Patent application number | Description | Published |
20090081180 | ANTIMICROBIAL POLYMER CONJUGATES - Water-soluble polymer conjugates of antimicrobial agents retaining at least a portion of the antimicrobial activity of the agent, pharmaceutical compositions containing the polymer conjugates, and methods for treating microbial infections with the pharmaceutical compositions. | 03-26-2009 |
20110263834 | Simple Method for Simultaneous Removal of Multiple Impurities from Culture Supernatants to Ultralow Levels - This invention is directed to methods for removing, preferably simultaneously and in one step, multiple impurities form crude culture samples, and, in particular, the removal of media components, protein, nucleic acids, lipids, and lipopolysaccharides to ultralow levels. Preferably the purification process comprises: (1) binding of the target substance containing one or more contaminants to a chromatography matrix; (2) washing the bound target substance with one or more buffers containing a synergistic combination of a lyotropic agent or organic solvent, a detergent, and a salt component; and (3) desorbing the target substance from the chromatography matrix, so that the eluate contains ultra low levels of contaminants. The reduction of impurities that can be achieved is preferably 91-99.9% as compared to the amount of impurities in the target substance before purification. The invention is also directed to the targets products that have been so purified. | 10-27-2011 |
20120135030 | Method of Producing Protein-Carbohydrate Vaccines Reduced in Free Carbohydrate - This invention is directed to processes for reducing the level of free carbohydrate from a solution of protein-linked carbohydrate (conjugate) and non-linked carbohydrate. In this process, the conjugate is adsorbed to a hydrophobic membrane while the carbohydrate is not. The conjugate is then desorbed from the membrane, yielding a solution that is substantially reduced in free carbohydrate. | 05-31-2012 |
20120214187 | Method for Enhancing the Sensitivity of Antibody Based Assays - There is a constant need for increased sensitivity of antibody-based assays as well as a need for high affinity antibodies. Higher affinity molecules such as antibodies increase the specificity and sensitivity of assays. Both increased sensitivity and higher affinity can be achieved when multiple copies of a binding molecule are coupled to a flexible backbone. According to one embodiment of the invention, multiple copies of a detection molecule, such as, for example, an antibody or antibody fragment, are covalently linked to a high molecular weight water soluble polymer creates multivalent antibody constructs. The affinity or avidity increases markedly as multivalency increases and also, multiple copies of a signal molecule can be similarly added to the polymer. Thus, the construct comprises multiple copies of detection and signal molecules on a high molecular weight, water soluble, flexible polymer. Broadly, the invention comprises a multiplicity of detection molecules (D) and a multiplicity of signal molecules (S) on a polymer (P), such that P | 08-23-2012 |
20120288518 | Chemical Reagents for the Activation of Polysaccharides in the Preparation of Conjugate Vaccines - This invention provides novel reagents for cyanating polysaccharides in aqueous or part aqueous solutions so that they may be covalently linked to proteins either directly or through a spacer. These reagents include 1-cyano-4-pyrrolidinopyridinium tetrafluoroborate (CPPT), 1-cyano-imidazole (1-CI), 1-cyanobenzotriazole (1-CBT), or 2-cyanopyridazine-3(2H)one (2-CPO), or a functional derivative or modification thereof. The examples illustrate the use of these reagents with a variety of polysaccharides and proteins showing that the methods are generally applicable. | 11-15-2012 |
20130052204 | (POLY)-GLYCEROLPHOSPHATE-BASED ANTI-GRAM POSITIVE BACTERIAL VACCINE - Provided are an immunogenic composition comprising polyglycerol phosphate (PGP) and methods for using the composition for treating or preventing staphylococcal infections. The PGP may be conjugated to a T-cell dependent antigen. Also provided are methods for synthesizing PGP and methods for conjugating PGP to a T-cell dependent antigen. | 02-28-2013 |
20130302877 | Differential Functionalization of Polymers with Amino-Oxy Reagents for Diagnostic Assays - This invention relates to a method of conveniently functionalizing the reducing end of a carbohydrate polymer. The method also allows for the length of the polymer to be differentially functionalized. The invention provides a method for preparing polymers with a different functional groups or functionality on the sides than on the reducing end. An advantage of the method of the invention is that the procedures are simpler, preferably requiring less time, fewer steps, reduced temperatures and less harsh chemical components than conventional procedures for differential modification, with the further advantage that the reactions can be carried out in aqueous media. | 11-14-2013 |
20140186388 | Method for Producing Protein-Carbohydrate Vaccines Reduced in Free Carbohydrate - This invention is directed to processes for reducing the level of free carbohydrate from a solution of protein-linked carbohydrate (conjugate) and non-linked carbohydrate. In this process, the conjugate is adsorbed to a hydrophobic membrane while the carbohydrate is not. The conjugate is then desorbed from the membrane, yielding a solution that is substantially reduced in free carbohydrate. | 07-03-2014 |
20140316110 | Chemical Reagents for the Activation of Polysaccharides in the Preparation of Conjugate Vaccines - This invention provides novel reagents for cyanating polysaccharides in aqueous or part aqueous solutions so that they may be covalently linked to proteins either directly or through a spacer. These reagents include 1-cyano-4-pyrrolidinopyridinium tetrafluoroborate (CPPT), 1-cyano-imidazole (1-CI), 1-cyanobenzotriazole (1-CBT), or 2-cyanopyridazine-3(2H)one (2-CPO), or a functional derivative or modification thereof. The examples illustrate the use of these reagents with a variety of polysaccharides and proteins showing that the methods are generally applicable. | 10-23-2014 |
20140316111 | Chemical Reagents for the Activation of Polysaccharides in the Preparation of Conjugate Vaccines - This invention provides novel reagents for cyanating polysaccharides in aqueous or part aqueous solutions so that they may be covalently linked to proteins either directly or through a spacer. These reagents include 1-cyano-4-pyrrolidinopyridinium tetrafluoroborate (CPPT), 1-cyanoimidazole (1-CI), 1-cyanobenzotriazole (1-CBT), or 2-cyanopyridazine-3(2H)one (2-CPO), or a functional derivative or modification thereof. The examples illustrate the use of these reagents with a variety of polysaccharides and proteins showing that the methods are generally applicable. | 10-23-2014 |
20140323688 | Chemical Reagents for the Activation of Polysaccharides in the Preparation of Conjugate Vaccines - This invention provides novel reagents for cyanating polysaccharides in aqueous or part aqueous solutions so that they may be covalently linked to proteins either directly or through a spacer. These reagents include 1-cyano-4-pyrrolidinopyridinium tetrafluoroborate (CPPT), 1-cyano-imidazole (1-CI), 1-cyanobenzotriazole (1-CBT), or 2-cyanopyridazine-3(2H)one (2-CPO), or a functional derivative or modification thereof. The examples illustrate the use of these reagents with a variety of polysaccharides and proteins showing that the methods are generally applicable. | 10-30-2014 |
Patent application number | Description | Published |
20120222233 | Propane Vacuum - A vacuum cleaner having a propane fuel source, a sealed vacuum chamber and a total weight of not more than forty pounds. A vacuum cleaner system for a portable vacuum cleaner having a propane fuel source, a sealed vacuum chamber and a total weight of not more than forty pounds, and having and at least one removably attachable harness, at least one removably attachable shoulder strap, at one removably attachable set of wheels and/or at least one wheeled tray. | 09-06-2012 |
20130047367 | Propane Vacuum - A vacuum cleaner having a propane fuel source, a sealed vacuum chamber and a total weight of not more than forty pounds. A vacuum cleaner system for a portable vacuum cleaner having a propane fuel source, a sealed vacuum chamber and a total weight of not more than forty pounds, and having and at least one removably attachable harness, at least one removably attachable shoulder strap, at one removably attachable set of wheels and/or at least one wheeled tray. | 02-28-2013 |
20130061419 | PROPANE VACUUM - A vacuum cleaner having a propane fuel source, a sealed vacuum chamber and a total weight of not more than forty pounds. A vacuum cleaner system for a portable vacuum cleaner having a propane fuel source, a sealed vacuum chamber and a total weight of not more than forty pounds, and having and at least one removably attachable harness, at least one removably attachable carrier shoulder strap, at least one removably attachable handle, at least one removably attachable wheel and/or at least one rolling tray. | 03-14-2013 |
Patent application number | Description | Published |
20130022570 | CROSSLINKED POLYVINYLAMINE, POLYALLYLAMINE, AND POLYETHYLENEIMINE FOR USE AS BILE ACID SEQUESTRANTS - The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like. | 01-24-2013 |
20140356316 | AMINE POLYMERS FOR USE AS BILE ACID SEQUESTRANTS - The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like. | 12-04-2014 |
Patent application number | Description | Published |
20120020803 | TURBINE BLADES, SYSTEMS AND METHODS - A blade for use in a wind turbine comprises a pressure side and suction side meeting at a trailing edge and leading edge, the pressure side having a pressure side surface and the suction side having a suction side surface, the pressure side surface and suction side surface for providing lift to the turbine blade upon the flow of air from the leading edge to the trailing edge and over the pressure side and suction side surfaces, the pressure side and suction side extending from a root portion to a tip portion of the turbine blade. In some situations, the root portion is non-aerodynamic. The aerodynamics of such a blade is improved with the aid of pneumatic blowing through one or more blown passages for providing pressurized air (or other fluid) to a suction side and/or pressure side of the blade. | 01-26-2012 |
20130022463 | TURBINE BLADES AND SYSTEMS WITH FORWARD BLOWING SLOTS - A blade for use in a wind turbine comprises a pressure side and suction side meeting at a trailing edge and leading edge. The pressure side and suction side provide lift to the turbine blade upon the flow of air from the leading edge to the trailing edge and over the pressure side and suction side. The blade includes one or more openings at the suction side, in some cases between the leading edge and the trailing edge. The one or more openings are configured to provide a pressurized fluid towards the leading edge of the blade, in some cases at an angle between about 0° and 70° with respect to an axis oriented from a centerline of the blade toward the leading edge. | 01-24-2013 |
20130022477 | TURBINES WITH INTEGRATED COMPRESSORS AND POWER GENERATORS - A turbine system comprises a rotor operatively coupled to a plurality of blades, at least one blade of the plurality of blades having one or more blown passages for providing a pressurized fluid to a pressure side and/or suction side of the at least one blade. The rotor is selectively or simultaneously coupled to a compressor and a power generator. In some situations, the rotor is selectively coupled to one of the power generator and the compressor with the aid of a clutch. | 01-24-2013 |
Patent application number | Description | Published |
20090319540 | SYNCHRONIZATION ADAPTER FOR SYNCHRONIZING DATA TO APPLICATIONS THAT DO NOT DIRECTLY SUPPORT SYNCHRONIZATION - A synchronization adapter is coupled to the application that does not support synchronization and generates the necessary synchronization metadata for all data in the application that is to be synchronized. The synchronization adapter then combines the metadata to the actual data to be synchronized to form a synchronization feed. The synchronization feed is stored in an internal cache (or data store) which is internal to the application, or an external cache (or data store), which is external to the application, or it can be stored in both caches. The synchronization adapter also intermittently determines whether the application data has changed, thus warranting a change in its metadata, or whether a synchronization operation is warranted to synchronization operation is warranted to synchronize the data with data in another application. In either case, the synchronization adapter makes the changes to the data, or performs a synchronization operation. | 12-24-2009 |
20120303704 | CROSS LANGUAGE OBJECT SHARING - Methods, system, and computer storage media are provided for enabling cross-language object sharing by providing shareable typename information agreed upon by clients that wish to share object with each other. A first client creates an object by communicating a create request, which includes typename information associated with the object. The object is created and the typename information, along with data and properties associated with the object, is stored. A second client requests to open that object. The data, properties, and typename information stored in associated with the object is communicated to the second client so that the second client is able to create a correct instance of the object. | 11-29-2012 |
20120311725 | MODERATION OF SHARED DATA OBJECTS - Methods, system, and computer storage media are provided for moderating actions performed on shared data objects. Rule enforcement logic is received for an application that is associated with one or more data objects shared between various clients. The rule enforcement logic is stored at a data server that also stores data associated with data objects. A moderator, also stored on the data server, is used to enforce the rule enforcement logic corresponding to the application when a client attempts to perform an action to a data object associated with the application. | 12-06-2012 |
20120317170 | SUBSCRIBING TO MULTIPLE RESOURCES THROUGH A COMMON CONNECTION - Methods, systems, and computer-readable media are provided to allow multiple server resources to share a single connection to a client device. The single connection may be maintained between a notification queue on the server side and the client device. Multiple server resources share the notification queue. When a resource changes or a service wants to communicate information to a client, corresponding messages are sent to the notification queue over a connection within the data center. Once in the notification queue, the updates are communicated to the client device. | 12-13-2012 |
20120324034 | PROVIDING ACCESS TO SHARED STATE DATA - Methods, systems, and computer-readable media for manipulating in-memory data entities are provided. Embodiments of the present invention use a Representational State Transfer (“REST”) web service to manipulate the in-memory data entities. In one embodiment, a “snap shot” is taken of the in-memory data entities at a point in time to create representations of the entities. A hierarchy of the representations is built. The hierarchy is used to make the entities addressable via a URI. Embodiments of the invention may then map the entity representations in the hierarchy to the entities. An embodiment of the invention uses handlers to process a REST style request addressed to an entity representation. The handler reads the command and determines whether the command is authorized for performance on the entity and performs that command, if appropriate. | 12-20-2012 |
20130041867 | SYNCHRONIZATION ADAPTER FOR SYNCHRONIZING DATA TO APPLICATIONS THAT DO NOT DIRECTLY SUPPORT SYNCHRONIZATION - A synchronization adapter is coupled to the application that does not support synchronization and generates the necessary synchronization metadata for all data in the application that is to be synchronized. The synchronization adapter then combines the metadata to the actual data to be synchronized to form a synchronization feed. The synchronization feed is stored in an internal cache (or data store) which is internal to the application, or an external cache (or data store), which is external to the application, or it can be stored in both caches. The synchronization adapter also intermittently determines whether the application data has changed, thus warranting a change in its metadata, or whether a synchronization operation is warranted to synchronization operation is warranted to synchronize the data with data in another application. In either case, the synchronization adapter makes the changes to the data, or performs a synchronization operation. | 02-14-2013 |
20150341470 | SUBSCRIBING TO MULTIPLE RESOURCES THROUGH A COMMON CONNECTION - Methods, systems, and computer-readable media are provided to allow multiple server resources to share a single connection to a client device. The single connection may be maintained between a notification queue on the server side and the client device. Multiple server resources share the notification queue. When a resource changes or a service wants to communicate information to a client, corresponding messages are sent to the notification queue over a connection within the data center. Once in the notification queue, the updates are communicated to the client device. | 11-26-2015 |
Patent application number | Description | Published |
20090327301 | Distributed Configuration Management Using Constitutional Documents - Described is a technology in a distributed configuration network management environment, in which constitutional (governing, authoritative) documents are used to perform management tasks. The constitutional documents are structured so as to be consistent, self-contained and independently validated, yet may be combined with other constitutional documents to perform a management task. A constitutional document includes a schematic language statement, data transformation statements, and rule statements. In usage, the structured document is distributed to an agent on a client machine, which processes the structured document by transforming data and applying rules, such as to enforce network policy on client machines. | 12-31-2009 |
20090327457 | Distributed Configuration Management Using Loosely-Coupled Action-Style Documents - Described is a technology in a distributed configuration network management environment, in which action-style documents are used as guides in processing structured documents to perform management tasks. For example, the action-style documents may be used by a standard stylesheet processor to validate a constitutional document, and process input lines of that constitutional document into output lines of a document. When executed, the output lines perform a management task. In this manner, for example, policy statements of an administrator are transformed into a single type of self-contained document that is consistently interpreted, and thus consistently executed, regardless of its source or when it was authored. | 12-31-2009 |
20130145174 | INFRASTRUCTURE INDEPENDENT RECOVERY KEY RELEASE - Aspects of the subject matter described herein relate to recovering locked data. In aspects, stakeholders of locked volume(s) are identified. Security data of the volume(s) that can be used to unlock the volume(s) is collected from one or more computing devices hosting the volume(s). The security data and stakeholder data is stored on a recovery store. If a stakeholder needs to unlock a volume, the stakeholder may communicate with a recovery manager, provide certain data, and receive data that may be used to unlock the volume. Auditing may be performed for attempts to obtain the unlocking data from the recovery store. | 06-06-2013 |
20130148810 | SINGLE USE RECOVERY KEY - Aspects of the subject matter described herein relate to disclosing recovery keys. In aspects, when a recovery key is disclosed, data is updated to indicate that the recovery key has been disclosed. A machine that has locked data may determine whether a recovery key for the locked data has been disclosed and whether a new key needs to be generated for the locked data. If a new key needs to be generated for the locked data, the machine may generate the new key and send it to a recovery store for storage. In addition, old keys that protect the locked data may be deleted after the new key has been generated and stored. | 06-13-2013 |
20130160139 | Volume Encryption Lifecycle Management - Aspects of the subject matter described herein relate to encryption lifecycle management. In aspects, an orchestrating agent is installed on a device upon which encryption management is desired. During the lifecycle of the device, the orchestrating agent facilitates performing actions to protect the data of the device. For example, at certain points during the actions, the orchestrating agent may deduce the presence of external entities needed to perform the actions and interact with those entities to protect the data. During its facilitating activities, the orchestrating agent may also escrow protector data to use to unlock the data for legitimate stakeholders of the data. | 06-20-2013 |
Patent application number | Description | Published |
20100162361 | REPLICATING SELECTED SECRETS TO LOCAL DOMAIN CONTROLLERS - A domain controller hierarchy includes one or more hub domain controllers in communication with one or more local domain controllers, such as local domain controllers at a branch office. The hub domain controller(s) is writable, while the local domain controller(s) is typically read-only. Non-secure and secure information is partitioned to specific local domain controllers at the one or more hub domain controllers. The non-secure and secure information is then passed from the hub domain controller only to the local domain controller associated with the given partition at the hub domain controller on request. For example, a user requests a logon at a client computer system at a local branch office, and the logon is passed from the local domain controller to the hub domain controller. If authenticated, the user logon account is passed to the local domain controller, where it can be cached to authenticate subsequent requests. | 06-24-2010 |
20130013787 | REPLICATING SELECTED SECRETS TO LOCAL DOMAIN CONTROLLERS - A domain controller hierarchy includes one or more hub domain controllers in communication with one or more local domain controllers, such as local domain controllers at a branch office. The hub domain controller(s) is writable, while the local domain controller(s) is typically read-only. Non-secure and secure information is partitioned to specific local domain controllers at the one or more hub domain controllers. The non-secure and secure information is then passed from the hub domain controller only to the local domain controller associated with the given partition at the hub domain controller on request. For example, a user requests a logon at a client computer system at a local branch office, and the logon is passed from the local domain controller to the hub domain controller. If authenticated, the user logon account is passed to the local domain controller, where it can be cached to authenticate subsequent requests. | 01-10-2013 |