096 | SELECTING VIDEO THUMBNAIL BASED ON SURROUNDING CONTEXT - Some embodiments of the inventive subject matter include a computer program product for determining a thumbnail image for a video. The computer program product can include computer usable program code configured to analyze the video. The computer usable program code can be further configured to determine video themes based on the analyzing the video. The computer usable program code can be further configured to produce a first group of thumbnail images for the video themes. The computer usable program code can be further configured to determine a forum theme for an electronic forum in which the video will be accessible. The computer usable program code can be further configured to choose, from the first group of thumbnail images, a matching thumbnail image that is thematically consistent with the forum theme. The computer usable program code can be further configured to present the matching thumbnail image in the forum. | 06-05-2014 |
20140157097 | SELECTING VIDEO THUMBNAIL BASED ON SURROUNDING CONTEXT - Some embodiments of the inventive subject matter include a method for embedding, in a website, a video and a thumbnail image associated with the video. The method can include requesting, over a network, the video from a video source. The method can include transmitting, to the video source, theme information indicating a theme of the website. The method can include receiving the video and the thumbnail image, wherein the thumbnail image is thematically consistent with the theme of the website. The method can include embedding the video in the website. The method can include presenting the thumbnail image in association with the video. | 06-05-2014 |
Patent application number | Description | Published |
20130055058 | Animation for Recalculating Formulas, Sparklines and Conditional Formatting in an Electronic Document - Animation for the recalculation of formulas in a spreadsheet may be provided. A user interface may be displayed on a computer for updating formula output values. The computer may then receive an update of formula input values in a formula utilized for generating the formula output values. The computer may then animate a display the formula output values being replaced with recalculated formula output values based on the received update. Animation for sparklines and conditionally formatted content in a spreadsheet may also be provided. A user interface may be provided for displaying sparklines and conditionally formatted content in the spreadsheet. The computer may then receive an update of one or more values associated with the sparklines and the conditionally formatted content. The computer may then animate a change in the display of the sparklines and the conditionally formatted content based on the received update. | 02-28-2013 |
20130055123 | Animation for Expanding/Collapsing Content and for Sorting Content in an Electronic Document - Animation for the expansion and collapse of content in a user interface may be provided. The user interface may be displayed by a computer and may contain a content surface for editing content. The content may include a top data row and data items in rows below the top data row on the content surface. The computer may then receive an input to expand/collapse the data items into the top data row. The computer may then animate a display of the data items expanding/collapsing into the top data row. Animation for the sorting of content in a user interface may also be provided. The user interface may be displayed by a computer and may contain a content surface for editing a plurality of rows containing content. The computer may then receive a request to sort the content. The computer may then animate a sort of the content. | 02-28-2013 |
20130055131 | Animation for Cut and Paste of Content - Animation for the cut and paste of content in an electronic document may be provided. A user interface may be displayed on a computer which includes a content surface for editing the content. The computer may then cut the content from a first location in response to a received request. The computer may then paste the content to a second location on the content surface in response to a received request. The pasting of the content from the first location to the second location may be displayed as a gradual transition of the content on the content surface. | 02-28-2013 |
20130055167 | Animation for Expanding/Collapsing Content and for Sorting Content in an Electronic Document - Animation for the expansion and collapse of content in a user interface may be provided. The user interface may be displayed by a computer and may contain a content surface for editing content. The content may include a top data row and data items in rows below the top data row on the content surface. The computer may then receive an input to expand/collapse the data items into the top data row. The computer may then animate a display of the data items expanding/collapsing into the top data row. Animation for the sorting of content in a user interface may also be provided. The user interface may be displayed by a computer and may contain a content surface for editing a plurality of rows containing content. The computer may then receive a request to sort the content. The computer may then animate a sort of the content. | 02-28-2013 |
20130191714 | FILL BY EXAMPLE ANIMATION AND VISUALS - Animation and visuals are displayed when automatically filling/changing values within a document. A scan animation may be displayed to assist a user in understanding that an action is about to occur using their recent edit(s). A fill animation may be displayed while the suggested values are automatically filled within the document. For example, the suggested values may be displayed according to an uncommitted state (e.g. light grey text) as compared to a committed state (e.g. black text) of related values. The suggested values may be accepted/rejected while they are displayed according to the uncommitted state. When the suggested values are rejected, the suggested values are removed from the display. When the suggested values are accepted, the suggested values are transitioned to the committed state. When a user performs an edit on one or more of the suggested values, a change animation may be displayed. | 07-25-2013 |
Patent application number | Description | Published |
20100184822 | Method of modulating the activity of a nucleic acid molecule - The present invention relates, in general, to agents that modulate the pharmacological activity of nucleic acid molecules and, in particular, to agents that bind therapeutic or diagnostic nucleic acid molecules in a sequence independent manner and modulate (e.g., inhibit or reverse) their activity. The invention also relates to compositions comprising such agents and to methods of using same. | 07-22-2010 |
20120107268 | LYMPH NODE-TARGETING NANOPARTICLES - Provided are nanoparticles comprising heparin, chitosan, and at least one immunomodulatory agent, e.g. a cytokine. The cytokine can be selected from the group consisting of TNF, IL-12, IL-2, IL-23, IL-1α, IL-10, IL-18, and combinations thereof. Further provided are methods of making a nanoparticle comprising mixing a first composition comprising heparin with a second composition comprising chitosan in the presence of at least one cytokine to form a third composition. Further provided are methods of modulating an immune response comprising co-administering to a subject an antigen or vaccine with nanoparticles comprising heparin, chitosan, and at least one cytokine. | 05-03-2012 |
20140155284 | SYSTEM FOR IDENTIFICATION OF MICROORGANISM AND DETECTION OF INFECTIOUS DISEASE - Methods for the identification of microorganisms or infectious disorders are disclosed, comprising obtaining a suitable sample from sources such as persons, animals, plants, food, water or soil. The methods also comprise providing tailored nucleic acid substrate(s) designed to react with a type 1 topoisomerase from one or more microorganism(s) or infectious agent(s), and incubating said substrate with said sample, or extracts or preparations from the sample, so that the substrate is processed by said topoisomerase if said microorganism(s) or infectious agent(s) is present in the sample. Microfluidic-implemented methods of detecting an enzyme, in particular a DNA-modifying enzyme, are also provided, as well as methods for detecting a cell, or a microorganism expressing said enzyme. The enzyme is detected by providing a nucleic acid substrate, which is specifically targeted by that enzyme. | 06-05-2014 |
20150018228 | ENZYME DETECTION BY MICROFLUIDICS - Microfluidic-implemented methods of detecting an enzyme, in particular a DNA-modifying enzyme, are provided, as well as methods for detecting a cell, or a microorganism expressing said enzyme. The enzyme is detected by providing a nucleic acid substrate, which is specifically targeted by that enzyme. | 01-15-2015 |
20150023909 | LYMPH NODE-TARGETING NANOPARTICLES - Provided are nanoparticles comprising heparin, chitosan, and at least one immunomodulatory agent, e.g. a cytokine. The cytokine can be selected from the group consisting of TNF, IL-12, IL-2, IL-23, IL-1α, IL-10, IL-18, and combinations thereof. Further provided are methods of making a nanoparticle comprising mixing a first composition comprising heparin with a second composition comprising chitosan in the presence of at least one cytokine to form a third composition. Further provided are methods of modulating an immune response comprising co-administering to a subject an antigen or vaccine with nanoparticles comprising heparin, chitosan, and at least one cytokine. | 01-22-2015 |
Patent application number | Description | Published |
20100055154 | COAXIAL ELECTROSPUN FIBERS AND STRUCTURES AND METHODS OF FORMING THE SAME - Nanofibers and microfibers having a core and a polymer shell surrounding the core are provided. The shell includes a plurality of channels that extend from an outer shell surface to the core, and one or more agents, such as pharmacological materials, proteins, viruses, plasmid DNA, bacterial cells, drug-loaded nanoparticles, are encapsulated within the core. The one or more agents discharge from the core through the channels at a controlled rate. The channels are formed by porogen material within the polymer shell. | 03-04-2010 |
20100211151 | DEVICE AND METHOD FOR HEALING WOUNDS - Embodiments of the invention include a method and device for promoting healing of an injury in a living being. The embodiments comprise an injury covering portion, which portion comprises an electroactive polymer, such as poled polyvinylidine difluoride (PVDF) or a copolymer of PVDF. The electroactive polymer has either pyroelectric properties, piezoelectric properties, or both. | 08-19-2010 |
20110142806 | Electroactive Scaffold - A scaffold assembly and related methods of manufacturing and/or using the scaffold for stem cell culture and tissue engineering applications are disclosed which at least partially mimic a native biological environment by providing biochemical, topographical, mechanical and electrical cues by using an electroactive material. The assembly includes at least one layer of substantially aligned, electrospun polymer fiber having an operative connection for individual voltage application. A method of cell tissue engineering and/or stem cell differentiation uses the assembly seeded with a sample of cells suspended in cell culture media, incubates and applies voltage to one or more layers, and thus produces cells and/or a tissue construct. In another aspect, the invention provides a method of manufacturing the assembly including the steps of providing a first pre-electroded substrate surface; electrospinning a first substantially aligned polymer fiber layer onto the first surface; providing a second pre-electroded substrate surface; electrospinning a second substantially aligned polymer fiber layer onto the second surface; and, retaining together the layered surfaces with a clamp and/or an adhesive compound. | 06-16-2011 |
20120141547 | METHODS OF MAKING CELL SHEETS, TISSUE SHEETS AND TISSUE ENGINEERED BLOOD VESSELS - Methods of making cell sheets, tissue sheets and tissue-engineered blood vessels are provided. The methods include culturing cells on a nanoimprinted coated scaffold under hypoxic conditions to form an aligned cell sheet and then removing the aligned cell sheet from the scaffold. The cell sheets, tissue sheets and tissue-engineered blood vessels made the methods are also disclosed. The cell sheets, tissue sheets and tissue-engineered blood vessels may be implanted in subjects to treat a variety of conditions. | 06-07-2012 |
20120282343 | COMPOSITIONS FOR ORAL GENE THERAPY AND METHODS OF USING SAME - The present invention provides nanoparticle compositions comprising a cationic biopolymer and at least one biologically active substance, pharmaceutical compositions comprising such nanoparticles and methods for the oral administration of biologically active molecules which are susceptible to degradation in the gastro-intestinal tract using nanoparticle. The present invention further provides compositions and methods for the oral administration of gene therapy. | 11-08-2012 |
20130129632 | Quantum dot materials, methods for making them, and uses thereof - The disclosure provides quantum dot materials, compositions and methods useful in the treatment of various disorders. In particular, the disclosure provides cadmium-free and lead-free quantum dots. | 05-23-2013 |
20140178465 | METHOD AND USE OF NANO-SCALE DEVICES FOR REDUCTION OF TISSUE INJURY IN ISCHEMIC AND REPERFUSION INJURY - A method for protection of tissues subject to ischemic and/or reperfusion damage is provided. The method includes administering to the tissue a composition comprising nanodevices. The nanodevices can take the form of, for example, polymeric nanoparticles or lipidic nanoparticles. The nanodevices also find use in methods for reducing ischemic injury in tissue at risk of such injury, such as heart and brain tissue. | 06-26-2014 |
20140271793 | THERAPEUTIC ELECTROSPUN FIBER COMPOSITIONS - The instant invention provides electrospun fiber compositions comprising one or more polymers and one or more biologically active agents. In specific embodiments, the biologically active agents are nerve growth factors. In certain embodiments, the electrospun fiber compositions comprising one or more biologically active agents are on the surface of a film, or a tube. The tubes comprising the electrospun fiber compositions of the invention can be used, for example, as nerve guide conduits. | 09-18-2014 |
20150142026 | THERAPEUTIC ELECTROSPUN FIBER COMPOSITIONS - The instant invention provides electrospun fiber compositions comprising one or more polymers and one or more biologically active agents. In specific embodiments, the biologically active agents are nerve growth factors. In certain embodiments, the electrospun fiber compositions comprising one or more biologically active agents are on the surface of a film, or a tube. The tubes comprising the electrospun fiber compositions of the invention can be used, for example, as nerve guide conduits. | 05-21-2015 |
20150218510 | Electroactive Scaffold - A method of manufacturing and/or using a scaffold assembly for stem cell culture and tissue engineering applications is disclosed. The scaffold at least partially mimics a native biological environment by providing biochemical, topographical, mechanical and electrical cues by using an electroactive material. The assembly includes at least one layer of substantially aligned, electrospun polymer fiber having an operative connection for individual voltage application. A method of cell tissue engineering and/or stem cell differentiation that uses the assembly seeded with a sample of cells suspended in cell culture media, incubates and applies voltage to one or more layers, and thus produces cells and/or a tissue construct. In another aspect, the invention provides a method of manufacturing the assembly including the steps of providing a first pre-electroded substrate surface; electrospinning a first substantially aligned polymer fiber layer onto the first surface; providing a second pre-electroded substrate surface; electrospinning a second substantially aligned polymer fiber layer onto the second surface; and, retaining together the layered surfaces with a clamp and/or an adhesive compound. | 08-06-2015 |
20160081858 | Compositions and Methods for the Prevention of Scarring and/or Promotion of Wound Healing - The present disclosure provides methods of preventing and/or reducing scar contracture and methods of promoting wound healing by utilizing an electrospun biocompatible scaffold. | 03-24-2016 |
Patent application number | Description | Published |
20090176975 | METHODS AND COMPOSITIONS FOR DETECTING PROMOTER ACTIVITY AND EXPRESSING FUSION PROTEINS - The present invention provides nucleic acid molecules comprising one or more nucleic acid sequences encoding a polypeptide having a detectable activity. The present invention also provides methods of joining such nucleic acid molecules to nucleic acid molecules to be assayed for promoter activity. The present invention also relates to methods of preparing fusion proteins comprising a polypeptide of interest and a polypeptide having a detectable activity. | 07-09-2009 |
20100009342 | CONTROL OF CHEMICAL MODIFICATION - Provided is a method for controlling the degree of labeling (DOL) of a carrier molecule or solid support by the addition of a reactive label competitor to the labeling reaction. When the reactive label competitor is added to the labeling solution the competitor competes with the carrier molecule or solid support for the label, reducing the number of labels available to conjugates to the carrier molecule or solid support. This provides for a facile method that predictably alters the DOL of a carrier molecule or solid support. | 01-14-2010 |
20110046201 | METHODS AND COMPOSITIONS FOR SEAMLESS CLONING OF NUCLEIC ACID MOLECULES - The present invention is in the fields of biotechnology and molecular biology. More particularly, the present invention relates to cloning or subcloning one or more nucleic acid molecules comprising one or more type IIs restriction enzyme recognition sites. The present invention also embodies cloning such nucleic acid molecules using recombinational cloning methods such as those employing recombination sites and recombination proteins. The present invention also relates to nucleic acid molecules (including RNA and iRNA), as well as proteins, expressed from host cells produced using the methods of the present invention. | 02-24-2011 |
20110269120 | METHODS AND COMPOSITIONS FOR DETECTING PROMOTER ACTIVITY AND EXPRESSING FUSIONPROTEINS - The present invention provides nucleic acid molecules comprising one or more nucleic acid sequences encoding a polypeptide having a detectable activity. The present invention also provides methods of joining such nucleic acid molecules to nucleic acid molecules to be assayed for promoter activity. The present invention also relates to methods of preparing fusion proteins comprising a polypeptide of interest and a polypeptide having a detectable activity. | 11-03-2011 |
20120077211 | STABLE COMPOSITIONS COMPRISING CHROMOGENIC COMPOUNDS AND METHODS OF USE - Compositions, assays, methods, and kits are disclosed for use in applications that utilize oxidation of a chromogenic electron donor such as diaminobenzidine (DAB) to generate a signal. Applications include, but are not limited to, immunohistochemistry, chromogenic in situ hybridization, Western blots, Northern blots, Southern blots, ELISA assays, and microarray detection. The compositions, assays, methods, and kits disclosed herein make use of a novel, stabilized formulation of DAB and a novel, stabilized formulation of hydrogen peroxide. | 03-29-2012 |
20120149069 | METHODS AND COMPOSITIONS FOR SEAMLESS CLONING OF NUCLEIC ACID MOLECULES - The present invention is in the fields of biotechnology and molecular biology. More particularly, the present invention relates to cloning or subcloning one or more nucleic acid molecules comprising one or more type IIs restriction enzyme recognition sites. The present invention also embodies cloning such nucleic acid molecules using recombinational cloning methods such as those employing recombination sites and recombination proteins. The present invention also relates to nucleic acid molecules (including RNA and iRNA), as well as proteins, expressed from host cells produced using the methods of the present invention. | 06-14-2012 |
20130236899 | Methods And Compositions For Detecting Multiple Analytes With A Single Signal - Compositions, methods, and devices for the detection of multiple analytes with a single signal are provided. | 09-12-2013 |
20130316350 | NUCLEIC ACID MOLECULES CONTAINING RECOMBINATION SITES AND METHODS OF USING THE SAME - The present invention relates to the fields of biotechnology and molecular biology. In particular, the present invention relates to the construction and use of nucleic acid molecules comprising cloning sites which differ in nucleotide sequence. In particular embodiments, the present invention relates to nucleic acid molecules which contain recombination sites with different primer binding sites. These different primer binding sites may be used to sequence different ends of nucleic acid segments located between the two recombination sites. | 11-28-2013 |
20130323796 | METHODS AND COMPOSITIONS FOR SYNTHESIS OF NUCLEIC ACID MOLECULES USING MULTIPLERECOGNITION SITES - The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination .sites and/or multiple topoisomerase recognition sites. The methods permit the simultaneous cloning of two or more different nucleic acid molecules. In some embodiments the molecules are fused together while in other embodiments the molecules are inserted into distinct sites in a vector. The invention also generally provides for linking or joining through recombination a .number of molecules and/or compounds (e.g., chemical compounds, drugs, proteins or peptides, lipids, nucleic acids, carbohydrates, etc.) which may be the same or different. The invention also provides host cells comprising nucleic acid molecules of the invention or prepared according to the methods of the invention, and also provides kits comprising the compositions, host cells and nucleic acid molecules of the invention, which may be used to synthesize nucleic acid molecules according to the methods of the invention. | 12-05-2013 |
20140051843 | METHODS AND COMPOSITIONS FOR DETECTING PROMOTER ACTIVITY AND EXPRESSING FUSION PROTEINS - The present invention provides nucleic acid molecules comprising one or more nucleic acid sequences encoding a polypeptide having a detectable activity. The present invention also provides methods of joining such nucleic acid molecules to nucleic acid molecules to be assayed for promoter activity. The present invention also relates to methods of preparing fusion proteins comprising a polypeptide of interest and a polypeptide having a detectable activity. | 02-20-2014 |
20140170710 | METHODS AND COMPOSITIONS FOR SEAMLESS CLONING OF NUCLEIC ACID MOLECULES - The present invention is in the fields of biotechnology and molecular biology. More particularly, the present invention relates to cloning or subcloning one or more nucleic acid molecules comprising one or more type IIs restriction enzyme recognition sites. The present invention also embodies cloning such nucleic acid molecules using recombinational cloning methods such as those employing recombination sites and recombination proteins. The present invention also relates to nucleic acid molecules (including RNA and iRNA), as well as proteins, expressed from host cells produced using the methods of the present invention. | 06-19-2014 |
20150152460 | METHODS AND COMPOSITIONS FOR SEAMLESS CLONING OF NUCLEIC ACID MOLECULES - The present invention is in the fields of biotechnology and molecular biology. More particularly, the present invention relates to cloning or subcloning one or more nucleic acid molecules comprising one or more type IIs restriction enzyme recognition sites. The present invention also embodies cloning such nucleic acid molecules using recombinational cloning methods such as those employing recombination sites and recombination proteins. The present invention also relates to nucleic acid molecules (including RNA and iRNA), as well as proteins, expressed from host cells produced using the methods of the present invention. | 06-04-2015 |
20150225729 | METHODS AND COMPOSITIONS FOR SYNTHESIS OF NUCLEIC ACID MOLECULES USING MULTIPLERECOGNITION SITES - The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination sites and/or multiple topoisomerase recognition sites. The methods permit the simultaneous cloning of two or more different nucleic acid molecules. In some embodiments the molecules are fused together while in other embodiments the molecules are inserted into distinct sites in a vector. The invention also generally provides for linking or joining through recombination a number of molecules and/or compounds (e.g., chemical compounds, drugs, proteins or peptides, lipids, nucleic acids, carbohydrates, etc.) which may be the same or different. The invention also provides host cells comprising nucleic acid molecules of the invention or prepared according to the methods of the invention, and also provides kits comprising the compositions, host cells and nucleic acid molecules of the invention, which may be used to synthesize nucleic acid molecules according to the methods of the invention. | 08-13-2015 |
Patent application number | Description | Published |
20140186387 | SIGNAL PEPTIDE FUSION PARTNERS FACILITATING LISTERIAL EXPRESSION OF ANTIGENIC SEQUENCES AND METHODS OF PREPARATION AND USE THEREOF - The present invention provides nucleic acids, expression systems, and vaccine strains which provide efficient expression and secretion of antigens of interest into the cytosol of host cells, and elicit effective CD4 and CD8 T cell responses by functionally linking Listerial or other bacterial signal peptides/secretion chaperones as N-terminal fusion partners in translational reading frame with selected recombinant encoded protein antigens. These N-terminal fusion partners are deleted (either by actual deletion, by mutation, or by a combination of these approaches) for any PEST sequences native to the sequence, and/or for certain hydrophobic residues. | 07-03-2014 |
20140205653 | COMPOSITIONS COMPRISING CYCLIC PURINE DINUCLEOTIDES HAVING DEFINED STEREOCHEMISTRIES AND METHODS FOR THEIR PREPARATION AND USE - It is an object of the present invention to provide novel and highly active cyclic-di-nucleotide (CDN) immune stimulators that activates DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides that induce STING-dependent TBK1 activation, wherein the cyclic purine dinuclotides present in the composition are substantially pure Rp,Rp or Rp,Sp stereoisomers, and particularly substantially pure Rp,Rp, or RpSp CDN thiophosphate diastereomers. | 07-24-2014 |
20150056224 | COMPOSITIONS AND METHODS FOR ACTIVATING STIMULATOR OF INTERFERON GENE-DEPENDENT SIGNALLING - The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce STING-dependent type I interferon production, wherein the cyclic purine dinucleotides present in the composition are substantially pure 2′,5′,2′,5′ and 2′,5′,3′,5′ CDNs, and preferably Rp,Rp stereosiomers thereof. | 02-26-2015 |
20150125485 | METHODS AND COMPOSITIONS USING LISTERIA FOR ENHANCING IMMUNOGENICITY BY PRIME BOOST - Provided herein are prime-boost regimens and materials used therein. The prime-boost regimens enhance the immune response to a target antigen. The vaccines used for boost are comprised of recombinant attenuated metabolically active | 05-07-2015 |
Patent application number | Description | Published |
20150244410 | METHOD AND APPARATUS FOR INCORPORATING PASSIVE DEVICES IN AN INTEGRATED PASSIVE DEVICE SEPARATE FROM A DIE - A circuit including a first die, an integrated passive device and a second layer. The first die includes a first substrate and active devices. The integrated passive device includes a first layer, a second substrate and passive devices. The second substrate includes vias. The passive devices are implemented at least on the first layer or the second substrate. A resistivity per unit area of the second substrate is greater than a resistivity per unit area of the first substrate. The second layer is disposed between the first die and the integrated passive device. The second layer includes pillars. Each of the pillars connects a corresponding one of the active devices to (i) one of the vias, or (ii) one of the passive devices. The first die, the integrated passive device and the second layer are disposed relative to each other to form a stack. | 08-27-2015 |
20150288334 | POWER AMPLIFIER - An apparatus includes a differential amplifier. The differential amplifier includes a first side circuit configured to receive a first input signal, a second side circuit configured to receive a second input signal, and a resonant tank circuit coupled between the first and second side circuits. A first capacitor and first switch may be provided in series between a source and drain of a cascode transistor. A second capacitor and second switch may be provided in series between a source and drain of an input transistor. A method includes receiving a first input signal by a first side circuit, receiving a second input signal by a second side circuit, controlling a resource of a resonant tank circuit, and outputting an output signal according to the first and second input signals. The resource of the resonant tank circuit may be controlled according to a transmission mode, frequency band, or both. | 10-08-2015 |
20150288400 | IMPEDANCE MATCHING FOR VARIABLE IMPEDANCE ANTENNAS - An impedance matching circuit for a wireless communication device includes: a first node that receives a first impedance; a second node that is connected to an antenna having a second impedance; a first variable capacitor that is connected between the first node and a third node; a second variable capacitor that is connected between the third node and a reference potential; a first inductive element that is connected in parallel with the second variable capacitor between the third node and the reference potential; and a third variable capacitor and a second inductive element that are connected in series between the third node and the second node. | 10-08-2015 |
20150289360 | CIRCUITS INCORPORATING INTEGRATED PASSIVE DEVICES HAVING INDUCTANCES IN 3D CONFIGURATIONS AND STACKED WITH CORRESPONDING DIES - A circuit including a die and an integrated passive device. The die includes a first substrate and at least one active device. The integrated passive device includes a first layer, a second substrate, a second layer and an inductance. The inductance includes vias, where the vias are implemented in the second substrate. The inductance is implemented on the first layer, the second substrate, and the second layer. A resistivity per unit area of the second substrate is greater than a resistivity per unit area of the first substrate. The third layer is disposed between the die and the integrated passive device. The third layer includes pillars, where the pillars respectively connect ends of the inductance to the at least one active device. The die, the integrated passive device and the third layer are disposed relative to each other to form a stack. | 10-08-2015 |
20150349732 | COMMON-SOURCE POWER AMPLIFIERS - A system includes a first amplifier stage and a second amplifier stage. The first amplifier stage is configured to amplify an input signal and generate first output signals. The first amplifier stage includes a common-source differential amplifier. The common-source differential amplifier includes a plurality of metal-oxide semiconductor field-effect transistors (MOSFETs) having source terminals connected to a common potential. The second amplifier stage includes a first differential amplifier and a second differential amplifier configured to respectively generate first and second differential outputs based on the first output signals. Each of the first and second differential amplifiers includes a plurality of MOSFETs having source terminals connected to the common potential via a respective balun. | 12-03-2015 |
20150364418 | CIRCUITS INCORPORATING INTEGRATED PASSIVE DEVICES HAVING INDUCTANCES IN 3D CONFIGURATIONS AND STACKED WITH CORRESPONDING DIES - A circuit including: a die a first substrate and at least one active device; an integrated passive device including a first layer, a second substrate, a second layer and an inductance; and a third layer. The inductance includes vias and is an electrostatic discharge inductance. The vias are implemented in the second substrate. The inductance is implemented on the first layer, the second substrate, and the second layer. A resistivity per unit area of the second substrate is greater than a resistivity per unit area of the first substrate. The third layer is disposed between the die and the integrated passive device. The third layer includes pillars. The pillars respectively connect ends of the inductance to the at least one active device. The die, the integrated passive device and the third layer are disposed relative to each other to form a stack. | 12-17-2015 |
Patent application number | Description | Published |
20090311190 | SELF-ASSEMBLED, MICROPATTERNED, AND RADIO FREQUENCY (RF) SHIELDED BIOCONTAINERS AND THEIR USES FOR REMOTE SPATIALLY CONTROLLED CHEMICAL DELIVERY - The present invention relates to a nanoscale or microscale particle for encapsulation and delivery of materials or substances, including, but not limited to, cells, drugs, tissue, gels and polymers contained within the particle, with subsequent release of the therapeutic materials in situ, methods of fabricating the particle by folding a 2D precursor into the 3D particle, and the use of the particle in in-vivo or in-vitro applications The particle can be in any polyhedral shape and its surfaces can have either no perforations or nano/microscale perforations The particle is coated with a biocompatible metal, e g gold, or polymer e g parvlene, layer and the surfaces and hinges of the particle are made of any metal or polymer combinations. | 12-17-2009 |
20140249403 | SELF-ASSEMBLED, MICROPATTERNED, AND RADIO FREQUENCY (RF) SHIELDED BIOCONTAINERS AND THEIR USES FOR REMOTE SPATIALLY CONTROLLED CHEMICAL DELIVERY - The present invention relates to a nanoscale or microscale particle for encapsulation and delivery of materials or substances, including, but not limited to, cells, drugs, tissue, gels and polymers contained within the particle, with subsequent release of the therapeutic materials in situ, methods of fabricating the particle by folding a 2D precursor into the 3D particle, and the use of the particle in in-vivo or in-vitro applications. The particle can be in any polyhedral shape and its surfaces can have either no perforations or nano/microscale perforations. The particle is coated with a biocompatible metal, e g gold, or polymer e g parvlene, layer and the surfaces and hinges of the particle are made of any metal or polymer combinations. | 09-04-2014 |
Patent application number | Description | Published |
20100326071 | RECONFIGURABLE LITHOGRAPHIC STRUCTURES - A lithographically structured device has an actuation layer and a control layer operatively connected to the actuation layer. The actuation layer includes a stress layer and a neutral layer that is constructed of materials and with a structure such that it stores torsional energy upon being constructed. The control layer is constructed to maintain the actuation layer substantially in a first configuration in a local environmental condition and is responsive to a change in the local environmental condition such that it permits a release of stored torsional energy to cause a change in a structural configuration of the lithographically structured device to a second configuration, the control layer thereby providing a trigger mechanism. The lithographically structured device has a maximum dimension that is less than about 10 mm when it is in the second configuration. | 12-30-2010 |
20130116541 | Self-Assembled, Micropatterned, and Radio Frequency (RF) Shielded Biocontainers and Their Uses for Remote Spatially Controlled Chemical Delivery - The present invention relates to a nanoscale or microscale particle for encapsulation and delivery of materials or substances, including, but not limited to, cells, drugs, tissue, gels and polymers contained within the particle, with subsequent release of the therapeutic materials in situ, methods of fabricating the particle by folding a 2D precursor into the 3D particle, and the use of the particle in in-vivo or in-vitro applications The particle can be in any polyhedral shape and its surfaces can have either no perforations or nano/microscale perforations The particle is coated with a biocompatible metal, e g gold, or polymer e g parvlene, layer and the surfaces and hinges of the particle are made of any metal or polymer combinations. | 05-09-2013 |
Patent application number | Description | Published |
20080263749 | BANDLESS HEARING PROTECTION MUFFS - The present disclosure generally relates to devices for covering an ear, and more particularly to such devices that are self-attaching and used for sound optimization, such as noise reduction. More specifically, the present disclosure is directed to hearing protection muffs that comprise a sound attenuating cap, a self-attachment member for engaging the sound attenuating cap to the ear of a user, and optionally a sealing member. Advantageously, the muffs of the present disclosure have good sound attenuating properties and do not require a band or other external attachment device to secure the muffs to the ear. | 10-30-2008 |
20080264429 | Clip-style hearing protector - A hearing protection device for a human ear. The device has an arm that clips about the pinna. A plug member caps or enters ear canal. The device is biased to provide some force against the plug member so that is stays in position during use. An optional handle may be provided to assist with temporarily pulling the plug member away from the ear canal or providing adjustment. The device may be adapted for use as an ear phone. | 10-30-2008 |
20080264715 | Bandless hearing protector and method - A hearing protection device and method for a human ear. A plug member caps or enters ear canal, and may be shaped to conform to the external auditory meatus. The device is biased at least in part by a pressure pad to provide some force against the plug member. An optional handle may be provided to assist with temporarily pulling the plug member away from the ear canal or providing adjustment. An optional bow member clips about the pinna. The device may be adapted for use as an ear phone. | 10-30-2008 |
20080314393 | Self-conforming sound attenuation earplug - A self-conforming sound attenuation earplug, including: a stem, at least one support joined with the stem and extending radially outward from the stem, and a shell engaging the support and encircling the stem to form a space between the shell and the stem. At least one of the support material and the shell material is a deformable-resilient material. | 12-25-2008 |
20090095566 | Bandless hearing protector and method - A hearing protection device and method of use intended for a human ear. A plug member caps or enters ear canal, and may be shaped to conform to the external auditory meatus. The plug member may be part of a replacement assembly. The device is biased at least in part by a pressure pad to provide some force against the plug member. An optional handle may be provided to assist with temporarily pulling the plug member away from the ear canal or providing adjustment. An optional bow member clips about the pinna. The device may be adapted for use as an ear phone. | 04-16-2009 |
20100043806 | Self-conforming sound attenuation earplug - A self-conforming sound attenuation earplug for location in an ear canal. The earplug includes a stem. At least one support is joined with the stem and located between the stem ear end and the stem user end, and extends radially outward from the stem. A shell is made of a deformable-resilient shell material and has a tapered exterior that increases in circumference when moving from the stem ear end to the stem user end. The shell engages at least a portion of the support and engages at least a portion of the stem located between the stem ear end and the stem user end. At least a portion of the support is free from contact with the shell and the support material is a different type of material than the shell material. | 02-25-2010 |
Patent application number | Description | Published |
20100063280 | PROCESS FOR PREPARING CCR-5 RECEPTOR ANTAGONISTS UTILIZING 4-SUBSTITUTED 1-CYCLOPROPANE-SULFONYL-PIPERIDINYL COMPOUNDS - The present invention discloses a novel process to prepare 4-substituted 1-Cyclopropane-sulfonyl-Piperidinyl compounds, which are useful intermediates for the preparation of antagonists of CCR5 receptor and therefore useful for the treatment of HIV virus infected mammals. It specifically discloses a novel process to synthesize 4-[4-[(R)-[1-[cyclopropylsulfonyl)-4-piperidinyl](3-fluorophenyl)methyl]-3(S)-methyl-1-piperazinyl]-1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-methylpiperidine] compounds. | 03-11-2010 |
20120220769 | PROCESS FOR PREPARING A 2-ALKYNYL SUBSTITUTED 5-AMINO-PYRAZOLO-[4,3-e]-1,2,4-TRIAZOLO[1,5-c]PYRIMIDINE - A process for preparing 7-[2-[4-(6-fluoro-3-methyl-1,2-benzisoxazol-5-yl)-1-piperazinyl]ethyl]-2-(1-propynyl)-7H-pyrazolo-[4,3-e]-[1,2,4]-triazolo[1,5-c]pyrimidin-5-amine, intermediates useful in that process, and processes for preparing said intermediates are disclosed. | 08-30-2012 |
20120232100 | SOLID FORMS OF 3-(5-AMINO-2-METHYL-4-OXO-4H-QUINAZOLIN-3-YL)-PIPERIDINE-2,6-DIONE, AND THEIR PHARMACEUTICAL COMPOSITIONS AND USES - Solid forms comprising 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione, compositions comprising the solid forms, methods of making the solid forms and methods of their uses are disclosed | 09-13-2012 |
20130217919 | ASYMMETRIC SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOSULFONE COMPOUNDS - Processes for synthesizing aminosulfone compounds are provided. Aminosulfone compounds obtained using methods provided herein are useful in production or synthesis of sulfone group containing isoindoline based compounds. | 08-22-2013 |
20140046058 | PROCESSES FOR THE PREPARATION OF (S)-3-(4-((4-(MORPHOLINOMETHYL)BENZYL)OXY)-1-OXOISOINDOLIN-2-YL)PIPERIDIN- E-2,6-DIONE AND PHARMACEUTICALLY ACCEPTABLE FORMS THEREOF - Provided are processes for the preparation of enantiomerically enriched or enantiomerically pure 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione, or a pharmaceutically acceptable form thereof. | 02-13-2014 |
20140330016 | SYNTHESIS OF 3-(5-AMINO-2-METHYL-4-OXOQUINAZOLIN-3(4H)-YL)PIPERIDINE-2,6-DIONE - Provided herein are processes for the preparation of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione, or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt thereof. | 11-06-2014 |
20140378484 | SOLID FORMS OF 3-(5-AMINO-2-METHYL-4-OXO-4H-QUINAZOLIN-3-YL)-PIPERIDINE-2,6-DIONE, AND THEIR PHARMACEUTICAL COMPOSITIONS AND USES - Solid forms comprising 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione, compositions comprising the solid forms, methods of making the solid forms and methods of their uses are disclosed | 12-25-2014 |
20150056280 | ISOTOPOLOGUES OF 5-AZACYTIDINE - The present disclosure provides pharmaceutical compositions comprising cytidine analogs for oral administration, wherein the compositions release the cytidine analog substantially in the stomach. Also provided are methods of treating diseases and disorders using the oral formulations provided herein. | 02-26-2015 |
20150203469 | ISOTOPOLOGUES OF 3-(5-AMINO-2-METHYL-4-OXOQUINAZOLIN-3(4H)-YL) PIPERIDINE-2-6-DIONE AND METHODS OF PREPARATION THEREOF - Provided herein are deuterated isotopologues of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione, or enantiomers or mixtures of enantiomers thereof; or a pharmaceutically acceptable salt, solvate, cocrystal or polymorph thereof, and processes for making the same. Pharmaceutical compositions comprising the isotopes-enriched compounds, and methods of using such compounds are also provided. | 07-23-2015 |
20150274694 | SYNTHESIS OF 3-(5-AMINO-2-METHYL-4-OXOQUINAZOLIN-3(4H)-YL)PIPERIDINE-2,6-DIONE - Provided herein are processes for the preparation of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione, or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt thereof. | 10-01-2015 |
Patent application number | Description | Published |
20110137028 | METHODS OF SYNTHESIS AND PURIFICATION OF HETEROARYL COMPOUNDS - Provided herein are methods to prepare Heteroaryl Compounds having the following structure: | 06-09-2011 |
20130142873 | PHARMACEUTICAL COMPOSITIONS OF 7-(6-(2-HYDROXYPROPAN-2-YL)PYRIDIN-3-YL)-1-((TRANS)-4-METHOXYCYCLOHEXYL)-- 3,4-DIHYDROPYRAZINO [2,3-B]PYRAZIN-2(1H)-ONE, A SOLID FORM THEREOF AND METHODS OF THEIR USE - Provided herein are compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, solid forms, isotopologues and metabolites thereof, and methods of their use for the treatment of a disease, disorder, or condition. | 06-06-2013 |
20130245254 | METHODS OF SYNTHESIS AND PURIFICATION OF HETEROARYL COMPOUNDS - Provided herein are methods to prepare Heteroaryl Compounds having the following structure: | 09-19-2013 |
20140155593 | METHODS OF SYNTHESIS AND PURIFICATION OF HETEROARYL COMPOUNDS - Provided herein are methods to prepare Heteroaryl Compounds having the following structure: | 06-05-2014 |
20140315908 | PHARMACEUTICAL FORMULATIONS, PROCESSES, SOLID FORMS AND METHODS OF USE RELATING TO 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL)PYRIDIN-3-YL)-3,4-DIHYDROPYR- AZINO[2,3-b]PYRAZIN-2(1H)-ONE - Provided herein are formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one. | 10-23-2014 |